This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of cardiovascular pathology, including new cardiac devices, molecular panels and genetics, the latest tumor classifications, up-to-date COVID-19 information, and imaging, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Cardiovascular is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Covers all areas of cardiovascular pathology, organizing chapters by how specimens are most often encountered in practice—biopsy, surgical specimens, transplant, and autopsy—as well as by anatomic site
Contains significantly updated information throughout (text, images, illustrations, and references) including the latest World Health Organization and International Collaboration on Cancer Reporting tumor classifications, new details related to staging and grading of tumors of the heart and lungs, and COVID-19 information
Evaluates a new generation of cardiac devices in surgical and autopsy specimens in both images and text
Includes new material on genetics and sudden cardiac death and cardiomyopathy, recent recommended amyloid treatment therapies, and new information on the reclassification of pulmonary arterial hypertension
Features more than 1,400 images, including carefully annotated histology and gross pathology photos, vivid medical illustrations, photomicrographs, and electron micrographs to help practicing and in-training pathologists reach a confident diagnosis
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedications - p. v 6. Preface - p. vi 7. Acknowledgments - p. vii 8. Sections - p. xi 9. List of Tables - p. xii 10. SECTION 1: HEART, ENDOMYOCARDIAL BIOPSY - p. 1 11. CONGENITAL/GENETIC - p. 1 12. Endocardial Fibroelastosis Syndrome - p. 1 13. Arrhythmogenic Cardiomyopathy - p. 5 14. Fatty Acid Metabolic Disorders - p. 11 15. Mitochondrial Myopathies - p. 13 16. Muscular Dystrophies - p. 17 17. Glycogen Storage Diseases - p. 21 18. Fabry Disease, Heart - p. 23 19. LAMP2 Mutation (Danon Disease) - p. 27 20. ACQUIRED - p. 29 21. Amyloid Deposition, Heart - p. 29 22. Hemochromatosis, Heart - p. 37 23. Anthracycline Cardiotoxicity - p. 39 24. Catecholamine Cardiomyopathy - p. 41 25. Cocaine Cardiotoxicity - p. 43 26. Immune Checkpoint Inhibitor Toxicity - p. 45 27. INFLAMMATORY - p. 49 28. Lymphocytic Myocarditis - p. 49 29. Giant Cell Myocarditis - p. 53 30. Eosinophilic (Löffler) Myocarditis - p. 55 31. Sarcoidosis, Heart - p. 59 32. Acute Rheumatic Carditis - p. 61 33. Eosinophilic Granulomatosis With Polyangiitis - p. 65 34. Viral Myocarditis - p. 67 35. Toxoplasmosis, Heart - p. 69 36. Chagas Disease, Heart - p. 71 37. Lyme Disease and Rickettsial Myocarditis - p. 75 38. SARS-CoV-2 (COVID-19)-Related Cardiovascular Disease - p. 79 39. Lupus Erythematosus, Heart - p. 83 40. TRANSPLANT REJECTION - p. 89 41. Acute Cellular Transplant Rejection, Heart - p. 89 42. Antibody-Mediated Transplant Rejection, Heart - p. 95 43. Quilty Lesions - p. 101 44. Previous Biopsy Sites, Heart Transplant - p. 105 45. Posttransplant Lymphoproliferative Disorder, Heart - p. 107 46. Harvesting Injury/Acute Ischemia, Heart - p. 109 47. SECTION 2: HEART, RESECTION - p. 113 48. HEART EXPLANT - p. 113 49. Hypertrophic Cardiomyopathy - p. 113 50. Idiopathic Dilated Cardiomyopathy - p. 121 51. Ischemic Heart Disease - p. 125 52. Overview of Coronary Artery Stents - p. 129 53. Cardiac Allograft Vasculopathy - p. 133 54. Radiation Injury, Heart - p. 139 55. Cardiac Conduction System Disease - p. 141 56. Ventricular Assist Devices - p. 149 57. Approach to Cardiomyopathy (Worksheet) - p. 155 58. Approach to Cardiomyopathy Diagnosis - p. 157 59. SECTION 3: HEART, TUMORS - p. 163 60. BENIGN - p. 163 61. Cardiac Myxoma - p. 163 62. Papillary Fibroelastoma - p. 171 63. Cardiac Rhabdomyoma - p. 175 64. Cardiac Fibroma - p. 179 65. Ectopic Tissues, Heart - p. 183 66. Lipomatous Hypertrophy of Atrial Septum - p. 185 67. MALIGNANT - p. 187 68. Cardiac Lymphoma - p. 187 69. Cardiac Angiosarcoma - p. 189 70. Cardiac Sarcoma, Other - p. 193 71. Cardiac Metastases - p. 197 72. SECTION 4: CARDIAC VALVES, NATIVE - p. 203 73. AORTIC - p. 203 74. Unicommissural Aortic Valve - p. 203 75. Bicuspid Aortic Valve - p. 209 76. Senile Calcific Aortic Stenosis - p. 213 77. Discrete Membranous Subaortic Stenosis - p. 217 78. MITRAL - p. 219 79. Myxomatous Mitral Valve Disease - p. 219 80. Rheumatic Heart Disease - p. 223 81. TRICUSPID - p. 227 82. Carcinoid Heart Disease - p. 227 83. Ebstein Anomaly - p. 231 84. PULMONARY - p. 233 85. Congenital Pulmonary Stenosis - p. 233 86. ENDOCARDITIS - p. 235 87. Endocarditis, Native Valve - p. 235 88. Nonbacterial Thrombotic Endocarditis - p. 239 89. SECTION 5: CARDIAC VALVES - p. 243 90. PROSTHETIC - p. 243 91. Leaflet Degeneration, Prosthetic Valves - p. 243 92. Thrombosis of Prosthetic Valves - p. 249 93. Endocarditis, Prosthetic Valve - p. 251 94. Mechanical Heart Valve Prostheses: Modes of Failure - p. 257 95. Catheter-Deployed Valve Therapies - p. 259 96. SECTION 6: PERICARDIUM - p. 265 97. INFLAMMATORY - p. 265 98. Acute Pericarditis - p. 265 99. Constrictive Pericarditis - p. 271 100. Tuberculous Pericarditis - p. 273 101. TUMORS - p. 275 102. Lymphoma, Pericardium - p. 275 103. Metastatic Tumor, Pericardium - p. 277 104. Mesothelioma, Pericardium - p. 281 105. Mesothelial/Monocytic Incidental Cardiac Excrescence - p. 285 106. SECTION 7: VASCULAR DISEASE - p. 287 107. ENDARTERECTOMY/ATHERECTOMY/THROMBECTOMY - p. 287 108. Overview of Peripheral Vascular Specimens - p. 287 109. Thromboembolus, Vascular - p. 295 110. THORACIC AORTA - p. 299 111. Aortic Degenerative Diseases - p. 299 112. Genetic Diseases of the Aorta - p. 307 113. Noninfectious Aortitis - p. 311 114. Takayasu Arteritis - p. 315 115. Aortic Dissection - p. 319 116. Aortic Coarctation - p. 323 117. ABDOMINAL AORTA - p. 327 118. Aortic Atherosclerosis and Complications - p. 327 119. Chronic Periaortitis and IgG4-Related Disease - p. 333 120. Mycotic Aneurysm - p. 335 121. CORONARY ARTERIES - p. 339 122. Atherosclerosis, Coronary - p. 339 123. Coronary Artery Dissection - p. 343 124. Kawasaki Disease - p. 347 125. Coronary Artery Emboli - p. 351 126. TEMPORAL ARTERIES - p. 353 127. Giant Cell/Temporal Arteritis - p. 353 128. PERIPHERAL VESSELS - p. 357 129. Buerger Disease (Thromboangiitis Obliterans) - p. 357 130. Fibromuscular Dysplasia - p. 361 131. Segmental Arterial Mediolysis - p. 367 132. Mönckeberg Medial Calcific Sclerosis - p. 369 133. Behçet Disease - p. 371 134. Infectious Vasculitis - p. 375 135. Lymphocytic Venulitis - p. 381 136. Varicosities - p. 383 137. Hypertensive Renovascular Diseases - p. 385 138. VASCULAR TISSUE GRAFTS - p. 389 139. Vascular Graft Pseudoaneurysm - p. 389 140. SECTION 8: VASCULAR TUMORS - p. 393 141. BENIGN - p. 393 142. Hemangioma - p. 393 143. Angiomyolipoma - p. 405 144. Glomus Tumor - p. 409 145. Cystic Lymphangioma - p. 417 146. Arteriovenous Malformations - p. 419 147. MALIGNANT - p. 423 148. Epithelioid Hemangioendothelioma - p. 423 149. Kaposi Sarcoma - p. 427 150. Angiosarcoma - p. 433 151. SECTION 9: AUTOPSY - p. 439 152. CARDIAC - p. 439 153. Coronary Artery Bypass Grafting - p. 439 154. Valve Replacement (Including Transcatheter) - p. 445 155. Infective Endocarditis - p. 451 156. Ventricular Assist Device Insertion - p. 457 157. Heart Transplant - p. 461 158. VASCULAR - p. 467 159. Thoracic Aortic Aneurysm Repair - p. 467 160. Abdominal Aortic Aneurysm - p. 473 161. Cerebral Aneurysm and Vascular Malformation - p. 477 162. INDEX - p. 483
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of cardiovascular pathology, including new cardiac devices, molecular panels and genetics, the latest tumor classifications, up-to-date COVID-19 information, and imaging, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Cardiovascular is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Covers all areas of cardiovascular pathology, organizing chapters by how specimens are most often encountered in practice—biopsy, surgical specimens, transplant, and autopsy—as well as by anatomic site
Contains significantly updated information throughout (text, images, illustrations, and references) including the latest World Health Organization and International Collaboration on Cancer Reporting tumor classifications, new details related to staging and grading of tumors of the heart and lungs, and COVID-19 information
Evaluates a new generation of cardiac devices in surgical and autopsy specimens in both images and text
Includes new material on genetics and sudden cardiac death and cardiomyopathy, recent recommended amyloid treatment therapies, and new information on the reclassification of pulmonary arterial hypertension
Features more than 1,400 images, including carefully annotated histology and gross pathology photos, vivid medical illustrations, photomicrographs, and electron micrographs to help practicing and in-training pathologists reach a confident diagnosis
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedications - p. v 6. Preface - p. vi 7. Acknowledgments - p. vii 8. Sections - p. xi 9. List of Tables - p. xii 10. SECTION 1: HEART, ENDOMYOCARDIAL BIOPSY - p. 1 11. CONGENITAL/GENETIC - p. 1 12. Endocardial Fibroelastosis Syndrome - p. 1 13. Arrhythmogenic Cardiomyopathy - p. 5 14. Fatty Acid Metabolic Disorders - p. 11 15. Mitochondrial Myopathies - p. 13 16. Muscular Dystrophies - p. 17 17. Glycogen Storage Diseases - p. 21 18. Fabry Disease, Heart - p. 23 19. LAMP2 Mutation (Danon Disease) - p. 27 20. ACQUIRED - p. 29 21. Amyloid Deposition, Heart - p. 29 22. Hemochromatosis, Heart - p. 37 23. Anthracycline Cardiotoxicity - p. 39 24. Catecholamine Cardiomyopathy - p. 41 25. Cocaine Cardiotoxicity - p. 43 26. Immune Checkpoint Inhibitor Toxicity - p. 45 27. INFLAMMATORY - p. 49 28. Lymphocytic Myocarditis - p. 49 29. Giant Cell Myocarditis - p. 53 30. Eosinophilic (Löffler) Myocarditis - p. 55 31. Sarcoidosis, Heart - p. 59 32. Acute Rheumatic Carditis - p. 61 33. Eosinophilic Granulomatosis With Polyangiitis - p. 65 34. Viral Myocarditis - p. 67 35. Toxoplasmosis, Heart - p. 69 36. Chagas Disease, Heart - p. 71 37. Lyme Disease and Rickettsial Myocarditis - p. 75 38. SARS-CoV-2 (COVID-19)-Related Cardiovascular Disease - p. 79 39. Lupus Erythematosus, Heart - p. 83 40. TRANSPLANT REJECTION - p. 89 41. Acute Cellular Transplant Rejection, Heart - p. 89 42. Antibody-Mediated Transplant Rejection, Heart - p. 95 43. Quilty Lesions - p. 101 44. Previous Biopsy Sites, Heart Transplant - p. 105 45. Posttransplant Lymphoproliferative Disorder, Heart - p. 107 46. Harvesting Injury/Acute Ischemia, Heart - p. 109 47. SECTION 2: HEART, RESECTION - p. 113 48. HEART EXPLANT - p. 113 49. Hypertrophic Cardiomyopathy - p. 113 50. Idiopathic Dilated Cardiomyopathy - p. 121 51. Ischemic Heart Disease - p. 125 52. Overview of Coronary Artery Stents - p. 129 53. Cardiac Allograft Vasculopathy - p. 133 54. Radiation Injury, Heart - p. 139 55. Cardiac Conduction System Disease - p. 141 56. Ventricular Assist Devices - p. 149 57. Approach to Cardiomyopathy (Worksheet) - p. 155 58. Approach to Cardiomyopathy Diagnosis - p. 157 59. SECTION 3: HEART, TUMORS - p. 163 60. BENIGN - p. 163 61. Cardiac Myxoma - p. 163 62. Papillary Fibroelastoma - p. 171 63. Cardiac Rhabdomyoma - p. 175 64. Cardiac Fibroma - p. 179 65. Ectopic Tissues, Heart - p. 183 66. Lipomatous Hypertrophy of Atrial Septum - p. 185 67. MALIGNANT - p. 187 68. Cardiac Lymphoma - p. 187 69. Cardiac Angiosarcoma - p. 189 70. Cardiac Sarcoma, Other - p. 193 71. Cardiac Metastases - p. 197 72. SECTION 4: CARDIAC VALVES, NATIVE - p. 203 73. AORTIC - p. 203 74. Unicommissural Aortic Valve - p. 203 75. Bicuspid Aortic Valve - p. 209 76. Senile Calcific Aortic Stenosis - p. 213 77. Discrete Membranous Subaortic Stenosis - p. 217 78. MITRAL - p. 219 79. Myxomatous Mitral Valve Disease - p. 219 80. Rheumatic Heart Disease - p. 223 81. TRICUSPID - p. 227 82. Carcinoid Heart Disease - p. 227 83. Ebstein Anomaly - p. 231 84. PULMONARY - p. 233 85. Congenital Pulmonary Stenosis - p. 233 86. ENDOCARDITIS - p. 235 87. Endocarditis, Native Valve - p. 235 88. Nonbacterial Thrombotic Endocarditis - p. 239 89. SECTION 5: CARDIAC VALVES - p. 243 90. PROSTHETIC - p. 243 91. Leaflet Degeneration, Prosthetic Valves - p. 243 92. Thrombosis of Prosthetic Valves - p. 249 93. Endocarditis, Prosthetic Valve - p. 251 94. Mechanical Heart Valve Prostheses: Modes of Failure - p. 257 95. Catheter-Deployed Valve Therapies - p. 259 96. SECTION 6: PERICARDIUM - p. 265 97. INFLAMMATORY - p. 265 98. Acute Pericarditis - p. 265 99. Constrictive Pericarditis - p. 271 100. Tuberculous Pericarditis - p. 273 101. TUMORS - p. 275 102. Lymphoma, Pericardium - p. 275 103. Metastatic Tumor, Pericardium - p. 277 104. Mesothelioma, Pericardium - p. 281 105. Mesothelial/Monocytic Incidental Cardiac Excrescence - p. 285 106. SECTION 7: VASCULAR DISEASE - p. 287 107. ENDARTERECTOMY/ATHERECTOMY/THROMBECTOMY - p. 287 108. Overview of Peripheral Vascular Specimens - p. 287 109. Thromboembolus, Vascular - p. 295 110. THORACIC AORTA - p. 299 111. Aortic Degenerative Diseases - p. 299 112. Genetic Diseases of the Aorta - p. 307 113. Noninfectious Aortitis - p. 311 114. Takayasu Arteritis - p. 315 115. Aortic Dissection - p. 319 116. Aortic Coarctation - p. 323 117. ABDOMINAL AORTA - p. 327 118. Aortic Atherosclerosis and Complications - p. 327 119. Chronic Periaortitis and IgG4-Related Disease - p. 333 120. Mycotic Aneurysm - p. 335 121. CORONARY ARTERIES - p. 339 122. Atherosclerosis, Coronary - p. 339 123. Coronary Artery Dissection - p. 343 124. Kawasaki Disease - p. 347 125. Coronary Artery Emboli - p. 351 126. TEMPORAL ARTERIES - p. 353 127. Giant Cell/Temporal Arteritis - p. 353 128. PERIPHERAL VESSELS - p. 357 129. Buerger Disease (Thromboangiitis Obliterans) - p. 357 130. Fibromuscular Dysplasia - p. 361 131. Segmental Arterial Mediolysis - p. 367 132. Mönckeberg Medial Calcific Sclerosis - p. 369 133. Behçet Disease - p. 371 134. Infectious Vasculitis - p. 375 135. Lymphocytic Venulitis - p. 381 136. Varicosities - p. 383 137. Hypertensive Renovascular Diseases - p. 385 138. VASCULAR TISSUE GRAFTS - p. 389 139. Vascular Graft Pseudoaneurysm - p. 389 140. SECTION 8: VASCULAR TUMORS - p. 393 141. BENIGN - p. 393 142. Hemangioma - p. 393 143. Angiomyolipoma - p. 405 144. Glomus Tumor - p. 409 145. Cystic Lymphangioma - p. 417 146. Arteriovenous Malformations - p. 419 147. MALIGNANT - p. 423 148. Epithelioid Hemangioendothelioma - p. 423 149. Kaposi Sarcoma - p. 427 150. Angiosarcoma - p. 433 151. SECTION 9: AUTOPSY - p. 439 152. CARDIAC - p. 439 153. Coronary Artery Bypass Grafting - p. 439 154. Valve Replacement (Including Transcatheter) - p. 445 155. Infective Endocarditis - p. 451 156. Ventricular Assist Device Insertion - p. 457 157. Heart Transplant - p. 461 158. VASCULAR - p. 467 159. Thoracic Aortic Aneurysm Repair - p. 467 160. Abdominal Aortic Aneurysm - p. 473 161. Cerebral Aneurysm and Vascular Malformation - p. 477 162. INDEX - p. 483
