This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners and trainees at all levels of experience and training. Covering all aspects of cytology, including gynecologic, nongynecologic exfoliative, fine-needle aspiration, and imaging, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Cytopathology is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Covers all areas of cytopathology, including clinical, radiologic, and immunohistochemical as well as cytopathologic features and molecular correlates where applicable
Contains new chapters on ancillary molecular tests specific to thyroid, prognostic/therapy-related immunomarkers in cell blocks, and small biopsies
Provides new immunohistochemical and molecular coverage, including new immunostains and genomic targets
Incorporates new reporting terminology (such as serous fluid and effusions) and updates to existing reporting terminologies
Reflects the expanded use of fine-needle aspiration for small biopsies (FNA-B) with many more images added and updated throughout
Keeps you up-to-date with current and emerging reporting systems on pancreaticobiliary, salivary, breast, and soft tissue cytology
Features more than 3,000 print and online images, including carefully annotated histology and gross pathology photos, full-color illustrations, clinical photographs, and radiologic images to help practicing and in-training pathologists reach a confident diagnosis
Includes new videos on such topics as the cytoprepratory process, cell transfer cell block and smears, collodion bag cell block, and more
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert cytopathology reference at the point of care
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Additional Contributors - p. v 7. Preface - p. v 8. Acknowledgments - p. ix 9. Sections - p. xi 10. TABLE OF CONTENTS - p. xiii 11. Part I: Gynecologic Cytopathology - p. xiii 12. SECTION 1: OVERVIEW - p. xiii 13. List of Tables - p. xiii 14. Chapter 1: Pap Test and Cervical Cancer Screening: History and Reporting Terminology - p. xiii 15. Chapter 2: Cytopreparation, Instrumentation, and Automated Screening in Gynecologic Cytology - p. 7 16. Chapter 3: Specimen Adequacy in Cervicovaginal Cytology - p. 9 17. SECTION 2: BENIGN AND INFECTIOUS CONDITIONS - p. 11 18. Chapter 4: Normal Pap Test - p. 11 19. Chapter 5: Infectious and Other Organisms in Pap Tests - p. 15 20. Chapter 6: Nonneoplastic Findings, Mimics, and Artifacts - p. 17 21. SECTION 3: SQUAMOUS CELL ABNORMALITIES AND MIMICS - p. 25 22. Chapter 7: Low-Grade Squamous Intraepithelial Lesion and Mimics - p. 25 23. Chapter 8: High-Grade Squamous Intraepithelial Lesion and Mimics - p. 29 24. Chapter 9: Atypical Squamous Cells of Undetermined Significance - p. 33 25. Chapter 10: Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intraepithelial Lesion - p. 35 26. Chapter 11: Squamous Cell Carcinoma of Cervix, Variants and Mimics - p. 37 27. SECTION 4: GLANDULAR CELL ABNORMALITIES AND MIMICS - p. 43 28. Chapter 12: Endocervical Adenocarcinoma In Situ, Variants and Mimics - p. 43 29. Chapter 13: Endocervical Adenocarcinoma, Variants and Mimics - p. 51 30. Chapter 14: Adenocarcinoma, Gastric Type - p. 55 31. Chapter 15: Endometrial Cancers: Usual Types, Variants, and Mimics - p. 57 32. Chapter 16: Atypical Glandular Cells: Endocervicals, Endometrials, and Glandulars, NOS - p. 63 33. Chapter 17: Endometrial Cells in Pap Test and Glandular Cells Status Post Hysterectomy - p. 69 34. SECTION 5: EXTRAUTERINE CARCINOMAS AND OTHER MALIGNANCIES OF FEMALE GENITAL TRACT - p. 71 35. Chapter 18: Extrauterine Carcinomas and Presentations in Cervicovaginal Cytology - p. 71 36. Chapter 19: Neuroendocrine Carcinoma of Cervix - p. 75 37. Chapter 20: Other Uncommon Malignancies in Cervicovaginal Cytology - p. 77 38. SECTION 6: MOLECULAR TESTING IN GYNECOLOGIC CYTOLOGY - p. 81 39. Chapter 21: HPV and Other Molecular Testing in Gynecologic Cytology - p. 81 40. SECTION 7: DIRECTLY SAMPLED ENDOMETRIAL CYTOLOGY - p. 87 41. Chapter 22: Directly Sampled Endometrial Cytology - p. 87 42. SECTION 8: ANAL CYTOLOGY - p. 93 43. Chapter 23: Anal Cytology - p. 93 44. Part II: Exfoliative Cytopathology - p. 97 45. SECTION 1: RESPIRATORY TRACT, INCLUDING LUNG FNAS - p. 97 46. Chapter 24: Specimen Types in Respiratory Cytology and Adequacy Criteria - p. 97 47. Chapter 25: Benign and Reactive Changes - p. 101 48. Chapter 26: Pneumocystis Pneumonia and Mimics - p. 105 49. Chapter 27: Fungal Organisms in Respiratory Cytology - p. 107 50. Chapter 28: Parasitic Organisms in Respiratory Cytology - p. 109 51. Chapter 29: Viral Infections (Cytomegalovirus, Herpesvirus, and Others) - p. 111 52. Chapter 30: Mycobacteria and Other Bacterial Infections - p. 113 53. Chapter 31: Sarcoidosis and Other Immune-Related Conditions - p. 115 54. Chapter 32: Pulmonary Alveolar Proteinosis and Mimics - p. 117 55. Chapter 33: Miscellaneous Findings, Including Contaminants - p. 119 56. Chapter 34: Adenocarcinoma - p. 121 57. Chapter 35: Squamous Cell Carcinoma - p. 125 58. Chapter 36: Small Cell Carcinoma - p. 127 59. Chapter 37: Large Cell Neuroendocrine Carcinoma - p. 129 60. Chapter 38: Carcinoid and Atypical Carcinoid - p. 131 61. Chapter 39: Rare Benign and Low Malignant Potential Tumors - p. 133 62. Chapter 40: Rare Malignant Tumors - p. 135 63. Chapter 41: NUT Carcinoma - p. 137 64. Chapter 42: SMARCA4-Deficient Undifferentiated Tumor - p. 138 65. Chapter 43: Pulmonary Lymphoma - p. 139 66. Chapter 44: Pulmonary Metastasis - p. 141 67. SECTION 2: GASTROINTESTINAL TRACT - p. 143 68. Chapter 45: Specimen Types in Gastrointestinal Cytology and Normal Cellular Components - p. 143 69. Chapter 46: Parasitic Infections - p. 147 70. Chapter 47: Viral Infections - p. 149 71. Chapter 48: Esophagitis and Barrett Esophagus - p. 151 72. Chapter 49: Esophageal Adenocarcinoma - p. 153 73. Chapter 50: Esophageal Squamous Cell Carcinoma - p. 155 74. Chapter 51: Gastritis and Intestinal Metaplasia - p. 157 75. Chapter 52: Gastric Adenocarcinoma - p. 159 76. Chapter 53: Gastric Lymphoma - p. 161 77. Chapter 54: Ampulla/Bile Duct/Pancreatic Duct Reactive Changes - p. 163 78. Chapter 55: Ampulla/Bile Duct/Pancreatic Duct Adenocarcinoma - p. 165 79. Chapter 56: Colorectal Adenoma/Carcinoma - p. 167 80. Chapter 57: Neuroendocrine Tumor/Carcinoma - p. 169 81. Chapter 58: Spindle Cell Neoplasms of Gastrointestinal Tract, Including Gastrointestinal Stromal Tumors - p. 171 82. SECTION 3: CEREBROSPINAL FLUID - p. 173 83. Chapter 59: Normal Cerebrospinal Fluid and Contamination by Normal Elements - p. 173 84. Chapter 60: Infectious Meningitis - p. 179 85. Chapter 61: Aseptic and Mollaret Meningitis - p. 181 86. Chapter 62: Subarachnoid Hemorrhage - p. 183 87. Chapter 63: Neurodegenerative Diseases - p. 185 88. Chapter 64: Primary Brain Tumors - p. 187 89. Chapter 65: Leukemia and Lymphoma - p. 189 90. Chapter 66: Metastasis in Cerebrospinal Fluid - p. 191 91. SECTION 4: PLEURAL, PERITONEAL, PERICARDIAL, AND PELVIC FLUID AND WASHINGS - p. 193 92. Chapter 67: Normal Cellular Components, Reactive Mesothelial Proliferations, and Reporting Terminology - p. 193 93. Chapter 68: Infectious Conditions - p. 199 94. Chapter 69: Autoimmune Diseases - p. 201 95. Chapter 70: Malignant Effusion, Mesothelioma - p. 203 96. Chapter 71: Malignant Effusion, Carcinomas - p. 207 97. Chapter 72: Malignant Effusion, Sarcomas - p. 211 98. Chapter 73: Lymphoid Effusions and Lymphomas - p. 213 99. Chapter 74: Primary Effusion Lymphoma - p. 215 100. Chapter 75: Endometriosis and Endosalpingiosis - p. 217 101. Chapter 76: Ovarian Neoplasms - p. 219 102. Chapter 77: Immunocytochemistry, Histochemistry, and Other Ancillary Techniques - p. 221 103. SECTION 5: URINARY CYTOLOGY - p. 225 104. Chapter 78: Normal Urinary Cytology, Specimen Types, and Reporting Terminology - p. 225 105. Chapter 79: Ileal Conduit Specimens - p. 231 106. Chapter 80: Noninfectious Benign Conditions - p. 233 107. Chapter 81: Infectious Benign Conditions - p. 235 108. Chapter 82: Reactive Urothelial Changes - p. 237 109. Chapter 83: Low-Grade Urothelial Lesions - p. 239 110. Chapter 84: Atypical Urothelial Cells - p. 240 111. Chapter 85: High-Grade Urothelial Dysplasia/Carcinoma/Carcinoma In Situ - p. 241 112. Chapter 86: Squamous Cell Carcinoma of Urinary Bladder - p. 243 113. Chapter 87: Adenocarcinoma of Urinary Bladder - p. 245 114. Chapter 88: Other Malignancies in Urinary Cytology - p. 247 115. Chapter 89: Renal Pelvic Cytology - p. 249 116. Chapter 90: Ancillary Testing, UroVysion, and Others - p. 251 117. Part III: Fine-Needle Aspiration, Superficial - p. 253 118. SECTION 1: OVERVIEW - p. 253 119. Chapter 91: Superficial Aspiration Technique - p. 253 120. SECTION 2: THYROID GLAND - p. 257 121. Chapter 92: Ultrasound-Guided Thyroid Fine-Needle Aspiration - p. 257 122. Chapter 93: Thyroid Fine-Needle Aspiration Reporting Terminology and Specimen Adequacy - p. 265 123. Chapter 94: Adenomatous (Benign Follicular) Nodule - p. 267 124. Chapter 95: Chronic Lymphocytic/Hashimoto Thyroiditis - p. 269 125. Chapter 96: Granulomatous Thyroiditis - p. 271 126. Chapter 97: Graves Disease/Diffuse Toxic Goiter - p. 273 127. Chapter 98: Pigmented Thyroid Lesions and Crystals - p. 274 128. Chapter 99: Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance - p. 275 129. Chapter 100: Follicular Neoplasm/Suspicious for a Follicular Neoplasm - p. 279 130. Chapter 101: Follicular Neoplasm, Oncocytic (Hürthle Cell) Type - p. 283 131. Chapter 102: Papillary Thyroid Carcinoma, Classic Subtype - p. 285 132. Chapter 103: Papillary Thyroid Carcinoma Subtypes - p. 289 133. Chapter 104: Medullary Thyroid Carcinoma - p. 297 134. Chapter 105: Poorly Differentiated Thyroid Carcinoma - p. 301 135. Chapter 106: Anaplastic Thyroid Carcinoma - p. 303 136. Chapter 107: Thyroid Lymphoma - p. 305 137. Chapter 108: Metastatic Carcinoma to Thyroid - p. 307 138. Chapter 109: Other Nonneoplastic and Neoplastic Thyroid Lesions Encountered on Thyroid FNA - p. 309 139. SECTION 3: PARATHYROID GLAND - p. 315 140. Chapter 110: Parathyroid Cyst, Adenoma, and Carcinoma - p. 315 141. SECTION 4: LYMPH NODES - p. 321 142. OVERVIEW - p. 321 143. Chapter 111: Lymph Node Aspiration: Indications, Techniques, and Reporting - p. 321 144. Chapter 112: FNA Sample Prep and Triage in Evaluating Suspected Lymphoma - p. 325 145. BENIGN, INFECTIOUS, AND REACTIVE HYPERPLASIA - p. 327 146. Chapter 113: Inflammatory and Reactive Lymphoid Hyperplasia - p. 327 147. Chapter 114: Granulomatous Lymphadenitis, Infectious and Sarcoid - p. 329 148. Chapter 115: Rosai-Dorfman Disease - p. 333 149. METASTATIC MALIGNANCIES - p. 335 150. Chapter 116: Metastatic Malignancies (Carcinoma, Melanoma) - p. 335 151. Chapter 117: HPV-Positive Head and Neck Squamous Cell Carcinoma - p. 337 152. NODAL B-CELL LYMPHOMA - p. 341 153. Chapter 118: Small Lymphocytic Lymphoma - p. 341 154. Chapter 119: Lymphoplasmacytic Lymphoma - p. 343 155. Chapter 120: Mantle Cell Lymphoma - p. 345 156. Chapter 121: Nodal Marginal Zone Lymphoma - p. 347 157. Chapter 122: Follicular Lymphoma - p. 349 158. Chapter 123: Burkitt Lymphoma - p. 351 159. Chapter 124: Large B-Cell Lymphoma - p. 353 160. EXTRANODAL B-CELL LYMPHOMA - p. 355 161. Chapter 125: Plasmacytoma - p. 355 162. Chapter 126: Mediastinal Large B-Cell Lymphoma - p. 357 163. Chapter 127: Plasmablastic Lymphoma - p. 359 164. T-CELL LYMPHOMA - p. 361 165. Chapter 128: Peripheral T-Cell Lymphoma - p. 361 166. Chapter 129: Mycosis Fungoides - p. 363 167. Chapter 130: Angioimmunoblastic Lymphoma - p. 365 168. Chapter 131: ALK(+) Anaplastic Large Cell Lymphoma - p. 367 169. Chapter 132: T-Cell Lymphoblastic Lymphoma - p. 369 170. HODGKIN LYMPHOMA - p. 371 171. Chapter 133: Nodular Lymphocyte-Predominant Hodgkin Lymphoma - p. 371 172. Chapter 134: Classic Hodgkin Lymphoma - p. 373 173. SECTION 5: SALIVARY GLAND - p. 375 174. OVERVIEW - p. 375 175. Chapter 135: Approach to Interpretation of Salivary Gland Aspiration Biopsies and Reporting Terminology (Milan System) - p. 375 176. BENIGN LESIONS - p. 381 177. Chapter 136: Normal Salivary Gland and Sialadenitis on Aspiration - p. 381 178. Chapter 137: Cysts - p. 383 179. Chapter 138: Pleomorphic Adenoma - p. 385 180. Chapter 139: Warthin Tumor - p. 387 181. Chapter 140: Myoepithelioma - p. 389 182. Chapter 141: Oncocytoma, Salivary Gland - p. 390 183. MALIGNANT NEOPLASMS - p. 391 184. Chapter 142: Adenoid Cystic Carcinoma - p. 391 185. Chapter 143: Acinic Cell Carcinoma - p. 393 186. Chapter 144: Mucoepidermoid Carcinoma - p. 395 187. Chapter 145: Basaloid Neoplasms, Benign and Malignant - p. 397 188. Chapter 146: Carcinoma Ex Pleomorphic Adenoma - p. 399 189. Chapter 147: Adenocarcinoma, NOS - p. 401 190. Chapter 148: Polymorphous Adenocarcinoma - p. 403 191. Chapter 149: Salivary Duct Carcinoma - p. 405 192. Chapter 150: Secretory Carcinoma - p. 407 193. Chapter 151: Myoepithelial Carcinoma - p. 409 194. Chapter 152: Cribriform Adenocarcinoma - p. 410 195. Chapter 153: Metastatic Carcinoma - p. 411 196. Chapter 154: Primary and Metastatic Nonepithelial Tumors - p. 413 197. SECTION 6: BREAST - p. 415 198. OVERVIEW - p. 415 199. Chapter 155: Role of Fine-Needle Aspiration of Breast, Techniques and Triple Test - p. 415 200. BENIGN BREAST LESIONS - p. 419 201. Chapter 156: Inflammatory and Granulomatous Conditions - p. 419 202. Chapter 157: Fat Necrosis - p. 421 203. Chapter 158: Nonproliferative and Proliferative Changes in Breast - p. 423 204. Chapter 159: Radial Scar/Complex Sclerosing Lesion - p. 427 205. Chapter 160: Gynecomastia - p. 429 206. Chapter 161: Mucocele-Like Lesion - p. 431 207. BENIGN NEOPLASMS - p. 433 208. Chapter 162: Fibroadenoma - p. 433 209. Chapter 163: Granular Cell Tumor of Breast - p. 437 210. Chapter 164: Papillary Neoplasms - p. 439 211. Chapter 165: Myofibroblastoma, Mammary - p. 445 212. MALIGNANT NEOPLASMS - p. 447 213. Chapter 166: Ductal Carcinoma and Variants of Invasive Mammary Carcinoma - p. 447 214. Chapter 167: Lobular Carcinoma - p. 455 215. Chapter 168: Phyllodes Tumor - p. 457 216. Chapter 169: Angiosarcoma and Other Sarcomas - p. 459 217. Chapter 170: Lymphomas and Metastatic Tumors - p. 463 218. NIPPLE DISCHARGE - p. 465 219. Chapter 171: Cytology Specimens for Risk Assessment of Breast Cancer - p. 465 220. SECTION 7: SKIN AND SUBCUTANEOUS CYTOLOGY - p. 467 221. Chapter 172: Cutaneous and Adnexal Cytology - p. 467 222. Part IV: Fine-Needle Aspiration, Deep Organs and Tissues - p. 473 223. SECTION 1: OVERVIEW - p. 473 224. Chapter 173: Techniques and Modalities of Deep Aspiration Biopsies - p. 473 225. SECTION 2: MEDIASTINUM - p. 479 226. OVERVIEW - p. 479 227. Chapter 174: Anatomic Compartments and Constituent Tumors - p. 479 228. NONNEOPLASTIC LESIONS - p. 483 229. Chapter 175: Mediastinal Cysts and Inflammatory Lesions - p. 483 230. NEOPLASMS - p. 485 231. Chapter 176: Thymoma - p. 485 232. Chapter 177: Thymic Carcinoma - p. 487 233. Chapter 178: Germ Cell Tumors - p. 489 234. Chapter 179: Neurogenic Tumors - p. 491 235. Chapter 180: Metastatic Tumors of Mediastinum - p. 493 236. SECTION 3: LIVER - p. 495 237. OVERVIEW - p. 495 238. Chapter 181: Cytology of Normal Liver - p. 495 239. Chapter 182: Inflammatory and Infectious Conditions of Liver - p. 499 240. BENIGN HEPATIC NEOPLASMS - p. 501 241. Chapter 183: Hepatocellular Adenoma - p. 501 242. Chapter 184: Focal Nodular Hyperplasia - p. 503 243. Chapter 185: Hemangioma, Liver - p. 505 244. MALIGNANT NEOPLASMS - p. 507 245. Chapter 186: Hepatocellular Carcinoma - p. 507 246. Chapter 187: Hepatoblastoma - p. 509 247. Chapter 188: Liver Metastasis - p. 511 248. SECTION 4: KIDNEY - p. 513 249. OVERVIEW - p. 513 250. Chapter 189: Cytology of Normal Kidney - p. 513 251. BENIGN LESIONS AND NEOPLASMS - p. 517 252. Chapter 190: Renal Cysts - p. 517 253. Chapter 191: Angiomyolipoma - p. 519 254. Chapter 192: Oncocytoma, Kidney - p. 521 255. Chapter 193: Metanephric Adenoma - p. 523 256. Chapter 194: Metanephric Stromal Tumor - p. 525 257. Chapter 195: Xanthogranulomatous Pyelonephritis/Malakoplakia - p. 526 258. MALIGNANT NEOPLASMS - p. 527 259. Chapter 196: Clear Cell Renal Cell Carcinoma - p. 527 260. Chapter 197: Papillary Renal Cell Carcinoma - p. 531 261. Chapter 198: Clear Cell Papillary Renal Cell Carcinoma - p. 533 262. Chapter 199: Chromophobe Renal Cell Carcinoma - p. 535 263. Chapter 200: TFE3- and TFEB-Rearranged Renal Cell Carcinomas - p. 537 264. Chapter 201: Collecting Duct Carcinoma - p. 539 265. Chapter 202: Renal Medullary Carcinoma - p. 540 266. Chapter 203: Mucinous Tubular and Spindle Cell Carcinoma of Kidney - p. 541 267. Chapter 204: Carcinoid Tumor - p. 542 268. Chapter 205: Primary Renal Sarcomas in Adults - p. 543 269. Chapter 206: Renal Lymphomas - p. 544 270. Chapter 207: Nephroblastoma (Wilms Tumor) - p. 545 271. Chapter 208: Clear Cell Sarcoma of Kidney - p. 547 272. Chapter 209: Congenital Mesoblastic Nephroma - p. 549 273. Chapter 210: Rhabdoid Tumor of Kidney - p. 551 274. Chapter 211: Metastatic Tumors to Kidney - p. 552 275. TUMORS OF RENAL PELVIS - p. 553 276. Chapter 212: Urothelial Carcinoma - p. 553 277. SECTION 5: ADRENAL GLAND - p. 555 278. OVERVIEW - p. 555 279. Chapter 213: Cytology of Normal Adrenal Gland - p. 555 280. ADRENAL CORTICAL LESIONS - p. 559 281. Chapter 214: Adrenal Cortical Adenoma - p. 559 282. Chapter 215: Adrenal Cortical Carcinoma - p. 561 283. Chapter 216: Metastatic Tumors to Adrenal Gland - p. 563 284. ADRENAL MEDULLARY LESIONS - p. 565 285. Chapter 217: Pheochromocytoma - p. 565 286. SECTION 6: PANCREAS - p. 567 287. OVERVIEW - p. 567 288. Chapter 218: Cytology of Normal Pancreas - p. 567 289. Chapter 219: Pancreaticobiliary Cytology Reporting Terminology, Cyst Evaluation - p. 571 290. NONNEOPLASTIC LESIONS - p. 573 291. Chapter 220: Pancreatitis - p. 573 292. Chapter 221: Lymphoepithelial Cyst of Pancreas - p. 575 293. Chapter 222: Intra- and Peripancreatic Splenules - p. 576 294. NEOPLASMS - p. 577 295. Chapter 223: Serous Microcystic Adenoma - p. 577 296. Chapter 224: Mucinous Cystic Neoplasm - p. 579 297. Chapter 225: Intraductal Papillary Mucinous Neoplasm - p. 581 298. Chapter 226: Solid Pseudopapillary Neoplasm - p. 583 299. Chapter 227: Pancreatic Neuroendocrine Tumor - p. 585 300. Chapter 228: Pancreatic Ductal Adenocarcinoma - p. 587 301. Chapter 229: Unusual Variants of Ductal Carcinoma - p. 589 302. Chapter 230: Acinar Cell Carcinoma - p. 593 303. SECTION 7: BONE - p. 595 304. OVERVIEW - p. 595 305. Chapter 231: Lymphoma and Secondary Tumors of Pancreas - p. 595 306. Chapter 232: Approach to Cytologic/Small Biopsy Diagnosis of Primary Bone Tumors - p. 597 307. NEOPLASMS - p. 601 308. Chapter 233: Chondromas of Bone and Soft Tissue - p. 601 309. Chapter 234: Chondroblastoma - p. 603 310. Chapter 235: Giant Cell Tumor - p. 605 311. Chapter 236: Osteoblastoma - p. 607 312. Chapter 237: Adamantinoma - p. 609 313. Chapter 238: Langerhans Cell Histiocytosis - p. 611 314. Chapter 239: Chordoma - p. 613 315. Chapter 240: Osteosarcoma - p. 615 316. Chapter 241: Chondrosarcoma - p. 619 317. Chapter 242: Ewing Sarcoma - p. 623 318. Chapter 243: Bone Lymphoma - p. 627 319. Chapter 244: Metastatic Tumors of Bone - p. 629 320. SECTION 8: SOFT TISSUE - p. 631 321. OVERVIEW - p. 631 322. Chapter 245: Approach to Cytologic/Small Biopsy Diagnosis of Primary Soft Tissue Lesions - p. 631 323. ADIPOCYTIC TUMORS - p. 635 324. Chapter 246: Benign Adipose Tissue Tumors - p. 635 325. Chapter 247: Liposarcoma - p. 637 326. FIBROBLASTIC/MYOFIBROBLASTIC LESIONS - p. 641 327. Chapter 248: Fibrosarcoma - p. 641 328. Chapter 249: Myofibroblastoma - p. 643 329. Chapter 250: Low-Grade Myofibroblastic Sarcoma - p. 645 330. FIBROHISTIOCYTIC TUMORS - p. 647 331. Chapter 251: Giant Cell Tumor of Tendon Sheath - p. 647 332. Chapter 252: Undifferentiated Pleomorphic Sarcoma - p. 649 333. TUMORS OF MUSCLE ORIGIN - p. 651 334. Chapter 253: Smooth Muscle Tumors - p. 651 335. Chapter 254: Skeletal Muscle Tumors - p. 653 336. VASCULAR TUMORS - p. 657 337. Chapter 255: Hemangioma, Soft Tissue - p. 657 338. Chapter 256: Epithelioid Hemangioendothelioma - p. 659 339. Chapter 257: Angiosarcoma - p. 661 340. OTHER TUMORS - p. 663 341. Chapter 258: Other Reactive and Neoplastic Soft Tissue Entities - p. 663 342. Chapter 259: Mesenchymal Chondrosarcoma - p. 665 343. Chapter 260: Solitary Fibrous Tumor - p. 666 344. Chapter 261: Intramuscular Myxoma - p. 667 345. Chapter 262: Synovial Sarcoma - p. 669 346. Chapter 263: Epithelioid Sarcoma - p. 671 347. Chapter 264: Alveolar Soft Part Sarcoma - p. 673 348. Chapter 265: Clear Cell Sarcoma of Soft Tissue - p. 675 349. Chapter 266: Desmoplastic Small Round Cell Tumor - p. 677 350. SECTION 9: OPHTHALMIC AND NEUROPATHOLOGY - p. 679 351. Chapter 267: Approach to Ophthalmic Cytology - p. 679 352. Chapter 268: Ophthalmic Cytopathology, Infectious - p. 685 353. Chapter 269: Ophthalmic Cytopathology, Neoplastic - p. 689 354. Chapter 270: Neuropathology Squash Preparations, Infectious - p. 695 355. Chapter 271: Neuropathology Squash Preparations, Glial Neoplasms - p. 699 356. Chapter 272: Neuropathology Squash Preparations, Nonglial Neoplasms - p. 703 357. Part V: Management and Ancillary Testing - p. 707 358. SECTION 1: CYTOPREPARATORY AND QUALITY MANAGEMENT - p. 707 359. Chapter 273: Cytopreparatory Techniques and Instrumentation in Nongynecologic Cytology - p. 707 360. Chapter 274: Quality Improvement and Laboratory Management for Cytopathology - p. 715 361. SECTION 2: ANCILLARY TESTING - p. 721 362. Chapter 275: Immunocytochemistry - p. 721 363. Chapter 276: Molecular Techniques - p. 727 364. INDEX - p. 733
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners and trainees at all levels of experience and training. Covering all aspects of cytology, including gynecologic, nongynecologic exfoliative, fine-needle aspiration, and imaging, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Cytopathology is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Covers all areas of cytopathology, including clinical, radiologic, and immunohistochemical as well as cytopathologic features and molecular correlates where applicable
Contains new chapters on ancillary molecular tests specific to thyroid, prognostic/therapy-related immunomarkers in cell blocks, and small biopsies
Provides new immunohistochemical and molecular coverage, including new immunostains and genomic targets
Incorporates new reporting terminology (such as serous fluid and effusions) and updates to existing reporting terminologies
Reflects the expanded use of fine-needle aspiration for small biopsies (FNA-B) with many more images added and updated throughout
Keeps you up-to-date with current and emerging reporting systems on pancreaticobiliary, salivary, breast, and soft tissue cytology
Features more than 3,000 print and online images, including carefully annotated histology and gross pathology photos, full-color illustrations, clinical photographs, and radiologic images to help practicing and in-training pathologists reach a confident diagnosis
Includes new videos on such topics as the cytoprepratory process, cell transfer cell block and smears, collodion bag cell block, and more
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert cytopathology reference at the point of care
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Additional Contributors - p. v 7. Preface - p. v 8. Acknowledgments - p. ix 9. Sections - p. xi 10. TABLE OF CONTENTS - p. xiii 11. Part I: Gynecologic Cytopathology - p. xiii 12. SECTION 1: OVERVIEW - p. xiii 13. List of Tables - p. xiii 14. Chapter 1: Pap Test and Cervical Cancer Screening: History and Reporting Terminology - p. xiii 15. Chapter 2: Cytopreparation, Instrumentation, and Automated Screening in Gynecologic Cytology - p. 7 16. Chapter 3: Specimen Adequacy in Cervicovaginal Cytology - p. 9 17. SECTION 2: BENIGN AND INFECTIOUS CONDITIONS - p. 11 18. Chapter 4: Normal Pap Test - p. 11 19. Chapter 5: Infectious and Other Organisms in Pap Tests - p. 15 20. Chapter 6: Nonneoplastic Findings, Mimics, and Artifacts - p. 17 21. SECTION 3: SQUAMOUS CELL ABNORMALITIES AND MIMICS - p. 25 22. Chapter 7: Low-Grade Squamous Intraepithelial Lesion and Mimics - p. 25 23. Chapter 8: High-Grade Squamous Intraepithelial Lesion and Mimics - p. 29 24. Chapter 9: Atypical Squamous Cells of Undetermined Significance - p. 33 25. Chapter 10: Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intraepithelial Lesion - p. 35 26. Chapter 11: Squamous Cell Carcinoma of Cervix, Variants and Mimics - p. 37 27. SECTION 4: GLANDULAR CELL ABNORMALITIES AND MIMICS - p. 43 28. Chapter 12: Endocervical Adenocarcinoma In Situ, Variants and Mimics - p. 43 29. Chapter 13: Endocervical Adenocarcinoma, Variants and Mimics - p. 51 30. Chapter 14: Adenocarcinoma, Gastric Type - p. 55 31. Chapter 15: Endometrial Cancers: Usual Types, Variants, and Mimics - p. 57 32. Chapter 16: Atypical Glandular Cells: Endocervicals, Endometrials, and Glandulars, NOS - p. 63 33. Chapter 17: Endometrial Cells in Pap Test and Glandular Cells Status Post Hysterectomy - p. 69 34. SECTION 5: EXTRAUTERINE CARCINOMAS AND OTHER MALIGNANCIES OF FEMALE GENITAL TRACT - p. 71 35. Chapter 18: Extrauterine Carcinomas and Presentations in Cervicovaginal Cytology - p. 71 36. Chapter 19: Neuroendocrine Carcinoma of Cervix - p. 75 37. Chapter 20: Other Uncommon Malignancies in Cervicovaginal Cytology - p. 77 38. SECTION 6: MOLECULAR TESTING IN GYNECOLOGIC CYTOLOGY - p. 81 39. Chapter 21: HPV and Other Molecular Testing in Gynecologic Cytology - p. 81 40. SECTION 7: DIRECTLY SAMPLED ENDOMETRIAL CYTOLOGY - p. 87 41. Chapter 22: Directly Sampled Endometrial Cytology - p. 87 42. SECTION 8: ANAL CYTOLOGY - p. 93 43. Chapter 23: Anal Cytology - p. 93 44. Part II: Exfoliative Cytopathology - p. 97 45. SECTION 1: RESPIRATORY TRACT, INCLUDING LUNG FNAS - p. 97 46. Chapter 24: Specimen Types in Respiratory Cytology and Adequacy Criteria - p. 97 47. Chapter 25: Benign and Reactive Changes - p. 101 48. Chapter 26: Pneumocystis Pneumonia and Mimics - p. 105 49. Chapter 27: Fungal Organisms in Respiratory Cytology - p. 107 50. Chapter 28: Parasitic Organisms in Respiratory Cytology - p. 109 51. Chapter 29: Viral Infections (Cytomegalovirus, Herpesvirus, and Others) - p. 111 52. Chapter 30: Mycobacteria and Other Bacterial Infections - p. 113 53. Chapter 31: Sarcoidosis and Other Immune-Related Conditions - p. 115 54. Chapter 32: Pulmonary Alveolar Proteinosis and Mimics - p. 117 55. Chapter 33: Miscellaneous Findings, Including Contaminants - p. 119 56. Chapter 34: Adenocarcinoma - p. 121 57. Chapter 35: Squamous Cell Carcinoma - p. 125 58. Chapter 36: Small Cell Carcinoma - p. 127 59. Chapter 37: Large Cell Neuroendocrine Carcinoma - p. 129 60. Chapter 38: Carcinoid and Atypical Carcinoid - p. 131 61. Chapter 39: Rare Benign and Low Malignant Potential Tumors - p. 133 62. Chapter 40: Rare Malignant Tumors - p. 135 63. Chapter 41: NUT Carcinoma - p. 137 64. Chapter 42: SMARCA4-Deficient Undifferentiated Tumor - p. 138 65. Chapter 43: Pulmonary Lymphoma - p. 139 66. Chapter 44: Pulmonary Metastasis - p. 141 67. SECTION 2: GASTROINTESTINAL TRACT - p. 143 68. Chapter 45: Specimen Types in Gastrointestinal Cytology and Normal Cellular Components - p. 143 69. Chapter 46: Parasitic Infections - p. 147 70. Chapter 47: Viral Infections - p. 149 71. Chapter 48: Esophagitis and Barrett Esophagus - p. 151 72. Chapter 49: Esophageal Adenocarcinoma - p. 153 73. Chapter 50: Esophageal Squamous Cell Carcinoma - p. 155 74. Chapter 51: Gastritis and Intestinal Metaplasia - p. 157 75. Chapter 52: Gastric Adenocarcinoma - p. 159 76. Chapter 53: Gastric Lymphoma - p. 161 77. Chapter 54: Ampulla/Bile Duct/Pancreatic Duct Reactive Changes - p. 163 78. Chapter 55: Ampulla/Bile Duct/Pancreatic Duct Adenocarcinoma - p. 165 79. Chapter 56: Colorectal Adenoma/Carcinoma - p. 167 80. Chapter 57: Neuroendocrine Tumor/Carcinoma - p. 169 81. Chapter 58: Spindle Cell Neoplasms of Gastrointestinal Tract, Including Gastrointestinal Stromal Tumors - p. 171 82. SECTION 3: CEREBROSPINAL FLUID - p. 173 83. Chapter 59: Normal Cerebrospinal Fluid and Contamination by Normal Elements - p. 173 84. Chapter 60: Infectious Meningitis - p. 179 85. Chapter 61: Aseptic and Mollaret Meningitis - p. 181 86. Chapter 62: Subarachnoid Hemorrhage - p. 183 87. Chapter 63: Neurodegenerative Diseases - p. 185 88. Chapter 64: Primary Brain Tumors - p. 187 89. Chapter 65: Leukemia and Lymphoma - p. 189 90. Chapter 66: Metastasis in Cerebrospinal Fluid - p. 191 91. SECTION 4: PLEURAL, PERITONEAL, PERICARDIAL, AND PELVIC FLUID AND WASHINGS - p. 193 92. Chapter 67: Normal Cellular Components, Reactive Mesothelial Proliferations, and Reporting Terminology - p. 193 93. Chapter 68: Infectious Conditions - p. 199 94. Chapter 69: Autoimmune Diseases - p. 201 95. Chapter 70: Malignant Effusion, Mesothelioma - p. 203 96. Chapter 71: Malignant Effusion, Carcinomas - p. 207 97. Chapter 72: Malignant Effusion, Sarcomas - p. 211 98. Chapter 73: Lymphoid Effusions and Lymphomas - p. 213 99. Chapter 74: Primary Effusion Lymphoma - p. 215 100. Chapter 75: Endometriosis and Endosalpingiosis - p. 217 101. Chapter 76: Ovarian Neoplasms - p. 219 102. Chapter 77: Immunocytochemistry, Histochemistry, and Other Ancillary Techniques - p. 221 103. SECTION 5: URINARY CYTOLOGY - p. 225 104. Chapter 78: Normal Urinary Cytology, Specimen Types, and Reporting Terminology - p. 225 105. Chapter 79: Ileal Conduit Specimens - p. 231 106. Chapter 80: Noninfectious Benign Conditions - p. 233 107. Chapter 81: Infectious Benign Conditions - p. 235 108. Chapter 82: Reactive Urothelial Changes - p. 237 109. Chapter 83: Low-Grade Urothelial Lesions - p. 239 110. Chapter 84: Atypical Urothelial Cells - p. 240 111. Chapter 85: High-Grade Urothelial Dysplasia/Carcinoma/Carcinoma In Situ - p. 241 112. Chapter 86: Squamous Cell Carcinoma of Urinary Bladder - p. 243 113. Chapter 87: Adenocarcinoma of Urinary Bladder - p. 245 114. Chapter 88: Other Malignancies in Urinary Cytology - p. 247 115. Chapter 89: Renal Pelvic Cytology - p. 249 116. Chapter 90: Ancillary Testing, UroVysion, and Others - p. 251 117. Part III: Fine-Needle Aspiration, Superficial - p. 253 118. SECTION 1: OVERVIEW - p. 253 119. Chapter 91: Superficial Aspiration Technique - p. 253 120. SECTION 2: THYROID GLAND - p. 257 121. Chapter 92: Ultrasound-Guided Thyroid Fine-Needle Aspiration - p. 257 122. Chapter 93: Thyroid Fine-Needle Aspiration Reporting Terminology and Specimen Adequacy - p. 265 123. Chapter 94: Adenomatous (Benign Follicular) Nodule - p. 267 124. Chapter 95: Chronic Lymphocytic/Hashimoto Thyroiditis - p. 269 125. Chapter 96: Granulomatous Thyroiditis - p. 271 126. Chapter 97: Graves Disease/Diffuse Toxic Goiter - p. 273 127. Chapter 98: Pigmented Thyroid Lesions and Crystals - p. 274 128. Chapter 99: Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance - p. 275 129. Chapter 100: Follicular Neoplasm/Suspicious for a Follicular Neoplasm - p. 279 130. Chapter 101: Follicular Neoplasm, Oncocytic (Hürthle Cell) Type - p. 283 131. Chapter 102: Papillary Thyroid Carcinoma, Classic Subtype - p. 285 132. Chapter 103: Papillary Thyroid Carcinoma Subtypes - p. 289 133. Chapter 104: Medullary Thyroid Carcinoma - p. 297 134. Chapter 105: Poorly Differentiated Thyroid Carcinoma - p. 301 135. Chapter 106: Anaplastic Thyroid Carcinoma - p. 303 136. Chapter 107: Thyroid Lymphoma - p. 305 137. Chapter 108: Metastatic Carcinoma to Thyroid - p. 307 138. Chapter 109: Other Nonneoplastic and Neoplastic Thyroid Lesions Encountered on Thyroid FNA - p. 309 139. SECTION 3: PARATHYROID GLAND - p. 315 140. Chapter 110: Parathyroid Cyst, Adenoma, and Carcinoma - p. 315 141. SECTION 4: LYMPH NODES - p. 321 142. OVERVIEW - p. 321 143. Chapter 111: Lymph Node Aspiration: Indications, Techniques, and Reporting - p. 321 144. Chapter 112: FNA Sample Prep and Triage in Evaluating Suspected Lymphoma - p. 325 145. BENIGN, INFECTIOUS, AND REACTIVE HYPERPLASIA - p. 327 146. Chapter 113: Inflammatory and Reactive Lymphoid Hyperplasia - p. 327 147. Chapter 114: Granulomatous Lymphadenitis, Infectious and Sarcoid - p. 329 148. Chapter 115: Rosai-Dorfman Disease - p. 333 149. METASTATIC MALIGNANCIES - p. 335 150. Chapter 116: Metastatic Malignancies (Carcinoma, Melanoma) - p. 335 151. Chapter 117: HPV-Positive Head and Neck Squamous Cell Carcinoma - p. 337 152. NODAL B-CELL LYMPHOMA - p. 341 153. Chapter 118: Small Lymphocytic Lymphoma - p. 341 154. Chapter 119: Lymphoplasmacytic Lymphoma - p. 343 155. Chapter 120: Mantle Cell Lymphoma - p. 345 156. Chapter 121: Nodal Marginal Zone Lymphoma - p. 347 157. Chapter 122: Follicular Lymphoma - p. 349 158. Chapter 123: Burkitt Lymphoma - p. 351 159. Chapter 124: Large B-Cell Lymphoma - p. 353 160. EXTRANODAL B-CELL LYMPHOMA - p. 355 161. Chapter 125: Plasmacytoma - p. 355 162. Chapter 126: Mediastinal Large B-Cell Lymphoma - p. 357 163. Chapter 127: Plasmablastic Lymphoma - p. 359 164. T-CELL LYMPHOMA - p. 361 165. Chapter 128: Peripheral T-Cell Lymphoma - p. 361 166. Chapter 129: Mycosis Fungoides - p. 363 167. Chapter 130: Angioimmunoblastic Lymphoma - p. 365 168. Chapter 131: ALK(+) Anaplastic Large Cell Lymphoma - p. 367 169. Chapter 132: T-Cell Lymphoblastic Lymphoma - p. 369 170. HODGKIN LYMPHOMA - p. 371 171. Chapter 133: Nodular Lymphocyte-Predominant Hodgkin Lymphoma - p. 371 172. Chapter 134: Classic Hodgkin Lymphoma - p. 373 173. SECTION 5: SALIVARY GLAND - p. 375 174. OVERVIEW - p. 375 175. Chapter 135: Approach to Interpretation of Salivary Gland Aspiration Biopsies and Reporting Terminology (Milan System) - p. 375 176. BENIGN LESIONS - p. 381 177. Chapter 136: Normal Salivary Gland and Sialadenitis on Aspiration - p. 381 178. Chapter 137: Cysts - p. 383 179. Chapter 138: Pleomorphic Adenoma - p. 385 180. Chapter 139: Warthin Tumor - p. 387 181. Chapter 140: Myoepithelioma - p. 389 182. Chapter 141: Oncocytoma, Salivary Gland - p. 390 183. MALIGNANT NEOPLASMS - p. 391 184. Chapter 142: Adenoid Cystic Carcinoma - p. 391 185. Chapter 143: Acinic Cell Carcinoma - p. 393 186. Chapter 144: Mucoepidermoid Carcinoma - p. 395 187. Chapter 145: Basaloid Neoplasms, Benign and Malignant - p. 397 188. Chapter 146: Carcinoma Ex Pleomorphic Adenoma - p. 399 189. Chapter 147: Adenocarcinoma, NOS - p. 401 190. Chapter 148: Polymorphous Adenocarcinoma - p. 403 191. Chapter 149: Salivary Duct Carcinoma - p. 405 192. Chapter 150: Secretory Carcinoma - p. 407 193. Chapter 151: Myoepithelial Carcinoma - p. 409 194. Chapter 152: Cribriform Adenocarcinoma - p. 410 195. Chapter 153: Metastatic Carcinoma - p. 411 196. Chapter 154: Primary and Metastatic Nonepithelial Tumors - p. 413 197. SECTION 6: BREAST - p. 415 198. OVERVIEW - p. 415 199. Chapter 155: Role of Fine-Needle Aspiration of Breast, Techniques and Triple Test - p. 415 200. BENIGN BREAST LESIONS - p. 419 201. Chapter 156: Inflammatory and Granulomatous Conditions - p. 419 202. Chapter 157: Fat Necrosis - p. 421 203. Chapter 158: Nonproliferative and Proliferative Changes in Breast - p. 423 204. Chapter 159: Radial Scar/Complex Sclerosing Lesion - p. 427 205. Chapter 160: Gynecomastia - p. 429 206. Chapter 161: Mucocele-Like Lesion - p. 431 207. BENIGN NEOPLASMS - p. 433 208. Chapter 162: Fibroadenoma - p. 433 209. Chapter 163: Granular Cell Tumor of Breast - p. 437 210. Chapter 164: Papillary Neoplasms - p. 439 211. Chapter 165: Myofibroblastoma, Mammary - p. 445 212. MALIGNANT NEOPLASMS - p. 447 213. Chapter 166: Ductal Carcinoma and Variants of Invasive Mammary Carcinoma - p. 447 214. Chapter 167: Lobular Carcinoma - p. 455 215. Chapter 168: Phyllodes Tumor - p. 457 216. Chapter 169: Angiosarcoma and Other Sarcomas - p. 459 217. Chapter 170: Lymphomas and Metastatic Tumors - p. 463 218. NIPPLE DISCHARGE - p. 465 219. Chapter 171: Cytology Specimens for Risk Assessment of Breast Cancer - p. 465 220. SECTION 7: SKIN AND SUBCUTANEOUS CYTOLOGY - p. 467 221. Chapter 172: Cutaneous and Adnexal Cytology - p. 467 222. Part IV: Fine-Needle Aspiration, Deep Organs and Tissues - p. 473 223. SECTION 1: OVERVIEW - p. 473 224. Chapter 173: Techniques and Modalities of Deep Aspiration Biopsies - p. 473 225. SECTION 2: MEDIASTINUM - p. 479 226. OVERVIEW - p. 479 227. Chapter 174: Anatomic Compartments and Constituent Tumors - p. 479 228. NONNEOPLASTIC LESIONS - p. 483 229. Chapter 175: Mediastinal Cysts and Inflammatory Lesions - p. 483 230. NEOPLASMS - p. 485 231. Chapter 176: Thymoma - p. 485 232. Chapter 177: Thymic Carcinoma - p. 487 233. Chapter 178: Germ Cell Tumors - p. 489 234. Chapter 179: Neurogenic Tumors - p. 491 235. Chapter 180: Metastatic Tumors of Mediastinum - p. 493 236. SECTION 3: LIVER - p. 495 237. OVERVIEW - p. 495 238. Chapter 181: Cytology of Normal Liver - p. 495 239. Chapter 182: Inflammatory and Infectious Conditions of Liver - p. 499 240. BENIGN HEPATIC NEOPLASMS - p. 501 241. Chapter 183: Hepatocellular Adenoma - p. 501 242. Chapter 184: Focal Nodular Hyperplasia - p. 503 243. Chapter 185: Hemangioma, Liver - p. 505 244. MALIGNANT NEOPLASMS - p. 507 245. Chapter 186: Hepatocellular Carcinoma - p. 507 246. Chapter 187: Hepatoblastoma - p. 509 247. Chapter 188: Liver Metastasis - p. 511 248. SECTION 4: KIDNEY - p. 513 249. OVERVIEW - p. 513 250. Chapter 189: Cytology of Normal Kidney - p. 513 251. BENIGN LESIONS AND NEOPLASMS - p. 517 252. Chapter 190: Renal Cysts - p. 517 253. Chapter 191: Angiomyolipoma - p. 519 254. Chapter 192: Oncocytoma, Kidney - p. 521 255. Chapter 193: Metanephric Adenoma - p. 523 256. Chapter 194: Metanephric Stromal Tumor - p. 525 257. Chapter 195: Xanthogranulomatous Pyelonephritis/Malakoplakia - p. 526 258. MALIGNANT NEOPLASMS - p. 527 259. Chapter 196: Clear Cell Renal Cell Carcinoma - p. 527 260. Chapter 197: Papillary Renal Cell Carcinoma - p. 531 261. Chapter 198: Clear Cell Papillary Renal Cell Carcinoma - p. 533 262. Chapter 199: Chromophobe Renal Cell Carcinoma - p. 535 263. Chapter 200: TFE3- and TFEB-Rearranged Renal Cell Carcinomas - p. 537 264. Chapter 201: Collecting Duct Carcinoma - p. 539 265. Chapter 202: Renal Medullary Carcinoma - p. 540 266. Chapter 203: Mucinous Tubular and Spindle Cell Carcinoma of Kidney - p. 541 267. Chapter 204: Carcinoid Tumor - p. 542 268. Chapter 205: Primary Renal Sarcomas in Adults - p. 543 269. Chapter 206: Renal Lymphomas - p. 544 270. Chapter 207: Nephroblastoma (Wilms Tumor) - p. 545 271. Chapter 208: Clear Cell Sarcoma of Kidney - p. 547 272. Chapter 209: Congenital Mesoblastic Nephroma - p. 549 273. Chapter 210: Rhabdoid Tumor of Kidney - p. 551 274. Chapter 211: Metastatic Tumors to Kidney - p. 552 275. TUMORS OF RENAL PELVIS - p. 553 276. Chapter 212: Urothelial Carcinoma - p. 553 277. SECTION 5: ADRENAL GLAND - p. 555 278. OVERVIEW - p. 555 279. Chapter 213: Cytology of Normal Adrenal Gland - p. 555 280. ADRENAL CORTICAL LESIONS - p. 559 281. Chapter 214: Adrenal Cortical Adenoma - p. 559 282. Chapter 215: Adrenal Cortical Carcinoma - p. 561 283. Chapter 216: Metastatic Tumors to Adrenal Gland - p. 563 284. ADRENAL MEDULLARY LESIONS - p. 565 285. Chapter 217: Pheochromocytoma - p. 565 286. SECTION 6: PANCREAS - p. 567 287. OVERVIEW - p. 567 288. Chapter 218: Cytology of Normal Pancreas - p. 567 289. Chapter 219: Pancreaticobiliary Cytology Reporting Terminology, Cyst Evaluation - p. 571 290. NONNEOPLASTIC LESIONS - p. 573 291. Chapter 220: Pancreatitis - p. 573 292. Chapter 221: Lymphoepithelial Cyst of Pancreas - p. 575 293. Chapter 222: Intra- and Peripancreatic Splenules - p. 576 294. NEOPLASMS - p. 577 295. Chapter 223: Serous Microcystic Adenoma - p. 577 296. Chapter 224: Mucinous Cystic Neoplasm - p. 579 297. Chapter 225: Intraductal Papillary Mucinous Neoplasm - p. 581 298. Chapter 226: Solid Pseudopapillary Neoplasm - p. 583 299. Chapter 227: Pancreatic Neuroendocrine Tumor - p. 585 300. Chapter 228: Pancreatic Ductal Adenocarcinoma - p. 587 301. Chapter 229: Unusual Variants of Ductal Carcinoma - p. 589 302. Chapter 230: Acinar Cell Carcinoma - p. 593 303. SECTION 7: BONE - p. 595 304. OVERVIEW - p. 595 305. Chapter 231: Lymphoma and Secondary Tumors of Pancreas - p. 595 306. Chapter 232: Approach to Cytologic/Small Biopsy Diagnosis of Primary Bone Tumors - p. 597 307. NEOPLASMS - p. 601 308. Chapter 233: Chondromas of Bone and Soft Tissue - p. 601 309. Chapter 234: Chondroblastoma - p. 603 310. Chapter 235: Giant Cell Tumor - p. 605 311. Chapter 236: Osteoblastoma - p. 607 312. Chapter 237: Adamantinoma - p. 609 313. Chapter 238: Langerhans Cell Histiocytosis - p. 611 314. Chapter 239: Chordoma - p. 613 315. Chapter 240: Osteosarcoma - p. 615 316. Chapter 241: Chondrosarcoma - p. 619 317. Chapter 242: Ewing Sarcoma - p. 623 318. Chapter 243: Bone Lymphoma - p. 627 319. Chapter 244: Metastatic Tumors of Bone - p. 629 320. SECTION 8: SOFT TISSUE - p. 631 321. OVERVIEW - p. 631 322. Chapter 245: Approach to Cytologic/Small Biopsy Diagnosis of Primary Soft Tissue Lesions - p. 631 323. ADIPOCYTIC TUMORS - p. 635 324. Chapter 246: Benign Adipose Tissue Tumors - p. 635 325. Chapter 247: Liposarcoma - p. 637 326. FIBROBLASTIC/MYOFIBROBLASTIC LESIONS - p. 641 327. Chapter 248: Fibrosarcoma - p. 641 328. Chapter 249: Myofibroblastoma - p. 643 329. Chapter 250: Low-Grade Myofibroblastic Sarcoma - p. 645 330. FIBROHISTIOCYTIC TUMORS - p. 647 331. Chapter 251: Giant Cell Tumor of Tendon Sheath - p. 647 332. Chapter 252: Undifferentiated Pleomorphic Sarcoma - p. 649 333. TUMORS OF MUSCLE ORIGIN - p. 651 334. Chapter 253: Smooth Muscle Tumors - p. 651 335. Chapter 254: Skeletal Muscle Tumors - p. 653 336. VASCULAR TUMORS - p. 657 337. Chapter 255: Hemangioma, Soft Tissue - p. 657 338. Chapter 256: Epithelioid Hemangioendothelioma - p. 659 339. Chapter 257: Angiosarcoma - p. 661 340. OTHER TUMORS - p. 663 341. Chapter 258: Other Reactive and Neoplastic Soft Tissue Entities - p. 663 342. Chapter 259: Mesenchymal Chondrosarcoma - p. 665 343. Chapter 260: Solitary Fibrous Tumor - p. 666 344. Chapter 261: Intramuscular Myxoma - p. 667 345. Chapter 262: Synovial Sarcoma - p. 669 346. Chapter 263: Epithelioid Sarcoma - p. 671 347. Chapter 264: Alveolar Soft Part Sarcoma - p. 673 348. Chapter 265: Clear Cell Sarcoma of Soft Tissue - p. 675 349. Chapter 266: Desmoplastic Small Round Cell Tumor - p. 677 350. SECTION 9: OPHTHALMIC AND NEUROPATHOLOGY - p. 679 351. Chapter 267: Approach to Ophthalmic Cytology - p. 679 352. Chapter 268: Ophthalmic Cytopathology, Infectious - p. 685 353. Chapter 269: Ophthalmic Cytopathology, Neoplastic - p. 689 354. Chapter 270: Neuropathology Squash Preparations, Infectious - p. 695 355. Chapter 271: Neuropathology Squash Preparations, Glial Neoplasms - p. 699 356. Chapter 272: Neuropathology Squash Preparations, Nonglial Neoplasms - p. 703 357. Part V: Management and Ancillary Testing - p. 707 358. SECTION 1: CYTOPREPARATORY AND QUALITY MANAGEMENT - p. 707 359. Chapter 273: Cytopreparatory Techniques and Instrumentation in Nongynecologic Cytology - p. 707 360. Chapter 274: Quality Improvement and Laboratory Management for Cytopathology - p. 715 361. SECTION 2: ANCILLARY TESTING - p. 721 362. Chapter 275: Immunocytochemistry - p. 721 363. Chapter 276: Molecular Techniques - p. 727 364. INDEX - p. 733
