Part of the highly regarded Diagnostic Pathology series and written by Danny A. Milner, Jr., MD, this updated volume covers all aspects of infectious disease pathology, including anatomic manifestations and how to ensure a complete and accurate sign out at the microscope. Concise, focused chapters, supported by thousands of high-quality images, make this second edition an excellent point-of-care resource for pathologists at all levels of experience and training—both as a quick reference and as an efficient review to improve knowledge and skills.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributing Authors - p. v 7. Preface - p. v 8. Acknowledgments - p. ix 9. Sections - p. xi 10. SECTION 1: OVERVIEW - p. xiii 11. Chapter 1: Standard Methods for Infectious Diseases - p. xiii 12. SECTION 2: VIRAL INFECTIONS - p. 9 13. MORPHOLOGIC DIAGNOSIS OF VIRAL INFECTIONS - p. 9 14. DNA VIRUSES - p. 9 15. Chapter 2: Herpes Simplex Virus 1 and 2 (HSV-1, HSV-2) Infections - p. 9 16. Chapter 3: Varicella-Zoster Virus (HHV-3) Infections - p. 17 17. Chapter 4: Epstein-Barr Virus (HHV-4) Infection - p. 21 18. Chapter 5: Cytomegalovirus (HHV-5) Infections - p. 23 19. Chapter 6: Kaposi Sarcoma-Associated Herpesvirus (HHV-8) Infection - p. 29 20. Chapter 7: Herpes B Virus Infection - p. 35 21. Chapter 8: Adenovirus Infection - p. 37 22. Chapter 9: Hepatitis B and D Virus Infections - p. 41 23. Chapter 10: Measles Virus Infection - p. 45 24. Chapter 11: Parvovirus B19 Infection - p. 47 25. Chapter 12: JC Virus, BK Virus, and Other Polyomavirus Infections - p. 51 26. Chapter 13: Pox Virus Infections - p. 57 27. Chapter 14: Human Papillomavirus Infection - p. 61 28. RNA VIRUSES - p. 71 29. Chapter 15: Rabies Virus Infection - p. 71 30. Chapter 16: Respiratory Syncytial Virus Infection - p. 73 31. VIRAL INFECTIONS REQUIRING ANCILLARY TESTS - p. 75 32. DNA VIRUSES - p. 75 33. Chapter 17: Human Herpesvirus 6 and 7 (HHV-6, HHV-7) Infections - p. 75 34. RNA VIRUSES - p. 77 35. Chapter 18: Arbovirus Infections - p. 77 36. Chapter 19: Zika Virus Infection - p. 83 37. Chapter 20: Ebola, Marburg, and Other Hemorrhagic Fever Virus Infections - p. 87 38. Chapter 21: Enterovirus Infection - p. 91 39. Chapter 22: Poliovirus Infection - p. 93 40. Chapter 23: Lymphocytic Choriomeningitis Virus Infection - p. 95 41. Chapter 24: Mumps Virus Infection - p. 97 42. Chapter 25: Rubella Virus Infection - p. 99 43. Chapter 26: Human Immunodeficiency Virus Infection - p. 101 44. Chapter 27: Human T-Lymphotropic Virus Type I Infection - p. 105 45. Chapter 28: Influenza Virus Infections - p. 107 46. Chapter 29: Parainfluenza Virus Infections - p. 111 47. Chapter 30: Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Other Coronavirus Infections - p. 113 48. Chapter 31: Rhinovirus, Human Metapneumovirus, and Other Respiratory Virus Infections - p. 115 49. Chapter 32: Rotavirus, Norovirus, and Astrovirus Infections - p. 117 50. Chapter 33: Hepatitis A and E Virus Infections - p. 119 51. Chapter 34: Hepatitis C Virus Infection - p. 123 52. SECTION 3: PRION DISEASES - p. 127 53. Chapter 35: Transmissible Spongiform Encephalopathies - p. 127 54. SECTION 4: BACTERIAL INFECTIONS - p. 133 55. MORPHOLOGIC DIAGNOSIS OF BACTERIAL INFECTIONS - p. 133 56. Chapter 36: Bacterial Infections - p. 133 57. Chapter 37: Anaplasmosis and Ehrlichiosis - p. 137 58. Chapter 38: Pertussis - p. 141 59. Chapter 39: Malakoplakia - p. 143 60. Chapter 40: Actinomycosis - p. 145 61. Chapter 41: Botryomycosis - p. 147 62. Chapter 42: Helicobacteriosis - p. 149 63. Chapter 43: Leprosy - p. 151 64. Chapter 44: Nocardiosis - p. 155 65. Chapter 45: Spirochetosis - p. 159 66. Chapter 46: Whipple Disease - p. 161 67. BACTERIAL INFECTIONS REQUIRING CULTURE/ANCILLARY CONFIRMATION - p. 165 68. GRAM-POSITIVE BACILLI - p. 165 69. Chapter 47: Bacillus Species Infections - p. 165 70. Chapter 48: Corynebacterium Species Infections - p. 169 71. Chapter 49: Listeria Species Infection - p. 173 72. Chapter 50: Rhodococcus Species Infection - p. 175 73. ANAEROBES - p. 177 74. Chapter 51: Gram-Negative Anaerobes - p. 177 75. Chapter 52: Clostridioides and Other Gram-Positive Anaerobes - p. 181 76. GRAM-POSITIVE COCCI - p. 185 77. Chapter 53: Staphylococcus Species Infections - p. 185 78. Chapter 54: Streptococcus and Enterococcus Species Infections - p. 191 79. GRAM-NEGATIVE BACILLI - p. 195 80. Chapter 55: Pathologically Important Enterobacteriaceae - p. 195 81. Chapter 56: Fastidious Organisms - p. 203 82. Chapter 57: Nonfermentative Organisms - p. 209 83. GRAM-NEGATIVE COCCI - p. 215 84. Chapter 58: Neisseria and Moraxella Species Infections - p. 215 85. GRAM-NEGATIVE CURVED AND SPIRAL ORGANISMS - p. 219 86. Chapter 59: Borrelia Species Infections - p. 219 87. Chapter 60: Leptospira Species Infection - p. 223 88. Chapter 61: Syphilis and Other Treponematoses - p. 225 89. Chapter 62: Campylobacter and Vibrio Species Infections - p. 229 90. MYCOBACTERIA BACILLI - p. 233 91. Chapter 63: Mycobacterium tuberculosis Complex Infections - p. 233 92. Chapter 64: Mycobacteria Other Than Tuberculosis Infections - p. 239 93. INTRACELLULAR BACTERIAL INFECTIONS - p. 243 94. Chapter 65: Chlamydophila and Chlamydia Species Infections - p. 243 95. Chapter 66: Rickettsia Species Infection - p. 247 96. Chapter 67: Coxiella Species Infection - p. 251 97. SECTION 5: FUNGAL INFECTIONS - p. 255 98. MORPHOLOGIC DIAGNOSIS OF FUNGAL INFECTIONS - p. 255 99. Chapter 68: Fungal Classification and Diagnosis - p. 255 100. Chapter 69: Aspergillosis - p. 261 101. Chapter 70: Blastomycosis - p. 267 102. Chapter 71: Candidiasis - p. 273 103. Chapter 72: Chromoblastomycosis - p. 277 104. Chapter 73: Coccidioidomycosis - p. 281 105. Chapter 74: Cryptococcosis - p. 283 106. Chapter 75: Histoplasmosis - p. 289 107. Chapter 76: Mucormycosis - p. 295 108. Chapter 77: Mycetoma - p. 299 109. Chapter 78: Paracoccidioidomycosis - p. 303 110. Chapter 79: Penicilliosis - p. 305 111. Chapter 80: Phaeohyphomycosis - p. 307 112. Chapter 81: Pneumocystosis - p. 309 113. Chapter 82: Rhinosporidiosis - p. 313 114. Chapter 83: Sporotrichosis - p. 315 115. Chapter 84: Tineasis - p. 319 116. CHALLENGING MORPHOLOGY IN FUNGAL INFECTIONS REQUIRING CULTURE/ANCILLARY TESTS - p. 321 117. Chapter 85: Fusariosis and Other Hyalohyphomycoses - p. 321 118. Chapter 86: Scedosporiosis - p. 323 119. Chapter 87: Scopulariopsis Infections - p. 325 120. Chapter 88: Trichosporonosis - p. 327 121. SECTION 6: PROTOZOAN PARASITIC INFECTIONS - p. 331 122. MORPHOLOGIC DIAGNOSIS OF PROTOZOA IN ANATOMIC PATHOLOGY - p. 331 123. Chapter 89: Protozoa Classification and Diagnosis - p. 331 124. GASTROINTESTINAL AND OTHER LUMINAL PROTOZOA - p. 335 125. Chapter 90: Balantidiasis - p. 335 126. Chapter 91: Cryptosporidiosis and Other Coccidia Infections - p. 337 127. Chapter 92: Entamebiasis - p. 341 128. Chapter 93: Giardiasis - p. 345 129. Chapter 94: Microsporidiosis - p. 347 130. Chapter 95: Trichomoniasis - p. 349 131. INTRAVASCULAR PROTOZOA - p. 351 132. Chapter 96: African Trypanosomiasis - p. 351 133. Chapter 97: Babesiosis - p. 355 134. Chapter 98: Malaria - p. 359 135. DEEP TISSUE PROTOZOA - p. 369 136. Chapter 99: Free-Living Amebiasis - p. 369 137. Chapter 100: American Trypanosomiasis - p. 375 138. Chapter 101: Leishmaniasis - p. 377 139. Chapter 102: Toxoplasmosis - p. 381 140. SECTION 7: HELMINTHIC PARASITIC INFECTIONS - p. 385 141. NEMATODES - p. 385 142. Chapter 103: Ancylostomiasis and Necatoriasis - p. 385 143. Chapter 104: Ascariasis - p. 391 144. Chapter 105: Human Filariasis - p. 393 145. Chapter 106: Onchocerciasis - p. 397 146. Chapter 107: Strongyloidiasis - p. 399 147. Chapter 108: Trichuriasis - p. 401 148. Chapter 109: Other Tissue Nematode Infections - p. 403 149. TREMATODES - p. 407 150. Chapter 110: Schistosomiasis - p. 407 151. Chapter 111: Other Tissue Trematode Infections - p. 415 152. CESTODES - p. 417 153. Chapter 112: Echinococcosis - p. 417 154. Chapter 113: Cysticercosis - p. 421 155. Chapter 114: Coenurosis - p. 427 156. SECTION 8: INFESTATIONS AND OTHER INVERTEBRATE-RELATED MALADIES - p. 429 157. DIRECT EVIDENCE OF INVERTEBRATES IN TISSUE - p. 429 158. Chapter 115: Myiasis - p. 429 159. Chapter 116: Scabies - p. 433 160. Chapter 117: Demodex Infestations - p. 435 161. Chapter 118: Tungiasis - p. 437 162. INDIRECT EVIDENCE OF INVERTEBRATES IN TISSUE - p. 439 163. Chapter 119: Tissue Damage From Arachnids and Insects - p. 439 164. INDEX - p. 447
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Part of the highly regarded Diagnostic Pathology series and written by Danny A. Milner, Jr., MD, this updated volume covers all aspects of infectious disease pathology, including anatomic manifestations and how to ensure a complete and accurate sign out at the microscope. Concise, focused chapters, supported by thousands of high-quality images, make this second edition an excellent point-of-care resource for pathologists at all levels of experience and training—both as a quick reference and as an efficient review to improve knowledge and skills.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributing Authors - p. v 7. Preface - p. v 8. Acknowledgments - p. ix 9. Sections - p. xi 10. SECTION 1: OVERVIEW - p. xiii 11. Chapter 1: Standard Methods for Infectious Diseases - p. xiii 12. SECTION 2: VIRAL INFECTIONS - p. 9 13. MORPHOLOGIC DIAGNOSIS OF VIRAL INFECTIONS - p. 9 14. DNA VIRUSES - p. 9 15. Chapter 2: Herpes Simplex Virus 1 and 2 (HSV-1, HSV-2) Infections - p. 9 16. Chapter 3: Varicella-Zoster Virus (HHV-3) Infections - p. 17 17. Chapter 4: Epstein-Barr Virus (HHV-4) Infection - p. 21 18. Chapter 5: Cytomegalovirus (HHV-5) Infections - p. 23 19. Chapter 6: Kaposi Sarcoma-Associated Herpesvirus (HHV-8) Infection - p. 29 20. Chapter 7: Herpes B Virus Infection - p. 35 21. Chapter 8: Adenovirus Infection - p. 37 22. Chapter 9: Hepatitis B and D Virus Infections - p. 41 23. Chapter 10: Measles Virus Infection - p. 45 24. Chapter 11: Parvovirus B19 Infection - p. 47 25. Chapter 12: JC Virus, BK Virus, and Other Polyomavirus Infections - p. 51 26. Chapter 13: Pox Virus Infections - p. 57 27. Chapter 14: Human Papillomavirus Infection - p. 61 28. RNA VIRUSES - p. 71 29. Chapter 15: Rabies Virus Infection - p. 71 30. Chapter 16: Respiratory Syncytial Virus Infection - p. 73 31. VIRAL INFECTIONS REQUIRING ANCILLARY TESTS - p. 75 32. DNA VIRUSES - p. 75 33. Chapter 17: Human Herpesvirus 6 and 7 (HHV-6, HHV-7) Infections - p. 75 34. RNA VIRUSES - p. 77 35. Chapter 18: Arbovirus Infections - p. 77 36. Chapter 19: Zika Virus Infection - p. 83 37. Chapter 20: Ebola, Marburg, and Other Hemorrhagic Fever Virus Infections - p. 87 38. Chapter 21: Enterovirus Infection - p. 91 39. Chapter 22: Poliovirus Infection - p. 93 40. Chapter 23: Lymphocytic Choriomeningitis Virus Infection - p. 95 41. Chapter 24: Mumps Virus Infection - p. 97 42. Chapter 25: Rubella Virus Infection - p. 99 43. Chapter 26: Human Immunodeficiency Virus Infection - p. 101 44. Chapter 27: Human T-Lymphotropic Virus Type I Infection - p. 105 45. Chapter 28: Influenza Virus Infections - p. 107 46. Chapter 29: Parainfluenza Virus Infections - p. 111 47. Chapter 30: Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Other Coronavirus Infections - p. 113 48. Chapter 31: Rhinovirus, Human Metapneumovirus, and Other Respiratory Virus Infections - p. 115 49. Chapter 32: Rotavirus, Norovirus, and Astrovirus Infections - p. 117 50. Chapter 33: Hepatitis A and E Virus Infections - p. 119 51. Chapter 34: Hepatitis C Virus Infection - p. 123 52. SECTION 3: PRION DISEASES - p. 127 53. Chapter 35: Transmissible Spongiform Encephalopathies - p. 127 54. SECTION 4: BACTERIAL INFECTIONS - p. 133 55. MORPHOLOGIC DIAGNOSIS OF BACTERIAL INFECTIONS - p. 133 56. Chapter 36: Bacterial Infections - p. 133 57. Chapter 37: Anaplasmosis and Ehrlichiosis - p. 137 58. Chapter 38: Pertussis - p. 141 59. Chapter 39: Malakoplakia - p. 143 60. Chapter 40: Actinomycosis - p. 145 61. Chapter 41: Botryomycosis - p. 147 62. Chapter 42: Helicobacteriosis - p. 149 63. Chapter 43: Leprosy - p. 151 64. Chapter 44: Nocardiosis - p. 155 65. Chapter 45: Spirochetosis - p. 159 66. Chapter 46: Whipple Disease - p. 161 67. BACTERIAL INFECTIONS REQUIRING CULTURE/ANCILLARY CONFIRMATION - p. 165 68. GRAM-POSITIVE BACILLI - p. 165 69. Chapter 47: Bacillus Species Infections - p. 165 70. Chapter 48: Corynebacterium Species Infections - p. 169 71. Chapter 49: Listeria Species Infection - p. 173 72. Chapter 50: Rhodococcus Species Infection - p. 175 73. ANAEROBES - p. 177 74. Chapter 51: Gram-Negative Anaerobes - p. 177 75. Chapter 52: Clostridioides and Other Gram-Positive Anaerobes - p. 181 76. GRAM-POSITIVE COCCI - p. 185 77. Chapter 53: Staphylococcus Species Infections - p. 185 78. Chapter 54: Streptococcus and Enterococcus Species Infections - p. 191 79. GRAM-NEGATIVE BACILLI - p. 195 80. Chapter 55: Pathologically Important Enterobacteriaceae - p. 195 81. Chapter 56: Fastidious Organisms - p. 203 82. Chapter 57: Nonfermentative Organisms - p. 209 83. GRAM-NEGATIVE COCCI - p. 215 84. Chapter 58: Neisseria and Moraxella Species Infections - p. 215 85. GRAM-NEGATIVE CURVED AND SPIRAL ORGANISMS - p. 219 86. Chapter 59: Borrelia Species Infections - p. 219 87. Chapter 60: Leptospira Species Infection - p. 223 88. Chapter 61: Syphilis and Other Treponematoses - p. 225 89. Chapter 62: Campylobacter and Vibrio Species Infections - p. 229 90. MYCOBACTERIA BACILLI - p. 233 91. Chapter 63: Mycobacterium tuberculosis Complex Infections - p. 233 92. Chapter 64: Mycobacteria Other Than Tuberculosis Infections - p. 239 93. INTRACELLULAR BACTERIAL INFECTIONS - p. 243 94. Chapter 65: Chlamydophila and Chlamydia Species Infections - p. 243 95. Chapter 66: Rickettsia Species Infection - p. 247 96. Chapter 67: Coxiella Species Infection - p. 251 97. SECTION 5: FUNGAL INFECTIONS - p. 255 98. MORPHOLOGIC DIAGNOSIS OF FUNGAL INFECTIONS - p. 255 99. Chapter 68: Fungal Classification and Diagnosis - p. 255 100. Chapter 69: Aspergillosis - p. 261 101. Chapter 70: Blastomycosis - p. 267 102. Chapter 71: Candidiasis - p. 273 103. Chapter 72: Chromoblastomycosis - p. 277 104. Chapter 73: Coccidioidomycosis - p. 281 105. Chapter 74: Cryptococcosis - p. 283 106. Chapter 75: Histoplasmosis - p. 289 107. Chapter 76: Mucormycosis - p. 295 108. Chapter 77: Mycetoma - p. 299 109. Chapter 78: Paracoccidioidomycosis - p. 303 110. Chapter 79: Penicilliosis - p. 305 111. Chapter 80: Phaeohyphomycosis - p. 307 112. Chapter 81: Pneumocystosis - p. 309 113. Chapter 82: Rhinosporidiosis - p. 313 114. Chapter 83: Sporotrichosis - p. 315 115. Chapter 84: Tineasis - p. 319 116. CHALLENGING MORPHOLOGY IN FUNGAL INFECTIONS REQUIRING CULTURE/ANCILLARY TESTS - p. 321 117. Chapter 85: Fusariosis and Other Hyalohyphomycoses - p. 321 118. Chapter 86: Scedosporiosis - p. 323 119. Chapter 87: Scopulariopsis Infections - p. 325 120. Chapter 88: Trichosporonosis - p. 327 121. SECTION 6: PROTOZOAN PARASITIC INFECTIONS - p. 331 122. MORPHOLOGIC DIAGNOSIS OF PROTOZOA IN ANATOMIC PATHOLOGY - p. 331 123. Chapter 89: Protozoa Classification and Diagnosis - p. 331 124. GASTROINTESTINAL AND OTHER LUMINAL PROTOZOA - p. 335 125. Chapter 90: Balantidiasis - p. 335 126. Chapter 91: Cryptosporidiosis and Other Coccidia Infections - p. 337 127. Chapter 92: Entamebiasis - p. 341 128. Chapter 93: Giardiasis - p. 345 129. Chapter 94: Microsporidiosis - p. 347 130. Chapter 95: Trichomoniasis - p. 349 131. INTRAVASCULAR PROTOZOA - p. 351 132. Chapter 96: African Trypanosomiasis - p. 351 133. Chapter 97: Babesiosis - p. 355 134. Chapter 98: Malaria - p. 359 135. DEEP TISSUE PROTOZOA - p. 369 136. Chapter 99: Free-Living Amebiasis - p. 369 137. Chapter 100: American Trypanosomiasis - p. 375 138. Chapter 101: Leishmaniasis - p. 377 139. Chapter 102: Toxoplasmosis - p. 381 140. SECTION 7: HELMINTHIC PARASITIC INFECTIONS - p. 385 141. NEMATODES - p. 385 142. Chapter 103: Ancylostomiasis and Necatoriasis - p. 385 143. Chapter 104: Ascariasis - p. 391 144. Chapter 105: Human Filariasis - p. 393 145. Chapter 106: Onchocerciasis - p. 397 146. Chapter 107: Strongyloidiasis - p. 399 147. Chapter 108: Trichuriasis - p. 401 148. Chapter 109: Other Tissue Nematode Infections - p. 403 149. TREMATODES - p. 407 150. Chapter 110: Schistosomiasis - p. 407 151. Chapter 111: Other Tissue Trematode Infections - p. 415 152. CESTODES - p. 417 153. Chapter 112: Echinococcosis - p. 417 154. Chapter 113: Cysticercosis - p. 421 155. Chapter 114: Coenurosis - p. 427 156. SECTION 8: INFESTATIONS AND OTHER INVERTEBRATE-RELATED MALADIES - p. 429 157. DIRECT EVIDENCE OF INVERTEBRATES IN TISSUE - p. 429 158. Chapter 115: Myiasis - p. 429 159. Chapter 116: Scabies - p. 433 160. Chapter 117: Demodex Infestations - p. 435 161. Chapter 118: Tungiasis - p. 437 162. INDIRECT EVIDENCE OF INVERTEBRATES IN TISSUE - p. 439 163. Chapter 119: Tissue Damage From Arachnids and Insects - p. 439 164. INDEX - p. 447
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