This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Providing a clear understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer in an era of personalized medicine, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Molecular Oncology is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, molecular pathologist, oncologist, or pathologist in training as an ideal day-to-day reference or as a reliable learning resource.
1. SECTION 1: INTRODUCTION - p. xiii 2. Chapter 1: Structure of Chromosomes and Nucleic Acids - p. xiii 3. Chapter 2: DNA Replication, Transcription, and Translation - p. 7 4. Chapter 3: Gene Mutations - p. 11 5. SECTION 2: COMMON TECHNIQUES FOR ANALYSIS OF ALTERATIONS IN CHROMOSOMES AND DNA - p. 15 6. Chapter 4: Cytogenetics and FISH - p. 15 7. Chapter 5: Chromosomal Microarray - p. 21 8. Chapter 6: Amplification Methods - p. 25 9. Chapter 7: DNA High-Resolution Melting Curve Analysis - p. 29 10. Chapter 8: Sequencing Technologies - p. 31 11. Chapter 9: High-Throughput Methods in Molecular Pathology - p. 35 12. Chapter 10: DNA Methylation Analysis - p. 37 13. SECTION 3: MOLECULAR GENETIC TESTS IN HEMATOPOIETIC TUMORS - p. 39 14. Chapter 11: BCR::ABL1 Fusion - p. 39 15. Chapter 12: PML::RARA Fusion - p. 45 16. Chapter 13: Reverse Transcription PCR for Myeloid Leukemia Transcripts - p. 47 17. Chapter 14: FLT3, NPM1, and CEBPA Mutations - p. 49 18. Chapter 15: JAK2 Mutations and Rearrangements - p. 53 19. Chapter 16: MPL Mutations - p. 55 20. Chapter 17: Calreticulin (CALR) Mutations - p. 57 21. Chapter 18: CSF3R Mutations - p. 59 22. Chapter 19: SETBP1 Mutations - p. 61 23. Chapter 20: KIT Mutations - p. 63 24. Chapter 21: IDH1 and IDH2 Mutations - p. 67 25. Chapter 22: Other Mutations and Gene Panel Testing in Myeloid Neoplasms - p. 69 26. Chapter 23: Immunoglobulin Heavy (IGH) Chain Gene Rearrangements - p. 71 27. Chapter 24: T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements - p. 75 28. Chapter 25: T-Cell Receptor Beta (TRB) Chain Gene Rearrangements - p. 79 29. Chapter 26: Southern Blot Analysis of Antigen Receptor Genes - p. 83 30. Chapter 27: EBV-Associated Human Neoplasms - p. 85 31. Chapter 28: MYD88 Mutation - p. 93 32. Chapter 29: NOTCH1 Mutation - p. 95 33. Chapter 30: EZH2 Mutation - p. 97 34. SECTION 4: MOLECULAR GENETIC TESTS IN SOLID TUMORS, BONE AND SOFT TISSUE TUMORS, AND CNS TUMORS - p. 101 35. Chapter 31: ALK Rearrangements and Mutations - p. 101 36. Chapter 32: ROS1 Rearrangements - p. 105 37. Chapter 33: RET Rearrangements - p. 107 38. Chapter 34: FISH for MET Amplifications - p. 109 39. Chapter 35: FISH for ERBB2 (HER2) Amplifications - p. 113 40. Chapter 36: KRAS Mutations - p. 115 41. Chapter 37: BRAF Mutations - p. 117 42. Chapter 38: EGFR Mutations - p. 119 43. Chapter 39: Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next-Generation Sequencing) - p. 121 44. Chapter 40: Targeted Hotspot Gene Panel Table - p. 123 45. Chapter 41: MGMT Promoter Gene Methylation Assay - p. 129 46. SECTION 5: MOLECULAR PATHOLOGY OF MYELOID NEOPLASMS - p. 131 47. Chapter 42: Molecular Work-Up of Myeloid Neoplasms - p. 131 48. MYELOPROLIFERATIVE NEOPLASMS - p. 135 49. Chapter 43: Chronic Myeloid Leukemia, BCR::ABL1-Positive - p. 135 50. Chapter 44: Chronic Neutrophilic Leukemia - p. 143 51. Chapter 45: Polycythemia Vera - p. 147 52. Chapter 46: Primary Myelofibrosis - p. 151 53. Chapter 47: Essential Thrombocythemia - p. 155 54. Chapter 48: Chronic Eosinophilic Leukemia, NOS - p. 159 55. Chapter 49: Myeloproliferative Neoplasm, Unclassifiable - p. 161 56. MASTOCYTOSIS - p. 165 57. Chapter 50: Mastocytosis - p. 165 58. MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND GENE REARRANGEMENT - p. 173 59. Chapter 51: Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions - p. 173 60. PREMALIGNANT CLONAL HEMATOPOIESIS AND CYTOPENIAS - p. 177 61. Chapter 52: VEXAS Syndrome - p. 177 62. Chapter 53: Clonal Hematopoiesis and Premalignant Clonal Cytopenia - p. 181 63. MYELODYSPLASTIC SYNDROME (MDS) - p. 183 64. Chapter 54: Overview and Classification of Myelodysplastic Syndrome - p. 183 65. Chapter 55: Myelodysplastic Syndrome With Mutated SF3B1 - p. 187 66. Chapter 56: Myelodysplastic Syndrome, NOS - p. 191 67. Chapter 57: Myelodysplastic Syndrome With del(5q) - p. 199 68. Chapter 58: Myelodysplastic Syndrome With TP53 Multihit Mutations - p. 203 69. Chapter 59: Myelodysplastic Syndrome/Acute Myeloid Leukemia - p. 205 70. Chapter 60: Pediatric Myelodysplastic Syndrome and Refractory Cytopenia of Childhood - p. 207 71. MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS - p. 213 72. Chapter 61: Overview of Myelodysplastic/Myeloproliferative Neoplasms - p. 213 73. Chapter 62: Chronic Myelomonocytic Leukemia - p. 215 74. Chapter 63: Atypical Chronic Myeloid Leukemia - p. 219 75. Chapter 64: Juvenile Myelomonocytic Leukemia - p. 223 76. Chapter 65: Myelodysplastic/Myeloproliferative Neoplasm, NOS - p. 227 77. ACUTE MYELOID LEUKEMIA - p. 231 78. Chapter 66: Overview of Acute Myeloid Leukemia - p. 231 79. Chapter 67: Acute Myeloid Leukemia With t(8;21)/RUNX1::RUNX1T1 - p. 239 80. Chapter 68: Acute Myeloid Leukemia With inv(16) or t(16;16)/CBFB::MYH11 - p. 243 81. Chapter 69: Acute Promyelocytic Leukemia With t(15;17)/PML::RARA - p. 247 82. Chapter 70: Acute Myeloid Leukemia With t(9;11)/MLLT3::KMT2A - p. 253 83. Chapter 71: Acute Myeloid Leukemia With t(6:9)/DEK::NUP214 - p. 257 84. Chapter 72: Acute Myeloid Leukemia With inv(3) or t(3;3)/GATA2; MECOM - p. 259 85. Chapter 73: Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)/RBM15::MRTFA - p. 261 86. Chapter 74: Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities - p. 263 87. Chapter 75: Acute Myeloid Leukemia, NOS - p. 269 88. Chapter 76: Myeloid Sarcoma - p. 275 89. Chapter 77: Myeloid Proliferations Associated With Down Syndrome - p. 279 90. BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM - p. 283 91. Chapter 78: Blastic Plasmacytoid Dendritic Cell Neoplasm - p. 283 92. SECTION 6: MOLECULAR PATHOLOGY OF LYMPHOID NEOPLASMS - p. 289 93. Chapter 79: Overview of Lymphoid Neoplasms - p. 289 94. Chapter 80: Molecular Work-Up of Lymphoid Neoplasms - p. 295 95. DETERMINATION OF CLONALITY IN B-, T-, AND NK-CELL NEOPLASMS - p. 297 96. Chapter 81: Lymphoma-Associated Chromosomal Translocations - p. 297 97. PRECURSOR LYMPHOID NEOPLASMS - p. 301 98. Chapter 82: B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities - p. 301 99. Chapter 83: B-Lymphoblastic Leukemia/Lymphoma, BCR::ABL1-Like (Ph-Like ALL) - p. 305 100. Chapter 84: T-Lymphoblastic Leukemia/Lymphoma - p. 309 101. MATURE B-CELL NEOPLASMS - p. 315 102. Chapter 85: Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia - p. 315 103. Chapter 86: B-Cell Prolymphocytic Leukemia - p. 321 104. Chapter 87: Splenic Marginal Zone Lymphoma - p. 325 105. Chapter 88: Hairy Cell Leukemia - p. 331 106. Chapter 89: Splenic B-Cell Lymphoma/Leukemia, Unclassifiable - p. 335 107. Chapter 90: Lymphoplasmacytic Lymphoma - p. 343 108. Chapter 91: Monoclonal Gammopathy of Undetermined Significance - p. 349 109. Chapter 92: Multiple Myeloma (Plasma Cell Myeloma) - p. 353 110. Chapter 93: Follicular Lymphoma - p. 361 111. Chapter 94: Mantle Cell Lymphoma - p. 369 112. Chapter 95: Diffuse Large B-Cell Lymphoma - p. 375 113. Chapter 96: Burkitt Lymphoma - p. 385 114. MATURE T- AND NK-CELL NEOPLASMS - p. 393 115. Chapter 97: T-Cell Prolymphocytic Leukemia - p. 393 116. Chapter 98: Chronic Lymphoproliferative Disorder of NK Cells - p. 397 117. Chapter 99: Aggressive NK-Cell Leukemia - p. 401 118. Chapter 100: Extranodal NK-/T-Cell Lymphoma - p. 405 119. Chapter 101: Adult T-Cell Leukemia/Lymphoma - p. 409 120. Chapter 102: Intestinal T-Cell Lymphoma - p. 415 121. Chapter 103: Hepatosplenic T-Cell Lymphoma - p. 423 122. Chapter 104: Subcutaneous Panniculitis-Like T-Cell Lymphoma - p. 427 123. Chapter 105: Mycosis Fungoides/Sézary Syndrome - p. 431 124. Chapter 106: Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders - p. 437 125. Chapter 107: Peripheral T-Cell Lymphoma, NOS - p. 441 126. Chapter 108: Nodal Follicular Helper T-Cell Lymphoma - p. 447 127. Chapter 109: Anaplastic Large Cell Lymphoma, ALK-Negative - p. 455 128. Chapter 110: Anaplastic Large Cell Lymphoma, ALK-Positive - p. 461 129. SECTION 7: MOLECULAR PATHOLOGY OF DENDRITIC CELL AND HISTIOCYTIC NEOPLASMS - p. 467 130. Chapter 111: Histiocytic Sarcoma - p. 467 131. Chapter 112: Langerhans Cell Histiocytosis - p. 477 132. Chapter 113: Interdigitating Dendritic Cell Sarcoma - p. 483 133. Chapter 114: Follicular Dendritic Cell Sarcoma - p. 487 134. SECTION 8: MOLECULAR PATHOLOGY OF SOLID TUMORS - p. 491 135. HEAD AND NECK, INCLUDING SINONASAL TUMORS AND SALIVARY GLANDS - p. 491 136. Chapter 115: HPV-Associated Head and Neck Carcinomas - p. 491 137. Chapter 116: Head and Neck Mucosal Squamous Cell Carcinoma, Non-HPV Related - p. 499 138. Chapter 117: Important Alterations in Non-HPV-Related Head and Neck Squamous Cell Carcinoma - p. 505 139. Chapter 118: Translocation-Specific Salivary Gland Tumors - p. 507 140. Chapter 119: Translocation-Specific Salivary Gland Tumors (Continued) - p. 517 141. Chapter 120: Nasopharyngeal EBV-Related Squamous Cell Carcinoma - p. 525 142. Chapter 121: Other Head and Neck Tumors - p. 529 143. THYROID - p. 537 144. Chapter 122: Papillary Thyroid Carcinoma - p. 537 145. Chapter 123: Follicular Thyroid Carcinoma - p. 541 146. Chapter 124: Poorly Differentiated Thyroid Carcinoma - p. 544 147. Chapter 125: Anaplastic Thyroid Carcinoma - p. 549 148. Chapter 126: Medullary Thyroid Carcinoma - p. 553 149. LUNG - p. 559 150. Chapter 127: Adenocarcinoma, Lung - p. 559 151. Chapter 128: Squamous Cell Carcinoma, Lung - p. 567 152. Chapter 129: Small Cell Neuroendocrine Carcinoma - p. 571 153. Chapter 130: Mesothelioma - p. 575 154. LUMINAL GASTROINTESTINAL TRACT - p. 579 155. Chapter 131: Gastric Adenocarcinoma - p. 579 156. Chapter 132: Colorectal Adenocarcinoma and Precancerous Lesions - p. 583 157. Chapter 133: Gastrointestinal Stromal Tumor - p. 589 158. LIVER - p. 597 159. Chapter 134: HNF1A-Inactivated Hepatocellular Adenoma - p. 597 160. Chapter 135: β-Catenin-Activated Hepatocellular Adenoma - p. 601 161. Chapter 136: Inflammatory Hepatocellular Adenoma - p. 605 162. Chapter 137: Hepatocellular Carcinoma - p. 609 163. PANCREATICOBILIARY - p. 613 164. Chapter 138: Pancreatic Ductal Adenocarcinoma - p. 613 165. Chapter 139: Pancreatic Mucinous Cystic Neoplasm - p. 617 166. Chapter 140: Pancreatic Intraductal Papillary Mucinous Neoplasm - p. 619 167. Chapter 141: Cholangiocarcinoma - p. 621 168. TESTIS - p. 623 169. Chapter 142: Testicular Germ Cell Tumors - p. 623 170. KIDNEY - p. 629 171. Chapter 143: Clear Cell Renal Cell Carcinoma - p. 629 172. Chapter 144: Chromophobe Renal Cell Carcinoma - p. 633 173. Chapter 145: Papillary Renal Cell Carcinoma - p. 635 174. Chapter 146: TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas - p. 637 175. Chapter 147: Wilms Tumor - p. 641 176. Chapter 148: Clear Cell Sarcoma of Kidney - p. 647 177. Chapter 149: Oncocytoma - p. 649 178. Chapter 150: Rhabdoid Tumor of Kidney - p. 651 179. BLADDER - p. 653 180. Chapter 151: Urothelial Carcinoma - p. 653 181. ADRENAL - p. 659 182. Chapter 152: Pheochromocytoma/Paraganglioma - p. 659 183. Chapter 153: Adrenal Cortical Carcinoma - p. 665 184. Chapter 154: Neuroblastoma - p. 671 185. Chapter 155: Adrenal Cortical Adenoma - p. 679 186. PROSTATE - p. 683 187. Chapter 156: Prostatic Adenocarcinoma, Acinar Type and High-Grade Prostatic Intraepithelial Neoplasia - p. 683 188. BREAST - p. 687 189. Chapter 157: ADH and DCIS (Dysplastic, Premalignant) - p. 687 190. Chapter 158: Ductal Carcinomas - p. 693 191. Chapter 159: Lobular Carcinoma - p. 699 192. Chapter 160: Invasive Ductal Carcinoma of No Special Type With Medullary Features - p. 705 193. Chapter 161: Metaplastic Breast Carcinoma - p. 709 194. Chapter 162: Phyllodes Tumors - p. 715 195. Chapter 163: Basal-Like and Triple-Negative Breast Carcinomas - p. 719 196. CERVIX/VULVA/VAGINA - p. 729 197. Chapter 164: Preneoplastic Conditions, Cervix/Vulva/Vagina - p. 729 198. Chapter 165: Squamous Cell Carcinoma, Cervix/Vulva/Vagina - p. 733 199. Chapter 166: Adenocarcinoma, Cervix/Vulva/Vagina - p. 737 200. UTERUS - p. 741 201. Chapter 167: Endometrial Intraepithelial Neoplasia - p. 741 202. Chapter 168: Uterine Endometrioid Carcinoma - p. 743 203. Chapter 169: Uterine Serous Carcinoma - p. 747 204. Chapter 170: Clear Cell Carcinoma, Uterus - p. 749 205. Chapter 171: Uterine Sarcomas - p. 753 206. OVARIES/FALLOPIAN TUBE - p. 761 207. Chapter 172: Serous Tumors of Ovary and Fallopian Tube - p. 761 208. Chapter 173: Other Surface Epithelial Tumors of Ovary - p. 767 209. Chapter 174: Sex Cord-Stromal Tumors of Ovary - p. 773 210. Chapter 175: Germ Cell Tumor, Ovary - p. 779 211. SKIN - p. 783 212. Chapter 176: Premalignant Conditions, Skin - p. 783 213. Chapter 177: Melanoma - p. 787 214. Chapter 178: Squamous Cell Carcinoma, Skin - p. 791 215. Chapter 179: Basal Cell Carcinoma, Skin - p. 795 216. Chapter 180: Sebaceous Tumors - p. 799 217. Chapter 181: Dermatofibroma and Dermatofibrosarcoma Protuberans - p. 801 218. BONE - p. 803 219. Chapter 182: Overview of Molecular Pathology of Bone and Soft Tissue Tumors - p. 803 220. Chapter 183: Osteosarcomas - p. 809 221. Chapter 184: Ewing Sarcoma - p. 817 222. Chapter 185: Other Small Round Blue Cell Sarcomas - p. 823 223. Chapter 186: Giant Cell Tumor of Bone - p. 831 224. Chapter 187: Intermediate and Malignant Cartilaginous Tumors of Bone - p. 837 225. SOFT TISSUE - p. 847 226. Chapter 188: Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors - p. 847 227. Chapter 189: Liposarcomas - p. 857 228. Chapter 190: Muscle Sarcomas - p. 867 229. Chapter 191: Intermediate and Malignant Vascular Tumors - p. 877 230. Chapter 192: Malignant Peripheral Nerve Sheath Tumor - p. 885 231. Chapter 193: Representative Genetic Findings in Bone and Soft Tissue Tumors - p. 891 232. SARCOMAS OF UNCERTAIN DIFFERENTIATION - p. 897 233. Chapter 194: Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations - p. 897 234. Chapter 195: Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations (Continued) - p. 907 235. CNS - p. 915 236. Chapter 196: Glioblastoma, IDH Wildtype - p. 915 237. Chapter 197: Astrocytoma, IDH-Mutant - p. 919 238. Chapter 198: Pilocytic Astrocytoma - p. 923 239. Chapter 199: Oligodendroglioma, IDH Mutant, and 1p/19q Codeleted - p. 927 240. Chapter 200: Ependymal Tumors - p. 931 241. Chapter 201: Medulloblastoma - p. 937 242. Chapter 202: Choroid Plexus Tumors - p. 943 243. Chapter 203: Meningioma - p. 947 244. Chapter 204: Retinoblastoma - p. 951 245. SECTION 9: QUALITY ASSURANCE AND REGULATORY ISSUES - p. 955 246. Chapter 205: Federal Agencies and Regulation of Laboratories - p. 955 247. Chapter 206: FDA Regulations - p. 959 248. Chapter 207: Proficiency Testing and Accreditation - p. 965 249. INDEX - p. 969
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Providing a clear understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer in an era of personalized medicine, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Molecular Oncology is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, molecular pathologist, oncologist, or pathologist in training as an ideal day-to-day reference or as a reliable learning resource.
1. SECTION 1: INTRODUCTION - p. xiii 2. Chapter 1: Structure of Chromosomes and Nucleic Acids - p. xiii 3. Chapter 2: DNA Replication, Transcription, and Translation - p. 7 4. Chapter 3: Gene Mutations - p. 11 5. SECTION 2: COMMON TECHNIQUES FOR ANALYSIS OF ALTERATIONS IN CHROMOSOMES AND DNA - p. 15 6. Chapter 4: Cytogenetics and FISH - p. 15 7. Chapter 5: Chromosomal Microarray - p. 21 8. Chapter 6: Amplification Methods - p. 25 9. Chapter 7: DNA High-Resolution Melting Curve Analysis - p. 29 10. Chapter 8: Sequencing Technologies - p. 31 11. Chapter 9: High-Throughput Methods in Molecular Pathology - p. 35 12. Chapter 10: DNA Methylation Analysis - p. 37 13. SECTION 3: MOLECULAR GENETIC TESTS IN HEMATOPOIETIC TUMORS - p. 39 14. Chapter 11: BCR::ABL1 Fusion - p. 39 15. Chapter 12: PML::RARA Fusion - p. 45 16. Chapter 13: Reverse Transcription PCR for Myeloid Leukemia Transcripts - p. 47 17. Chapter 14: FLT3, NPM1, and CEBPA Mutations - p. 49 18. Chapter 15: JAK2 Mutations and Rearrangements - p. 53 19. Chapter 16: MPL Mutations - p. 55 20. Chapter 17: Calreticulin (CALR) Mutations - p. 57 21. Chapter 18: CSF3R Mutations - p. 59 22. Chapter 19: SETBP1 Mutations - p. 61 23. Chapter 20: KIT Mutations - p. 63 24. Chapter 21: IDH1 and IDH2 Mutations - p. 67 25. Chapter 22: Other Mutations and Gene Panel Testing in Myeloid Neoplasms - p. 69 26. Chapter 23: Immunoglobulin Heavy (IGH) Chain Gene Rearrangements - p. 71 27. Chapter 24: T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements - p. 75 28. Chapter 25: T-Cell Receptor Beta (TRB) Chain Gene Rearrangements - p. 79 29. Chapter 26: Southern Blot Analysis of Antigen Receptor Genes - p. 83 30. Chapter 27: EBV-Associated Human Neoplasms - p. 85 31. Chapter 28: MYD88 Mutation - p. 93 32. Chapter 29: NOTCH1 Mutation - p. 95 33. Chapter 30: EZH2 Mutation - p. 97 34. SECTION 4: MOLECULAR GENETIC TESTS IN SOLID TUMORS, BONE AND SOFT TISSUE TUMORS, AND CNS TUMORS - p. 101 35. Chapter 31: ALK Rearrangements and Mutations - p. 101 36. Chapter 32: ROS1 Rearrangements - p. 105 37. Chapter 33: RET Rearrangements - p. 107 38. Chapter 34: FISH for MET Amplifications - p. 109 39. Chapter 35: FISH for ERBB2 (HER2) Amplifications - p. 113 40. Chapter 36: KRAS Mutations - p. 115 41. Chapter 37: BRAF Mutations - p. 117 42. Chapter 38: EGFR Mutations - p. 119 43. Chapter 39: Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next-Generation Sequencing) - p. 121 44. Chapter 40: Targeted Hotspot Gene Panel Table - p. 123 45. Chapter 41: MGMT Promoter Gene Methylation Assay - p. 129 46. SECTION 5: MOLECULAR PATHOLOGY OF MYELOID NEOPLASMS - p. 131 47. Chapter 42: Molecular Work-Up of Myeloid Neoplasms - p. 131 48. MYELOPROLIFERATIVE NEOPLASMS - p. 135 49. Chapter 43: Chronic Myeloid Leukemia, BCR::ABL1-Positive - p. 135 50. Chapter 44: Chronic Neutrophilic Leukemia - p. 143 51. Chapter 45: Polycythemia Vera - p. 147 52. Chapter 46: Primary Myelofibrosis - p. 151 53. Chapter 47: Essential Thrombocythemia - p. 155 54. Chapter 48: Chronic Eosinophilic Leukemia, NOS - p. 159 55. Chapter 49: Myeloproliferative Neoplasm, Unclassifiable - p. 161 56. MASTOCYTOSIS - p. 165 57. Chapter 50: Mastocytosis - p. 165 58. MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND GENE REARRANGEMENT - p. 173 59. Chapter 51: Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions - p. 173 60. PREMALIGNANT CLONAL HEMATOPOIESIS AND CYTOPENIAS - p. 177 61. Chapter 52: VEXAS Syndrome - p. 177 62. Chapter 53: Clonal Hematopoiesis and Premalignant Clonal Cytopenia - p. 181 63. MYELODYSPLASTIC SYNDROME (MDS) - p. 183 64. Chapter 54: Overview and Classification of Myelodysplastic Syndrome - p. 183 65. Chapter 55: Myelodysplastic Syndrome With Mutated SF3B1 - p. 187 66. Chapter 56: Myelodysplastic Syndrome, NOS - p. 191 67. Chapter 57: Myelodysplastic Syndrome With del(5q) - p. 199 68. Chapter 58: Myelodysplastic Syndrome With TP53 Multihit Mutations - p. 203 69. Chapter 59: Myelodysplastic Syndrome/Acute Myeloid Leukemia - p. 205 70. Chapter 60: Pediatric Myelodysplastic Syndrome and Refractory Cytopenia of Childhood - p. 207 71. MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS - p. 213 72. Chapter 61: Overview of Myelodysplastic/Myeloproliferative Neoplasms - p. 213 73. Chapter 62: Chronic Myelomonocytic Leukemia - p. 215 74. Chapter 63: Atypical Chronic Myeloid Leukemia - p. 219 75. Chapter 64: Juvenile Myelomonocytic Leukemia - p. 223 76. Chapter 65: Myelodysplastic/Myeloproliferative Neoplasm, NOS - p. 227 77. ACUTE MYELOID LEUKEMIA - p. 231 78. Chapter 66: Overview of Acute Myeloid Leukemia - p. 231 79. Chapter 67: Acute Myeloid Leukemia With t(8;21)/RUNX1::RUNX1T1 - p. 239 80. Chapter 68: Acute Myeloid Leukemia With inv(16) or t(16;16)/CBFB::MYH11 - p. 243 81. Chapter 69: Acute Promyelocytic Leukemia With t(15;17)/PML::RARA - p. 247 82. Chapter 70: Acute Myeloid Leukemia With t(9;11)/MLLT3::KMT2A - p. 253 83. Chapter 71: Acute Myeloid Leukemia With t(6:9)/DEK::NUP214 - p. 257 84. Chapter 72: Acute Myeloid Leukemia With inv(3) or t(3;3)/GATA2; MECOM - p. 259 85. Chapter 73: Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)/RBM15::MRTFA - p. 261 86. Chapter 74: Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities - p. 263 87. Chapter 75: Acute Myeloid Leukemia, NOS - p. 269 88. Chapter 76: Myeloid Sarcoma - p. 275 89. Chapter 77: Myeloid Proliferations Associated With Down Syndrome - p. 279 90. BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM - p. 283 91. Chapter 78: Blastic Plasmacytoid Dendritic Cell Neoplasm - p. 283 92. SECTION 6: MOLECULAR PATHOLOGY OF LYMPHOID NEOPLASMS - p. 289 93. Chapter 79: Overview of Lymphoid Neoplasms - p. 289 94. Chapter 80: Molecular Work-Up of Lymphoid Neoplasms - p. 295 95. DETERMINATION OF CLONALITY IN B-, T-, AND NK-CELL NEOPLASMS - p. 297 96. Chapter 81: Lymphoma-Associated Chromosomal Translocations - p. 297 97. PRECURSOR LYMPHOID NEOPLASMS - p. 301 98. Chapter 82: B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities - p. 301 99. Chapter 83: B-Lymphoblastic Leukemia/Lymphoma, BCR::ABL1-Like (Ph-Like ALL) - p. 305 100. Chapter 84: T-Lymphoblastic Leukemia/Lymphoma - p. 309 101. MATURE B-CELL NEOPLASMS - p. 315 102. Chapter 85: Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia - p. 315 103. Chapter 86: B-Cell Prolymphocytic Leukemia - p. 321 104. Chapter 87: Splenic Marginal Zone Lymphoma - p. 325 105. Chapter 88: Hairy Cell Leukemia - p. 331 106. Chapter 89: Splenic B-Cell Lymphoma/Leukemia, Unclassifiable - p. 335 107. Chapter 90: Lymphoplasmacytic Lymphoma - p. 343 108. Chapter 91: Monoclonal Gammopathy of Undetermined Significance - p. 349 109. Chapter 92: Multiple Myeloma (Plasma Cell Myeloma) - p. 353 110. Chapter 93: Follicular Lymphoma - p. 361 111. Chapter 94: Mantle Cell Lymphoma - p. 369 112. Chapter 95: Diffuse Large B-Cell Lymphoma - p. 375 113. Chapter 96: Burkitt Lymphoma - p. 385 114. MATURE T- AND NK-CELL NEOPLASMS - p. 393 115. Chapter 97: T-Cell Prolymphocytic Leukemia - p. 393 116. Chapter 98: Chronic Lymphoproliferative Disorder of NK Cells - p. 397 117. Chapter 99: Aggressive NK-Cell Leukemia - p. 401 118. Chapter 100: Extranodal NK-/T-Cell Lymphoma - p. 405 119. Chapter 101: Adult T-Cell Leukemia/Lymphoma - p. 409 120. Chapter 102: Intestinal T-Cell Lymphoma - p. 415 121. Chapter 103: Hepatosplenic T-Cell Lymphoma - p. 423 122. Chapter 104: Subcutaneous Panniculitis-Like T-Cell Lymphoma - p. 427 123. Chapter 105: Mycosis Fungoides/Sézary Syndrome - p. 431 124. Chapter 106: Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders - p. 437 125. Chapter 107: Peripheral T-Cell Lymphoma, NOS - p. 441 126. Chapter 108: Nodal Follicular Helper T-Cell Lymphoma - p. 447 127. Chapter 109: Anaplastic Large Cell Lymphoma, ALK-Negative - p. 455 128. Chapter 110: Anaplastic Large Cell Lymphoma, ALK-Positive - p. 461 129. SECTION 7: MOLECULAR PATHOLOGY OF DENDRITIC CELL AND HISTIOCYTIC NEOPLASMS - p. 467 130. Chapter 111: Histiocytic Sarcoma - p. 467 131. Chapter 112: Langerhans Cell Histiocytosis - p. 477 132. Chapter 113: Interdigitating Dendritic Cell Sarcoma - p. 483 133. Chapter 114: Follicular Dendritic Cell Sarcoma - p. 487 134. SECTION 8: MOLECULAR PATHOLOGY OF SOLID TUMORS - p. 491 135. HEAD AND NECK, INCLUDING SINONASAL TUMORS AND SALIVARY GLANDS - p. 491 136. Chapter 115: HPV-Associated Head and Neck Carcinomas - p. 491 137. Chapter 116: Head and Neck Mucosal Squamous Cell Carcinoma, Non-HPV Related - p. 499 138. Chapter 117: Important Alterations in Non-HPV-Related Head and Neck Squamous Cell Carcinoma - p. 505 139. Chapter 118: Translocation-Specific Salivary Gland Tumors - p. 507 140. Chapter 119: Translocation-Specific Salivary Gland Tumors (Continued) - p. 517 141. Chapter 120: Nasopharyngeal EBV-Related Squamous Cell Carcinoma - p. 525 142. Chapter 121: Other Head and Neck Tumors - p. 529 143. THYROID - p. 537 144. Chapter 122: Papillary Thyroid Carcinoma - p. 537 145. Chapter 123: Follicular Thyroid Carcinoma - p. 541 146. Chapter 124: Poorly Differentiated Thyroid Carcinoma - p. 544 147. Chapter 125: Anaplastic Thyroid Carcinoma - p. 549 148. Chapter 126: Medullary Thyroid Carcinoma - p. 553 149. LUNG - p. 559 150. Chapter 127: Adenocarcinoma, Lung - p. 559 151. Chapter 128: Squamous Cell Carcinoma, Lung - p. 567 152. Chapter 129: Small Cell Neuroendocrine Carcinoma - p. 571 153. Chapter 130: Mesothelioma - p. 575 154. LUMINAL GASTROINTESTINAL TRACT - p. 579 155. Chapter 131: Gastric Adenocarcinoma - p. 579 156. Chapter 132: Colorectal Adenocarcinoma and Precancerous Lesions - p. 583 157. Chapter 133: Gastrointestinal Stromal Tumor - p. 589 158. LIVER - p. 597 159. Chapter 134: HNF1A-Inactivated Hepatocellular Adenoma - p. 597 160. Chapter 135: β-Catenin-Activated Hepatocellular Adenoma - p. 601 161. Chapter 136: Inflammatory Hepatocellular Adenoma - p. 605 162. Chapter 137: Hepatocellular Carcinoma - p. 609 163. PANCREATICOBILIARY - p. 613 164. Chapter 138: Pancreatic Ductal Adenocarcinoma - p. 613 165. Chapter 139: Pancreatic Mucinous Cystic Neoplasm - p. 617 166. Chapter 140: Pancreatic Intraductal Papillary Mucinous Neoplasm - p. 619 167. Chapter 141: Cholangiocarcinoma - p. 621 168. TESTIS - p. 623 169. Chapter 142: Testicular Germ Cell Tumors - p. 623 170. KIDNEY - p. 629 171. Chapter 143: Clear Cell Renal Cell Carcinoma - p. 629 172. Chapter 144: Chromophobe Renal Cell Carcinoma - p. 633 173. Chapter 145: Papillary Renal Cell Carcinoma - p. 635 174. Chapter 146: TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas - p. 637 175. Chapter 147: Wilms Tumor - p. 641 176. Chapter 148: Clear Cell Sarcoma of Kidney - p. 647 177. Chapter 149: Oncocytoma - p. 649 178. Chapter 150: Rhabdoid Tumor of Kidney - p. 651 179. BLADDER - p. 653 180. Chapter 151: Urothelial Carcinoma - p. 653 181. ADRENAL - p. 659 182. Chapter 152: Pheochromocytoma/Paraganglioma - p. 659 183. Chapter 153: Adrenal Cortical Carcinoma - p. 665 184. Chapter 154: Neuroblastoma - p. 671 185. Chapter 155: Adrenal Cortical Adenoma - p. 679 186. PROSTATE - p. 683 187. Chapter 156: Prostatic Adenocarcinoma, Acinar Type and High-Grade Prostatic Intraepithelial Neoplasia - p. 683 188. BREAST - p. 687 189. Chapter 157: ADH and DCIS (Dysplastic, Premalignant) - p. 687 190. Chapter 158: Ductal Carcinomas - p. 693 191. Chapter 159: Lobular Carcinoma - p. 699 192. Chapter 160: Invasive Ductal Carcinoma of No Special Type With Medullary Features - p. 705 193. Chapter 161: Metaplastic Breast Carcinoma - p. 709 194. Chapter 162: Phyllodes Tumors - p. 715 195. Chapter 163: Basal-Like and Triple-Negative Breast Carcinomas - p. 719 196. CERVIX/VULVA/VAGINA - p. 729 197. Chapter 164: Preneoplastic Conditions, Cervix/Vulva/Vagina - p. 729 198. Chapter 165: Squamous Cell Carcinoma, Cervix/Vulva/Vagina - p. 733 199. Chapter 166: Adenocarcinoma, Cervix/Vulva/Vagina - p. 737 200. UTERUS - p. 741 201. Chapter 167: Endometrial Intraepithelial Neoplasia - p. 741 202. Chapter 168: Uterine Endometrioid Carcinoma - p. 743 203. Chapter 169: Uterine Serous Carcinoma - p. 747 204. Chapter 170: Clear Cell Carcinoma, Uterus - p. 749 205. Chapter 171: Uterine Sarcomas - p. 753 206. OVARIES/FALLOPIAN TUBE - p. 761 207. Chapter 172: Serous Tumors of Ovary and Fallopian Tube - p. 761 208. Chapter 173: Other Surface Epithelial Tumors of Ovary - p. 767 209. Chapter 174: Sex Cord-Stromal Tumors of Ovary - p. 773 210. Chapter 175: Germ Cell Tumor, Ovary - p. 779 211. SKIN - p. 783 212. Chapter 176: Premalignant Conditions, Skin - p. 783 213. Chapter 177: Melanoma - p. 787 214. Chapter 178: Squamous Cell Carcinoma, Skin - p. 791 215. Chapter 179: Basal Cell Carcinoma, Skin - p. 795 216. Chapter 180: Sebaceous Tumors - p. 799 217. Chapter 181: Dermatofibroma and Dermatofibrosarcoma Protuberans - p. 801 218. BONE - p. 803 219. Chapter 182: Overview of Molecular Pathology of Bone and Soft Tissue Tumors - p. 803 220. Chapter 183: Osteosarcomas - p. 809 221. Chapter 184: Ewing Sarcoma - p. 817 222. Chapter 185: Other Small Round Blue Cell Sarcomas - p. 823 223. Chapter 186: Giant Cell Tumor of Bone - p. 831 224. Chapter 187: Intermediate and Malignant Cartilaginous Tumors of Bone - p. 837 225. SOFT TISSUE - p. 847 226. Chapter 188: Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors - p. 847 227. Chapter 189: Liposarcomas - p. 857 228. Chapter 190: Muscle Sarcomas - p. 867 229. Chapter 191: Intermediate and Malignant Vascular Tumors - p. 877 230. Chapter 192: Malignant Peripheral Nerve Sheath Tumor - p. 885 231. Chapter 193: Representative Genetic Findings in Bone and Soft Tissue Tumors - p. 891 232. SARCOMAS OF UNCERTAIN DIFFERENTIATION - p. 897 233. Chapter 194: Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations - p. 897 234. Chapter 195: Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations (Continued) - p. 907 235. CNS - p. 915 236. Chapter 196: Glioblastoma, IDH Wildtype - p. 915 237. Chapter 197: Astrocytoma, IDH-Mutant - p. 919 238. Chapter 198: Pilocytic Astrocytoma - p. 923 239. Chapter 199: Oligodendroglioma, IDH Mutant, and 1p/19q Codeleted - p. 927 240. Chapter 200: Ependymal Tumors - p. 931 241. Chapter 201: Medulloblastoma - p. 937 242. Chapter 202: Choroid Plexus Tumors - p. 943 243. Chapter 203: Meningioma - p. 947 244. Chapter 204: Retinoblastoma - p. 951 245. SECTION 9: QUALITY ASSURANCE AND REGULATORY ISSUES - p. 955 246. Chapter 205: Federal Agencies and Regulation of Laboratories - p. 955 247. Chapter 206: FDA Regulations - p. 959 248. Chapter 207: Proficiency Testing and Accreditation - p. 965 249. INDEX - p. 969
