This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of pediatric neoplasms, including recent molecular advances in the field, this volume incorporates the most up-to-date scientific and technical knowledge to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Pediatric Neoplasms is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Covers all areas of pediatric tumor pathology, with details on more than 270 of the most frequently encountered benign and malignant neoplastic entities, including rare but important edge cases
Addresses each organ system in the body (including skin), as well as soft tissue, bones, and joints, with an overall focus on benign, borderline, and malignant infectious, congenital, and genetic conditions
Includes new chapters on Intramuscular Fast-Flow Anomaly, Kaposiform Lymphangiomatosis, Lipofibromatosis, Pediatric Hepatocellular Carcinoma, Renal Metanephric Tumors, Choriocarcinoma, and more
Contains significantly updated information throughout, including new content, images, and references
Features an intuitive chapter layout designed to help identify crucial elements of each diagnosis, along with associated differential diagnoses and pitfalls, to resolve problems more quickly during routine sign-out of cases
Details the increasing use of molecular diagnostics in pediatric tumor pathology
Features more than 2,600 images, including histology and gross pathology images, full-color medical illustrations, clinical photographs, and radiology images to help practicing and in-training pathologists reach a confident diagnosis
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Contributing Authors - p. iv 7. Preface - p. iv 8. Acknowledgments - p. ix 9. Sections - p. xi 10. TABLE OF CONTENTS - p. xi 11. Part I: Skin - p. xi 12. SECTION 1: BENIGN - p. xi 13. List of Tables - p. xi 14. Chapter 1: Blue Nevus - p. xi 15. Chapter 2: Epidermal Nevus - p. 7 16. Chapter 3: Epidermodysplasia Verruciformis - p. 11 17. Chapter 4: Langerhans Cell Histiocytosis - p. 13 18. Chapter 5: Melanocytic Nevus - p. 17 19. Chapter 6: Nevus Sebaceus - p. 23 20. Chapter 7: Pilomatricoma - p. 25 21. Chapter 8: Pyogenic Granuloma - p. 29 22. Chapter 9: Rhabdomyomatous Mesenchymal Hamartoma - p. 31 23. Chapter 10: Spitz Nevus - p. 33 24. Chapter 11: Syringoma - p. 37 25. Chapter 12: Trichilemmoma - p. 39 26. Chapter 13: Trichoepithelioma - p. 43 27. Chapter 14: Verruca Vulgaris - p. 47 28. SECTION 2: BORDERLINE - p. 49 29. Chapter 15: Dysplastic Nevus - p. 49 30. SECTION 3: MALIGNANT PRIMARY - p. 53 31. Chapter 16: Malignant Melanoma - p. 53 32. Part II: Soft Tissue - p. 63 33. SECTION 1: BENIGN - p. 63 34. Chapter 17: Calcifying Aponeurotic Fibroma - p. 63 35. Chapter 18: Calcifying Fibrous Tumor - p. 67 36. Chapter 19: Cellular Neurothekeoma - p. 69 37. Chapter 20: Congenital Hemangioma - p. 71 38. Chapter 21: Lipomatosis - p. 75 39. Chapter 22: Fetal Rhabdomyoma - p. 77 40. Chapter 23: Fibrodysplasia Ossificans Progressiva - p. 81 41. Chapter 24: Fibrolipomatous Hamartoma of Nerve - p. 83 42. Chapter 25: Fibromatosis Colli - p. 85 43. Chapter 26: Fibrous Hamartoma of Infancy - p. 87 44. Chapter 27: Fibrous Histiocytoma - p. 89 45. Chapter 28: Fibrous Umbilical Polyp - p. 93 46. Chapter 29: Gardner Fibroma - p. 95 47. Chapter 30: Giant Cell Fibroblastoma/Dermatofibrosarcoma Protuberans - p. 97 48. Chapter 31: Glomuvenous Malformation - p. 103 49. Chapter 32: Infantile Hemangioma - p. 105 50. Chapter 33: Inclusion Body Fibromatosis - p. 109 51. Chapter 34: Infantile/Juvenile Hyaline Fibromatosis - p. 113 52. Chapter 35: Inflammatory Myofibroblastic Tumor - p. 115 53. Chapter 36: Juvenile Xanthogranuloma - p. 121 54. Chapter 37: Lipoblastoma - p. 123 55. Chapter 38: Lipofibromatosis - p. 125 56. Chapter 39: Myofibroma and Myopericytoma - p. 127 57. Chapter 40: Myositis Ossificans - p. 133 58. Chapter 41: Neurofibroma - p. 135 59. Chapter 42: Nodular Fasciitis - p. 141 60. Chapter 43: Proliferative Fasciitis/Myositis - p. 145 61. Chapter 44: Schwannoma - p. 147 62. Chapter 45: Spindle Cell Hemangioma - p. 151 63. Chapter 46: Tufted Angioma - p. 153 64. SECTION 2: BORDERLINE - p. 155 65. Chapter 47: Angiomatoid Fibrous Histiocytoma - p. 155 66. Chapter 48: Desmoid Fibromatosis - p. 159 67. Chapter 49: Kaposiform Hemangioendothelioma - p. 163 68. SECTION 3: MALIGNANT PRIMARY - p. 167 69. Chapter 50: Alveolar Soft Part Sarcoma - p. 167 70. Chapter 51: Clear Cell Sarcoma of Soft Tissue - p. 171 71. Chapter 52: Desmoplastic Small Round Cell Tumor - p. 175 72. Chapter 53: Epithelioid Sarcoma - p. 181 73. Chapter 54: Infantile Fibrosarcoma - p. 187 74. Chapter 55: Low-Grade Fibromyxoid Sarcoma/Sclerosing Epithelioid Fibrosarcoma - p. 191 75. Chapter 56: Malignant Peripheral Nerve Sheath Tumor - p. 195 76. Chapter 57: Rhabdomyosarcoma - p. 201 77. Chapter 58: Synovial Sarcoma - p. 211 78. Chapter 59: Undifferentiated Small Round Cell Sarcomas - p. 217 79. Part III: Bone and Joint - p. 219 80. SECTION 1: BENIGN - p. 219 81. Chapter 60: Aneurysmal Bone Cyst - p. 219 82. Chapter 61: Chondroblastoma - p. 225 83. Chapter 62: Chondromyxoid Fibroma - p. 229 84. Chapter 63: Enchondroma - p. 235 85. Chapter 64: Fibrous Dysplasia - p. 237 86. Chapter 65: Giant Cell Tumor of Bone - p. 239 87. Chapter 66: Non-Ossifying Fibroma - p. 243 88. Chapter 67: Osteoblastoma - p. 245 89. Chapter 68: Osteochondroma - p. 249 90. Chapter 69: Osteofibrous Dysplasia - p. 253 91. Chapter 70: Osteoid Osteoma - p. 255 92. Chapter 71: Simple Bone Cyst - p. 261 93. Chapter 72: Synovial Lipomatosis (Hoffa Disease) - p. 265 94. Chapter 73: Tenosynovial Giant Cell Tumor - p. 267 95. SECTION 2: MALIGNANT PRIMARY - p. 271 96. Chapter 74: Adamantinoma - p. 271 97. Chapter 75: Chondrosarcoma - p. 275 98. Chapter 76: Chordoma - p. 281 99. Chapter 77: Ewing Sarcoma - p. 283 100. Chapter 78: Osteosarcoma - p. 289 101. Part IV: Breast - p. 301 102. SECTION 1: BENIGN - p. 301 103. Chapter 79: Fibroadenoma - p. 301 104. Chapter 80: Fibrocystic Change - p. 307 105. Chapter 81: Gynecomastia - p. 311 106. Chapter 82: Juvenile Fibroadenoma - p. 313 107. Chapter 83: Juvenile Hypertrophy - p. 315 108. Chapter 84: Juvenile Papillomatosis - p. 317 109. Chapter 85: Pseudoangiomatous Stromal Hyperplasia - p. 319 110. Chapter 86: Tubular Adenoma - p. 323 111. SECTION 2: BORDERLINE - p. 325 112. Chapter 87: Phyllodes Tumor - p. 325 113. SECTION 3: MALIGNANT PRIMARY - p. 331 114. Chapter 88: Secretory Carcinoma - p. 331 115. Part V: Central Nervous System - p. 337 116. SECTION 1: GLIOMAS, GLIONEURONAL TUMORS, AND NEURONAL TUMORS - p. 337 117. Chapter 89: Angiocentric Glioma - p. 337 118. Chapter 90: Astroblastoma, MN1-Altered - p. 345 119. Chapter 91: Diffuse Hemispheric Glioma, H3 G34-Mutant - p. 351 120. Chapter 92: Diffuse Midline Glioma, H3 K27-Altered - p. 353 121. Chapter 93: Diffuse Pediatric-Type High-Grade Glioma, H3-Wildtype and IDH-Wildtype - p. 359 122. Chapter 94: Ependymoma - p. 367 123. Chapter 95: Other Glioneuronal and Neuronal Tumors - p. 375 124. Chapter 96: Infant-Type Hemispheric Glioma - p. 383 125. Chapter 97: Meningioangiomatosis - p. 385 126. Chapter 98: Pediatric Low-Grade Glioma/Glioneuronal Tumors, Including *MYB*-, *MYBL1*-, *MAPK*-Altered Tumors - p. 389 127. Chapter 99: Pilocytic Astrocytoma - p. 393 128. Chapter 100: Pleomorphic Xanthoastrocytoma - p. 399 129. Chapter 101: Polymorphous Low-Grade Neuroepithelial Tumor of the Young - p. 405 130. Chapter 102: Subependymal Giant Cell Astrocytoma - p. 409 131. SECTION 2: CHOROID PLEXUS TUMORS - p. 415 132. Chapter 103: Choroid Plexus Tumors - p. 415 133. SECTION 3: CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS - p. 425 134. Chapter 104: Atypical Teratoid/Rhabdoid Tumor - p. 425 135. Chapter 105: Other Central Nervous System Embryonal Tumors - p. 433 136. Chapter 106: Medulloblastoma - p. 445 137. SECTION 4: PINEAL TUMORS - p. 455 138. Chapter 107: Pineal Parenchymal Tumors - p. 455 139. SECTION 5: TUMORS OF THE SELLAR REGION - p. 465 140. Chapter 108: Craniopharyngioma - p. 465 141. Chapter 109: Pituitary Blastoma - p. 473 142. Part VI: Endocrine - p. 479 143. SECTION 1: ENDOCRINE TUMORS - p. 479 144. Chapter 110: Adrenal Cortical Neoplasms - p. 479 145. Chapter 111: Follicular Thyroid Neoplasms - p. 489 146. Chapter 112: Medullary Thyroid Carcinoma - p. 495 147. Chapter 113: Neuroblastic Tumors - p. 501 148. Chapter 114: Papillary Thyroid Carcinoma - p. 513 149. Part VII: Head and Neck - p. 521 150. SECTION 1: BENIGN - p. 521 151. Chapter 115: Congenital Granular Cell Epulis - p. 521 152. Chapter 116: Melanotic Neuroectodermal Tumor of Infancy - p. 527 153. Chapter 117: Pleomorphic Adenoma - p. 529 154. Chapter 118: Salivary Gland Anlage Tumor - p. 535 155. Chapter 119: Sialoblastoma - p. 537 156. SECTION 2: MALIGNANT PRIMARY - p. 539 157. Chapter 120: Acinic Cell Carcinoma - p. 539 158. Chapter 121: Mucoepidermoid Carcinoma - p. 543 159. Chapter 122: Retinoblastoma - p. 549 160. Part VIII: Thoracic - p. 553 161. SECTION 1: BENIGN - p. 553 162. Chapter 123: Cardiac Fibroma - p. 553 163. Chapter 124: Cardiac Rhabdomyoma - p. 557 164. Chapter 125: Cystic Teratoma of Heart - p. 559 165. Chapter 126: Conduction System Hamartoma - p. 561 166. Chapter 127: Laryngotracheal Papillomatosis - p. 565 167. SECTION 2: MALIGNANT PRIMARY - p. 567 168. Chapter 128: Pleuropulmonary Blastoma - p. 567 169. Chapter 129: Thymoma - p. 573 170. Part IX: Alimentary Canal - p. 589 171. SECTION 1: BENIGN - p. 589 172. Chapter 130: Familial Adenomatous Polyposis - p. 589 173. Chapter 131: Hamartomatous Polyps, Including Juvenile Polyps - p. 595 174. Chapter 132: Inflammatory Polyps - p. 599 175. Chapter 133: Neuroendocrine Tumors - p. 603 176. SECTION 2: MALIGNANT PRIMARY - p. 607 177. Chapter 134: Gastrointestinal Stromal Tumor - p. 607 178. Part X: Liver/Pancreas - p. 613 179. SECTION 1: BENIGN - p. 613 180. Chapter 135: Focal Nodular Hyperplasia - p. 613 181. Chapter 136: Hepatic Adenomas - p. 617 182. Chapter 137: Hepatic Hemangiomas - p. 621 183. Chapter 138: Islet Cell Adenoma - p. 625 184. Chapter 139: Mesenchymal Hamartoma of Liver - p. 627 185. Chapter 140: Nesidioblastosis - p. 629 186. Chapter 141: Nodular Regenerative Hyperplasia - p. 631 187. SECTION 2: MALIGNANT PRIMARY - p. 633 188. Chapter 142: Fibrolamellar Hepatocellular Carcinoma - p. 633 189. Chapter 143: Hepatoblastoma - p. 639 190. Chapter 144: Pancreatoblastoma - p. 645 191. Chapter 145: Pediatric Hepatocellular Carcinoma - p. 649 192. Chapter 146: Solid Pseudopapillary Neoplasm - p. 653 193. Chapter 147: Undifferentiated Embryonal Sarcoma - p. 657 194. Part XI: Renal - p. 659 195. SECTION 1: BENIGN - p. 659 196. Chapter 148: Pediatric Cystic Nephroma - p. 659 197. Chapter 149: Ossifying Renal Tumor of Infancy - p. 665 198. Chapter 150: Renal Metanephric Tumors - p. 667 199. SECTION 2: MALIGNANT PRIMARY - p. 675 200. Chapter 151: Clear Cell Sarcoma of Kidney - p. 675 201. Chapter 152: Congenital Mesoblastic Nephroma - p. 681 202. Chapter 153: Malignant Rhabdoid Tumor of Kidney - p. 685 203. Chapter 154: *SMARCB1*-Deficient Renal Medullary Carcinoma - p. 689 204. Chapter 155: TFE3- and TFEB-Rearranged Renal Cell Carcinomas - p. 691 205. Chapter 156: Tuberous Sclerosis Complex - p. 699 206. Chapter 157: Nephroblastic Tumors, Including Wilms - p. 709 207. Part XII: Reproductive - p. 721 208. SECTION 1: GERM CELL TUMORS - p. 721 209. Chapter 158: Choriocarcinoma (Nongestational) - p. 721 210. Chapter 159: Embryonal Carcinoma - p. 725 211. Chapter 160: Germinoma Family of Tumors - p. 729 212. Chapter 161: Germ Cell Neoplasia In Situ - p. 733 213. Chapter 162: Gonadoblastoma - p. 739 214. Chapter 163: Teratomas - p. 741 215. Chapter 164: Yolk Sac Tumor - p. 749 216. SECTION 2: SEX CORD-STROMAL TUMORS - p. 753 217. Chapter 165: Fibroma-Thecoma - p. 753 218. Chapter 166: Juvenile Granulosa Cell Tumor - p. 757 219. Chapter 167: Sertoli-Leydig Cell Tumors - p. 759 220. Part XIII: Hematopoietic - p. 763 221. SECTION 1: MALIGNANT PRIMARY - p. 763 222. Chapter 168: Acute Myeloid Leukemias - p. 763 223. Chapter 169: Anaplastic Large Cell Lymphoma, ALK (+) - p. 773 224. Chapter 170: Autoimmune Lymphoproliferative Syndrome - p. 781 225. Chapter 171: B-Acute Lymphoblastic Leukemias/Lymphomas - p. 793 226. Chapter 172: Burkitt Lymphoma - p. 801 227. Chapter 173: Childhood Myelodysplastic Syndrome - p. 807 228. Chapter 174: Classic Hodgkin Lymphoma - p. 813 229. Chapter 175: Diffuse Large B-Cell Lymphoma - p. 821 230. Chapter 176: Early T-Cell Precursor Acute Lymphoblastic Leukemia - p. 827 231. Chapter 177: Juvenile Myelomonocytic Leukemia - p. 829 232. Chapter 178: Mastocytosis - p. 833 233. Chapter 179: Myeloid Neoplasms With Germline Predisposition - p. 841 234. Chapter 180: Myeloid Proliferations Related to Down Syndrome - p. 843 235. Chapter 181: Myeloid Sarcoma - p. 847 236. Chapter 182: Nodular Lymphocyte-Predominant Hodgkin Lymphoma - p. 853 237. Chapter 183: Overview of Lymphoproliferative Disorders Associated With Primary Immunodeficiency Disorders - p. 865 238. Chapter 184: Pediatric-Type Follicular Lymphoma - p. 871 239. Chapter 185: Posttransplant Lymphoproliferative Disorders - p. 875 240. Chapter 186: Primary Mediastinal (Thymic) Large B-Cell Lymphoma - p. 881 241. Chapter 187: T-Cell Lymphoblastic Leukemias/Lymphomas - p. 891 242. INDEX - p. 897
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of pediatric neoplasms, including recent molecular advances in the field, this volume incorporates the most up-to-date scientific and technical knowledge to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Pediatric Neoplasms is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Covers all areas of pediatric tumor pathology, with details on more than 270 of the most frequently encountered benign and malignant neoplastic entities, including rare but important edge cases
Addresses each organ system in the body (including skin), as well as soft tissue, bones, and joints, with an overall focus on benign, borderline, and malignant infectious, congenital, and genetic conditions
Includes new chapters on Intramuscular Fast-Flow Anomaly, Kaposiform Lymphangiomatosis, Lipofibromatosis, Pediatric Hepatocellular Carcinoma, Renal Metanephric Tumors, Choriocarcinoma, and more
Contains significantly updated information throughout, including new content, images, and references
Features an intuitive chapter layout designed to help identify crucial elements of each diagnosis, along with associated differential diagnoses and pitfalls, to resolve problems more quickly during routine sign-out of cases
Details the increasing use of molecular diagnostics in pediatric tumor pathology
Features more than 2,600 images, including histology and gross pathology images, full-color medical illustrations, clinical photographs, and radiology images to help practicing and in-training pathologists reach a confident diagnosis
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Contributing Authors - p. iv 7. Preface - p. iv 8. Acknowledgments - p. ix 9. Sections - p. xi 10. TABLE OF CONTENTS - p. xi 11. Part I: Skin - p. xi 12. SECTION 1: BENIGN - p. xi 13. List of Tables - p. xi 14. Chapter 1: Blue Nevus - p. xi 15. Chapter 2: Epidermal Nevus - p. 7 16. Chapter 3: Epidermodysplasia Verruciformis - p. 11 17. Chapter 4: Langerhans Cell Histiocytosis - p. 13 18. Chapter 5: Melanocytic Nevus - p. 17 19. Chapter 6: Nevus Sebaceus - p. 23 20. Chapter 7: Pilomatricoma - p. 25 21. Chapter 8: Pyogenic Granuloma - p. 29 22. Chapter 9: Rhabdomyomatous Mesenchymal Hamartoma - p. 31 23. Chapter 10: Spitz Nevus - p. 33 24. Chapter 11: Syringoma - p. 37 25. Chapter 12: Trichilemmoma - p. 39 26. Chapter 13: Trichoepithelioma - p. 43 27. Chapter 14: Verruca Vulgaris - p. 47 28. SECTION 2: BORDERLINE - p. 49 29. Chapter 15: Dysplastic Nevus - p. 49 30. SECTION 3: MALIGNANT PRIMARY - p. 53 31. Chapter 16: Malignant Melanoma - p. 53 32. Part II: Soft Tissue - p. 63 33. SECTION 1: BENIGN - p. 63 34. Chapter 17: Calcifying Aponeurotic Fibroma - p. 63 35. Chapter 18: Calcifying Fibrous Tumor - p. 67 36. Chapter 19: Cellular Neurothekeoma - p. 69 37. Chapter 20: Congenital Hemangioma - p. 71 38. Chapter 21: Lipomatosis - p. 75 39. Chapter 22: Fetal Rhabdomyoma - p. 77 40. Chapter 23: Fibrodysplasia Ossificans Progressiva - p. 81 41. Chapter 24: Fibrolipomatous Hamartoma of Nerve - p. 83 42. Chapter 25: Fibromatosis Colli - p. 85 43. Chapter 26: Fibrous Hamartoma of Infancy - p. 87 44. Chapter 27: Fibrous Histiocytoma - p. 89 45. Chapter 28: Fibrous Umbilical Polyp - p. 93 46. Chapter 29: Gardner Fibroma - p. 95 47. Chapter 30: Giant Cell Fibroblastoma/Dermatofibrosarcoma Protuberans - p. 97 48. Chapter 31: Glomuvenous Malformation - p. 103 49. Chapter 32: Infantile Hemangioma - p. 105 50. Chapter 33: Inclusion Body Fibromatosis - p. 109 51. Chapter 34: Infantile/Juvenile Hyaline Fibromatosis - p. 113 52. Chapter 35: Inflammatory Myofibroblastic Tumor - p. 115 53. Chapter 36: Juvenile Xanthogranuloma - p. 121 54. Chapter 37: Lipoblastoma - p. 123 55. Chapter 38: Lipofibromatosis - p. 125 56. Chapter 39: Myofibroma and Myopericytoma - p. 127 57. Chapter 40: Myositis Ossificans - p. 133 58. Chapter 41: Neurofibroma - p. 135 59. Chapter 42: Nodular Fasciitis - p. 141 60. Chapter 43: Proliferative Fasciitis/Myositis - p. 145 61. Chapter 44: Schwannoma - p. 147 62. Chapter 45: Spindle Cell Hemangioma - p. 151 63. Chapter 46: Tufted Angioma - p. 153 64. SECTION 2: BORDERLINE - p. 155 65. Chapter 47: Angiomatoid Fibrous Histiocytoma - p. 155 66. Chapter 48: Desmoid Fibromatosis - p. 159 67. Chapter 49: Kaposiform Hemangioendothelioma - p. 163 68. SECTION 3: MALIGNANT PRIMARY - p. 167 69. Chapter 50: Alveolar Soft Part Sarcoma - p. 167 70. Chapter 51: Clear Cell Sarcoma of Soft Tissue - p. 171 71. Chapter 52: Desmoplastic Small Round Cell Tumor - p. 175 72. Chapter 53: Epithelioid Sarcoma - p. 181 73. Chapter 54: Infantile Fibrosarcoma - p. 187 74. Chapter 55: Low-Grade Fibromyxoid Sarcoma/Sclerosing Epithelioid Fibrosarcoma - p. 191 75. Chapter 56: Malignant Peripheral Nerve Sheath Tumor - p. 195 76. Chapter 57: Rhabdomyosarcoma - p. 201 77. Chapter 58: Synovial Sarcoma - p. 211 78. Chapter 59: Undifferentiated Small Round Cell Sarcomas - p. 217 79. Part III: Bone and Joint - p. 219 80. SECTION 1: BENIGN - p. 219 81. Chapter 60: Aneurysmal Bone Cyst - p. 219 82. Chapter 61: Chondroblastoma - p. 225 83. Chapter 62: Chondromyxoid Fibroma - p. 229 84. Chapter 63: Enchondroma - p. 235 85. Chapter 64: Fibrous Dysplasia - p. 237 86. Chapter 65: Giant Cell Tumor of Bone - p. 239 87. Chapter 66: Non-Ossifying Fibroma - p. 243 88. Chapter 67: Osteoblastoma - p. 245 89. Chapter 68: Osteochondroma - p. 249 90. Chapter 69: Osteofibrous Dysplasia - p. 253 91. Chapter 70: Osteoid Osteoma - p. 255 92. Chapter 71: Simple Bone Cyst - p. 261 93. Chapter 72: Synovial Lipomatosis (Hoffa Disease) - p. 265 94. Chapter 73: Tenosynovial Giant Cell Tumor - p. 267 95. SECTION 2: MALIGNANT PRIMARY - p. 271 96. Chapter 74: Adamantinoma - p. 271 97. Chapter 75: Chondrosarcoma - p. 275 98. Chapter 76: Chordoma - p. 281 99. Chapter 77: Ewing Sarcoma - p. 283 100. Chapter 78: Osteosarcoma - p. 289 101. Part IV: Breast - p. 301 102. SECTION 1: BENIGN - p. 301 103. Chapter 79: Fibroadenoma - p. 301 104. Chapter 80: Fibrocystic Change - p. 307 105. Chapter 81: Gynecomastia - p. 311 106. Chapter 82: Juvenile Fibroadenoma - p. 313 107. Chapter 83: Juvenile Hypertrophy - p. 315 108. Chapter 84: Juvenile Papillomatosis - p. 317 109. Chapter 85: Pseudoangiomatous Stromal Hyperplasia - p. 319 110. Chapter 86: Tubular Adenoma - p. 323 111. SECTION 2: BORDERLINE - p. 325 112. Chapter 87: Phyllodes Tumor - p. 325 113. SECTION 3: MALIGNANT PRIMARY - p. 331 114. Chapter 88: Secretory Carcinoma - p. 331 115. Part V: Central Nervous System - p. 337 116. SECTION 1: GLIOMAS, GLIONEURONAL TUMORS, AND NEURONAL TUMORS - p. 337 117. Chapter 89: Angiocentric Glioma - p. 337 118. Chapter 90: Astroblastoma, MN1-Altered - p. 345 119. Chapter 91: Diffuse Hemispheric Glioma, H3 G34-Mutant - p. 351 120. Chapter 92: Diffuse Midline Glioma, H3 K27-Altered - p. 353 121. Chapter 93: Diffuse Pediatric-Type High-Grade Glioma, H3-Wildtype and IDH-Wildtype - p. 359 122. Chapter 94: Ependymoma - p. 367 123. Chapter 95: Other Glioneuronal and Neuronal Tumors - p. 375 124. Chapter 96: Infant-Type Hemispheric Glioma - p. 383 125. Chapter 97: Meningioangiomatosis - p. 385 126. Chapter 98: Pediatric Low-Grade Glioma/Glioneuronal Tumors, Including *MYB*-, *MYBL1*-, *MAPK*-Altered Tumors - p. 389 127. Chapter 99: Pilocytic Astrocytoma - p. 393 128. Chapter 100: Pleomorphic Xanthoastrocytoma - p. 399 129. Chapter 101: Polymorphous Low-Grade Neuroepithelial Tumor of the Young - p. 405 130. Chapter 102: Subependymal Giant Cell Astrocytoma - p. 409 131. SECTION 2: CHOROID PLEXUS TUMORS - p. 415 132. Chapter 103: Choroid Plexus Tumors - p. 415 133. SECTION 3: CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS - p. 425 134. Chapter 104: Atypical Teratoid/Rhabdoid Tumor - p. 425 135. Chapter 105: Other Central Nervous System Embryonal Tumors - p. 433 136. Chapter 106: Medulloblastoma - p. 445 137. SECTION 4: PINEAL TUMORS - p. 455 138. Chapter 107: Pineal Parenchymal Tumors - p. 455 139. SECTION 5: TUMORS OF THE SELLAR REGION - p. 465 140. Chapter 108: Craniopharyngioma - p. 465 141. Chapter 109: Pituitary Blastoma - p. 473 142. Part VI: Endocrine - p. 479 143. SECTION 1: ENDOCRINE TUMORS - p. 479 144. Chapter 110: Adrenal Cortical Neoplasms - p. 479 145. Chapter 111: Follicular Thyroid Neoplasms - p. 489 146. Chapter 112: Medullary Thyroid Carcinoma - p. 495 147. Chapter 113: Neuroblastic Tumors - p. 501 148. Chapter 114: Papillary Thyroid Carcinoma - p. 513 149. Part VII: Head and Neck - p. 521 150. SECTION 1: BENIGN - p. 521 151. Chapter 115: Congenital Granular Cell Epulis - p. 521 152. Chapter 116: Melanotic Neuroectodermal Tumor of Infancy - p. 527 153. Chapter 117: Pleomorphic Adenoma - p. 529 154. Chapter 118: Salivary Gland Anlage Tumor - p. 535 155. Chapter 119: Sialoblastoma - p. 537 156. SECTION 2: MALIGNANT PRIMARY - p. 539 157. Chapter 120: Acinic Cell Carcinoma - p. 539 158. Chapter 121: Mucoepidermoid Carcinoma - p. 543 159. Chapter 122: Retinoblastoma - p. 549 160. Part VIII: Thoracic - p. 553 161. SECTION 1: BENIGN - p. 553 162. Chapter 123: Cardiac Fibroma - p. 553 163. Chapter 124: Cardiac Rhabdomyoma - p. 557 164. Chapter 125: Cystic Teratoma of Heart - p. 559 165. Chapter 126: Conduction System Hamartoma - p. 561 166. Chapter 127: Laryngotracheal Papillomatosis - p. 565 167. SECTION 2: MALIGNANT PRIMARY - p. 567 168. Chapter 128: Pleuropulmonary Blastoma - p. 567 169. Chapter 129: Thymoma - p. 573 170. Part IX: Alimentary Canal - p. 589 171. SECTION 1: BENIGN - p. 589 172. Chapter 130: Familial Adenomatous Polyposis - p. 589 173. Chapter 131: Hamartomatous Polyps, Including Juvenile Polyps - p. 595 174. Chapter 132: Inflammatory Polyps - p. 599 175. Chapter 133: Neuroendocrine Tumors - p. 603 176. SECTION 2: MALIGNANT PRIMARY - p. 607 177. Chapter 134: Gastrointestinal Stromal Tumor - p. 607 178. Part X: Liver/Pancreas - p. 613 179. SECTION 1: BENIGN - p. 613 180. Chapter 135: Focal Nodular Hyperplasia - p. 613 181. Chapter 136: Hepatic Adenomas - p. 617 182. Chapter 137: Hepatic Hemangiomas - p. 621 183. Chapter 138: Islet Cell Adenoma - p. 625 184. Chapter 139: Mesenchymal Hamartoma of Liver - p. 627 185. Chapter 140: Nesidioblastosis - p. 629 186. Chapter 141: Nodular Regenerative Hyperplasia - p. 631 187. SECTION 2: MALIGNANT PRIMARY - p. 633 188. Chapter 142: Fibrolamellar Hepatocellular Carcinoma - p. 633 189. Chapter 143: Hepatoblastoma - p. 639 190. Chapter 144: Pancreatoblastoma - p. 645 191. Chapter 145: Pediatric Hepatocellular Carcinoma - p. 649 192. Chapter 146: Solid Pseudopapillary Neoplasm - p. 653 193. Chapter 147: Undifferentiated Embryonal Sarcoma - p. 657 194. Part XI: Renal - p. 659 195. SECTION 1: BENIGN - p. 659 196. Chapter 148: Pediatric Cystic Nephroma - p. 659 197. Chapter 149: Ossifying Renal Tumor of Infancy - p. 665 198. Chapter 150: Renal Metanephric Tumors - p. 667 199. SECTION 2: MALIGNANT PRIMARY - p. 675 200. Chapter 151: Clear Cell Sarcoma of Kidney - p. 675 201. Chapter 152: Congenital Mesoblastic Nephroma - p. 681 202. Chapter 153: Malignant Rhabdoid Tumor of Kidney - p. 685 203. Chapter 154: *SMARCB1*-Deficient Renal Medullary Carcinoma - p. 689 204. Chapter 155: TFE3- and TFEB-Rearranged Renal Cell Carcinomas - p. 691 205. Chapter 156: Tuberous Sclerosis Complex - p. 699 206. Chapter 157: Nephroblastic Tumors, Including Wilms - p. 709 207. Part XII: Reproductive - p. 721 208. SECTION 1: GERM CELL TUMORS - p. 721 209. Chapter 158: Choriocarcinoma (Nongestational) - p. 721 210. Chapter 159: Embryonal Carcinoma - p. 725 211. Chapter 160: Germinoma Family of Tumors - p. 729 212. Chapter 161: Germ Cell Neoplasia In Situ - p. 733 213. Chapter 162: Gonadoblastoma - p. 739 214. Chapter 163: Teratomas - p. 741 215. Chapter 164: Yolk Sac Tumor - p. 749 216. SECTION 2: SEX CORD-STROMAL TUMORS - p. 753 217. Chapter 165: Fibroma-Thecoma - p. 753 218. Chapter 166: Juvenile Granulosa Cell Tumor - p. 757 219. Chapter 167: Sertoli-Leydig Cell Tumors - p. 759 220. Part XIII: Hematopoietic - p. 763 221. SECTION 1: MALIGNANT PRIMARY - p. 763 222. Chapter 168: Acute Myeloid Leukemias - p. 763 223. Chapter 169: Anaplastic Large Cell Lymphoma, ALK (+) - p. 773 224. Chapter 170: Autoimmune Lymphoproliferative Syndrome - p. 781 225. Chapter 171: B-Acute Lymphoblastic Leukemias/Lymphomas - p. 793 226. Chapter 172: Burkitt Lymphoma - p. 801 227. Chapter 173: Childhood Myelodysplastic Syndrome - p. 807 228. Chapter 174: Classic Hodgkin Lymphoma - p. 813 229. Chapter 175: Diffuse Large B-Cell Lymphoma - p. 821 230. Chapter 176: Early T-Cell Precursor Acute Lymphoblastic Leukemia - p. 827 231. Chapter 177: Juvenile Myelomonocytic Leukemia - p. 829 232. Chapter 178: Mastocytosis - p. 833 233. Chapter 179: Myeloid Neoplasms With Germline Predisposition - p. 841 234. Chapter 180: Myeloid Proliferations Related to Down Syndrome - p. 843 235. Chapter 181: Myeloid Sarcoma - p. 847 236. Chapter 182: Nodular Lymphocyte-Predominant Hodgkin Lymphoma - p. 853 237. Chapter 183: Overview of Lymphoproliferative Disorders Associated With Primary Immunodeficiency Disorders - p. 865 238. Chapter 184: Pediatric-Type Follicular Lymphoma - p. 871 239. Chapter 185: Posttransplant Lymphoproliferative Disorders - p. 875 240. Chapter 186: Primary Mediastinal (Thymic) Large B-Cell Lymphoma - p. 881 241. Chapter 187: T-Cell Lymphoblastic Leukemias/Lymphomas - p. 891 242. INDEX - p. 897
