This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of placental pathology and the critical role the placenta plays in the unique interface between mother and fetus, this volume incorporates the most up-to-date scientific and technical knowledge to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Placenta is a visually stunning, one-stop resource for every practicing pathologist, fellow, resident, or student as an ideal day-to-day reference or as a reliable training resource, and is useful to even the most experienced placental pathologist for diagnostic criteria, grading, and relevance of placental tissue samples.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Contributing Authors - p. v 7. Preface - p. v 8. Acknowledgments - p. ix 9. Sections - p. xi 10. TABLE OF CONTENTS - p. xiii 11. SECTION 1: OVERVIEW OF GROSS AND MICROSCOPIC CHANGES - p. xiii 12. UMBILICAL CORD - p. xiii 13. List of Tables - p. xiii 14. Chapter 1: Gross Evaluation and Normal Histology of Umbilical Cord - p. xiii 15. Chapter 2: Umbilical Cord Coiling - p. 13 16. Chapter 3: Knots - p. 17 17. Chapter 4: Umbilical Cord Edema and Thinning - p. 21 18. Chapter 5: Histopathologic Changes of Umbilical Cord - p. 25 19. EXTRAPLACENTAL MEMBRANES - p. 31 20. Chapter 6: Gross Evaluation and Normal Histology of Membranes - p. 31 21. Chapter 7: Histopathologic Changes of Membranes - p. 35 22. CHORIONIC PLATE - p. 41 23. Chapter 8: Gross Evaluation and Normal Histology of Chorionic Plate - p. 41 24. Chapter 9: Histopathologic Changes of Chorionic Plate - p. 47 25. STEM VILLI - p. 51 26. Chapter 10: Gross Evaluation and Normal Histology of Stem Villi - p. 51 27. Chapter 11: Histopathologic Changes of Stem Villi - p. 53 28. CHORIONIC VILLI - p. 57 29. Chapter 12: Gross Evaluation and Normal Histology of Chorionic Villi - p. 57 30. Chapter 13: Histopathologic Changes of Chorionic Villi - p. 63 31. SEPTA, INTERVILLOUS SPACE, AND BASAL PLATE - p. 71 32. Chapter 14: Gross Evaluation and Normal Histology of Septa, Intervillous Space, and Basal Plate - p. 71 33. Chapter 15: Histopathologic Changes of Septa, Intervillous Space, and Basal Plate - p. 73 34. DECIDUA - p. 75 35. Chapter 16: Gross Evaluation and Normal Histology of Decidua - p. 75 36. Chapter 17: Histopathologic Changes of Decidua - p. 79 37. FALLOPIAN TUBE - p. 83 38. Chapter 18: Fallopian Tube After Opportunistic Salpingectomy - p. 83 39. SECTION 2: PLACENTAL DIAGNOSES - p. 91 40. MECONIUM - p. 91 41. Chapter 19: Meconium-Stained Placenta - p. 91 42. INTRAUTERINE INFLAMMATION/INFECTION - p. 99 43. Chapter 20: Maternal and Fetal Inflammatory Response - p. 99 44. Chapter 21: Group B Streptococcus - p. 107 45. Chapter 22: Escherichia coli and Other Enterobacteriaceae - p. 111 46. Chapter 23: Listeria monocytogenes - p. 115 47. Chapter 24: Fusobacterium Species and Other Anaerobic Bacteria - p. 119 48. Chapter 25: Other Bacterial and Mycobacterial Species - p. 123 49. Chapter 26: Candida - p. 129 50. PLACENTAL INFECTIONS WITH VILLITIS AND OTHER FINDINGS - p. 133 51. Chapter 27: Parvovirus B19 - p. 133 52. Chapter 28: Cytomegalovirus - p. 139 53. Chapter 29: Herpes Simplex Virus - p. 145 54. Chapter 30: Other Herpesviruses - p. 151 55. Chapter 31: SARS-CoV-2 (COVID-19) - p. 155 56. Chapter 32: Other Viruses - p. 157 57. Chapter 33: Syphilis - p. 165 58. Chapter 34: Coccidioidomycosis - p. 169 59. Chapter 35: Parasites - p. 171 60. CHRONIC INFLAMMATORY LESIONS - p. 177 61. Chapter 36: Cellular Composition of Chronic Inflammatory Lesions - p. 177 62. Chapter 37: Chronic Villitis - p. 179 63. Chapter 38: Chronic Histiocytic Intervillositis - p. 185 64. Chapter 39: Basal Chronic Villitis and Chronic Deciduitis - p. 189 65. Chapter 40: Chronic Chorioamnionitis and Chorionic Histiocytic Hyperplasia - p. 193 66. Chapter 41: Eosinophilic/T-Cell Chorionic Vasculitis - p. 197 67. MASSIVE PERIVILLOUS FIBRIN DEPOSITION AND MATERNAL FLOOR INFARCTION - p. 201 68. Chapter 42: Massive Perivillous Fibrin Deposition and Maternal Floor Infarction - p. 201 69. FETAL VASCULAR MALPERFUSION - p. 207 70. Chapter 43: Large Vessel Fetal Vascular Malperfusion - p. 207 71. Chapter 44: Distal Villous Lesions of Fetal Vascular Malperfusion - p. 215 72. MATERNAL VASCULAR MALPERFUSION - p. 219 73. Chapter 45: Small-for-Gestational-Age Placenta - p. 219 74. Chapter 46: Accelerated Villous Maturation - p. 223 75. Chapter 47: Distal Villous Hypoplasia - p. 227 76. Chapter 48: Decidual Arteriopathy - p. 231 77. Chapter 49: Infarcts - p. 235 78. Chapter 50: Acute Abruption and Retroplacental Hematoma - p. 241 79. Chapter 51: Chronic Abruption - p. 247 80. VILLOUS HYPERVASCULAR LESIONS - p. 253 81. Chapter 52: Chorangiosis - p. 253 82. Chapter 53: Chorangiomatosis - p. 255 83. Chapter 54: Chorangioma - p. 257 84. GESTATIONAL TROPHOBLASTIC DISEASE, RELATED LESIONS, AND OTHER TUMORS - p. 261 85. Chapter 55: Hydropic Degeneration - p. 261 86. Chapter 56: Partial Hydatidiform Mole - p. 269 87. Chapter 57: Complete Hydatidiform Mole - p. 277 88. Chapter 58: Gestational Choriocarcinoma - p. 287 89. Chapter 59: Placental Site Nodule and Atypical Placental Site Nodule - p. 291 90. Chapter 60: Exaggerated Placental Site - p. 297 91. Chapter 61: Placental Site Trophoblastic Tumor - p. 301 92. Chapter 62: Epithelioid Trophoblastic Tumor - p. 305 93. Chapter 63: Metastatic Tumors - p. 311 94. Chapter 64: Uterine Tumors Associated With Placenta - p. 319 95. PLACENTAL MESENCHYMAL DYSPLASIA - p. 321 96. Chapter 65: Placental Mesenchymal Dysplasia - p. 321 97. SECTION 3: PLACENTAL EVALUATION IN SPECIAL CIRCUMSTANCES - p. 325 98. DIABETES IN PREGNANCY AND MATERNAL OBESITY - p. 325 99. Chapter 66: Diabetes and Obesity in Pregnancy - p. 325 100. Chapter 67: Placentomegaly - p. 333 101. Chapter 68: Delayed Villous Maturation - p. 339 102. PREECLAMPSIA AND MATERNAL VASCULAR MALPERFUSION - p. 343 103. Chapter 69: Preeclampsia and Related Hypertensive Disorders - p. 343 104. FETAL-MATERNAL HEMORRHAGE - p. 349 105. Chapter 70: Fetal-Maternal Hemorrhage - p. 349 106. Chapter 71: Thrombohematoma and Intervillous Thrombus - p. 353 107. FETAL HYDROPS - p. 357 108. Chapter 72: Hemolytic Disease of Fetus and Newborn - p. 357 109. Chapter 73: Non-Immune-Mediated Hydrops - p. 359 110. FETAL GROWTH RESTRICTION - p. 363 111. Chapter 74: Placental Causes of Poor Fetal Growth - p. 363 112. PREMATURITY - p. 369 113. Chapter 75: Placental Findings in Premature Birth - p. 369 114. ABNORMAL PLACENTAL IMPLANTATION - p. 373 115. Chapter 76: Placenta Accreta Spectrum - p. 373 116. Chapter 77: Ectopic Pregnancy - p. 385 117. INTRAUTERINE FETAL DEMISE - p. 391 118. Chapter 78: 1st-Trimester Pregnancy Loss - p. 391 119. Chapter 79: 2nd-Trimester Fetal Demise - p. 401 120. Chapter 80: 3rd-Trimester Fetal Demise - p. 409 121. Chapter 81: Recurrent Pregnancy Loss - p. 415 122. Chapter 82: In Utero Demise-to-Delivery Interval Changes - p. 419 123. Chapter 83: Hypoxic-Ischemic Encephalopathy - p. 423 124. MULTIPLE GESTATIONS - p. 433 125. Chapter 84: Complications of Monochorionic-Monoamniotic Twin Gestations - p. 433 126. Chapter 85: Twin Growth Discrepancy - p. 441 127. Chapter 86: Twin-Twin Transfusion Syndrome - p. 445 128. Chapter 87: Twin Anemia-Polycythemia Sequence - p. 449 129. Chapter 88: After In Utero Intervention for Twin-Twin Transfusion Syndrome - p. 451 130. Chapter 89: Triplet and Higher Order Placenta - p. 455 131. MATERNAL COMPLICATIONS OF PREGNANCY - p. 459 132. Chapter 90: Maternal Mortality - p. 459 133. Chapter 91: Postpartum Hemorrhage - p. 469 134. Chapter 92: Evaluation of Postpartum Hysterectomy - p. 481 135. SECTION 4: APPENDIX - p. 489 136. REFERENCE CHARTS FOR PLACENTAL EVALUATION - p. 489 137. Chapter 93: Weights for Singleton Placentas - p. 489 138. Chapter 94: Weights for Twin Placentas - p. 492 139. Chapter 95: Weights for Triplet Placentas - p. 493 140. Chapter 96: Reference Values for Fetal and Placental Growth in Early Pregnancy - p. 494 141. SAMPLE TEMPLATES FOR PLACENTAL EVALUATION - p. 495 142. Chapter 97: Singleton Placenta Gross Evaluation - p. 495 143. Chapter 98: Twin Placenta Gross Evaluation - p. 496 144. Chapter 99: Placenta Microscopic Evaluation - p. 497 145. Chapter 100: Placenta Triage - p. 501 146. INDEX - p. 503
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of placental pathology and the critical role the placenta plays in the unique interface between mother and fetus, this volume incorporates the most up-to-date scientific and technical knowledge to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Placenta is a visually stunning, one-stop resource for every practicing pathologist, fellow, resident, or student as an ideal day-to-day reference or as a reliable training resource, and is useful to even the most experienced placental pathologist for diagnostic criteria, grading, and relevance of placental tissue samples.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Contributing Authors - p. v 7. Preface - p. v 8. Acknowledgments - p. ix 9. Sections - p. xi 10. TABLE OF CONTENTS - p. xiii 11. SECTION 1: OVERVIEW OF GROSS AND MICROSCOPIC CHANGES - p. xiii 12. UMBILICAL CORD - p. xiii 13. List of Tables - p. xiii 14. Chapter 1: Gross Evaluation and Normal Histology of Umbilical Cord - p. xiii 15. Chapter 2: Umbilical Cord Coiling - p. 13 16. Chapter 3: Knots - p. 17 17. Chapter 4: Umbilical Cord Edema and Thinning - p. 21 18. Chapter 5: Histopathologic Changes of Umbilical Cord - p. 25 19. EXTRAPLACENTAL MEMBRANES - p. 31 20. Chapter 6: Gross Evaluation and Normal Histology of Membranes - p. 31 21. Chapter 7: Histopathologic Changes of Membranes - p. 35 22. CHORIONIC PLATE - p. 41 23. Chapter 8: Gross Evaluation and Normal Histology of Chorionic Plate - p. 41 24. Chapter 9: Histopathologic Changes of Chorionic Plate - p. 47 25. STEM VILLI - p. 51 26. Chapter 10: Gross Evaluation and Normal Histology of Stem Villi - p. 51 27. Chapter 11: Histopathologic Changes of Stem Villi - p. 53 28. CHORIONIC VILLI - p. 57 29. Chapter 12: Gross Evaluation and Normal Histology of Chorionic Villi - p. 57 30. Chapter 13: Histopathologic Changes of Chorionic Villi - p. 63 31. SEPTA, INTERVILLOUS SPACE, AND BASAL PLATE - p. 71 32. Chapter 14: Gross Evaluation and Normal Histology of Septa, Intervillous Space, and Basal Plate - p. 71 33. Chapter 15: Histopathologic Changes of Septa, Intervillous Space, and Basal Plate - p. 73 34. DECIDUA - p. 75 35. Chapter 16: Gross Evaluation and Normal Histology of Decidua - p. 75 36. Chapter 17: Histopathologic Changes of Decidua - p. 79 37. FALLOPIAN TUBE - p. 83 38. Chapter 18: Fallopian Tube After Opportunistic Salpingectomy - p. 83 39. SECTION 2: PLACENTAL DIAGNOSES - p. 91 40. MECONIUM - p. 91 41. Chapter 19: Meconium-Stained Placenta - p. 91 42. INTRAUTERINE INFLAMMATION/INFECTION - p. 99 43. Chapter 20: Maternal and Fetal Inflammatory Response - p. 99 44. Chapter 21: Group B Streptococcus - p. 107 45. Chapter 22: Escherichia coli and Other Enterobacteriaceae - p. 111 46. Chapter 23: Listeria monocytogenes - p. 115 47. Chapter 24: Fusobacterium Species and Other Anaerobic Bacteria - p. 119 48. Chapter 25: Other Bacterial and Mycobacterial Species - p. 123 49. Chapter 26: Candida - p. 129 50. PLACENTAL INFECTIONS WITH VILLITIS AND OTHER FINDINGS - p. 133 51. Chapter 27: Parvovirus B19 - p. 133 52. Chapter 28: Cytomegalovirus - p. 139 53. Chapter 29: Herpes Simplex Virus - p. 145 54. Chapter 30: Other Herpesviruses - p. 151 55. Chapter 31: SARS-CoV-2 (COVID-19) - p. 155 56. Chapter 32: Other Viruses - p. 157 57. Chapter 33: Syphilis - p. 165 58. Chapter 34: Coccidioidomycosis - p. 169 59. Chapter 35: Parasites - p. 171 60. CHRONIC INFLAMMATORY LESIONS - p. 177 61. Chapter 36: Cellular Composition of Chronic Inflammatory Lesions - p. 177 62. Chapter 37: Chronic Villitis - p. 179 63. Chapter 38: Chronic Histiocytic Intervillositis - p. 185 64. Chapter 39: Basal Chronic Villitis and Chronic Deciduitis - p. 189 65. Chapter 40: Chronic Chorioamnionitis and Chorionic Histiocytic Hyperplasia - p. 193 66. Chapter 41: Eosinophilic/T-Cell Chorionic Vasculitis - p. 197 67. MASSIVE PERIVILLOUS FIBRIN DEPOSITION AND MATERNAL FLOOR INFARCTION - p. 201 68. Chapter 42: Massive Perivillous Fibrin Deposition and Maternal Floor Infarction - p. 201 69. FETAL VASCULAR MALPERFUSION - p. 207 70. Chapter 43: Large Vessel Fetal Vascular Malperfusion - p. 207 71. Chapter 44: Distal Villous Lesions of Fetal Vascular Malperfusion - p. 215 72. MATERNAL VASCULAR MALPERFUSION - p. 219 73. Chapter 45: Small-for-Gestational-Age Placenta - p. 219 74. Chapter 46: Accelerated Villous Maturation - p. 223 75. Chapter 47: Distal Villous Hypoplasia - p. 227 76. Chapter 48: Decidual Arteriopathy - p. 231 77. Chapter 49: Infarcts - p. 235 78. Chapter 50: Acute Abruption and Retroplacental Hematoma - p. 241 79. Chapter 51: Chronic Abruption - p. 247 80. VILLOUS HYPERVASCULAR LESIONS - p. 253 81. Chapter 52: Chorangiosis - p. 253 82. Chapter 53: Chorangiomatosis - p. 255 83. Chapter 54: Chorangioma - p. 257 84. GESTATIONAL TROPHOBLASTIC DISEASE, RELATED LESIONS, AND OTHER TUMORS - p. 261 85. Chapter 55: Hydropic Degeneration - p. 261 86. Chapter 56: Partial Hydatidiform Mole - p. 269 87. Chapter 57: Complete Hydatidiform Mole - p. 277 88. Chapter 58: Gestational Choriocarcinoma - p. 287 89. Chapter 59: Placental Site Nodule and Atypical Placental Site Nodule - p. 291 90. Chapter 60: Exaggerated Placental Site - p. 297 91. Chapter 61: Placental Site Trophoblastic Tumor - p. 301 92. Chapter 62: Epithelioid Trophoblastic Tumor - p. 305 93. Chapter 63: Metastatic Tumors - p. 311 94. Chapter 64: Uterine Tumors Associated With Placenta - p. 319 95. PLACENTAL MESENCHYMAL DYSPLASIA - p. 321 96. Chapter 65: Placental Mesenchymal Dysplasia - p. 321 97. SECTION 3: PLACENTAL EVALUATION IN SPECIAL CIRCUMSTANCES - p. 325 98. DIABETES IN PREGNANCY AND MATERNAL OBESITY - p. 325 99. Chapter 66: Diabetes and Obesity in Pregnancy - p. 325 100. Chapter 67: Placentomegaly - p. 333 101. Chapter 68: Delayed Villous Maturation - p. 339 102. PREECLAMPSIA AND MATERNAL VASCULAR MALPERFUSION - p. 343 103. Chapter 69: Preeclampsia and Related Hypertensive Disorders - p. 343 104. FETAL-MATERNAL HEMORRHAGE - p. 349 105. Chapter 70: Fetal-Maternal Hemorrhage - p. 349 106. Chapter 71: Thrombohematoma and Intervillous Thrombus - p. 353 107. FETAL HYDROPS - p. 357 108. Chapter 72: Hemolytic Disease of Fetus and Newborn - p. 357 109. Chapter 73: Non-Immune-Mediated Hydrops - p. 359 110. FETAL GROWTH RESTRICTION - p. 363 111. Chapter 74: Placental Causes of Poor Fetal Growth - p. 363 112. PREMATURITY - p. 369 113. Chapter 75: Placental Findings in Premature Birth - p. 369 114. ABNORMAL PLACENTAL IMPLANTATION - p. 373 115. Chapter 76: Placenta Accreta Spectrum - p. 373 116. Chapter 77: Ectopic Pregnancy - p. 385 117. INTRAUTERINE FETAL DEMISE - p. 391 118. Chapter 78: 1st-Trimester Pregnancy Loss - p. 391 119. Chapter 79: 2nd-Trimester Fetal Demise - p. 401 120. Chapter 80: 3rd-Trimester Fetal Demise - p. 409 121. Chapter 81: Recurrent Pregnancy Loss - p. 415 122. Chapter 82: In Utero Demise-to-Delivery Interval Changes - p. 419 123. Chapter 83: Hypoxic-Ischemic Encephalopathy - p. 423 124. MULTIPLE GESTATIONS - p. 433 125. Chapter 84: Complications of Monochorionic-Monoamniotic Twin Gestations - p. 433 126. Chapter 85: Twin Growth Discrepancy - p. 441 127. Chapter 86: Twin-Twin Transfusion Syndrome - p. 445 128. Chapter 87: Twin Anemia-Polycythemia Sequence - p. 449 129. Chapter 88: After In Utero Intervention for Twin-Twin Transfusion Syndrome - p. 451 130. Chapter 89: Triplet and Higher Order Placenta - p. 455 131. MATERNAL COMPLICATIONS OF PREGNANCY - p. 459 132. Chapter 90: Maternal Mortality - p. 459 133. Chapter 91: Postpartum Hemorrhage - p. 469 134. Chapter 92: Evaluation of Postpartum Hysterectomy - p. 481 135. SECTION 4: APPENDIX - p. 489 136. REFERENCE CHARTS FOR PLACENTAL EVALUATION - p. 489 137. Chapter 93: Weights for Singleton Placentas - p. 489 138. Chapter 94: Weights for Twin Placentas - p. 492 139. Chapter 95: Weights for Triplet Placentas - p. 493 140. Chapter 96: Reference Values for Fetal and Placental Growth in Early Pregnancy - p. 494 141. SAMPLE TEMPLATES FOR PLACENTAL EVALUATION - p. 495 142. Chapter 97: Singleton Placenta Gross Evaluation - p. 495 143. Chapter 98: Twin Placenta Gross Evaluation - p. 496 144. Chapter 99: Placenta Microscopic Evaluation - p. 497 145. Chapter 100: Placenta Triage - p. 501 146. INDEX - p. 503
