This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the wide range of often difficult-to-diagnose variants and subtypes in soft tissue tumors, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Soft Tissue Tumors is a visually stunning, one-stop resource for every practicing pathologist, oncologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Provides up-to-date, comprehensive coverage of soft tissue pathology combined with accurate, concise clinicopathologic descriptions, helping you quickly identify tumors and establish actionable diagnoses
Contains hundreds of chapters with separate Benign, Intermediate, and Malignant sections to provide the fullest diagnostic picture possible
Features new chapters covering the recently recognized EWSR1::SMAD3 fibroblastic tumor, plexiform myofibroblastoma, anastomosing hemangioma, myxoid pleomorphic liposarcoma, and more
Includes details throughout on new immunostains and molecular genetics and testing
Features an image-rich layout with more than 4,200 print and online-only images—including high-quality photomicrographs, gross photographs, radiologic images, and detailed medical illustrations—to make tumor identification and diagnosis faster and easier
Provides an organized framework that includes "Approach to Diagnosis" chapters designed to help you successfully recognize and diagnose challenging soft tissue tumors with the availability of common patterns and histologic features
Includes updates based on the most recent WHO Classification of Tumors: Soft Tissue and Bone Tumors
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
1. SECTION 1: SOFT TISSUE INTRODUCTION - p. 3 2. INTRODUCTION AND OVERVIEW - p. 3 3. Chapter 1: Gross Examination - p. 3 4. Chapter 2: Grading and Staging - p. 5 5. ANCILLARY TECHNIQUES - p. 11 6. Chapter 3: Soft Tissue Immunohistochemistry - p. 11 7. Chapter 4: Molecular Features of Soft Tissue Tumors - p. 19 8. SECTION 2: DIAGNOSTIC APPROACH TO SOFT TISSUE TUMORS - p. 21 9. OVERVIEW - p. 21 10. Chapter 5: Biopsy and Resection of Soft Tissue Tumors - p. 21 11. CLINICAL APPROACH - p. 27 12. Chapter 6: Age- and Location-Based Approach to Diagnosis - p. 27 13. HISTOLOGIC APPROACH - p. 29 14. Chapter 7: Pattern-Based Approach to Diagnosis - p. 29 15. Chapter 8: Feature-Based Approach to Diagnosis - p. 37 16. SECTION 3: TUMORS OF ADIPOSE TISSUE - p. 45 17. BENIGN - p. 45 18. Chapter 9: Lipoma - p. 45 19. Chapter 10: Lipomatosis of Nerve - p. 53 20. Chapter 11: Synovial Lipomatosis - p. 55 21. Chapter 12: Angiolipoma - p. 57 22. Chapter 13: Spindle Cell/Pleomorphic Lipoma - p. 61 23. Chapter 14: Chondroid Lipoma - p. 67 24. Chapter 15: Myolipoma - p. 71 25. Chapter 16: Hibernoma - p. 75 26. Chapter 17: Myelolipoma - p. 79 27. Chapter 18: Lipoblastoma - p. 81 28. Chapter 19: Atypical Spindle Cell/Pleomorphic Lipomatous Tumor - p. 85 29. Chapter 20: Lipoblastoma-Like Tumor of Vulva - p. 89 30. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 93 31. Chapter 21: Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma - p. 93 32. MALIGNANT - p. 99 33. Chapter 22: Dedifferentiated Liposarcoma - p. 99 34. Chapter 23: Myxoid Liposarcoma - p. 107 35. Chapter 24: Pleomorphic Liposarcoma - p. 113 36. Chapter 25: Myxoid Pleomorphic Liposarcoma - p. 119 37. SECTION 4: FIBROBLASTIC/MYOFIBROBLASTIC LESIONS - p. 121 38. BENIGN - p. 121 39. Chapter 26: Nodular Fasciitis - p. 121 40. Chapter 27: Proliferative Fasciitis/Myositis - p. 129 41. Chapter 28: Ischemic Fasciitis - p. 133 42. Chapter 29: Myositis Ossificans - p. 135 43. Chapter 30: Fibroosseous Pseudotumor of Digits - p. 139 44. Chapter 31: Fibroma of Tendon Sheath - p. 143 45. Chapter 32: Desmoplastic Fibroblastoma - p. 148 46. Chapter 33: Elastofibroma - p. 151 47. Chapter 34: Angiofibroma of Soft Tissue - p. 153 48. Chapter 35: Mammary-Type Myofibroblastoma - p. 157 49. Chapter 36: Plexiform Myofibroblastoma - p. 161 50. Chapter 37: Intranodal Palisaded Myofibroblastoma - p. 163 51. Chapter 38: Pleomorphic Fibroma - p. 167 52. Chapter 39: Dermatomyofibroma - p. 169 53. Chapter 40: Fibroblastic Connective Tissue Nevus - p. 171 54. Chapter 41: Storiform Collagenoma - p. 173 55. Chapter 42: Keloid - p. 175 56. Chapter 43: Nuchal-Type Fibroma - p. 177 57. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 179 58. Chapter 44: Palmar/Plantar Fibromatosis - p. 179 59. Chapter 45: Desmoid-Type Fibromatosis - p. 181 60. Chapter 46: EWSR1::SMAD3 Fibroblastic Tumor - p. 187 61. INTERMEDIATE (RARELY METASTASIZING) - p. 191 62. Chapter 47: Dermatofibrosarcoma Protuberans - p. 191 63. Chapter 48: Solitary Fibrous Tumor - p. 201 64. Chapter 49: Low-Grade Myofibroblastic Sarcoma - p. 209 65. Chapter 50: Inflammatory Myofibroblastic Tumor - p. 213 66. Chapter 51: Myxoinflammatory Fibroblastic Sarcoma - p. 219 67. Chapter 52: Superficial CD34(+) Fibroblastic Tumor - p. 227 68. MALIGNANT - p. 231 69. Chapter 53: Adult-Type Fibrosarcoma - p. 231 70. Chapter 54: Myxofibrosarcoma - p. 233 71. Chapter 55: Low-Grade Fibromyxoid Sarcoma - p. 239 72. Chapter 56: Sclerosing Epithelioid Fibrosarcoma - p. 249 73. Chapter 57: Epithelioid Inflammatory Myofibroblastic Sarcoma - p. 255 74. SECTION 5: PEDIATRIC FIBROBLASTIC/MYOFIBROBLASTIC TUMORS - p. 259 75. BENIGN - p. 259 76. Chapter 58: Fibrous Hamartoma of Infancy - p. 259 77. Chapter 59: Calcifying Aponeurotic Fibroma - p. 265 78. Chapter 60: Calcifying Fibrous Tumor - p. 269 79. Chapter 61: Inclusion Body Fibromatosis - p. 271 80. Chapter 62: Hyaline Fibromatosis Syndrome - p. 273 81. Chapter 63: Fibromatosis Colli - p. 275 82. Chapter 64: Gardner Fibroma - p. 277 83. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 279 84. Chapter 65: Lipofibromatosis - p. 279 85. Chapter 66: Giant Cell Fibroblastoma - p. 281 86. INTERMEDIATE (RARELY METASTASIZING) - p. 285 87. Chapter 67: Infantile Fibrosarcoma - p. 285 88. SECTION 6: FIBROHISTIOCYTIC, HISTIOCYTIC, AND DENDRITIC CELL TUMORS - p. 289 89. BENIGN - p. 289 90. Chapter 68: Dermatofibroma and Fibrous Histiocytoma - p. 289 91. Chapter 69: Deep Fibrous Histiocytoma - p. 297 92. Chapter 70: Epithelioid Fibrous Histiocytoma - p. 299 93. Chapter 71: Localized-Type Tenosynovial Giant Cell Tumor - p. 301 94. Chapter 72: Diffuse-Type Tenosynovial Giant Cell Tumor - p. 307 95. Chapter 73: Cellular Neurothekeoma - p. 313 96. Chapter 74: Xanthomas - p. 317 97. Chapter 75: Solitary (Juvenile) Xanthogranuloma - p. 321 98. Chapter 76: Reticulohistiocytoma - p. 323 99. Chapter 77: Deep Granuloma Annulare - p. 327 100. Chapter 78: Rheumatoid Nodule - p. 329 101. Chapter 79: Langerhans Cell Histiocytosis - p. 331 102. Chapter 80: Extranodal Rosai-Dorfman Disease - p. 333 103. Chapter 81: Crystal-Storing Histiocytosis - p. 337 104. INTERMEDIATE (RARELY METASTASIZING) - p. 339 105. Chapter 82: Plexiform Fibrohistiocytic Tumor - p. 339 106. Chapter 83: Giant Cell Tumor of Soft Tissue - p. 343 107. MALIGNANT - p. 347 108. Chapter 84: Histiocytic Sarcoma - p. 347 109. Chapter 85: Follicular Dendritic Cell Sarcoma - p. 349 110. Chapter 86: Interdigitating Dendritic Cell Sarcoma - p. 353 111. SECTION 7: SMOOTH MUSCLE TUMORS - p. 355 112. BENIGN - p. 355 113. Chapter 87: Smooth Muscle Hamartoma - p. 355 114. Chapter 88: Cutaneous Leiomyoma - p. 359 115. Chapter 89: Deep Leiomyoma - p. 363 116. INTERMEDIATE - p. 367 117. Chapter 90: Epstein-Barr Virus-Associated Smooth Muscle Tumor - p. 367 118. MALIGNANT - p. 369 119. Chapter 91: Leiomyosarcoma - p. 369 120. SECTION 8: PERICYTIC (PERIVASCULAR) TUMORS - p. 375 121. BENIGN - p. 375 122. Chapter 92: Glomus Tumors (and Variants) - p. 375 123. Chapter 93: Myopericytoma - p. 383 124. Chapter 94: Myofibroma and Myofibromatosis - p. 387 125. Chapter 95: Angioleiomyoma - p. 391 126. SECTION 9: TUMORS OF SKELETAL MUSCLE - p. 393 127. BENIGN - p. 393 128. Chapter 96: Focal Myositis - p. 393 129. Chapter 97: Adult Rhabdomyoma - p. 397 130. Chapter 98: Fetal Rhabdomyoma - p. 399 131. Chapter 99: Genital Rhabdomyoma - p. 401 132. Chapter 100: Cardiac Rhabdomyoma - p. 403 133. INTERMEDIATE (RARELY METASTASIZING) - p. 405 134. Chapter 101: Inflammatory Rhabdomyoblastic Tumor - p. 405 135. MALIGNANT - p. 409 136. Chapter 102: Embryonal Rhabdomyosarcoma - p. 409 137. Chapter 103: Alveolar Rhabdomyosarcoma - p. 415 138. Chapter 104: Spindle Cell/Sclerosing Rhabdomyosarcoma - p. 421 139. Chapter 105: Pleomorphic Rhabdomyosarcoma - p. 427 140. Chapter 106: Epithelioid Rhabdomyosarcoma - p. 431 141. SECTION 10: VASCULAR TUMORS (INCLUDING LYMPHATICS) - p. 433 142. BENIGN - p. 433 143. Chapter 107: Papillary Endothelial Hyperplasia - p. 433 144. Chapter 108: Bacillary Angiomatosis - p. 437 145. Chapter 109: Cutaneous Epithelioid Angiomatous Nodule - p. 439 146. Chapter 110: Congenital Hemangioma - p. 441 147. Chapter 111: Infantile Hemangioma - p. 445 148. Chapter 112: Lobular Capillary Hemangioma - p. 449 149. Chapter 113: Epithelioid Hemangioma - p. 451 150. Chapter 114: Spindle Cell Hemangioma - p. 455 151. Chapter 115: Intramuscular Angioma - p. 459 152. Chapter 116: Hobnail Hemangioma - p. 463 153. Chapter 117: Acquired Tufted Angioma - p. 465 154. Chapter 118: Microvenular Hemangioma - p. 467 155. Chapter 119: Sinusoidal Hemangioma - p. 469 156. Chapter 120: Glomeruloid Hemangioma - p. 471 157. Chapter 121: Anastomosing Hemangioma - p. 473 158. Chapter 122: Synovial Hemangioma - p. 477 159. Chapter 123: Angiomatosis - p. 479 160. Chapter 124: Lymphangioma - p. 481 161. Chapter 125: Massive Localized Lymphedema - p. 485 162. Chapter 126: Atypical Vascular Lesion - p. 487 163. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 489 164. Chapter 127: Kaposiform Hemangioendothelioma - p. 489 165. INTERMEDIATE (RARELY METASTASIZING) - p. 491 166. Chapter 128: Papillary Intralymphatic Angioendothelioma - p. 491 167. Chapter 129: Retiform Hemangioendothelioma - p. 493 168. Chapter 130: Composite Hemangioendothelioma - p. 495 169. Chapter 131: Pseudomyogenic Hemangioendothelioma - p. 497 170. MALIGNANT - p. 501 171. Chapter 132: Epithelioid Hemangioendothelioma - p. 501 172. Chapter 133: Angiosarcoma - p. 507 173. Chapter 134: Kaposi Sarcoma - p. 513 174. SECTION 11: CHONDROOSSEOUS TUMORS - p. 521 175. BENIGN - p. 521 176. Chapter 135: Soft Tissue Chondroma - p. 521 177. Chapter 136: Synovial Chondromatosis - p. 529 178. MALIGNANT - p. 533 179. Chapter 137: Extraskeletal Osteosarcoma - p. 533 180. Chapter 138: Extraskeletal Mesenchymal Chondrosarcoma - p. 537 181. SECTION 12: PERIPHERAL NERVE SHEATH TUMORS - p. 541 182. BENIGN - p. 541 183. Chapter 139: Solitary Circumscribed Neuroma - p. 541 184. Chapter 140: Schwannoma - p. 545 185. Chapter 141: Neurofibroma - p. 559 186. Chapter 142: Perineurioma - p. 569 187. Chapter 143: Hybrid Nerve Sheath Tumor - p. 577 188. Chapter 144: Granular Cell Tumor - p. 581 189. Chapter 145: Dermal Nerve Sheath Myxoma - p. 587 190. Chapter 146: Ganglioneuroma - p. 591 191. Chapter 147: Neuromuscular Choristoma - p. 595 192. MALIGNANT - p. 597 193. Chapter 148: Malignant Peripheral Nerve Sheath Tumor - p. 597 194. Chapter 149: Epithelioid Malignant Peripheral Nerve Sheath Tumor - p. 605 195. Chapter 150: Malignant Melanotic Nerve Sheath Tumor - p. 609 196. Chapter 151: Ectomesenchymoma - p. 611 197. SECTION 13: GENITAL STROMAL TUMORS - p. 613 198. Chapter 152: Fibroepithelial Stromal Polyp - p. 613 199. Chapter 153: Angiomyofibroblastoma - p. 617 200. Chapter 154: Cellular Angiofibroma - p. 620 201. Chapter 155: Deep (Aggressive) Angiomyxoma - p. 625 202. SECTION 14: TUMORS OF MESOTHELIAL CELLS - p. 629 203. BENIGN - p. 629 204. Chapter 156: Adenomatoid Tumor - p. 629 205. Chapter 157: Peritoneal Inclusion Cyst - p. 633 206. MALIGNANT - p. 635 207. Chapter 158: Malignant Mesothelioma - p. 635 208. SECTION 15: HEMATOPOIETIC TUMORS IN SOFT TISSUE - p. 641 209. Chapter 159: Solitary Extramedullary Plasmacytoma - p. 641 210. Chapter 160: Myeloid Sarcoma - p. 645 211. Chapter 161: Lymphoma of Soft Tissue - p. 647 212. SECTION 16: TUMORS OF UNCERTAIN DIFFERENTIATION - p. 649 213. BENIGN - p. 649 214. Chapter 162: Intramuscular Myxoma - p. 649 215. Chapter 163: Juxtaarticular Myxoma - p. 655 216. Chapter 164: Superficial Angiomyxoma - p. 657 217. Chapter 165: Acral Fibromyxoma - p. 661 218. Chapter 166: Pleomorphic Hyalinizing Angiectatic Tumor - p. 665 219. Chapter 167: Aneurysmal Bone Cyst of Soft Tissue - p. 669 220. Chapter 168: Branchioma (Ectopic Hamartomatous Thymoma) - p. 671 221. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 675 222. Chapter 169: Hemosiderotic Fibrolipomatous Tumor - p. 675 223. INTERMEDIATE (RARELY METASTASIZING) - p. 677 224. Chapter 170: Atypical Fibroxanthoma - p. 677 225. Chapter 171: Angiomatoid Fibrous Histiocytoma - p. 683 226. Chapter 172: Ossifying Fibromyxoid Tumor - p. 691 227. Chapter 173: Myoepithelioma of Soft Tissue - p. 697 228. Chapter 174: Phosphaturic Mesenchymal Tumor - p. 705 229. MALIGNANT - p. 707 230. Chapter 175: Synovial Sarcoma - p. 707 231. Chapter 176: Epithelioid Sarcoma - p. 719 232. Chapter 177: Alveolar Soft Part Sarcoma - p. 725 233. Chapter 178: Clear Cell Sarcoma - p. 729 234. Chapter 179: Perivascular Epithelioid Cell Tumor (PEComa) - p. 733 235. Chapter 180: Desmoplastic Small Round Cell Tumor - p. 743 236. Chapter 181: Extraskeletal Ewing Sarcoma - p. 749 237. Chapter 182: Extraskeletal Myxoid Chondrosarcoma - p. 755 238. Chapter 183: Extrarenal Rhabdoid Tumor - p. 759 239. Chapter 184: Intimal Sarcoma - p. 763 240. SECTION 17: UNDIFFERENTIATED/UNCLASSIFIED SARCOMAS - p. 765 241. Chapter 185: Undifferentiated Pleomorphic Sarcoma - p. 765 242. Chapter 186: CIC-Rearranged Sarcoma - p. 771 243. Chapter 187: BCOR::CCNB3 Fusion-Positive Sarcoma - p. 779 244. Chapter 188: EWSR1::NFATC2 Sarcoma - p. 783 245. Chapter 189: EWSR1::PATZ1 Sarcoma - p. 789 246. Chapter 190: NTRK-Rearranged Spindle Cell Neoplasms - p. 791 247. Chapter 191: GLI1-Altered Epithelioid Mesenchymal Neoplasm - p. 795 248. SECTION 18: MESENCHYMAL TUMORS OF GASTROINTESTINAL TRACT - p. 797 249. Chapter 192: Benign Neural Polyps of Gastrointestinal Tract - p. 797 250. Chapter 193: Gastrointestinal Stromal Tumor - p. 803 251. Chapter 194: Gastrointestinal Schwannoma - p. 819 252. Chapter 195: Gastrointestinal Smooth Muscle Neoplasms - p. 821 253. Chapter 196: Inflammatory Fibroid Polyp - p. 825 254. Chapter 197: Gangliocytic Paraganglioma - p. 829 255. Chapter 198: Plexiform Fibromyxoma - p. 831 256. Chapter 199: Malignant Gastrointestinal Neuroectodermal Tumor - p. 835 257. Chapter 200: Gastroblastoma - p. 839 258. SECTION 19: OTHER ENTITIES - p. 843 259. BENIGN - p. 843 260. Chapter 201: Amyloidoma - p. 843 261. Chapter 202: Ganglion Cyst - p. 847 262. Chapter 203: Tumoral Calcinosis - p. 849 263. Chapter 204: Idiopathic Tumefactive Fibroinflammatory Lesions - p. 851 264. Chapter 205: Tenosynovitis With Psammomatous Calcifications - p. 855 265. Chapter 206: Myxochondroid Metaplasia of Plantar Foot - p. 857 266. Chapter 207: Cardiac Myxoma - p. 859 267. Chapter 208: Cardiac Fibroma - p. 863 268. Chapter 209: Congenital Granular Cell Epulis - p. 865 269. Chapter 210: Sinonasal Tract Angiofibroma - p. 867 270. Chapter 211: Sinonasal Glomangiopericytoma - p. 870 271. Chapter 212: Ectopic Meningioma and Meningothelial Hamartoma - p. 877 272. Chapter 213: Glial Heterotopia - p. 879 273. INTERMEDIATE - p. 881 274. Chapter 214: Paraganglioma - p. 881 275. Chapter 215: Peripheral Hemangioblastoma - p. 891 276. Chapter 216: Melanotic Neuroectodermal Tumor of Infancy - p. 893 277. Chapter 217: Ependymoma of Soft Tissue - p. 897 278. MALIGNANT - p. 899 279. Chapter 218: Metastatic Tumors to Soft Tissue Sites - p. 899 280. Chapter 219: Neuroblastoma and Ganglioneuroblastoma - p. 903 281. Chapter 220: Extraaxial Soft Tissue Chordoma - p. 913 282. Chapter 221: Embryonal Sarcoma of Liver - p. 915 283. Chapter 222: Primary Pulmonary Myxoid Sarcoma - p. 917 284. Chapter 223: Biphenotypic Sinonasal Sarcoma - p. 923 285. Chapter 224: Spindle Epithelial Tumor With Thymus-Like Elements - p. 927 286. INDEX - p. 929
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the wide range of often difficult-to-diagnose variants and subtypes in soft tissue tumors, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Soft Tissue Tumors is a visually stunning, one-stop resource for every practicing pathologist, oncologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Provides up-to-date, comprehensive coverage of soft tissue pathology combined with accurate, concise clinicopathologic descriptions, helping you quickly identify tumors and establish actionable diagnoses
Contains hundreds of chapters with separate Benign, Intermediate, and Malignant sections to provide the fullest diagnostic picture possible
Features new chapters covering the recently recognized EWSR1::SMAD3 fibroblastic tumor, plexiform myofibroblastoma, anastomosing hemangioma, myxoid pleomorphic liposarcoma, and more
Includes details throughout on new immunostains and molecular genetics and testing
Features an image-rich layout with more than 4,200 print and online-only images—including high-quality photomicrographs, gross photographs, radiologic images, and detailed medical illustrations—to make tumor identification and diagnosis faster and easier
Provides an organized framework that includes "Approach to Diagnosis" chapters designed to help you successfully recognize and diagnose challenging soft tissue tumors with the availability of common patterns and histologic features
Includes updates based on the most recent WHO Classification of Tumors: Soft Tissue and Bone Tumors
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
1. SECTION 1: SOFT TISSUE INTRODUCTION - p. 3 2. INTRODUCTION AND OVERVIEW - p. 3 3. Chapter 1: Gross Examination - p. 3 4. Chapter 2: Grading and Staging - p. 5 5. ANCILLARY TECHNIQUES - p. 11 6. Chapter 3: Soft Tissue Immunohistochemistry - p. 11 7. Chapter 4: Molecular Features of Soft Tissue Tumors - p. 19 8. SECTION 2: DIAGNOSTIC APPROACH TO SOFT TISSUE TUMORS - p. 21 9. OVERVIEW - p. 21 10. Chapter 5: Biopsy and Resection of Soft Tissue Tumors - p. 21 11. CLINICAL APPROACH - p. 27 12. Chapter 6: Age- and Location-Based Approach to Diagnosis - p. 27 13. HISTOLOGIC APPROACH - p. 29 14. Chapter 7: Pattern-Based Approach to Diagnosis - p. 29 15. Chapter 8: Feature-Based Approach to Diagnosis - p. 37 16. SECTION 3: TUMORS OF ADIPOSE TISSUE - p. 45 17. BENIGN - p. 45 18. Chapter 9: Lipoma - p. 45 19. Chapter 10: Lipomatosis of Nerve - p. 53 20. Chapter 11: Synovial Lipomatosis - p. 55 21. Chapter 12: Angiolipoma - p. 57 22. Chapter 13: Spindle Cell/Pleomorphic Lipoma - p. 61 23. Chapter 14: Chondroid Lipoma - p. 67 24. Chapter 15: Myolipoma - p. 71 25. Chapter 16: Hibernoma - p. 75 26. Chapter 17: Myelolipoma - p. 79 27. Chapter 18: Lipoblastoma - p. 81 28. Chapter 19: Atypical Spindle Cell/Pleomorphic Lipomatous Tumor - p. 85 29. Chapter 20: Lipoblastoma-Like Tumor of Vulva - p. 89 30. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 93 31. Chapter 21: Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma - p. 93 32. MALIGNANT - p. 99 33. Chapter 22: Dedifferentiated Liposarcoma - p. 99 34. Chapter 23: Myxoid Liposarcoma - p. 107 35. Chapter 24: Pleomorphic Liposarcoma - p. 113 36. Chapter 25: Myxoid Pleomorphic Liposarcoma - p. 119 37. SECTION 4: FIBROBLASTIC/MYOFIBROBLASTIC LESIONS - p. 121 38. BENIGN - p. 121 39. Chapter 26: Nodular Fasciitis - p. 121 40. Chapter 27: Proliferative Fasciitis/Myositis - p. 129 41. Chapter 28: Ischemic Fasciitis - p. 133 42. Chapter 29: Myositis Ossificans - p. 135 43. Chapter 30: Fibroosseous Pseudotumor of Digits - p. 139 44. Chapter 31: Fibroma of Tendon Sheath - p. 143 45. Chapter 32: Desmoplastic Fibroblastoma - p. 148 46. Chapter 33: Elastofibroma - p. 151 47. Chapter 34: Angiofibroma of Soft Tissue - p. 153 48. Chapter 35: Mammary-Type Myofibroblastoma - p. 157 49. Chapter 36: Plexiform Myofibroblastoma - p. 161 50. Chapter 37: Intranodal Palisaded Myofibroblastoma - p. 163 51. Chapter 38: Pleomorphic Fibroma - p. 167 52. Chapter 39: Dermatomyofibroma - p. 169 53. Chapter 40: Fibroblastic Connective Tissue Nevus - p. 171 54. Chapter 41: Storiform Collagenoma - p. 173 55. Chapter 42: Keloid - p. 175 56. Chapter 43: Nuchal-Type Fibroma - p. 177 57. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 179 58. Chapter 44: Palmar/Plantar Fibromatosis - p. 179 59. Chapter 45: Desmoid-Type Fibromatosis - p. 181 60. Chapter 46: EWSR1::SMAD3 Fibroblastic Tumor - p. 187 61. INTERMEDIATE (RARELY METASTASIZING) - p. 191 62. Chapter 47: Dermatofibrosarcoma Protuberans - p. 191 63. Chapter 48: Solitary Fibrous Tumor - p. 201 64. Chapter 49: Low-Grade Myofibroblastic Sarcoma - p. 209 65. Chapter 50: Inflammatory Myofibroblastic Tumor - p. 213 66. Chapter 51: Myxoinflammatory Fibroblastic Sarcoma - p. 219 67. Chapter 52: Superficial CD34(+) Fibroblastic Tumor - p. 227 68. MALIGNANT - p. 231 69. Chapter 53: Adult-Type Fibrosarcoma - p. 231 70. Chapter 54: Myxofibrosarcoma - p. 233 71. Chapter 55: Low-Grade Fibromyxoid Sarcoma - p. 239 72. Chapter 56: Sclerosing Epithelioid Fibrosarcoma - p. 249 73. Chapter 57: Epithelioid Inflammatory Myofibroblastic Sarcoma - p. 255 74. SECTION 5: PEDIATRIC FIBROBLASTIC/MYOFIBROBLASTIC TUMORS - p. 259 75. BENIGN - p. 259 76. Chapter 58: Fibrous Hamartoma of Infancy - p. 259 77. Chapter 59: Calcifying Aponeurotic Fibroma - p. 265 78. Chapter 60: Calcifying Fibrous Tumor - p. 269 79. Chapter 61: Inclusion Body Fibromatosis - p. 271 80. Chapter 62: Hyaline Fibromatosis Syndrome - p. 273 81. Chapter 63: Fibromatosis Colli - p. 275 82. Chapter 64: Gardner Fibroma - p. 277 83. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 279 84. Chapter 65: Lipofibromatosis - p. 279 85. Chapter 66: Giant Cell Fibroblastoma - p. 281 86. INTERMEDIATE (RARELY METASTASIZING) - p. 285 87. Chapter 67: Infantile Fibrosarcoma - p. 285 88. SECTION 6: FIBROHISTIOCYTIC, HISTIOCYTIC, AND DENDRITIC CELL TUMORS - p. 289 89. BENIGN - p. 289 90. Chapter 68: Dermatofibroma and Fibrous Histiocytoma - p. 289 91. Chapter 69: Deep Fibrous Histiocytoma - p. 297 92. Chapter 70: Epithelioid Fibrous Histiocytoma - p. 299 93. Chapter 71: Localized-Type Tenosynovial Giant Cell Tumor - p. 301 94. Chapter 72: Diffuse-Type Tenosynovial Giant Cell Tumor - p. 307 95. Chapter 73: Cellular Neurothekeoma - p. 313 96. Chapter 74: Xanthomas - p. 317 97. Chapter 75: Solitary (Juvenile) Xanthogranuloma - p. 321 98. Chapter 76: Reticulohistiocytoma - p. 323 99. Chapter 77: Deep Granuloma Annulare - p. 327 100. Chapter 78: Rheumatoid Nodule - p. 329 101. Chapter 79: Langerhans Cell Histiocytosis - p. 331 102. Chapter 80: Extranodal Rosai-Dorfman Disease - p. 333 103. Chapter 81: Crystal-Storing Histiocytosis - p. 337 104. INTERMEDIATE (RARELY METASTASIZING) - p. 339 105. Chapter 82: Plexiform Fibrohistiocytic Tumor - p. 339 106. Chapter 83: Giant Cell Tumor of Soft Tissue - p. 343 107. MALIGNANT - p. 347 108. Chapter 84: Histiocytic Sarcoma - p. 347 109. Chapter 85: Follicular Dendritic Cell Sarcoma - p. 349 110. Chapter 86: Interdigitating Dendritic Cell Sarcoma - p. 353 111. SECTION 7: SMOOTH MUSCLE TUMORS - p. 355 112. BENIGN - p. 355 113. Chapter 87: Smooth Muscle Hamartoma - p. 355 114. Chapter 88: Cutaneous Leiomyoma - p. 359 115. Chapter 89: Deep Leiomyoma - p. 363 116. INTERMEDIATE - p. 367 117. Chapter 90: Epstein-Barr Virus-Associated Smooth Muscle Tumor - p. 367 118. MALIGNANT - p. 369 119. Chapter 91: Leiomyosarcoma - p. 369 120. SECTION 8: PERICYTIC (PERIVASCULAR) TUMORS - p. 375 121. BENIGN - p. 375 122. Chapter 92: Glomus Tumors (and Variants) - p. 375 123. Chapter 93: Myopericytoma - p. 383 124. Chapter 94: Myofibroma and Myofibromatosis - p. 387 125. Chapter 95: Angioleiomyoma - p. 391 126. SECTION 9: TUMORS OF SKELETAL MUSCLE - p. 393 127. BENIGN - p. 393 128. Chapter 96: Focal Myositis - p. 393 129. Chapter 97: Adult Rhabdomyoma - p. 397 130. Chapter 98: Fetal Rhabdomyoma - p. 399 131. Chapter 99: Genital Rhabdomyoma - p. 401 132. Chapter 100: Cardiac Rhabdomyoma - p. 403 133. INTERMEDIATE (RARELY METASTASIZING) - p. 405 134. Chapter 101: Inflammatory Rhabdomyoblastic Tumor - p. 405 135. MALIGNANT - p. 409 136. Chapter 102: Embryonal Rhabdomyosarcoma - p. 409 137. Chapter 103: Alveolar Rhabdomyosarcoma - p. 415 138. Chapter 104: Spindle Cell/Sclerosing Rhabdomyosarcoma - p. 421 139. Chapter 105: Pleomorphic Rhabdomyosarcoma - p. 427 140. Chapter 106: Epithelioid Rhabdomyosarcoma - p. 431 141. SECTION 10: VASCULAR TUMORS (INCLUDING LYMPHATICS) - p. 433 142. BENIGN - p. 433 143. Chapter 107: Papillary Endothelial Hyperplasia - p. 433 144. Chapter 108: Bacillary Angiomatosis - p. 437 145. Chapter 109: Cutaneous Epithelioid Angiomatous Nodule - p. 439 146. Chapter 110: Congenital Hemangioma - p. 441 147. Chapter 111: Infantile Hemangioma - p. 445 148. Chapter 112: Lobular Capillary Hemangioma - p. 449 149. Chapter 113: Epithelioid Hemangioma - p. 451 150. Chapter 114: Spindle Cell Hemangioma - p. 455 151. Chapter 115: Intramuscular Angioma - p. 459 152. Chapter 116: Hobnail Hemangioma - p. 463 153. Chapter 117: Acquired Tufted Angioma - p. 465 154. Chapter 118: Microvenular Hemangioma - p. 467 155. Chapter 119: Sinusoidal Hemangioma - p. 469 156. Chapter 120: Glomeruloid Hemangioma - p. 471 157. Chapter 121: Anastomosing Hemangioma - p. 473 158. Chapter 122: Synovial Hemangioma - p. 477 159. Chapter 123: Angiomatosis - p. 479 160. Chapter 124: Lymphangioma - p. 481 161. Chapter 125: Massive Localized Lymphedema - p. 485 162. Chapter 126: Atypical Vascular Lesion - p. 487 163. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 489 164. Chapter 127: Kaposiform Hemangioendothelioma - p. 489 165. INTERMEDIATE (RARELY METASTASIZING) - p. 491 166. Chapter 128: Papillary Intralymphatic Angioendothelioma - p. 491 167. Chapter 129: Retiform Hemangioendothelioma - p. 493 168. Chapter 130: Composite Hemangioendothelioma - p. 495 169. Chapter 131: Pseudomyogenic Hemangioendothelioma - p. 497 170. MALIGNANT - p. 501 171. Chapter 132: Epithelioid Hemangioendothelioma - p. 501 172. Chapter 133: Angiosarcoma - p. 507 173. Chapter 134: Kaposi Sarcoma - p. 513 174. SECTION 11: CHONDROOSSEOUS TUMORS - p. 521 175. BENIGN - p. 521 176. Chapter 135: Soft Tissue Chondroma - p. 521 177. Chapter 136: Synovial Chondromatosis - p. 529 178. MALIGNANT - p. 533 179. Chapter 137: Extraskeletal Osteosarcoma - p. 533 180. Chapter 138: Extraskeletal Mesenchymal Chondrosarcoma - p. 537 181. SECTION 12: PERIPHERAL NERVE SHEATH TUMORS - p. 541 182. BENIGN - p. 541 183. Chapter 139: Solitary Circumscribed Neuroma - p. 541 184. Chapter 140: Schwannoma - p. 545 185. Chapter 141: Neurofibroma - p. 559 186. Chapter 142: Perineurioma - p. 569 187. Chapter 143: Hybrid Nerve Sheath Tumor - p. 577 188. Chapter 144: Granular Cell Tumor - p. 581 189. Chapter 145: Dermal Nerve Sheath Myxoma - p. 587 190. Chapter 146: Ganglioneuroma - p. 591 191. Chapter 147: Neuromuscular Choristoma - p. 595 192. MALIGNANT - p. 597 193. Chapter 148: Malignant Peripheral Nerve Sheath Tumor - p. 597 194. Chapter 149: Epithelioid Malignant Peripheral Nerve Sheath Tumor - p. 605 195. Chapter 150: Malignant Melanotic Nerve Sheath Tumor - p. 609 196. Chapter 151: Ectomesenchymoma - p. 611 197. SECTION 13: GENITAL STROMAL TUMORS - p. 613 198. Chapter 152: Fibroepithelial Stromal Polyp - p. 613 199. Chapter 153: Angiomyofibroblastoma - p. 617 200. Chapter 154: Cellular Angiofibroma - p. 620 201. Chapter 155: Deep (Aggressive) Angiomyxoma - p. 625 202. SECTION 14: TUMORS OF MESOTHELIAL CELLS - p. 629 203. BENIGN - p. 629 204. Chapter 156: Adenomatoid Tumor - p. 629 205. Chapter 157: Peritoneal Inclusion Cyst - p. 633 206. MALIGNANT - p. 635 207. Chapter 158: Malignant Mesothelioma - p. 635 208. SECTION 15: HEMATOPOIETIC TUMORS IN SOFT TISSUE - p. 641 209. Chapter 159: Solitary Extramedullary Plasmacytoma - p. 641 210. Chapter 160: Myeloid Sarcoma - p. 645 211. Chapter 161: Lymphoma of Soft Tissue - p. 647 212. SECTION 16: TUMORS OF UNCERTAIN DIFFERENTIATION - p. 649 213. BENIGN - p. 649 214. Chapter 162: Intramuscular Myxoma - p. 649 215. Chapter 163: Juxtaarticular Myxoma - p. 655 216. Chapter 164: Superficial Angiomyxoma - p. 657 217. Chapter 165: Acral Fibromyxoma - p. 661 218. Chapter 166: Pleomorphic Hyalinizing Angiectatic Tumor - p. 665 219. Chapter 167: Aneurysmal Bone Cyst of Soft Tissue - p. 669 220. Chapter 168: Branchioma (Ectopic Hamartomatous Thymoma) - p. 671 221. INTERMEDIATE (LOCALLY AGGRESSIVE) - p. 675 222. Chapter 169: Hemosiderotic Fibrolipomatous Tumor - p. 675 223. INTERMEDIATE (RARELY METASTASIZING) - p. 677 224. Chapter 170: Atypical Fibroxanthoma - p. 677 225. Chapter 171: Angiomatoid Fibrous Histiocytoma - p. 683 226. Chapter 172: Ossifying Fibromyxoid Tumor - p. 691 227. Chapter 173: Myoepithelioma of Soft Tissue - p. 697 228. Chapter 174: Phosphaturic Mesenchymal Tumor - p. 705 229. MALIGNANT - p. 707 230. Chapter 175: Synovial Sarcoma - p. 707 231. Chapter 176: Epithelioid Sarcoma - p. 719 232. Chapter 177: Alveolar Soft Part Sarcoma - p. 725 233. Chapter 178: Clear Cell Sarcoma - p. 729 234. Chapter 179: Perivascular Epithelioid Cell Tumor (PEComa) - p. 733 235. Chapter 180: Desmoplastic Small Round Cell Tumor - p. 743 236. Chapter 181: Extraskeletal Ewing Sarcoma - p. 749 237. Chapter 182: Extraskeletal Myxoid Chondrosarcoma - p. 755 238. Chapter 183: Extrarenal Rhabdoid Tumor - p. 759 239. Chapter 184: Intimal Sarcoma - p. 763 240. SECTION 17: UNDIFFERENTIATED/UNCLASSIFIED SARCOMAS - p. 765 241. Chapter 185: Undifferentiated Pleomorphic Sarcoma - p. 765 242. Chapter 186: CIC-Rearranged Sarcoma - p. 771 243. Chapter 187: BCOR::CCNB3 Fusion-Positive Sarcoma - p. 779 244. Chapter 188: EWSR1::NFATC2 Sarcoma - p. 783 245. Chapter 189: EWSR1::PATZ1 Sarcoma - p. 789 246. Chapter 190: NTRK-Rearranged Spindle Cell Neoplasms - p. 791 247. Chapter 191: GLI1-Altered Epithelioid Mesenchymal Neoplasm - p. 795 248. SECTION 18: MESENCHYMAL TUMORS OF GASTROINTESTINAL TRACT - p. 797 249. Chapter 192: Benign Neural Polyps of Gastrointestinal Tract - p. 797 250. Chapter 193: Gastrointestinal Stromal Tumor - p. 803 251. Chapter 194: Gastrointestinal Schwannoma - p. 819 252. Chapter 195: Gastrointestinal Smooth Muscle Neoplasms - p. 821 253. Chapter 196: Inflammatory Fibroid Polyp - p. 825 254. Chapter 197: Gangliocytic Paraganglioma - p. 829 255. Chapter 198: Plexiform Fibromyxoma - p. 831 256. Chapter 199: Malignant Gastrointestinal Neuroectodermal Tumor - p. 835 257. Chapter 200: Gastroblastoma - p. 839 258. SECTION 19: OTHER ENTITIES - p. 843 259. BENIGN - p. 843 260. Chapter 201: Amyloidoma - p. 843 261. Chapter 202: Ganglion Cyst - p. 847 262. Chapter 203: Tumoral Calcinosis - p. 849 263. Chapter 204: Idiopathic Tumefactive Fibroinflammatory Lesions - p. 851 264. Chapter 205: Tenosynovitis With Psammomatous Calcifications - p. 855 265. Chapter 206: Myxochondroid Metaplasia of Plantar Foot - p. 857 266. Chapter 207: Cardiac Myxoma - p. 859 267. Chapter 208: Cardiac Fibroma - p. 863 268. Chapter 209: Congenital Granular Cell Epulis - p. 865 269. Chapter 210: Sinonasal Tract Angiofibroma - p. 867 270. Chapter 211: Sinonasal Glomangiopericytoma - p. 870 271. Chapter 212: Ectopic Meningioma and Meningothelial Hamartoma - p. 877 272. Chapter 213: Glial Heterotopia - p. 879 273. INTERMEDIATE - p. 881 274. Chapter 214: Paraganglioma - p. 881 275. Chapter 215: Peripheral Hemangioblastoma - p. 891 276. Chapter 216: Melanotic Neuroectodermal Tumor of Infancy - p. 893 277. Chapter 217: Ependymoma of Soft Tissue - p. 897 278. MALIGNANT - p. 899 279. Chapter 218: Metastatic Tumors to Soft Tissue Sites - p. 899 280. Chapter 219: Neuroblastoma and Ganglioneuroblastoma - p. 903 281. Chapter 220: Extraaxial Soft Tissue Chordoma - p. 913 282. Chapter 221: Embryonal Sarcoma of Liver - p. 915 283. Chapter 222: Primary Pulmonary Myxoid Sarcoma - p. 917 284. Chapter 223: Biphenotypic Sinonasal Sarcoma - p. 923 285. Chapter 224: Spindle Epithelial Tumor With Thymus-Like Elements - p. 927 286. INDEX - p. 929
