Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.
This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.
1. Cover - p. i 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. ii 5. List of Contributors - p. iv 6. Editor Biographies - p. xii 7. Foreword - p. xiii 8. Preface - p. xv 9. Chapter 1: The multitude of therapeutic targets in neurodegenerative proteinopathies - p. xvi 10. Chapter 2: Synuclein misfolding as a therapeutic target - p. 20 11. Chapter 3: Neuroinflammation as a therapeutic target in neurodegenerative diseases - p. 47 12. Chapter 4A: Stem cells in neurodegeneration: mind the gap - p. 80 13. Chapter 4B: The potential of stem cells in tackling neurodegenerative diseases - p. 100 14. Chapter 5: Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy - p. 114 15. Chapter 6: Parkinson’s disease - p. 156 16. Chapter 7: Lewy body dementia - p. 174 17. Chapter 8: Frontotemporal dementia - p. 198 18. Chapter 9: From huntingtin gene to Huntington’s disease-altering strategies - p. 249 19. Chapter 10: Amyotrophic lateral sclerosis: mechanisms and therapeutic strategies - p. 276 20. Index - p. 296
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.
This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.
1. Cover - p. i 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. ii 5. List of Contributors - p. iv 6. Editor Biographies - p. xii 7. Foreword - p. xiii 8. Preface - p. xv 9. Chapter 1: The multitude of therapeutic targets in neurodegenerative proteinopathies - p. xvi 10. Chapter 2: Synuclein misfolding as a therapeutic target - p. 20 11. Chapter 3: Neuroinflammation as a therapeutic target in neurodegenerative diseases - p. 47 12. Chapter 4A: Stem cells in neurodegeneration: mind the gap - p. 80 13. Chapter 4B: The potential of stem cells in tackling neurodegenerative diseases - p. 100 14. Chapter 5: Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy - p. 114 15. Chapter 6: Parkinson’s disease - p. 156 16. Chapter 7: Lewy body dementia - p. 174 17. Chapter 8: Frontotemporal dementia - p. 198 18. Chapter 9: From huntingtin gene to Huntington’s disease-altering strategies - p. 249 19. Chapter 10: Amyotrophic lateral sclerosis: mechanisms and therapeutic strategies - p. 276 20. Index - p. 296
