DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.
Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs.
Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors.
1. DNA Repair in Cancer Therapy - p. Page i 2. Cover - p. Page i 3. Front matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. List of Contributors - p. Page iv 7. Preface - p. Page vii 8. Acknowledgments - p. Page viii 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Overview of DNA repair pathways, current targets, and clinical trials bench to clinic - p. Page xi 12. Chapter 2 : MGMT—a critical DNA repair gene target for chemotherapy resistance - p. Page 47 13. Chapter 3 : Understanding the basics for translating the base excision repair pathway from benchtop to bedside in cancer treatment - p. Page 82 14. Chapter 4 : The role of PARP in DNA repair and its therapeutic exploitation - p. Page 108 15. Chapter 5 : Targeting the nucleotide excision repair pathway for therapeutic applications - p. Page 129 16. Chapter 6 : The DNA mismatch repair pathway - p. Page 148 17. Chapter 7 : Chemotherapeutic intervention by inhibiting DNA polymerases - p. Page 177 18. Chapter 8 : Targeting homologous recombination repair in cancer - p. Page 213 19. Chapter 9 : DNA double-strand repair by nonhomologous end joining and its clinical relevance - p. Page 265 20. Chapter 10 : Diversity and implication of MAPK signal transduction involved in the regulation of chemotherapy-induced DNA damage response - p. Page 293 21. Chapter 11 : Radiation DNA damage and use in cancer/therapeutics-translation of radiation modifiers - p. Page 324 22. Chapter 12 : The FANCA to FANCZ of DNA interstrand crosslink repair: Lessons from Fanconi anemia - p. Page 347 23. Chapter 13 : The role of DNA damage and repair in toxicity to postmitotic cells caused by cancer therapies - p. Page 374 24. Subject Index - p. Page 410
DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.
Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs.
Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors.
1. DNA Repair in Cancer Therapy - p. Page i 2. Cover - p. Page i 3. Front matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. List of Contributors - p. Page iv 7. Preface - p. Page vii 8. Acknowledgments - p. Page viii 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Overview of DNA repair pathways, current targets, and clinical trials bench to clinic - p. Page xi 12. Chapter 2 : MGMT—a critical DNA repair gene target for chemotherapy resistance - p. Page 47 13. Chapter 3 : Understanding the basics for translating the base excision repair pathway from benchtop to bedside in cancer treatment - p. Page 82 14. Chapter 4 : The role of PARP in DNA repair and its therapeutic exploitation - p. Page 108 15. Chapter 5 : Targeting the nucleotide excision repair pathway for therapeutic applications - p. Page 129 16. Chapter 6 : The DNA mismatch repair pathway - p. Page 148 17. Chapter 7 : Chemotherapeutic intervention by inhibiting DNA polymerases - p. Page 177 18. Chapter 8 : Targeting homologous recombination repair in cancer - p. Page 213 19. Chapter 9 : DNA double-strand repair by nonhomologous end joining and its clinical relevance - p. Page 265 20. Chapter 10 : Diversity and implication of MAPK signal transduction involved in the regulation of chemotherapy-induced DNA damage response - p. Page 293 21. Chapter 11 : Radiation DNA damage and use in cancer/therapeutics-translation of radiation modifiers - p. Page 324 22. Chapter 12 : The FANCA to FANCZ of DNA interstrand crosslink repair: Lessons from Fanconi anemia - p. Page 347 23. Chapter 13 : The role of DNA damage and repair in toxicity to postmitotic cells caused by cancer therapies - p. Page 374 24. Subject Index - p. Page 410
