With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access.
The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape.
Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry.
1. Section 1: Introduction and background - p. iii 2. List of Illustrations - p. iii 3. List of Tables - p. iii 4. Chapter 1: The development of the pharmaceutical industry - p. iii 5. Chapter 2: The nature of disease and the purpose of therapy - p. 16 6. Chapter 3: Therapeutic modalities - p. 30 7. Section 2: Drug discovery - p. 42 8. Chapter 4: Target selection - p. 42 9. Chapter 5: From drug target to drug discovery - p. 53 10. Chapter 6: High-throughput screening - p. 56 11. Chapter 7: The role of medicinal chemistry in the drug discovery process - p. 90 12. Chapter 8: Therapeutic antibodies - p. 107 13. Chapter 9: Emerging modalities: Nucleotide-based therapies, cell-based therapies, gene therapy - p. 122 14. Chapter 10: Metabolism and pharmacokinetic optimization strategies in drug discovery - p. 132 15. Chapter 11: Pharmacology - p. 155 16. Chapter 12: Nonclinical safety assessment - p. 173 17. Chapter 13: Therapeutic vaccines - p. 185 18. Section 3: Drug development - p. 216 19. Chapter 14: An introduction to drug development - p. 216 20. Chapter 15: Clinical assessment of safety - p. 223 21. Chapter 16: Pharmaceutical development - p. 232 22. Chapter 17: Clinical development - p. 244 23. Chapter 18: Clinical imaging in drug development - p. 257 24. Chapter 19: Intellectual property in drug discovery and development - p. 280 25. Chapter 20: Regulatory affairs - p. 288 26. Chapter 21: The role of pharmaceutical marketing - p. 308 27. Section 4: Facts and figures - p. 331 28. Chapter 22: Drug discovery and development: The future? - p. 331 29. Index - p. 348 30. Inside back cover - p. 348
With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access.
The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape.
Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry.
1. Section 1: Introduction and background - p. iii 2. List of Illustrations - p. iii 3. List of Tables - p. iii 4. Chapter 1: The development of the pharmaceutical industry - p. iii 5. Chapter 2: The nature of disease and the purpose of therapy - p. 16 6. Chapter 3: Therapeutic modalities - p. 30 7. Section 2: Drug discovery - p. 42 8. Chapter 4: Target selection - p. 42 9. Chapter 5: From drug target to drug discovery - p. 53 10. Chapter 6: High-throughput screening - p. 56 11. Chapter 7: The role of medicinal chemistry in the drug discovery process - p. 90 12. Chapter 8: Therapeutic antibodies - p. 107 13. Chapter 9: Emerging modalities: Nucleotide-based therapies, cell-based therapies, gene therapy - p. 122 14. Chapter 10: Metabolism and pharmacokinetic optimization strategies in drug discovery - p. 132 15. Chapter 11: Pharmacology - p. 155 16. Chapter 12: Nonclinical safety assessment - p. 173 17. Chapter 13: Therapeutic vaccines - p. 185 18. Section 3: Drug development - p. 216 19. Chapter 14: An introduction to drug development - p. 216 20. Chapter 15: Clinical assessment of safety - p. 223 21. Chapter 16: Pharmaceutical development - p. 232 22. Chapter 17: Clinical development - p. 244 23. Chapter 18: Clinical imaging in drug development - p. 257 24. Chapter 19: Intellectual property in drug discovery and development - p. 280 25. Chapter 20: Regulatory affairs - p. 288 26. Chapter 21: The role of pharmaceutical marketing - p. 308 27. Section 4: Facts and figures - p. 331 28. Chapter 22: Drug discovery and development: The future? - p. 331 29. Index - p. 348 30. Inside back cover - p. 348
