Drug Discovery and One Health Approach in Combating Infectious Diseases: A Multi-sectoral Approach to address Infections explores the intersection of drug discovery and the One Health Approach, along with the effectiveness of interdisciplinary approaches to combating infectious diseases. The book covers both holistic and innovative drug discovery methodologies and technologies such as natural compounds, harnessing genomics, proteomics, and nanotechnology. Additionally, the book reviews zoonotic diseases, vaccine development, ethical considerations, and regulatory pathways. Practice case studies demonstrate successful One Health and interdisciplinary initiatives to combating infectious disease.
This catalogue of knowledge provides a toolbox of innovative and interdisciplinary solutions of complex issues in drug discovery and infectious disease. It will be a valuable resource to professionals and researchers working in the fields of biomedical sciences, pharmaceutical sciences, infectious disease research, and public health, as well as those engaged in drug discovery, development, and the management of infectious diseases.
1. Part I. Introduction and basics - p. 1 2. Chapter 1. Introduction to drug discovery and One Health approach - p. 3 3. Chapter 2. Fundamentals of infectious diseases and global health threats - p. 21 4. Part II. One Health framework - p. 45 5. Chapter 3. The concept of One Health - p. 47 6. Chapter 4. Zoonotic diseases and their implications - p. 59 7. Chapter 5. Role of surveillance and epidemiology - p. 77 8. Part III. Drug discovery process - p. 99 9. Chapter 6. Overview of drug discovery and development process - p. 101 10. Chapter 7. Target identification and validation in drug discovery - p. 117 11. Chapter 8. High-throughput screening and rational drug design - p. 147 12. Part IV. Approaches to drug development - p. 163 13. Chapter 9. Traditional medicinal plants and natural compounds in One Health approach - p. 165 14. Chapter 10. Antibiotics and antiviral agents - p. 187 15. Chapter 11. Vaccines as preventive measures - p. 205 16. Part V. Advanced technologies in drug discovery - p. 237 17. Chapter 12. Genomics and proteomics - p. 239 18. Chapter 13. Structural biology and computer-aided drug design - p. 253 19. Chapter 14. Nanotechnology and drug delivery systems - p. 283 20. Part VI. One Health in action - p. 291 21. Chapter 15. Case studies of successful approaches - p. 293 22. Chapter 16. Collaborations and challenges between medical and veterinary professionals in One Health implementation - p. 303 23. Chapter 17. Environmental factors and disease transmission - p. 323 24. Part VII. Regulatory and ethical considerations - p. 345 25. Chapter 18. Regulatory pathways for the development of drugs and vaccines - p. 347 26. Chapter 19. Ethical considerations in One Health research - p. 363 27. Chapter 20. Future prospects: Emerging technologies - p. 381 28. Index - p. 391
Drug Discovery and One Health Approach in Combating Infectious Diseases: A Multi-sectoral Approach to address Infections explores the intersection of drug discovery and the One Health Approach, along with the effectiveness of interdisciplinary approaches to combating infectious diseases. The book covers both holistic and innovative drug discovery methodologies and technologies such as natural compounds, harnessing genomics, proteomics, and nanotechnology. Additionally, the book reviews zoonotic diseases, vaccine development, ethical considerations, and regulatory pathways. Practice case studies demonstrate successful One Health and interdisciplinary initiatives to combating infectious disease.
This catalogue of knowledge provides a toolbox of innovative and interdisciplinary solutions of complex issues in drug discovery and infectious disease. It will be a valuable resource to professionals and researchers working in the fields of biomedical sciences, pharmaceutical sciences, infectious disease research, and public health, as well as those engaged in drug discovery, development, and the management of infectious diseases.
1. Part I. Introduction and basics - p. 1 2. Chapter 1. Introduction to drug discovery and One Health approach - p. 3 3. Chapter 2. Fundamentals of infectious diseases and global health threats - p. 21 4. Part II. One Health framework - p. 45 5. Chapter 3. The concept of One Health - p. 47 6. Chapter 4. Zoonotic diseases and their implications - p. 59 7. Chapter 5. Role of surveillance and epidemiology - p. 77 8. Part III. Drug discovery process - p. 99 9. Chapter 6. Overview of drug discovery and development process - p. 101 10. Chapter 7. Target identification and validation in drug discovery - p. 117 11. Chapter 8. High-throughput screening and rational drug design - p. 147 12. Part IV. Approaches to drug development - p. 163 13. Chapter 9. Traditional medicinal plants and natural compounds in One Health approach - p. 165 14. Chapter 10. Antibiotics and antiviral agents - p. 187 15. Chapter 11. Vaccines as preventive measures - p. 205 16. Part V. Advanced technologies in drug discovery - p. 237 17. Chapter 12. Genomics and proteomics - p. 239 18. Chapter 13. Structural biology and computer-aided drug design - p. 253 19. Chapter 14. Nanotechnology and drug delivery systems - p. 283 20. Part VI. One Health in action - p. 291 21. Chapter 15. Case studies of successful approaches - p. 293 22. Chapter 16. Collaborations and challenges between medical and veterinary professionals in One Health implementation - p. 303 23. Chapter 17. Environmental factors and disease transmission - p. 323 24. Part VII. Regulatory and ethical considerations - p. 345 25. Chapter 18. Regulatory pathways for the development of drugs and vaccines - p. 347 26. Chapter 19. Ethical considerations in One Health research - p. 363 27. Chapter 20. Future prospects: Emerging technologies - p. 381 28. Index - p. 391
