Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers.
The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. v 6. About the Series Editor - p. vii 7. About the Editors - p. ix 8. Preface - p. xi 9. Contributors - p. xv 10. Chapter 1: Efflux transporters in cancer resistance: Molecular and functional characterization of P-glycoprotein - p. xvi 11. Chapter 2: Efflux transporters in anti-cancer drug resistance: Molecular and functional identification and characterization of multidrug resistance proteins (MRPs/ABCCs) - p. 30 12. Chapter 3: Efflux transporters in cancer resistance: Molecular and functional characterization of breast cancer resistance protein - p. 65 13. Chapter 4: Molecular imaging of membrane drug efflux transporters activity in cancer - p. 96 14. Chapter 5: MDR reversal for effective chemotherapy in breast cancer - p. 120 15. Chapter 6: ABC-transporters and drug efflux in hematologic cancers - p. 147 16. Chapter 7: Liver and gastrointestinal cancers - p. 195 17. Chapter 8: Drug efflux pumps in photodynamic therapy - p. 250 18. Chapter 9: Influence of transporters in treating cancers in the CNS - p. 276 19. Chapter 10: Retinal and choroidal cancers: Blood-retinal barriers considerations in ocular chemotherapy - p. 301 20. Chapter 11: Overcoming efflux transporter-mediated resistance in cancer by using nanomedicines - p. 335 21. Index - p. 371
Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers.
The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. v 6. About the Series Editor - p. vii 7. About the Editors - p. ix 8. Preface - p. xi 9. Contributors - p. xv 10. Chapter 1: Efflux transporters in cancer resistance: Molecular and functional characterization of P-glycoprotein - p. xvi 11. Chapter 2: Efflux transporters in anti-cancer drug resistance: Molecular and functional identification and characterization of multidrug resistance proteins (MRPs/ABCCs) - p. 30 12. Chapter 3: Efflux transporters in cancer resistance: Molecular and functional characterization of breast cancer resistance protein - p. 65 13. Chapter 4: Molecular imaging of membrane drug efflux transporters activity in cancer - p. 96 14. Chapter 5: MDR reversal for effective chemotherapy in breast cancer - p. 120 15. Chapter 6: ABC-transporters and drug efflux in hematologic cancers - p. 147 16. Chapter 7: Liver and gastrointestinal cancers - p. 195 17. Chapter 8: Drug efflux pumps in photodynamic therapy - p. 250 18. Chapter 9: Influence of transporters in treating cancers in the CNS - p. 276 19. Chapter 10: Retinal and choroidal cancers: Blood-retinal barriers considerations in ocular chemotherapy - p. 301 20. Chapter 11: Overcoming efflux transporter-mediated resistance in cancer by using nanomedicines - p. 335 21. Index - p. 371
