In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Pierre Gholam has put together topics that provide a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics: Epidemiology, Predisposing Factors and Outcomes; Genetic Predisposition to DILI; Causality Assessment Frequent Offenders and Patterns of Injury; Quantitative Systems Toxicology Approaches to Understand and Predict DILI; Liver Histology: Diagnostic and Prognostic Features; Acute Liver Failure Secondary to DILI; DILI in Persons with Pre-existing Chronic Liver Disease; DILI in the Setting of Statin Use; DILI in the Setting of Analgesic Use; DILI Secondary to Herbals and Dietary Supplements; and DILI Reporting and Resources for the Clinician. Readers will come away with the information they need to improve outcomes in patients with DILI.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury - p. 1 9. Genetic Predisposition to Drug-Induced Liver Injury - p. 11 10. Drug Hepatotoxicity: Causality Assessment - p. 25 11. Frequent Offenders and Patterns of Injury - p. 37 12. Quantitative Systems Toxicology Approaches to Understand and Predict Drug-Induced Liver Injury - p. 49 13. Liver Histology: Diagnostic and Prognostic Features - p. 61 14. Acute Liver Failure Secondary to Drug-Induced Liver Injury - p. 75 15. Drug-Induced Liver Injury in the Setting of Chronic Liver Disease - p. 89 16. Drug-Induced Liver Injury from Statins - p. 107 17. Drug-Induced Liver Injury in the Setting of Analgesic Use - p. 121 18. Drug-Induced Liver Injury Resources and Reporting for the Clinician - p. 131 19. Drug-induced Liver Injury Secondary to Herbal and Dietary Supplements - p. 141
In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Pierre Gholam has put together topics that provide a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics: Epidemiology, Predisposing Factors and Outcomes; Genetic Predisposition to DILI; Causality Assessment Frequent Offenders and Patterns of Injury; Quantitative Systems Toxicology Approaches to Understand and Predict DILI; Liver Histology: Diagnostic and Prognostic Features; Acute Liver Failure Secondary to DILI; DILI in Persons with Pre-existing Chronic Liver Disease; DILI in the Setting of Statin Use; DILI in the Setting of Analgesic Use; DILI Secondary to Herbals and Dietary Supplements; and DILI Reporting and Resources for the Clinician. Readers will come away with the information they need to improve outcomes in patients with DILI.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury - p. 1 9. Genetic Predisposition to Drug-Induced Liver Injury - p. 11 10. Drug Hepatotoxicity: Causality Assessment - p. 25 11. Frequent Offenders and Patterns of Injury - p. 37 12. Quantitative Systems Toxicology Approaches to Understand and Predict Drug-Induced Liver Injury - p. 49 13. Liver Histology: Diagnostic and Prognostic Features - p. 61 14. Acute Liver Failure Secondary to Drug-Induced Liver Injury - p. 75 15. Drug-Induced Liver Injury in the Setting of Chronic Liver Disease - p. 89 16. Drug-Induced Liver Injury from Statins - p. 107 17. Drug-Induced Liver Injury in the Setting of Analgesic Use - p. 121 18. Drug-Induced Liver Injury Resources and Reporting for the Clinician - p. 131 19. Drug-induced Liver Injury Secondary to Herbal and Dietary Supplements - p. 141
