Emerging Paradigms in Delivery of Therapeutic Agents for the Treatment of Glioblastoma describes the intense research and clinical developments that are required to optimize the available treatment options and the potential side effects to heal brain cancer. The success of this strategy includes the use of validated biomarkers, appropriate patient selection criteria, strategies to prevent adverse events, and the implementation of immunotherapy in multimodal treatment approach. In 18 chapters, this title sets forth the rationales for promising therapies like immunotherapy, including immune checkpoint blockade, chimeric antigen receptor T (CAR T) cell therapy, oncolytic virotherapy, and vaccine therapy.
In addition, the book reviews potential novel agents, the current status of preclinical and clinical trials, and the challenges and future perspectives in glioblastoma immuno-oncology. This book is a valuable resource for health professionals, scientists and researchers, health practitioners, students, and all those who wish to broaden their knowledge in the allied field.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Table of Contents - p. v 5. Contributors - p. xv 6. About the Editors - p. xix 7. Preface - p. xxiii 8. Acknowledgments - p. xxv 9. Chapter 1 Glioblastoma: Overview of the pathogenesis, clinical features, and diagnosis - p. 1 10. Chapter 2 The challenges of brain tumor therapeutics, the future of brain tumor nanotherapeutics - p. 21 11. Chapter 3 Role of various therapeutic targets in the treatment of glioblastoma - p. 47 12. Chapter 4 Nanocarrier(s)-mediated approaches and conventional therapies for the treatment of glioblastoma - p. 65 13. Chapter 5 siRNA- and miRNA-based strategies for the management of glioblastoma - p. 85 14. Chapter 6 Lipid-based nanocarrier(s) as delivery vehicles for brain tumor therapy - p. 121 15. Chapter 7 Polymeric nanoparticulate carrier(s) for brain tumor therapy - p. 145 16. Chapter 8 Herbal approaches for the treatment of glioblastoma - p. 181 17. Chapter 9 Thermoresponsive nanocarrier(s)-based therapy for glioblastoma - p. 203 18. Chapter 10 Peptide-anchored nanocarrier(s) therapy for glioblastoma - p. 225 19. Chapter 11 Theranostic applications of lipid-polymer based nanocarrier(s) for the treatment of glioblastoma - p. 249 20. Chapter 12 Targeted strategies in gene therapy for the treatment of glioblastoma - p. 269 21. Chapter 13 Nanocarrier-based combination therapy for the treatment of glioblastoma - p. 285 22. Chapter 14 Dendrimer-assisted nanotechnological ways for glioblastoma drug delivery - p. 299 23. Chapter 15 Graphene quantum dots based therapy for glioblastoma - p. 317 24. Index - p. 341
Emerging Paradigms in Delivery of Therapeutic Agents for the Treatment of Glioblastoma describes the intense research and clinical developments that are required to optimize the available treatment options and the potential side effects to heal brain cancer. The success of this strategy includes the use of validated biomarkers, appropriate patient selection criteria, strategies to prevent adverse events, and the implementation of immunotherapy in multimodal treatment approach. In 18 chapters, this title sets forth the rationales for promising therapies like immunotherapy, including immune checkpoint blockade, chimeric antigen receptor T (CAR T) cell therapy, oncolytic virotherapy, and vaccine therapy.
In addition, the book reviews potential novel agents, the current status of preclinical and clinical trials, and the challenges and future perspectives in glioblastoma immuno-oncology. This book is a valuable resource for health professionals, scientists and researchers, health practitioners, students, and all those who wish to broaden their knowledge in the allied field.
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Table of Contents - p. v 5. Contributors - p. xv 6. About the Editors - p. xix 7. Preface - p. xxiii 8. Acknowledgments - p. xxv 9. Chapter 1 Glioblastoma: Overview of the pathogenesis, clinical features, and diagnosis - p. 1 10. Chapter 2 The challenges of brain tumor therapeutics, the future of brain tumor nanotherapeutics - p. 21 11. Chapter 3 Role of various therapeutic targets in the treatment of glioblastoma - p. 47 12. Chapter 4 Nanocarrier(s)-mediated approaches and conventional therapies for the treatment of glioblastoma - p. 65 13. Chapter 5 siRNA- and miRNA-based strategies for the management of glioblastoma - p. 85 14. Chapter 6 Lipid-based nanocarrier(s) as delivery vehicles for brain tumor therapy - p. 121 15. Chapter 7 Polymeric nanoparticulate carrier(s) for brain tumor therapy - p. 145 16. Chapter 8 Herbal approaches for the treatment of glioblastoma - p. 181 17. Chapter 9 Thermoresponsive nanocarrier(s)-based therapy for glioblastoma - p. 203 18. Chapter 10 Peptide-anchored nanocarrier(s) therapy for glioblastoma - p. 225 19. Chapter 11 Theranostic applications of lipid-polymer based nanocarrier(s) for the treatment of glioblastoma - p. 249 20. Chapter 12 Targeted strategies in gene therapy for the treatment of glioblastoma - p. 269 21. Chapter 13 Nanocarrier-based combination therapy for the treatment of glioblastoma - p. 285 22. Chapter 14 Dendrimer-assisted nanotechnological ways for glioblastoma drug delivery - p. 299 23. Chapter 15 Graphene quantum dots based therapy for glioblastoma - p. 317 24. Index - p. 341
