Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors.
The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter.
1. An Introduction to Mass Spectrometry-Based Proteomics - p. iii 2. NMR in Structural and Cell Biology - p. iii 3. Single-Particle CryoEM of Macromolecular Complexes - p. iii 4. Site-Directed Mutagenesis - p. iii 5. Chemical Biology - p. iii 6. Drug Design - p. iii 7. Antibodies and Improved Engineered Formats (as Reagents) - p. iii 8. Lipids - p. iii 9. Lipidomics - p. iii 10. Synthesis and Structure of Glycerolipids - p. iii 11. Cholesterol and Other Steroids - p. iii 12. Glycolipids - p. iii 13. Lipid Signaling - p. iii 14. Membranes - p. iii 15. Membrane Conformation and the Modulation of Cell Function - p. iii 16. Membrane Potential: Concepts - p. iii 17. ATP Proton Pumps. Function and Regulation - p. iii 18. Neuronal Action Potentials and Ion Channel Allostery - p. iii 19. Carbohydrates - p. iii 20. Glycogen and Starch - p. iii 21. Proteoglycans - p. iii 22. Hyaluronan 2016–2021 - p. iii 23. Metabolism - p. iii 24. Metabolic Regulation - p. iii 25. Metabolomics in Cell Biology - p. iii 26. A Structure Perspective on Organelle Bioenergetics - p. iii 27. Vitamins: A Biochemical Perspective - p. iii 28. Nucleic Acid Synthesis/Breakdown, Edited by Blanton S. Tolbert - p. iii 29. RNA Synthesis/Function - p. iii 30. Transfer RNA - p. iii 31. Messenger RNA (mRNA): The Link Between DNA and Protein - p. iii 32. The Interplay Between Eukaryotic mRNA Degradation and Translation - p. iii 33. miRNAs/Small Noncoding RNAs - p. iii 34. Riboswitches and Ribozymes - p. iii 35. Ribosomal RNAs and Protein Synthesis - p. iii 36. Comparison of Bacterial and Eukaryotic Replisome Components - p. iii 37. DNA Synthesis/Repair - p. iii 38. Telomeres and Telomerase - p. iii 39. Telomere Biology - p. iii 40. Eukaryotic Nucleotide Excision Repair - p. iii 41. The Base Excision Repair (BER) Pathway - p. iii 42. Nonhomologous DNA End Joining in Mammalian Cells - p. iii 43. DNA Repair by Homologous Recombination - p. iii 44. Transcription - p. iii 45. RNA Epigenetics and Epitranscriptomics: The Emerging Gene Regulatory Landscape Through RNA Modifications - p. iii 46. Prokaryotic Transcription - p. iii 47. Eukaryotic Transcriptional Regulation - p. iii 48. Distant Activation of Transcription by Enhancers - p. iii 49. The Spliceosome and Pre-mRNA Splicing - p. iii 50. Advances in Physiological Outcomes of Alternative Splicing Transitions - p. iii 51. Nucleic Acid Technology - p. iii 52. Genome Editing and CRISPR Technology - p. iii 53. Transgenic Animal Models and Gene Replacement - p. iii 54. Viral Nucleic Acids - p. iii 55. Protein Synthesis/Degradation, Edited by Judith S. Bond - p. iii 56. Overview - p. iii 57. Protein Synthesis and Degradation - p. iii 58. Translation - p. iii 59. Components, Initiation, Elongation, Termination, and Regulation - p. iii 60. Biogenesis of Secretory Proteins in Eukaryotic and Prokaryotic Cells - p. iii 61. Mitochondrial Protein Synthesis - p. iii 62. The Endoplasmic Reticulum Signal Peptidase Complex - p. iii 63. Regulated Proteolysis of Signaling Molecules: The Proprotein Convertases - p. iii 64. Protein Degradation - Intracellular - p. iii 65. Ubiquitin, Ubiquitin-Like Proteins, and Proteasome-Mediated Degradation - p. iii 66. Endoplasmic Reticulum-Associated Degradation and Protein Quality Control - p. iii 67. Role of Lysosomes in Intracellular Degradation - p. iii 68. Protein Degradation - Protease Classes - p. iii 69. Matrix Metalloproteinases - p. iii 70. ADAMTS Proteases: Mediators of Physiological and Pathogenic Extracellular Proteolysis - p. iii 71. ADAMs Regulate Cell-Cell Interactions by Controlling the Function of the EGF-Receptor, TNFα and Notch - p. iii 72. Extracellular: Plasma Membrane Proteases – Serine Proteases - p. iii 73. The Calpain Proteolytic System - p. iii 74. Cathepsin E: An Aspartic Protease with Diverse Functions and Biomedical Implications - p. iii 75. Metalloproteases Meprin α and Meprin β in Health and Disease - p. iii 76. Kallikrein and Kallikrein-Related Peptidases - p. iii 77. Naturally-Occurring Polypeptide Inhibitors: Cystatins/Stefins, Inhibitors of Apoptosis (IAPs), Serpins, and Tissue Inhibitors of Metalloproteinases (TIMPs) - p. iii 78. Proteolytic Pathways - p. iii 79. Molecular Mechanisms Underlying the Actions of the Complement System - p. iii 80. Digestive Proteases: Roles in the Human Alimentary Tract - p. iii 81. Protein Degradation - Pathological Aspects - p. iii 82. Proteases of SARS Coronaviruses - p. iii 83. Diseases of Protein Folding: Huntington's Disease and Amyotrophic Lateral Sclerosis - p. iii 84. Aspartic Proteases of Alzheimer's Disease: β- and γ--Secretases - p. iii 85. Inhibitors of HIV Protease and Their Role as Drugs Against AIDS - p. iii 86. Blood Pressure, Proteases and Inhibitors - p. iii 87. Lysosomal Diseases - p. iii 88. Volume 2: Organizational Aspects of Cell Biology - Part 1 - p. iii 89. Imaging the Cell, Edited by Elliot L Elson - p. iii 90. Overview - p. iii 91. Light and Electron Microscopy: Introductory Survey - p. iii 92. Electron Microscopy - p. iii 93. Cellular Cryo-Electron Tomography - p. iii 94. Scanning Electron Microscopy in Cell Biology - p. iii 95. Cryo-Electron Tomography - p. iii 96. Immunoelectron Microscopy: High Resolution Immunocytochemistry - p. iii 97. Imaging Cellular Architecture in Three Dimensions Through Electron Microscopy - p. iii 98. Light Microscopy - p. iii 99. Genetically Encoded Fluorescent Probes and Live Cell Imaging - p. iii 100. Total Internal Reflection Fluorescence Microscopy - p. iii 101. Super Resolution Fluorescence Localization Microscopy - p. iii 102. Super-Resolution Light Microscopy: Stimulated Emission Depletion and Ground-State Depletion - p. iii 103. Structured Illumination Microscopy - p. iii 104. Fluorescence Correlation Spectroscopy: A Tool for Measuring Dynamic and Equilibrium Properties of Molecules in Cells - p. iii 105. Fluorescence Lifetime Imaging - Applications and Instrumental Principles - p. iii 106. High-Speed Localization Microscopy and Single-Particle Tracking - p. iii 107. Intravital Microscopy in Mammalian Organisms: From Tissue Physiology to Cell Biology - p. iii 108. Optogenetics - p. iii 109. Organelles, Edited by Tamotsu Yoshimori - p. iii 110. Overview - p. iii 111. Organelles: An Overview - p. iii 112. Structure and Function - p. iii 113. The Endoplasmic Reticulum - p. iii 114. Pre-Golgi Intermediate Compartment - p. iii 115. Golgi and TGN - p. iii 116. Early Endosomal Compartments - p. iii 117. The Late Endosome - p. iii 118. Signaling from Endosomes - p. iii 119. Conventional and Secretory Lysosomes - p. iii 120. Lysosome-Related Organelles - p. iii 121. At the Center of Macroautophagy: Autophagosomes - p. iii 122. The Peroxisome - p. iii 123. Lipid Droplets - p. iii 124. Mechanisms and Functions of Mitochondrial Dynamics - p. iii 125. Synaptosomes and Synaptic Vesicles - p. iii 126. Extracellular Vesicles - p. iii 127. EVs and Communication - p. iii 128. Intercellular Communication: What Syndecan-Syntenin May Teach us About the Molecular Mechanisms That Support Vesicular Exchanges - p. iii 129. Nuclear Organization (Nuclear Structure and Dynamics) - p. iii 130. Molecular Architecture of the Nuclear Pore Complex - p. iii 131. Vacuoles - p. iii 132. Plastids: The Versatile Anabolic Factories of Plant Cells - p. iii 133. Intraorganellar Communication, Edited by Paul A Gleeson - p. iii 134. Overview - p. iii 135. Interorganellar Communication – Overview - p. iii 136. Interplay and Processes - p. iii 137. Regulated Versus Constitutive Secretion – A Major Form of Intercellular Communication - p. iii 138. Homeostatic Regulatory Circuits of the Mammalian Cell: Focus on the Biosynthetic Membrane Transport Apparatus - p. iii 139. ER–Golgi Transport - p. iii 140. N-Glycans - p. iii 141. Intra-Golgi Transport - p. iii 142. Post-Golgi Transport - Cargo, Carriers, and Pathways - p. iii 143. Unconventional Protein Secretion: Interleukin-1β and Fibroblast Growth Factor 2 as Prototypic Examples of Leaderless Secretory Proteins - p. iii 144. Clathrin and Clathrin-Mediated Membrane Traffic - p. iii 145. Mechanisms of Endocytosis II Non-Clathrin - p. iii 146. Endosome to Lysosome Transport - p. iii 147. Retrograde Transport - p. iii 148. Extracellular O-Glycans - p. iii 149. Components - p. iii 150. Adaptor Proteins: Inter-Organelle Traffic Controllers - p. iii 151. SNAREs: Membrane Fusion and Beyond - p. iii 152. Rab GTPases and Other G Proteins - p. iii 153. Rabs of the Endosomal Recycling Pathway - p. iii 154. ESCRTing Around the Cell - p. iii 155. The Retromer Complex - p. iii 156. Vesicle Tethers - p. iii 157. BAR Domains and BAR Domain Superfamily Proteins - p. iii 158. Role of Phosphoinositides in Membrane Traffic - p. iii 159. Complex Cell Responses - p. iii 160. Endoplasmic Reticulum Stress in Disease - p. iii 161. Proteasomal and Lysosomal Degradation of Misfolded Proteins From the Endoplasmic Reticulum - p. iii 162. Volume 3: Organizational Aspects of Cell Biology - Part 2 - p. iii 163. Cytoskeleton and Motors, Edited by Irina N Kaverina - p. iii 164. Overview - p. iii 165. Cytoskeleton and Motors: The Overview - p. iii 166. Cytoskeletal Components - p. iii 167. Microtubules and Microtubule Associated Proteins (MAPs) - p. iii 168. Microtubules in Differentiated Cells - p. iii 169. Actin Assembly Dynamics and Its Regulation in Motile and Morphogenetic Processes - p. iii 170. Intermediate Filaments - p. iii 171. The Septin Cytoskeleton: Assembly and Functions in Intracellular Organization - p. iii 172. Bacterial and Archaeal Cytoskeletons - p. iii 173. Myosins - p. iii 174. The Expanding Universe of Kinesin Superfamily Molecular Motors (KIFs) – The Postmen Who Govern the Country - p. iii 175. Dyneins - p. iii 176. Complex Cytoskeletal Structures - p. iii 177. The Mitotic Spindle - p. iii 178. Centrosomes and Centrioles - p. iii 179. Cilia and Flagella - p. iii 180. Skeletal Muscle - p. iii 181. Filopodia and Lamellipodia - p. iii 182. The Extracellular Matrix - p. iii 183. Cell–Cell Adhesion and the Cytoskeleton - p. iii 184. Cell Adhesion to the Extracellular Matrix - p. iii 185. Cell Migration - p. iii 186. Rho GTPases - p. iii 187. Cell Polarity - p. iii 188. Intracellular Infectology, Edited by Thierry Soldati - p. iii 189. Overview - p. iii 190. Intracellular Infectiology – Overview - p. iii 191. Cell Processes - p. iii 192. Phagocytosis - p. iii 193. Macropinocytosis - p. iii 194. Microbicidal Mechanisms - p. iii 195. Bacterial Pathogen Subversion of Phagocytic Killing - p. iii 196. Cellular Invasion by Bacterial Pathogens - p. iii 197. Infectious Agents - p. iii 198. Bacterial Protein Toxins as Tools in Cell Biology and Physiology - p. iii 199. The Lytic Cycle of Human Apicomplexan Parasites - p. iii 200. Intracellular Parasites: Kinetoplastids - p. iii 201. Cell-Autonomous Defenses Against Intracellular Bacteria and Protozoa - p. iii 202. The Gut Microbiome - p. iii 203. Cell Biology of Virus Infection - p. iii 204. Virus Factories and Mini-Organelles Generated for Virus Replication - p. iii 205. Interactions Between Intracellular Fungal Pathogens and Host Phagocytes - p. iii 206. Prions - p. iii 207. Cellular and Organismal Responses to Infections in Caenorhabditis elegans - p. iii 208. HIV – The Cell Biology of Virus Infection and Replication - p. iii 209. Volume 4: Functional Aspects of Cell Biology - Part 1 - p. iii 210. Cell Communication, Edited by Hubert Hondermarck - p. iii 211. Overview - p. iii 212. Cell Communication – An Overview - p. iii 213. Growth Factor Mediated Cell Signaling - p. iii 214. Receptor Tyrosine Kinases and Their Ligands - p. iii 215. Cytokine Receptors and Their Ligands - p. iii 216. TGF-β Family Signaling - p. iii 217. G-Protein Coupled Receptors - p. iii 218. Guanylyl Cyclase Receptors - p. iii 219. Tumor Necrosis Factor Receptors: A Brief Digestion - p. iii 220. Signaling and Function of Death Receptors of the Tumor Necrosis Factor Receptor Superfamily - p. iii 221. Hedgehog Signalling in Development and Disease - p. iii 222. WNT Happens - p. iii 223. The Hippo Pathway - p. iii 224. The Notch Signaling Pathway - p. iii 225. Intracellular Pathways - p. iii 226. SH3 and SH2: Prototypic Domains to Mediate Regulatory Mechanisms in the Cell - p. iii 227. The MAPK Signaling Cascades - p. iii 228. The PI3K/Akt/mTOR Pathway - p. iii 229. The JAK–STAT–SOCS Signaling Cascade - p. iii 230. The PLC Pathway - p. iii 231. Calcium and Calmodulin Signaling - p. iii 232. Cellular Machineries - p. iii 233. Macromolecular Communication Between Nucleus and Cytoplasm - p. iii 234. The Molecular Architecture of Cadherin-Mediated Cell-Cell Adhesions - p. iii 235. Extracellular Regulation of Cell-to-Matrix Adhesion - p. iii 236. Cellular Outcomes - p. iii 237. Regulation of Cell Polarity - p. iii 238. Regulation of Cell Migration - p. iii 239. Neuronal Transport and Spatial Signaling Mechanisms in Neural Repair - p. iii 240. Transient Receptor Potential (TRP) Channels non Genomic Regulation by Sex Steroids: The Less Traveled Pathway - p. iii 241. Androgen and Estrogen Receptor Signaling - p. iii 242. Ethylene Signaling in Plants - p. iii 243. Glycobiology, Edited by Gerald W. Hart - p. iii 244. Overview - p. iii 245. Overview of Glycobiology - p. iii 246. Regulation of Cell Physiology by O-GlcNAc - p. iii 247. Carbohydrates Direct the Maturation and Trafficking of Glycoproteins in the Secretory Pathway - p. iii 248. Glycans and the Gut Microbiota - p. iii 249. Glycans in Inflammation - p. iii 250. Glycans, Notch Signaling and Development - p. iii 251. Roles of Glycans in Protozoal Host-Parasite Interactions - p. iii 252. Glycans and Cancer - p. iii 253. Glycans and Cardiovascular Diseases - p. iii 254. Glycans and Muscular Dystrophy - p. iii 255. Complex Glycans and Immune Regulation - p. iii 256. Mucins - p. iii 257. Glycan Based Vaccines - p. iii 258. Bacterial Glycoprotein Biosynthesis - p. iii 259. Human GlycoEnzymes and Related Genes - p. iii 260. Animal Lectins: Structure and Function - p. iii 261. Structures and Functions of Human Milk Oligosaccharides (HMOs) - p. iii 262. Glycosylation and Antibody Function - p. iii 263. N-Glycans and Diabetes - p. iii 264. Glycan Bioinformatics: Informatics Methods for Understanding Glycan Function - p. iii 265. The Mannose Receptor (CD206) and Its Siblings-The Back Story - p. iii 266. Volume 5: Functional Aspects of Cell Biology - Part 2 - p. iii 267. Cell Division/Death, Edited by Jason D Weber - p. iii 268. Overview - p. iii 269. Cell Division and Death: An Overview - p. iii 270. Regulation of Cell Growth - p. iii 271. mTORC1: Upstream and Downstream - p. iii 272. The Nucleolus - p. iii 273. Ribosomes and Stress - Linked from Birth to Death - p. iii 274. Extra-Ribosome Functions of Ribosomal Proteins - p. iii 275. Ribosomal RNA Processing - p. iii 276. Eukaryotic Ribosome Assembly, Quality Control and Export - p. iii 277. Internal Ribosome Entry Sites: Form and Function - p. iii 278. Targeted mRNA Degradation in Eukaryotes - p. iii 279. Apoptosis - p. iii 280. Cellular Senescence - p. iii 281. Caspase-Regulated Mechanisms of Cell Death - p. iii 282. Anoikis, 2022 - p. iii 283. Mitochondria in Cell Death Regulation - p. iii 284. The Caspase Family of Proteases - p. iii 285. Efferocytosis in the Tumor Microenvironment - p. iii 286. The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic Potential - p. iii 287. Inhibitors of Apoptosis are Critical Signaling Mediators in Inflammation and Cancer - p. iii 288. Mitotic Catastrophe - p. iii 289. Autophagy - p. iii 290. Cell Cycle - p. iii 291. Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors - p. iii 292. The Restriction Point - p. iii 293. CDK Inhibitors in Normal and Malignant Cells - p. iii 294. The INK4α/ARF Locus - p. iii 295. S Phase - p. iii 296. Traveling Through Mitosis With the Chromosomal Passenger Complex - p. iii 297. Mitosis in Animal Cells - p. iii 298. Regulation of Cytokinesis - p. iii 299. Regulation of the p53 Pathway - p. iii 300. Cellular Immunology, Edited by Michael L Dustin - p. iii 301. Overview - p. iii 302. Cellular Immunology: Overview – Introduction to Functional Cell Biology of Immunity - p. iii 303. Transcriptional Basis of B and T Cell Lineages and Memory Cells - p. iii 304. The T-Cell Receptor Signalosome - p. iii 305. T Follicular Helper Cells - p. iii 306. V(D)J Recombination: Orchestrating Diversity Without Damage - p. iii 307. T Cell Memory to Viral Infections - p. iii 308. Nuclear Factor of Activated T Cells and Tolerance - p. iii 309. NF-kappaB and the Immune System - p. iii 310. The Role of Asymmetric T Cell Fates in Controlling Memory Formation - p. iii 311. Transcriptional and Epigenomic Regulation of Lymphocytes - p. iii 312. Cell-Cell Interactions and the Immune System - p. iii 313. Functional Specialization of Dendritic Cell Subsets - p. iii 314. CD28 Costimulation and Regulatory T Cells - p. iii 315. Roles of Stromal Cells in the Immune System - p. iii 316. CXCL12/Stromal Cell-Derived Factor-1 and Hematopoiesis - p. iii 317. Lymphocyte-Endothelial Interactions - p. iii 318. T Cell Receptor Triggering - p. iii 319. Mechanistic Insights into T-Cell Antigen Recognition Through Single Molecule Microscopy - p. iii 320. Single-Cell Interrogation of the Immune System Using Microtools - p. iii 321. Cellular Structures Controlling T Cell Signaling in Time and Space - p. iii 322. Toll Like Receptors - p. iii 323. Innate Immunity - p. iii 324. Function of Epithelial Barriers - p. iii 325. Phagocytic Synapses - p. iii 326. The Phagocyte NADPH Oxidase: Structure and Assembly of the Key Multicomponent Enzyme of Innate Immunity - p. iii 327. Cytoplasmic Sensing in Innate Immunity - p. iii 328. Macrophage Class A Scavenger Receptors – A Functional Perspective - p. iii 329. Dendritic Cells - p. iii 330. Neutrophil Biology - p. iii 331. Specialized Subsets of Tissue Resident Macrophages in Secondary Lymphoid Organs - p. iii 332. CD4 T Cell Memory and Role of TNF Receptor Family - p. iii 333. Volume 6: Systems, Translational and Specialized Cell Aspects of Cell Biology - p. iii 334. Specialized Cells, Edited by David A Sassoon - p. iii 335. Selected Examples - p. iii 336. Nervous System: Neurons and Glial Cells - p. iii 337. White, Brown and Beige Adipocytes: From the Tissue to the Single-Cell Level - p. iii 338. Life and Death of Pancreatic β-cells - p. iii 339. Osteoclasts/Osteoblasts - p. iii 340. Development and Function of Macrophages - p. iii 341. Goblet and Paneth Cells: Producers of the Intestinal Barrier - p. iii 342. Stem Cells - p. iii 343. Stem Cells and Aging - p. iii 344. Epigenetic Regulation of Stem Cells - p. iii 345. The Adult Stem Cell Niche: Multiple Cellular Players in Tissue Homeostasis and Regeneration - p. iii 346. Cancer Stem Cells - p. iii 347. Mitochondrial and Lysosomal Metabolism in Hematopoietic Stem Cells - p. iii 348. Pluripotent Cells: New Tools for Disease Research and Therapies - p. iii 349. Molecular Regulation of Skeletal Muscle Stem Cells - p. iii 350. Systems Biology, Edited by Jason M Haugh - p. iii 351. Dynamic Integration - p. iii 352. Dynamics of Gradient Sensing and Chemotaxis - p. iii 353. Modeling Actin Dynamics - p. iii 354. Metabolism (Biotransformation) - p. iii 355. Dynamics of Microtubule Self-Assembly - p. iii 356. Dynamics of Protein Kinase Cascades - p. iii 357. Cdc42 and the Mechanisms of Yeast Cell Polarization - A Paradigm for Mesoscale Systems Biology - p. iii 358. Theory of Cargo and Membrane Trafficking - p. iii 359. Transcription Factor Networks - p. iii 360. Vertical Integration - p. iii 361. Vertical Integration - p. iii 362. Computational Approaches for Multiscale Modeling - p. iii 363. Cardiac Modeling - p. iii 364. Mathematical Approaches to Studying Inflammation - p. iii 365. Cancer Systems Biology - p. iii 366. Angiogenesis - p. iii 367. A Review on Various Mathematical Modeling Approaches for Wound Healing - p. iii 368. Multiscale Analysis of Morphogenesis - p. iii 369. Neurogenesis in the Adult Brain - p. iii 370. Horizontal Integration - p. iii 371. Understanding of ‘Networks’ In Vitro and/or In Vivo - p. iii 372. Connecting Evolutionary Genomics to Cell Biology - p. iii 373. Transcriptomics - p. iii 374. OMICS – Mass Spectrometry-Based Proteomics in Systems Biology Research - p. iii 375. Posttranslational Modifications: Key Players in Health and Disease - p. iii 376. Mass Spectrometry-based Methodologies for Studying Proteolytic Networks and the Degradome - p. iii 377. Drug Targeting - p. iii 378. Phosphoproteomics: Methods and Challenges - p. iii 379. Interactomes-Scaffolds of Cellular Systems - p. iii 380. Network Modeling of Tissues and Cell Types - p. iii 381. Stochastic Analysis of Nongenetic Cell-to-Cell Heterogeneity - p. iii 382. Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling - p. iii 383. High-Content Screening in Cell Biology - p. iii 384. Integrative Systems Biology - p. iii 385. Clinical/Translational Cell Biology, Edited by Borja Ibáñez - p. iii 386. Overview - p. iii 387. Cell Biological Bases for Pathology and Disease – An Overview - p. iii 388. General/Transversal Processes - p. iii 389. Inflammation as a Driver of Disease - p. iii 390. Fibrosis - p. iii 391. General and Emerging Concepts of Immunity - p. iii 392. Role of DNA Damage, Somatic Mutations, Telomere Shortening, and Epigenetic Alterations in Aging and Age-Related Disease - p. iii 393. Specific Pathologies/Diseases - p. iii 394. Cellular Mechanisms Involved in Weight Regulation - p. iii 395. Secretion and Impact of Gut Hormones in Obesity and Diabetes - p. iii 396. Endothelial Bone Morphogenetic Protein Signaling in Pulmonary Arterial Hypertension - p. iii 397. Cystic Fibrosis - p. iii 398. Alpha-1-Antitrypsin Deficiency: A Misfolded Secretory Glycoprotein Damages the Liver by Proteotoxicity and Its Reduced Secretion Predisposes to Emphysematous Lung Disease Because of Protease-Inhibitor Imbalance - p. iii 399. The Emerging Importance of Cellular Insulin Resistance in Diabetic Kidney Disease - p. iii 400. Non-Alcoholic Fatty Liver Disease and Steatohepatitis - p. iii 401. Hepatitis C - p. iii 402. Alzheimer׳s Disease: One of the Pandemics of the 21st Century - p. iii 403. Basic Concepts and Emergent Disease Mechanisms of Amyotrophic Lateral Sclerosis - p. iii 404. Neuroinflammation in Multiple Sclerosis - p. iii 405. Overview of Blood Coagulation and the Pathophysiology of Blood Coagulation Disorders - p. iii 406. Myeloproliferative Neoplasms - p. iii 407. Cancer – Proteases in Progression and Metastasis - p. iii 408. Small RNAs/Cancer - p. iii 409. Wound Healing: An Orchestrated Process of Cell Cycle, Adhesion and Signaling - p. iii 410. Cancer Cell Invasion through Tissue Barriers - p. iii 411. Subject Index - p. iii 412. Authors - p. iii
Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors.
The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter.
1. An Introduction to Mass Spectrometry-Based Proteomics - p. iii 2. NMR in Structural and Cell Biology - p. iii 3. Single-Particle CryoEM of Macromolecular Complexes - p. iii 4. Site-Directed Mutagenesis - p. iii 5. Chemical Biology - p. iii 6. Drug Design - p. iii 7. Antibodies and Improved Engineered Formats (as Reagents) - p. iii 8. Lipids - p. iii 9. Lipidomics - p. iii 10. Synthesis and Structure of Glycerolipids - p. iii 11. Cholesterol and Other Steroids - p. iii 12. Glycolipids - p. iii 13. Lipid Signaling - p. iii 14. Membranes - p. iii 15. Membrane Conformation and the Modulation of Cell Function - p. iii 16. Membrane Potential: Concepts - p. iii 17. ATP Proton Pumps. Function and Regulation - p. iii 18. Neuronal Action Potentials and Ion Channel Allostery - p. iii 19. Carbohydrates - p. iii 20. Glycogen and Starch - p. iii 21. Proteoglycans - p. iii 22. Hyaluronan 2016–2021 - p. iii 23. Metabolism - p. iii 24. Metabolic Regulation - p. iii 25. Metabolomics in Cell Biology - p. iii 26. A Structure Perspective on Organelle Bioenergetics - p. iii 27. Vitamins: A Biochemical Perspective - p. iii 28. Nucleic Acid Synthesis/Breakdown, Edited by Blanton S. Tolbert - p. iii 29. RNA Synthesis/Function - p. iii 30. Transfer RNA - p. iii 31. Messenger RNA (mRNA): The Link Between DNA and Protein - p. iii 32. The Interplay Between Eukaryotic mRNA Degradation and Translation - p. iii 33. miRNAs/Small Noncoding RNAs - p. iii 34. Riboswitches and Ribozymes - p. iii 35. Ribosomal RNAs and Protein Synthesis - p. iii 36. Comparison of Bacterial and Eukaryotic Replisome Components - p. iii 37. DNA Synthesis/Repair - p. iii 38. Telomeres and Telomerase - p. iii 39. Telomere Biology - p. iii 40. Eukaryotic Nucleotide Excision Repair - p. iii 41. The Base Excision Repair (BER) Pathway - p. iii 42. Nonhomologous DNA End Joining in Mammalian Cells - p. iii 43. DNA Repair by Homologous Recombination - p. iii 44. Transcription - p. iii 45. RNA Epigenetics and Epitranscriptomics: The Emerging Gene Regulatory Landscape Through RNA Modifications - p. iii 46. Prokaryotic Transcription - p. iii 47. Eukaryotic Transcriptional Regulation - p. iii 48. Distant Activation of Transcription by Enhancers - p. iii 49. The Spliceosome and Pre-mRNA Splicing - p. iii 50. Advances in Physiological Outcomes of Alternative Splicing Transitions - p. iii 51. Nucleic Acid Technology - p. iii 52. Genome Editing and CRISPR Technology - p. iii 53. Transgenic Animal Models and Gene Replacement - p. iii 54. Viral Nucleic Acids - p. iii 55. Protein Synthesis/Degradation, Edited by Judith S. Bond - p. iii 56. Overview - p. iii 57. Protein Synthesis and Degradation - p. iii 58. Translation - p. iii 59. Components, Initiation, Elongation, Termination, and Regulation - p. iii 60. Biogenesis of Secretory Proteins in Eukaryotic and Prokaryotic Cells - p. iii 61. Mitochondrial Protein Synthesis - p. iii 62. The Endoplasmic Reticulum Signal Peptidase Complex - p. iii 63. Regulated Proteolysis of Signaling Molecules: The Proprotein Convertases - p. iii 64. Protein Degradation - Intracellular - p. iii 65. Ubiquitin, Ubiquitin-Like Proteins, and Proteasome-Mediated Degradation - p. iii 66. Endoplasmic Reticulum-Associated Degradation and Protein Quality Control - p. iii 67. Role of Lysosomes in Intracellular Degradation - p. iii 68. Protein Degradation - Protease Classes - p. iii 69. Matrix Metalloproteinases - p. iii 70. ADAMTS Proteases: Mediators of Physiological and Pathogenic Extracellular Proteolysis - p. iii 71. ADAMs Regulate Cell-Cell Interactions by Controlling the Function of the EGF-Receptor, TNFα and Notch - p. iii 72. Extracellular: Plasma Membrane Proteases – Serine Proteases - p. iii 73. The Calpain Proteolytic System - p. iii 74. Cathepsin E: An Aspartic Protease with Diverse Functions and Biomedical Implications - p. iii 75. Metalloproteases Meprin α and Meprin β in Health and Disease - p. iii 76. Kallikrein and Kallikrein-Related Peptidases - p. iii 77. Naturally-Occurring Polypeptide Inhibitors: Cystatins/Stefins, Inhibitors of Apoptosis (IAPs), Serpins, and Tissue Inhibitors of Metalloproteinases (TIMPs) - p. iii 78. Proteolytic Pathways - p. iii 79. Molecular Mechanisms Underlying the Actions of the Complement System - p. iii 80. Digestive Proteases: Roles in the Human Alimentary Tract - p. iii 81. Protein Degradation - Pathological Aspects - p. iii 82. Proteases of SARS Coronaviruses - p. iii 83. Diseases of Protein Folding: Huntington's Disease and Amyotrophic Lateral Sclerosis - p. iii 84. Aspartic Proteases of Alzheimer's Disease: β- and γ--Secretases - p. iii 85. Inhibitors of HIV Protease and Their Role as Drugs Against AIDS - p. iii 86. Blood Pressure, Proteases and Inhibitors - p. iii 87. Lysosomal Diseases - p. iii 88. Volume 2: Organizational Aspects of Cell Biology - Part 1 - p. iii 89. Imaging the Cell, Edited by Elliot L Elson - p. iii 90. Overview - p. iii 91. Light and Electron Microscopy: Introductory Survey - p. iii 92. Electron Microscopy - p. iii 93. Cellular Cryo-Electron Tomography - p. iii 94. Scanning Electron Microscopy in Cell Biology - p. iii 95. Cryo-Electron Tomography - p. iii 96. Immunoelectron Microscopy: High Resolution Immunocytochemistry - p. iii 97. Imaging Cellular Architecture in Three Dimensions Through Electron Microscopy - p. iii 98. Light Microscopy - p. iii 99. Genetically Encoded Fluorescent Probes and Live Cell Imaging - p. iii 100. Total Internal Reflection Fluorescence Microscopy - p. iii 101. Super Resolution Fluorescence Localization Microscopy - p. iii 102. Super-Resolution Light Microscopy: Stimulated Emission Depletion and Ground-State Depletion - p. iii 103. Structured Illumination Microscopy - p. iii 104. Fluorescence Correlation Spectroscopy: A Tool for Measuring Dynamic and Equilibrium Properties of Molecules in Cells - p. iii 105. Fluorescence Lifetime Imaging - Applications and Instrumental Principles - p. iii 106. High-Speed Localization Microscopy and Single-Particle Tracking - p. iii 107. Intravital Microscopy in Mammalian Organisms: From Tissue Physiology to Cell Biology - p. iii 108. Optogenetics - p. iii 109. Organelles, Edited by Tamotsu Yoshimori - p. iii 110. Overview - p. iii 111. Organelles: An Overview - p. iii 112. Structure and Function - p. iii 113. The Endoplasmic Reticulum - p. iii 114. Pre-Golgi Intermediate Compartment - p. iii 115. Golgi and TGN - p. iii 116. Early Endosomal Compartments - p. iii 117. The Late Endosome - p. iii 118. Signaling from Endosomes - p. iii 119. Conventional and Secretory Lysosomes - p. iii 120. Lysosome-Related Organelles - p. iii 121. At the Center of Macroautophagy: Autophagosomes - p. iii 122. The Peroxisome - p. iii 123. Lipid Droplets - p. iii 124. Mechanisms and Functions of Mitochondrial Dynamics - p. iii 125. Synaptosomes and Synaptic Vesicles - p. iii 126. Extracellular Vesicles - p. iii 127. EVs and Communication - p. iii 128. Intercellular Communication: What Syndecan-Syntenin May Teach us About the Molecular Mechanisms That Support Vesicular Exchanges - p. iii 129. Nuclear Organization (Nuclear Structure and Dynamics) - p. iii 130. Molecular Architecture of the Nuclear Pore Complex - p. iii 131. Vacuoles - p. iii 132. Plastids: The Versatile Anabolic Factories of Plant Cells - p. iii 133. Intraorganellar Communication, Edited by Paul A Gleeson - p. iii 134. Overview - p. iii 135. Interorganellar Communication – Overview - p. iii 136. Interplay and Processes - p. iii 137. Regulated Versus Constitutive Secretion – A Major Form of Intercellular Communication - p. iii 138. Homeostatic Regulatory Circuits of the Mammalian Cell: Focus on the Biosynthetic Membrane Transport Apparatus - p. iii 139. ER–Golgi Transport - p. iii 140. N-Glycans - p. iii 141. Intra-Golgi Transport - p. iii 142. Post-Golgi Transport - Cargo, Carriers, and Pathways - p. iii 143. Unconventional Protein Secretion: Interleukin-1β and Fibroblast Growth Factor 2 as Prototypic Examples of Leaderless Secretory Proteins - p. iii 144. Clathrin and Clathrin-Mediated Membrane Traffic - p. iii 145. Mechanisms of Endocytosis II Non-Clathrin - p. iii 146. Endosome to Lysosome Transport - p. iii 147. Retrograde Transport - p. iii 148. Extracellular O-Glycans - p. iii 149. Components - p. iii 150. Adaptor Proteins: Inter-Organelle Traffic Controllers - p. iii 151. SNAREs: Membrane Fusion and Beyond - p. iii 152. Rab GTPases and Other G Proteins - p. iii 153. Rabs of the Endosomal Recycling Pathway - p. iii 154. ESCRTing Around the Cell - p. iii 155. The Retromer Complex - p. iii 156. Vesicle Tethers - p. iii 157. BAR Domains and BAR Domain Superfamily Proteins - p. iii 158. Role of Phosphoinositides in Membrane Traffic - p. iii 159. Complex Cell Responses - p. iii 160. Endoplasmic Reticulum Stress in Disease - p. iii 161. Proteasomal and Lysosomal Degradation of Misfolded Proteins From the Endoplasmic Reticulum - p. iii 162. Volume 3: Organizational Aspects of Cell Biology - Part 2 - p. iii 163. Cytoskeleton and Motors, Edited by Irina N Kaverina - p. iii 164. Overview - p. iii 165. Cytoskeleton and Motors: The Overview - p. iii 166. Cytoskeletal Components - p. iii 167. Microtubules and Microtubule Associated Proteins (MAPs) - p. iii 168. Microtubules in Differentiated Cells - p. iii 169. Actin Assembly Dynamics and Its Regulation in Motile and Morphogenetic Processes - p. iii 170. Intermediate Filaments - p. iii 171. The Septin Cytoskeleton: Assembly and Functions in Intracellular Organization - p. iii 172. Bacterial and Archaeal Cytoskeletons - p. iii 173. Myosins - p. iii 174. The Expanding Universe of Kinesin Superfamily Molecular Motors (KIFs) – The Postmen Who Govern the Country - p. iii 175. Dyneins - p. iii 176. Complex Cytoskeletal Structures - p. iii 177. The Mitotic Spindle - p. iii 178. Centrosomes and Centrioles - p. iii 179. Cilia and Flagella - p. iii 180. Skeletal Muscle - p. iii 181. Filopodia and Lamellipodia - p. iii 182. The Extracellular Matrix - p. iii 183. Cell–Cell Adhesion and the Cytoskeleton - p. iii 184. Cell Adhesion to the Extracellular Matrix - p. iii 185. Cell Migration - p. iii 186. Rho GTPases - p. iii 187. Cell Polarity - p. iii 188. Intracellular Infectology, Edited by Thierry Soldati - p. iii 189. Overview - p. iii 190. Intracellular Infectiology – Overview - p. iii 191. Cell Processes - p. iii 192. Phagocytosis - p. iii 193. Macropinocytosis - p. iii 194. Microbicidal Mechanisms - p. iii 195. Bacterial Pathogen Subversion of Phagocytic Killing - p. iii 196. Cellular Invasion by Bacterial Pathogens - p. iii 197. Infectious Agents - p. iii 198. Bacterial Protein Toxins as Tools in Cell Biology and Physiology - p. iii 199. The Lytic Cycle of Human Apicomplexan Parasites - p. iii 200. Intracellular Parasites: Kinetoplastids - p. iii 201. Cell-Autonomous Defenses Against Intracellular Bacteria and Protozoa - p. iii 202. The Gut Microbiome - p. iii 203. Cell Biology of Virus Infection - p. iii 204. Virus Factories and Mini-Organelles Generated for Virus Replication - p. iii 205. Interactions Between Intracellular Fungal Pathogens and Host Phagocytes - p. iii 206. Prions - p. iii 207. Cellular and Organismal Responses to Infections in Caenorhabditis elegans - p. iii 208. HIV – The Cell Biology of Virus Infection and Replication - p. iii 209. Volume 4: Functional Aspects of Cell Biology - Part 1 - p. iii 210. Cell Communication, Edited by Hubert Hondermarck - p. iii 211. Overview - p. iii 212. Cell Communication – An Overview - p. iii 213. Growth Factor Mediated Cell Signaling - p. iii 214. Receptor Tyrosine Kinases and Their Ligands - p. iii 215. Cytokine Receptors and Their Ligands - p. iii 216. TGF-β Family Signaling - p. iii 217. G-Protein Coupled Receptors - p. iii 218. Guanylyl Cyclase Receptors - p. iii 219. Tumor Necrosis Factor Receptors: A Brief Digestion - p. iii 220. Signaling and Function of Death Receptors of the Tumor Necrosis Factor Receptor Superfamily - p. iii 221. Hedgehog Signalling in Development and Disease - p. iii 222. WNT Happens - p. iii 223. The Hippo Pathway - p. iii 224. The Notch Signaling Pathway - p. iii 225. Intracellular Pathways - p. iii 226. SH3 and SH2: Prototypic Domains to Mediate Regulatory Mechanisms in the Cell - p. iii 227. The MAPK Signaling Cascades - p. iii 228. The PI3K/Akt/mTOR Pathway - p. iii 229. The JAK–STAT–SOCS Signaling Cascade - p. iii 230. The PLC Pathway - p. iii 231. Calcium and Calmodulin Signaling - p. iii 232. Cellular Machineries - p. iii 233. Macromolecular Communication Between Nucleus and Cytoplasm - p. iii 234. The Molecular Architecture of Cadherin-Mediated Cell-Cell Adhesions - p. iii 235. Extracellular Regulation of Cell-to-Matrix Adhesion - p. iii 236. Cellular Outcomes - p. iii 237. Regulation of Cell Polarity - p. iii 238. Regulation of Cell Migration - p. iii 239. Neuronal Transport and Spatial Signaling Mechanisms in Neural Repair - p. iii 240. Transient Receptor Potential (TRP) Channels non Genomic Regulation by Sex Steroids: The Less Traveled Pathway - p. iii 241. Androgen and Estrogen Receptor Signaling - p. iii 242. Ethylene Signaling in Plants - p. iii 243. Glycobiology, Edited by Gerald W. Hart - p. iii 244. Overview - p. iii 245. Overview of Glycobiology - p. iii 246. Regulation of Cell Physiology by O-GlcNAc - p. iii 247. Carbohydrates Direct the Maturation and Trafficking of Glycoproteins in the Secretory Pathway - p. iii 248. Glycans and the Gut Microbiota - p. iii 249. Glycans in Inflammation - p. iii 250. Glycans, Notch Signaling and Development - p. iii 251. Roles of Glycans in Protozoal Host-Parasite Interactions - p. iii 252. Glycans and Cancer - p. iii 253. Glycans and Cardiovascular Diseases - p. iii 254. Glycans and Muscular Dystrophy - p. iii 255. Complex Glycans and Immune Regulation - p. iii 256. Mucins - p. iii 257. Glycan Based Vaccines - p. iii 258. Bacterial Glycoprotein Biosynthesis - p. iii 259. Human GlycoEnzymes and Related Genes - p. iii 260. Animal Lectins: Structure and Function - p. iii 261. Structures and Functions of Human Milk Oligosaccharides (HMOs) - p. iii 262. Glycosylation and Antibody Function - p. iii 263. N-Glycans and Diabetes - p. iii 264. Glycan Bioinformatics: Informatics Methods for Understanding Glycan Function - p. iii 265. The Mannose Receptor (CD206) and Its Siblings-The Back Story - p. iii 266. Volume 5: Functional Aspects of Cell Biology - Part 2 - p. iii 267. Cell Division/Death, Edited by Jason D Weber - p. iii 268. Overview - p. iii 269. Cell Division and Death: An Overview - p. iii 270. Regulation of Cell Growth - p. iii 271. mTORC1: Upstream and Downstream - p. iii 272. The Nucleolus - p. iii 273. Ribosomes and Stress - Linked from Birth to Death - p. iii 274. Extra-Ribosome Functions of Ribosomal Proteins - p. iii 275. Ribosomal RNA Processing - p. iii 276. Eukaryotic Ribosome Assembly, Quality Control and Export - p. iii 277. Internal Ribosome Entry Sites: Form and Function - p. iii 278. Targeted mRNA Degradation in Eukaryotes - p. iii 279. Apoptosis - p. iii 280. Cellular Senescence - p. iii 281. Caspase-Regulated Mechanisms of Cell Death - p. iii 282. Anoikis, 2022 - p. iii 283. Mitochondria in Cell Death Regulation - p. iii 284. The Caspase Family of Proteases - p. iii 285. Efferocytosis in the Tumor Microenvironment - p. iii 286. The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic Potential - p. iii 287. Inhibitors of Apoptosis are Critical Signaling Mediators in Inflammation and Cancer - p. iii 288. Mitotic Catastrophe - p. iii 289. Autophagy - p. iii 290. Cell Cycle - p. iii 291. Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors - p. iii 292. The Restriction Point - p. iii 293. CDK Inhibitors in Normal and Malignant Cells - p. iii 294. The INK4α/ARF Locus - p. iii 295. S Phase - p. iii 296. Traveling Through Mitosis With the Chromosomal Passenger Complex - p. iii 297. Mitosis in Animal Cells - p. iii 298. Regulation of Cytokinesis - p. iii 299. Regulation of the p53 Pathway - p. iii 300. Cellular Immunology, Edited by Michael L Dustin - p. iii 301. Overview - p. iii 302. Cellular Immunology: Overview – Introduction to Functional Cell Biology of Immunity - p. iii 303. Transcriptional Basis of B and T Cell Lineages and Memory Cells - p. iii 304. The T-Cell Receptor Signalosome - p. iii 305. T Follicular Helper Cells - p. iii 306. V(D)J Recombination: Orchestrating Diversity Without Damage - p. iii 307. T Cell Memory to Viral Infections - p. iii 308. Nuclear Factor of Activated T Cells and Tolerance - p. iii 309. NF-kappaB and the Immune System - p. iii 310. The Role of Asymmetric T Cell Fates in Controlling Memory Formation - p. iii 311. Transcriptional and Epigenomic Regulation of Lymphocytes - p. iii 312. Cell-Cell Interactions and the Immune System - p. iii 313. Functional Specialization of Dendritic Cell Subsets - p. iii 314. CD28 Costimulation and Regulatory T Cells - p. iii 315. Roles of Stromal Cells in the Immune System - p. iii 316. CXCL12/Stromal Cell-Derived Factor-1 and Hematopoiesis - p. iii 317. Lymphocyte-Endothelial Interactions - p. iii 318. T Cell Receptor Triggering - p. iii 319. Mechanistic Insights into T-Cell Antigen Recognition Through Single Molecule Microscopy - p. iii 320. Single-Cell Interrogation of the Immune System Using Microtools - p. iii 321. Cellular Structures Controlling T Cell Signaling in Time and Space - p. iii 322. Toll Like Receptors - p. iii 323. Innate Immunity - p. iii 324. Function of Epithelial Barriers - p. iii 325. Phagocytic Synapses - p. iii 326. The Phagocyte NADPH Oxidase: Structure and Assembly of the Key Multicomponent Enzyme of Innate Immunity - p. iii 327. Cytoplasmic Sensing in Innate Immunity - p. iii 328. Macrophage Class A Scavenger Receptors – A Functional Perspective - p. iii 329. Dendritic Cells - p. iii 330. Neutrophil Biology - p. iii 331. Specialized Subsets of Tissue Resident Macrophages in Secondary Lymphoid Organs - p. iii 332. CD4 T Cell Memory and Role of TNF Receptor Family - p. iii 333. Volume 6: Systems, Translational and Specialized Cell Aspects of Cell Biology - p. iii 334. Specialized Cells, Edited by David A Sassoon - p. iii 335. Selected Examples - p. iii 336. Nervous System: Neurons and Glial Cells - p. iii 337. White, Brown and Beige Adipocytes: From the Tissue to the Single-Cell Level - p. iii 338. Life and Death of Pancreatic β-cells - p. iii 339. Osteoclasts/Osteoblasts - p. iii 340. Development and Function of Macrophages - p. iii 341. Goblet and Paneth Cells: Producers of the Intestinal Barrier - p. iii 342. Stem Cells - p. iii 343. Stem Cells and Aging - p. iii 344. Epigenetic Regulation of Stem Cells - p. iii 345. The Adult Stem Cell Niche: Multiple Cellular Players in Tissue Homeostasis and Regeneration - p. iii 346. Cancer Stem Cells - p. iii 347. Mitochondrial and Lysosomal Metabolism in Hematopoietic Stem Cells - p. iii 348. Pluripotent Cells: New Tools for Disease Research and Therapies - p. iii 349. Molecular Regulation of Skeletal Muscle Stem Cells - p. iii 350. Systems Biology, Edited by Jason M Haugh - p. iii 351. Dynamic Integration - p. iii 352. Dynamics of Gradient Sensing and Chemotaxis - p. iii 353. Modeling Actin Dynamics - p. iii 354. Metabolism (Biotransformation) - p. iii 355. Dynamics of Microtubule Self-Assembly - p. iii 356. Dynamics of Protein Kinase Cascades - p. iii 357. Cdc42 and the Mechanisms of Yeast Cell Polarization - A Paradigm for Mesoscale Systems Biology - p. iii 358. Theory of Cargo and Membrane Trafficking - p. iii 359. Transcription Factor Networks - p. iii 360. Vertical Integration - p. iii 361. Vertical Integration - p. iii 362. Computational Approaches for Multiscale Modeling - p. iii 363. Cardiac Modeling - p. iii 364. Mathematical Approaches to Studying Inflammation - p. iii 365. Cancer Systems Biology - p. iii 366. Angiogenesis - p. iii 367. A Review on Various Mathematical Modeling Approaches for Wound Healing - p. iii 368. Multiscale Analysis of Morphogenesis - p. iii 369. Neurogenesis in the Adult Brain - p. iii 370. Horizontal Integration - p. iii 371. Understanding of ‘Networks’ In Vitro and/or In Vivo - p. iii 372. Connecting Evolutionary Genomics to Cell Biology - p. iii 373. Transcriptomics - p. iii 374. OMICS – Mass Spectrometry-Based Proteomics in Systems Biology Research - p. iii 375. Posttranslational Modifications: Key Players in Health and Disease - p. iii 376. Mass Spectrometry-based Methodologies for Studying Proteolytic Networks and the Degradome - p. iii 377. Drug Targeting - p. iii 378. Phosphoproteomics: Methods and Challenges - p. iii 379. Interactomes-Scaffolds of Cellular Systems - p. iii 380. Network Modeling of Tissues and Cell Types - p. iii 381. Stochastic Analysis of Nongenetic Cell-to-Cell Heterogeneity - p. iii 382. Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling - p. iii 383. High-Content Screening in Cell Biology - p. iii 384. Integrative Systems Biology - p. iii 385. Clinical/Translational Cell Biology, Edited by Borja Ibáñez - p. iii 386. Overview - p. iii 387. Cell Biological Bases for Pathology and Disease – An Overview - p. iii 388. General/Transversal Processes - p. iii 389. Inflammation as a Driver of Disease - p. iii 390. Fibrosis - p. iii 391. General and Emerging Concepts of Immunity - p. iii 392. Role of DNA Damage, Somatic Mutations, Telomere Shortening, and Epigenetic Alterations in Aging and Age-Related Disease - p. iii 393. Specific Pathologies/Diseases - p. iii 394. Cellular Mechanisms Involved in Weight Regulation - p. iii 395. Secretion and Impact of Gut Hormones in Obesity and Diabetes - p. iii 396. Endothelial Bone Morphogenetic Protein Signaling in Pulmonary Arterial Hypertension - p. iii 397. Cystic Fibrosis - p. iii 398. Alpha-1-Antitrypsin Deficiency: A Misfolded Secretory Glycoprotein Damages the Liver by Proteotoxicity and Its Reduced Secretion Predisposes to Emphysematous Lung Disease Because of Protease-Inhibitor Imbalance - p. iii 399. The Emerging Importance of Cellular Insulin Resistance in Diabetic Kidney Disease - p. iii 400. Non-Alcoholic Fatty Liver Disease and Steatohepatitis - p. iii 401. Hepatitis C - p. iii 402. Alzheimer׳s Disease: One of the Pandemics of the 21st Century - p. iii 403. Basic Concepts and Emergent Disease Mechanisms of Amyotrophic Lateral Sclerosis - p. iii 404. Neuroinflammation in Multiple Sclerosis - p. iii 405. Overview of Blood Coagulation and the Pathophysiology of Blood Coagulation Disorders - p. iii 406. Myeloproliferative Neoplasms - p. iii 407. Cancer – Proteases in Progression and Metastasis - p. iii 408. Small RNAs/Cancer - p. iii 409. Wound Healing: An Orchestrated Process of Cell Cycle, Adhesion and Signaling - p. iii 410. Cancer Cell Invasion through Tissue Barriers - p. iii 411. Subject Index - p. iii 412. Authors - p. iii
