Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions.
Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving life-long, severe and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them. With the expanding breadth and depth of the field, there is no existing comprehensive resource available for those professionals interested in learning about or contributing to food allergy research and clinical care. This is a complete resource covering broad and detailed aspects of food allergy and adverse food reactions for clinicians, researchers, regulators, food industry, students and other stakeholders who need and will benefit from a rich resource with in-depth and practical information.
1. Introduction to non-IgE mediated food allergy - p. 247 2. FPIES: Definitions, epidemiology, clinical manifestations - p. 247 3. FPIES: Immune mechanisms - p. 264 4. Diagnosis of food protein induced enterocolitis syndrome - p. 276 5. FPIES: Management and natural course - p. 287 6. Food protein induced allergic proctocolitis: Definitions, pathophysiology, epidemiology, clinical manifestations - p. 287 7. Food protein-induced allergic proctocolitis: Diagnosis, management, and natural course - p. 309 8. Eosinophilic esophagitis: History, definition and epidemiology - p. 309 9. Eosinophilic esophagitis pathology and food allergy - p. 309 10. Eosinophilic esophagitis: Immune response - p. 309 11. EoE: Diagnosis - p. 351 12. Eosinophilic esophagitis: Role of allergens - p. 363 13. Dietary management of eosinophilic esophagitis - p. 378 14. Therapeutic management of eosinophilic esophagitis - p. 388 15. Eosinophilic gastritis: Definition, epidemiology, pathology, diagnosis - p. 390 16. Eosinophilic gastritis: Management and natural course - p. 390 17. Non-EoE eosinophilic gastrointestinal diseases - p. 390 18. Eosinophilic gastroenteritis/colitis: Management and natural course - p. 390 19. Diagnostics - p. 429 20. Clinical approach to the diagnosis of food allergy - p. 429 21. Differential diagnosis of food allergy - p. 440 22. Skin prick testing to support the diagnosis of food allergy - p. 462 23. Specific IgE to whole allergen extracts to support the diagnosis of food allergy - p. 476 24. Specific IgE to individual allergen components: Milk and egg - p. 484 25. Specific IgE to individual allergen components: Peanut - p. 495 26. Specific IgE to individual allergen components: Tree nuts and seeds - p. 496 27. Specific IgE to individual allergen components: Fish and shellfish - p. 511 28. Specific IgE to individual allergen components: Fruits and vegetables - p. 523 29. Pollen food syndromes - p. 537 30. Epitope testing - p. 550 31. Basophil activation test - p. 550 32. Mast cell activation test - p. 574 33. T cell function test in food allergy - p. 587 34. Gastroenterological assessments in children with suspected food allergy - p. 599 35. Diagnostic elimination diets - p. 614 36. Oral food challenge: Indications, dosing schedule and stopping criteria - p. 633 37. Integrating clinical history with allergy tests - p. 653 38. Putative biomarkers for severity and threshold of allergic reactions to foods - p. 665 39. Assessment for spontaneous resolution of food allergy - p. 675 40. Monitoring clinical response to immunomodulatory treatments - p. 687 41. Novel and emerging tests for food allergy - p. 687 42. Unproven methods in diagnosing food allergy - p. 707 43. Management - p. 716 44. Introduction: Multidisciplinary management of the food-allergic individual - p. 716 45. Management of food-induced allergic reactions: General - p. 716 46. Management of food induced allergic reactions in infants - p. 10 47. Written food allergy and anaphylaxis action plans - p. 33 48. Vaccines, medications and food allergy - p. 33 49. Nutritional management of infants with food allergies - p. 33 50. Nutritional management of food allergy - p. 33 51. Transition healthcare for adolescents and young adults with food allergy - p. 33 52. Food allergy in the educational setting - p. 33 53. Co-factors and reducing their impact - p. 119 54. Management of lipid transfer protien (LTP) food allergy - p. 119 55. Management of occupational food allergy - p. 141 56. Managing individuals with non-immune food hypersensitivity - p. 141 57. Proactive management of food allergy: Allergen introduction - p. 141 58. Food labelling and food allergies - p. 176 59. Managing food allergies in restaurants and food hospitality establishments - p. 176 60. Psychosocial consequences and their management - p. 224 61. Managing a food allergy: The challenges of travel and vacations - p. 224 62. Approach to patients with prior near-fatal anaphylaxis - p. 224 63. Approach to the patient with anaphylaxis to an undiagnosed food trigger - p. 224 64. Prevention - p. 224 65. Overview of current recommendations: Global - p. 224 66. Role of antenatal maternal diet - p. 224 67. Role of mode of delivery and gestation duration on food allergy - p. 224 68. Role of breastfeeding: Duration of breastfeeding and exclusive breastfeeding - p. 224 69. Maternal diet during breastfeeding: Could it influence food allergy risk in children? - p. 224 70. Role of infant early cow's milk formula exposure - p. 319 71. Hydrolysis of infant formula for food allergy prevention - p. 319 72. Early allergenic food introduction - p. 335 73. Diet diversity and food allergy - p. 335 74. Nutrients and food allergy prevention - p. 335 75. Practical dietary approaches for allergy prevention - p. 335 76. Prevention of food allergies with probiotics, prebiotics, and synbiotics - p. 387 77. The role of the skin barrier in food allergy prevention - p. 387 78. Environmental interventions to prevent food allergy - p. 387 79. Role of domestic animal exposure - p. 387 80. Novel methods for primary and secondary prevention of food allergy - p. 387 81. Therapeutic Approaches - p. 387 82. Overview of the therapeutic landscape in food allergy - p. 387 83. Regulatory considerations in developing food allergy treatments - p. 387 84. Clinical outcome measures in food allergy treatment - p. 387 85. Estimating value of food allergy treatments - p. 475 86. Understanding mechanisms underlying response to food allergy treatments - p. 475 87. Best practices for administering food immunotherapy in the clinic - p. 475 88. Oral immunotherapy for peanut allergy - p. 475 89. Oral immunotherapy for cow's milk and hen's egg allergy - p. 475 90. Oral immunotherapy for multiple food allergies - p. 475 91. Sublingual immunotherapy for food allergy - p. 475 92. Epicutaneous immunotherapy - p. 588 93. Innovative approaches to immunization - p. 588 94. Microbiome-based approaches to food allergy treatment - p. 602 95. Biologics in food allergy treatment - p. 602 96. Small molecules and food allergy - p. 602 97. Unmet needs in food allergy treatment - p. 602 98. Index - p. 602 99. Author Index - p. 697
Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions.
Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving life-long, severe and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them. With the expanding breadth and depth of the field, there is no existing comprehensive resource available for those professionals interested in learning about or contributing to food allergy research and clinical care. This is a complete resource covering broad and detailed aspects of food allergy and adverse food reactions for clinicians, researchers, regulators, food industry, students and other stakeholders who need and will benefit from a rich resource with in-depth and practical information.
1. Introduction to non-IgE mediated food allergy - p. 247 2. FPIES: Definitions, epidemiology, clinical manifestations - p. 247 3. FPIES: Immune mechanisms - p. 264 4. Diagnosis of food protein induced enterocolitis syndrome - p. 276 5. FPIES: Management and natural course - p. 287 6. Food protein induced allergic proctocolitis: Definitions, pathophysiology, epidemiology, clinical manifestations - p. 287 7. Food protein-induced allergic proctocolitis: Diagnosis, management, and natural course - p. 309 8. Eosinophilic esophagitis: History, definition and epidemiology - p. 309 9. Eosinophilic esophagitis pathology and food allergy - p. 309 10. Eosinophilic esophagitis: Immune response - p. 309 11. EoE: Diagnosis - p. 351 12. Eosinophilic esophagitis: Role of allergens - p. 363 13. Dietary management of eosinophilic esophagitis - p. 378 14. Therapeutic management of eosinophilic esophagitis - p. 388 15. Eosinophilic gastritis: Definition, epidemiology, pathology, diagnosis - p. 390 16. Eosinophilic gastritis: Management and natural course - p. 390 17. Non-EoE eosinophilic gastrointestinal diseases - p. 390 18. Eosinophilic gastroenteritis/colitis: Management and natural course - p. 390 19. Diagnostics - p. 429 20. Clinical approach to the diagnosis of food allergy - p. 429 21. Differential diagnosis of food allergy - p. 440 22. Skin prick testing to support the diagnosis of food allergy - p. 462 23. Specific IgE to whole allergen extracts to support the diagnosis of food allergy - p. 476 24. Specific IgE to individual allergen components: Milk and egg - p. 484 25. Specific IgE to individual allergen components: Peanut - p. 495 26. Specific IgE to individual allergen components: Tree nuts and seeds - p. 496 27. Specific IgE to individual allergen components: Fish and shellfish - p. 511 28. Specific IgE to individual allergen components: Fruits and vegetables - p. 523 29. Pollen food syndromes - p. 537 30. Epitope testing - p. 550 31. Basophil activation test - p. 550 32. Mast cell activation test - p. 574 33. T cell function test in food allergy - p. 587 34. Gastroenterological assessments in children with suspected food allergy - p. 599 35. Diagnostic elimination diets - p. 614 36. Oral food challenge: Indications, dosing schedule and stopping criteria - p. 633 37. Integrating clinical history with allergy tests - p. 653 38. Putative biomarkers for severity and threshold of allergic reactions to foods - p. 665 39. Assessment for spontaneous resolution of food allergy - p. 675 40. Monitoring clinical response to immunomodulatory treatments - p. 687 41. Novel and emerging tests for food allergy - p. 687 42. Unproven methods in diagnosing food allergy - p. 707 43. Management - p. 716 44. Introduction: Multidisciplinary management of the food-allergic individual - p. 716 45. Management of food-induced allergic reactions: General - p. 716 46. Management of food induced allergic reactions in infants - p. 10 47. Written food allergy and anaphylaxis action plans - p. 33 48. Vaccines, medications and food allergy - p. 33 49. Nutritional management of infants with food allergies - p. 33 50. Nutritional management of food allergy - p. 33 51. Transition healthcare for adolescents and young adults with food allergy - p. 33 52. Food allergy in the educational setting - p. 33 53. Co-factors and reducing their impact - p. 119 54. Management of lipid transfer protien (LTP) food allergy - p. 119 55. Management of occupational food allergy - p. 141 56. Managing individuals with non-immune food hypersensitivity - p. 141 57. Proactive management of food allergy: Allergen introduction - p. 141 58. Food labelling and food allergies - p. 176 59. Managing food allergies in restaurants and food hospitality establishments - p. 176 60. Psychosocial consequences and their management - p. 224 61. Managing a food allergy: The challenges of travel and vacations - p. 224 62. Approach to patients with prior near-fatal anaphylaxis - p. 224 63. Approach to the patient with anaphylaxis to an undiagnosed food trigger - p. 224 64. Prevention - p. 224 65. Overview of current recommendations: Global - p. 224 66. Role of antenatal maternal diet - p. 224 67. Role of mode of delivery and gestation duration on food allergy - p. 224 68. Role of breastfeeding: Duration of breastfeeding and exclusive breastfeeding - p. 224 69. Maternal diet during breastfeeding: Could it influence food allergy risk in children? - p. 224 70. Role of infant early cow's milk formula exposure - p. 319 71. Hydrolysis of infant formula for food allergy prevention - p. 319 72. Early allergenic food introduction - p. 335 73. Diet diversity and food allergy - p. 335 74. Nutrients and food allergy prevention - p. 335 75. Practical dietary approaches for allergy prevention - p. 335 76. Prevention of food allergies with probiotics, prebiotics, and synbiotics - p. 387 77. The role of the skin barrier in food allergy prevention - p. 387 78. Environmental interventions to prevent food allergy - p. 387 79. Role of domestic animal exposure - p. 387 80. Novel methods for primary and secondary prevention of food allergy - p. 387 81. Therapeutic Approaches - p. 387 82. Overview of the therapeutic landscape in food allergy - p. 387 83. Regulatory considerations in developing food allergy treatments - p. 387 84. Clinical outcome measures in food allergy treatment - p. 387 85. Estimating value of food allergy treatments - p. 475 86. Understanding mechanisms underlying response to food allergy treatments - p. 475 87. Best practices for administering food immunotherapy in the clinic - p. 475 88. Oral immunotherapy for peanut allergy - p. 475 89. Oral immunotherapy for cow's milk and hen's egg allergy - p. 475 90. Oral immunotherapy for multiple food allergies - p. 475 91. Sublingual immunotherapy for food allergy - p. 475 92. Epicutaneous immunotherapy - p. 588 93. Innovative approaches to immunization - p. 588 94. Microbiome-based approaches to food allergy treatment - p. 602 95. Biologics in food allergy treatment - p. 602 96. Small molecules and food allergy - p. 602 97. Unmet needs in food allergy treatment - p. 602 98. Index - p. 602 99. Author Index - p. 697
