Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented.
The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds.
The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. iv 6. List of Contributors - p. xv 7. Foreword - p. xix 8. Preface - p. xxi 9. Acknowledgments - p. xxiii 10. Part I: The Heart as an Endocrine Organ - p. xxiii 11. Chapter 1. Cardiac Natriuretic Peptides - p. 3 12. Chapter 2. Adrenomedullin - p. 41 13. Chapter 3. Endothelin-1 as a Cardiac-Derived Autocrine, Paracrine and Intracrine Factor in Heart Health and Disease - p. 59 14. Chapter 4. The Cardiokines: An Expanding Family of the Heart Secretome - p. 87 15. Chapter 5. Novel Small Peptide Hormones - p. 115 16. Part II: The Heart as an Endocrine Target - p. 132 17. Chapter 6. Gut-Derived Hormones—Cardiac Effects of Ghrelin and Glucagon-Like Peptide-1 - p. 139 18. Chapter 7. Fat Hormones, Adipokines - p. 167 19. Chapter 8. Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart - p. 207 20. Chapter 9. Renin Angiotensin Aldosterone System and Heart Function - p. 229 21. Chapter 10. Nuclear Receptors and the Adaptive Response of the Heart - p. 249 22. Chapter 11. Adrenergic Receptors - p. 285 23. Chapter 12. Insulin Signaling in Cardiac Health and Disease - p. 317 24. Index - p. 347
Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented.
The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds.
The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. iv 6. List of Contributors - p. xv 7. Foreword - p. xix 8. Preface - p. xxi 9. Acknowledgments - p. xxiii 10. Part I: The Heart as an Endocrine Organ - p. xxiii 11. Chapter 1. Cardiac Natriuretic Peptides - p. 3 12. Chapter 2. Adrenomedullin - p. 41 13. Chapter 3. Endothelin-1 as a Cardiac-Derived Autocrine, Paracrine and Intracrine Factor in Heart Health and Disease - p. 59 14. Chapter 4. The Cardiokines: An Expanding Family of the Heart Secretome - p. 87 15. Chapter 5. Novel Small Peptide Hormones - p. 115 16. Part II: The Heart as an Endocrine Target - p. 132 17. Chapter 6. Gut-Derived Hormones—Cardiac Effects of Ghrelin and Glucagon-Like Peptide-1 - p. 139 18. Chapter 7. Fat Hormones, Adipokines - p. 167 19. Chapter 8. Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart - p. 207 20. Chapter 9. Renin Angiotensin Aldosterone System and Heart Function - p. 229 21. Chapter 10. Nuclear Receptors and the Adaptive Response of the Heart - p. 249 22. Chapter 11. Adrenergic Receptors - p. 285 23. Chapter 12. Insulin Signaling in Cardiac Health and Disease - p. 317 24. Index - p. 347
