Many plant-derived bioactive compounds are the foundation effective drugs to cure diseases. Usually, the bioactive compounds in plant biomass are low, and the extraction of bioactive compounds from plants is not eco-friendly, which limits their application in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast. Engineering biology for microbial biosynthesis of plant-derived bioactive compounds summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing this content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks.
With a comprehensive coverage of the field, Engineering biology for microbial biosynthesis of plant-derived bioactive compounds is of great interest to undergraduate and graduate students, scientists, researchers as well as engineers who work on the microbial production of plant-derived bioactive compounds.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. Preface - p. xix 8. Chapter 1. Mining bioparts for the biosynthesis of plant-derived bioactive compounds via omics and bioinformatics technologies - p. 1 9. DNA assembly techniques for the reconstitution of plant natural product biosynthetic pathways in Saccharomyces cerevisiae - p. 33 10. Chapter 3. The application of gene-editing technologies in the biosynthesis of plant-derived bioactive compounds - p. 47 11. Chapter 4. Pathway engineering of plant-derived bioactive compounds in microbes - p. 73 12. Chapter 5. Construction and application of a genome-scale metabolic network model for plants - p. 89 13. Chapter 6. Metabolic design–build–test–learn cycle used for the biosynthesis of plant-derived bioactive compounds - p. 105 14. Chapter 7. Microbial cell factories for the synthesis of plant-derived bioactive compounds: metabolic flux dynamic regulation - p. 121 15. Chapter 8. Yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids - p. 145 16. Chapter 9. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids - p. 159 17. Chapter 10. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive flavonoids - p. 185 18. Chapter 11. Non-yeast fungal cell factories for the biosynthesis of plant-derived bioactive compounds - p. 215 19. Chapter 12. Fine-tuning and dynamic control of microbial cell factories for the biosynthesis of plant-derived bioactive compounds - p. 227 20. Chapter 13. Biofoundries for plant-derived bioactive compounds - p. 257 21. Chapter 14. Engineering biology fundamental for plant-derived bioactive compounds: challenges and prospects - p. 285 22. Chapter 15. Reprogramming microbial cell factories to overproduce plant natural products through directed genome evolution - p. 315 23. Index - p. 345
Many plant-derived bioactive compounds are the foundation effective drugs to cure diseases. Usually, the bioactive compounds in plant biomass are low, and the extraction of bioactive compounds from plants is not eco-friendly, which limits their application in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast. Engineering biology for microbial biosynthesis of plant-derived bioactive compounds summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing this content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks.
With a comprehensive coverage of the field, Engineering biology for microbial biosynthesis of plant-derived bioactive compounds is of great interest to undergraduate and graduate students, scientists, researchers as well as engineers who work on the microbial production of plant-derived bioactive compounds.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. Preface - p. xix 8. Chapter 1. Mining bioparts for the biosynthesis of plant-derived bioactive compounds via omics and bioinformatics technologies - p. 1 9. DNA assembly techniques for the reconstitution of plant natural product biosynthetic pathways in Saccharomyces cerevisiae - p. 33 10. Chapter 3. The application of gene-editing technologies in the biosynthesis of plant-derived bioactive compounds - p. 47 11. Chapter 4. Pathway engineering of plant-derived bioactive compounds in microbes - p. 73 12. Chapter 5. Construction and application of a genome-scale metabolic network model for plants - p. 89 13. Chapter 6. Metabolic design–build–test–learn cycle used for the biosynthesis of plant-derived bioactive compounds - p. 105 14. Chapter 7. Microbial cell factories for the synthesis of plant-derived bioactive compounds: metabolic flux dynamic regulation - p. 121 15. Chapter 8. Yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids - p. 145 16. Chapter 9. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids - p. 159 17. Chapter 10. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive flavonoids - p. 185 18. Chapter 11. Non-yeast fungal cell factories for the biosynthesis of plant-derived bioactive compounds - p. 215 19. Chapter 12. Fine-tuning and dynamic control of microbial cell factories for the biosynthesis of plant-derived bioactive compounds - p. 227 20. Chapter 13. Biofoundries for plant-derived bioactive compounds - p. 257 21. Chapter 14. Engineering biology fundamental for plant-derived bioactive compounds: challenges and prospects - p. 285 22. Chapter 15. Reprogramming microbial cell factories to overproduce plant natural products through directed genome evolution - p. 315 23. Index - p. 345
