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Enzinger and Weiss's Soft Tissue Tumors

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Since its first publication more than 35 years ago, Enzinger and Weiss’s Soft Tissue Tumors has established itself as the most comprehensive and authoritative reference available on soft tissue pathology. The 7th Edition from Drs. John R. Goldblum, Andrew L. Folpe, and Sharon W. Weiss, continues this tradition with detailed, well-written, logically organized coverage of the full spectrum of these often difficult and challenging tumors. It offers clear guidance to practicing and trainee pathologists on diagnosis of tumors by microscopy, immunohistochemistry, and molecular genetics, as well as a significant amount of clinically significant information of interest to the clinicians who most frequently see these diseases – dermatologists, orthopaedists, and oncologists.

  • Offers practical information on differential diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures, helping you accurately diagnose and confidently sign out pathology reports on even the most challenging cases.

  • Provides unsurpassed scope and depth in this complex area with microscopic findings correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, for a comprehensive and integrated approach to evaluation and diagnosis.

  • Incorporates new knowledge on recently identified entities, next-generation sequencing (NGS), molecular diagnostic techniques, and immunohistochemical and genetic features of soft tissue tumors, providing up-to-date diagnostic and prognostic information that will inform day-to-day therapeutic decisions.

  • Features nearly 2,000 high-quality images that clearly capture the clinical, macroscopic and microscopic features of benign and malignant conditions, helping you relate these characteristics to their specific classifications.

  • Utilizes a logical, well-structured format including summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity, enabling you to navigate the text quickly, improve turnaround time when diagnosing a specimen, and clearly report on the prognosis and therapeutic management options.
  • Includes abundant algorithms, tables, and graphs to facilitate rapid decision making.

1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Preface - p. vii 7. Preface to the First Edition - p. viii 8. Contributors - p. vi 9. 1 General Considerations - p. viii 10. 2 Clinical Evaluation and Treatment of Soft Tissue Tumors - p. 14 11. 3 Radiologic Evaluation of Soft Tissue Tumors - p. 31 12. 4 Molecular Genetic Pathology of Soft Tissue Tumors - p. 83 13. Organization of the Human Genome: Implications for Molecular Genetic Pathology - p. 83 14. Constitutional Mutations Predisposing to Soft Tissue Tumors - p. 85 15. Somatic Mutations in Soft Tissue Tumors: General Concepts - p. 87 16. Genetic Techniques - p. 93 17. Characteristic Genetic Changes in Soft Tissue Tumors - p. 99 18. Conclusion - p. 110 19. Acknowledgments - p. 110 20. 5 Approach to the Diagnosis of Soft Tissue Tumors - p. 120 21. 6 Immunohistochemistry for Analysis of Soft Tissue Tumors - p. 128 22. Intermediate Filaments - p. 128 23. Epithelial Membrane Antigen - p. 137 24. Markers of Muscle Differentiation - p. 138 25. Markers of Nerve Sheath Differentiation - p. 145 26. “Neuroectodermal” Markers - p. 149 27. Markers of Melanocytic Differentiation - p. 154 28. Markers of Endothelial Differentiation - p. 155 29. Markers of Gastrointestinal Stromal Tumors - p. 163 30. Immunohistochemistry as Surrogate for Tumor-Specific Molecular Alterations - p. 163 31. Other Markers - p. 174 32. Prognostic Markers - p. 182 33. Application of Immunohistochemistry to Sarcoma Diagnosis: Clinical Scenarios - p. 184 34. Conclusion - p. 186 35. 7 Benign Fibroblastic/Myofibroblastic Proliferations, Including Superficial Fibromatoses - p. 201 36. Classification of Benign Fibroblastic/Myofibroblastic Proliferations - p. 203 37. Nodular Fasciitis - p. 203 38. Proliferative Fasciitis - p. 214 39. Proliferative Myositis - p. 218 40. Organ-Associated Pseudosarcomatous Myofibroblastic Proliferations - p. 219 41. Ischemic Fasciitis (Atypical Decubital Fibroplasia) - p. 225 42. Fibroma of Tendon Sheath - p. 227 43. Pleomorphic Fibroma of The Skin - p. 231 44. Nuchal-Type Fibroma - p. 232 45. Gardner-Associated Fibroma - p. 234 46. Elastofibroma - p. 235 47. Nasopharyngeal Angiofibroma - p. 237 48. Keloid - p. 240 49. Desmoplastic Fibroblastoma (Collagenous Fibroma) - p. 244 50. Intranodal Palisaded Myofibroblastoma - p. 246 51. Mammary-Type Myofibroblastoma - p. 248 52. Superficial Acral Fibromyxoma (Digital Fibromyxoma) - p. 253 53. Soft Tissue Angiofibroma - p. 254 54. Superficial Fibromatoses - p. 256 55. Palmar Fibromatosis (Dupuytren Disease) - p. 257 56. Plantar Fibromatosis (Ledderhose Disease) - p. 260 57. Penile Fibromatosis (Peyronie Disease) - p. 263 58. Knuckle Pads - p. 265 59. 8 Fibrous Tumors of Infancy and Childhood - p. 274 60. 9 Borderline and Malignant Fibroblastic/Myofibroblastic Tumors - p. 305 61. Deep (Desmoid-Type) Fibromatoses - p. 305 62. Congenital/Infantile Fibrosarcoma - p. 318 63. Inflammatory Myofibroblastic Tumor - p. 322 64. Adult-Type Fibrosarcoma - p. 330 65. Fibrosarcoma Variants - p. 336 66. 10 Benign Fibrohistiocytic Tumors - p. 374 67. 11 Fibrohistiocytic Tumors of Intermediate Malignancy - p. 423 68. 12 Undifferentiated Pleomorphic Sarcoma - p. 451 69. 13 Benign Lipomatous Tumors - p. 475 70. 14 Liposarcoma - p. 519 71. 15 Benign Tumors of Smooth Muscle - p. 563 72. 16 Leiomyosarcoma - p. 590 73. 17 Gastrointestinal Stromal Tumor (GIST) and Extragastrointestinal GIST - p. 613 74. 18 Rhabdomyoma - p. 638 75. 19 Rhabdomyosarcoma - p. 651 76. 20 Benign Vascular Tumors and Malformations - p. 696 77. 21 Hemangioendothelioma - p. 756 78. 22 Malignant Vascular Tumors - p. 784 79. 23 Tumors and Malformations of Lymphatic Vessels - p. 816 80. 24 Perivascular Tumors - p. 836 81. 25 Benign Tumors and Tumorlike Lesions of Synovial Tissue - p. 862 82. 26 Benign Tumors of Peripheral Nerves - p. 884 83. 27 Malignant Peripheral Nerve Sheath Tumors - p. 958 84. 28 Peripheral Neuroblastic Tumors - p. 990 85. 29 Soft Tissue Tumors Showing Melanocytic Differentiation - p. 1008 86. 30 Cartilaginous and Osseous Soft Tissue Tumors - p. 1051 87. 31 Miscellaneous Benign Soft Tissue Tumors and Pseudotumors - p. 1084 88. 32 Soft Tissue Tumors of Intermediate Malignancy of Uncertain Type - p. 1106 89. 33 Other Malignant Soft Tissue Tumors, Including Those of Uncertain Type - p. 1174 90. Ewing Sarcoma - p. 1174 91. CIC-Rearranged Sarcoma - p. 1186 92. BCOR-Rearranged Sarcoma - p. 1191 93. Extraskeletal Myxoid Chondrosarcoma - p. 1194 94. Synovial Sarcoma - p. 1200 95. Alveolar Soft Part Sarcoma - p. 1218 96. Desmoplastic Small Round Cell Tumor - p. 1227 97. Epithelioid Sarcoma - p. 1231 98. Malignant Extrarenal Rhabdoid Tumor - p. 1242 99. Follicular Dendritic Cell Sarcoma - p. 1247 100. GLI1-Rearranged Malignant Epithelioid Neoplasm - p. 1249 101. Index - p. 1270

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Descripción

Since its first publication more than 35 years ago, Enzinger and Weiss’s Soft Tissue Tumors has established itself as the most comprehensive and authoritative reference available on soft tissue pathology. The 7th Edition from Drs. John R. Goldblum, Andrew L. Folpe, and Sharon W. Weiss, continues this tradition with detailed, well-written, logically organized coverage of the full spectrum of these often difficult and challenging tumors. It offers clear guidance to practicing and trainee pathologists on diagnosis of tumors by microscopy, immunohistochemistry, and molecular genetics, as well as a significant amount of clinically significant information of interest to the clinicians who most frequently see these diseases – dermatologists, orthopaedists, and oncologists.

  • Offers practical information on differential diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures, helping you accurately diagnose and confidently sign out pathology reports on even the most challenging cases.

  • Provides unsurpassed scope and depth in this complex area with microscopic findings correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, for a comprehensive and integrated approach to evaluation and diagnosis.

  • Incorporates new knowledge on recently identified entities, next-generation sequencing (NGS), molecular diagnostic techniques, and immunohistochemical and genetic features of soft tissue tumors, providing up-to-date diagnostic and prognostic information that will inform day-to-day therapeutic decisions.

  • Features nearly 2,000 high-quality images that clearly capture the clinical, macroscopic and microscopic features of benign and malignant conditions, helping you relate these characteristics to their specific classifications.

  • Utilizes a logical, well-structured format including summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity, enabling you to navigate the text quickly, improve turnaround time when diagnosing a specimen, and clearly report on the prognosis and therapeutic management options.
  • Includes abundant algorithms, tables, and graphs to facilitate rapid decision making.

1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Preface - p. vii 7. Preface to the First Edition - p. viii 8. Contributors - p. vi 9. 1 General Considerations - p. viii 10. 2 Clinical Evaluation and Treatment of Soft Tissue Tumors - p. 14 11. 3 Radiologic Evaluation of Soft Tissue Tumors - p. 31 12. 4 Molecular Genetic Pathology of Soft Tissue Tumors - p. 83 13. Organization of the Human Genome: Implications for Molecular Genetic Pathology - p. 83 14. Constitutional Mutations Predisposing to Soft Tissue Tumors - p. 85 15. Somatic Mutations in Soft Tissue Tumors: General Concepts - p. 87 16. Genetic Techniques - p. 93 17. Characteristic Genetic Changes in Soft Tissue Tumors - p. 99 18. Conclusion - p. 110 19. Acknowledgments - p. 110 20. 5 Approach to the Diagnosis of Soft Tissue Tumors - p. 120 21. 6 Immunohistochemistry for Analysis of Soft Tissue Tumors - p. 128 22. Intermediate Filaments - p. 128 23. Epithelial Membrane Antigen - p. 137 24. Markers of Muscle Differentiation - p. 138 25. Markers of Nerve Sheath Differentiation - p. 145 26. “Neuroectodermal” Markers - p. 149 27. Markers of Melanocytic Differentiation - p. 154 28. Markers of Endothelial Differentiation - p. 155 29. Markers of Gastrointestinal Stromal Tumors - p. 163 30. Immunohistochemistry as Surrogate for Tumor-Specific Molecular Alterations - p. 163 31. Other Markers - p. 174 32. Prognostic Markers - p. 182 33. Application of Immunohistochemistry to Sarcoma Diagnosis: Clinical Scenarios - p. 184 34. Conclusion - p. 186 35. 7 Benign Fibroblastic/Myofibroblastic Proliferations, Including Superficial Fibromatoses - p. 201 36. Classification of Benign Fibroblastic/Myofibroblastic Proliferations - p. 203 37. Nodular Fasciitis - p. 203 38. Proliferative Fasciitis - p. 214 39. Proliferative Myositis - p. 218 40. Organ-Associated Pseudosarcomatous Myofibroblastic Proliferations - p. 219 41. Ischemic Fasciitis (Atypical Decubital Fibroplasia) - p. 225 42. Fibroma of Tendon Sheath - p. 227 43. Pleomorphic Fibroma of The Skin - p. 231 44. Nuchal-Type Fibroma - p. 232 45. Gardner-Associated Fibroma - p. 234 46. Elastofibroma - p. 235 47. Nasopharyngeal Angiofibroma - p. 237 48. Keloid - p. 240 49. Desmoplastic Fibroblastoma (Collagenous Fibroma) - p. 244 50. Intranodal Palisaded Myofibroblastoma - p. 246 51. Mammary-Type Myofibroblastoma - p. 248 52. Superficial Acral Fibromyxoma (Digital Fibromyxoma) - p. 253 53. Soft Tissue Angiofibroma - p. 254 54. Superficial Fibromatoses - p. 256 55. Palmar Fibromatosis (Dupuytren Disease) - p. 257 56. Plantar Fibromatosis (Ledderhose Disease) - p. 260 57. Penile Fibromatosis (Peyronie Disease) - p. 263 58. Knuckle Pads - p. 265 59. 8 Fibrous Tumors of Infancy and Childhood - p. 274 60. 9 Borderline and Malignant Fibroblastic/Myofibroblastic Tumors - p. 305 61. Deep (Desmoid-Type) Fibromatoses - p. 305 62. Congenital/Infantile Fibrosarcoma - p. 318 63. Inflammatory Myofibroblastic Tumor - p. 322 64. Adult-Type Fibrosarcoma - p. 330 65. Fibrosarcoma Variants - p. 336 66. 10 Benign Fibrohistiocytic Tumors - p. 374 67. 11 Fibrohistiocytic Tumors of Intermediate Malignancy - p. 423 68. 12 Undifferentiated Pleomorphic Sarcoma - p. 451 69. 13 Benign Lipomatous Tumors - p. 475 70. 14 Liposarcoma - p. 519 71. 15 Benign Tumors of Smooth Muscle - p. 563 72. 16 Leiomyosarcoma - p. 590 73. 17 Gastrointestinal Stromal Tumor (GIST) and Extragastrointestinal GIST - p. 613 74. 18 Rhabdomyoma - p. 638 75. 19 Rhabdomyosarcoma - p. 651 76. 20 Benign Vascular Tumors and Malformations - p. 696 77. 21 Hemangioendothelioma - p. 756 78. 22 Malignant Vascular Tumors - p. 784 79. 23 Tumors and Malformations of Lymphatic Vessels - p. 816 80. 24 Perivascular Tumors - p. 836 81. 25 Benign Tumors and Tumorlike Lesions of Synovial Tissue - p. 862 82. 26 Benign Tumors of Peripheral Nerves - p. 884 83. 27 Malignant Peripheral Nerve Sheath Tumors - p. 958 84. 28 Peripheral Neuroblastic Tumors - p. 990 85. 29 Soft Tissue Tumors Showing Melanocytic Differentiation - p. 1008 86. 30 Cartilaginous and Osseous Soft Tissue Tumors - p. 1051 87. 31 Miscellaneous Benign Soft Tissue Tumors and Pseudotumors - p. 1084 88. 32 Soft Tissue Tumors of Intermediate Malignancy of Uncertain Type - p. 1106 89. 33 Other Malignant Soft Tissue Tumors, Including Those of Uncertain Type - p. 1174 90. Ewing Sarcoma - p. 1174 91. CIC-Rearranged Sarcoma - p. 1186 92. BCOR-Rearranged Sarcoma - p. 1191 93. Extraskeletal Myxoid Chondrosarcoma - p. 1194 94. Synovial Sarcoma - p. 1200 95. Alveolar Soft Part Sarcoma - p. 1218 96. Desmoplastic Small Round Cell Tumor - p. 1227 97. Epithelioid Sarcoma - p. 1231 98. Malignant Extrarenal Rhabdoid Tumor - p. 1242 99. Follicular Dendritic Cell Sarcoma - p. 1247 100. GLI1-Rearranged Malignant Epithelioid Neoplasm - p. 1249 101. Index - p. 1270

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