Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. iii 4. Translational Epigenetics Series - p. ii 5. Copyright - p. iv 6. List of Contributors - p. xi 7. Chapter 1. Epigenetic Dysregulation in Pediatric Leukemia - p. 1 8. Chapter 2. Role of Epigenetics in Testicular Cancer - p. 31 9. Chapter 3. Changes in the Epigenetic Landscape of Prostate Cancer - p. 59 10. Chapter 4. The Genetics and Epigenetics of Colorectal Cancer Health Disparity - p. 87 11. Chapter 5. Genetic and Epigenetic Modifications in Pancreatic Cancer - p. 117 12. Chapter 6. Epigenetics of Breast Cancer - p. 141 13. Chapter 7. Epigenetic Modulations in Ovarian Cancer - p. 169 14. Chapter 8. Epigenetic Epidemiology for Cancer Risk - p. 195 15. Chapter 9. Epigenetic Biomarkers in Cancer Epidemiology - p. 223 16. Chapter 10. Epigenetic Biomarkers and Racial Differences in Cancer - p. 243 17. Chapter 11. Predictive Value of Epigenetic Signatures - p. 275 18. Chapter 12. Epigenetic Signatures in the Diagnosis and Prognosis of Cancer - p. 313 19. Chapter 13. Future Challenges and Prospects for the Role of Epigenetic Mechanisms in Cancer Management - p. 345 20. Index - p. 373
Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. iii 4. Translational Epigenetics Series - p. ii 5. Copyright - p. iv 6. List of Contributors - p. xi 7. Chapter 1. Epigenetic Dysregulation in Pediatric Leukemia - p. 1 8. Chapter 2. Role of Epigenetics in Testicular Cancer - p. 31 9. Chapter 3. Changes in the Epigenetic Landscape of Prostate Cancer - p. 59 10. Chapter 4. The Genetics and Epigenetics of Colorectal Cancer Health Disparity - p. 87 11. Chapter 5. Genetic and Epigenetic Modifications in Pancreatic Cancer - p. 117 12. Chapter 6. Epigenetics of Breast Cancer - p. 141 13. Chapter 7. Epigenetic Modulations in Ovarian Cancer - p. 169 14. Chapter 8. Epigenetic Epidemiology for Cancer Risk - p. 195 15. Chapter 9. Epigenetic Biomarkers in Cancer Epidemiology - p. 223 16. Chapter 10. Epigenetic Biomarkers and Racial Differences in Cancer - p. 243 17. Chapter 11. Predictive Value of Epigenetic Signatures - p. 275 18. Chapter 12. Epigenetic Signatures in the Diagnosis and Prognosis of Cancer - p. 313 19. Chapter 13. Future Challenges and Prospects for the Role of Epigenetic Mechanisms in Cancer Management - p. 345 20. Index - p. 373
