Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry.
This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.
1. Chapter 1 : Introduction to epigenetics in psychiatry - p. Page xi 2. Chapter 2 : Outline of epigenetics - p. Page 19 3. Chapter 3 : A brief history of epigenetics in psychiatry - p. Page 41 4. Chapter 4 : Roles of epigenetics in the neural stem cell and neuron - p. Page 51 5. Chapter 5 : Role of epigenetics in the brain - p. Page 76 6. Chapter 6 : Epigenetic epidemiology of psychiatric disorders - p. Page 102 7. Chapter 7 : ATAC-seq and psychiatric disorders - p. Page 135 8. Chapter 8 : Single cell RNA sequencing in psychiatric disorders - p. Page 154 9. Chapter 9 : Single cell transcriptomics and epigenomics methods provide high resolution genomics profiling of brain disorders - p. Page 172 10. Chapter 10 : Laboratory techniques in psychiatric epigenetics - p. Page 188 11. Chapter 11 : Laboratory epigenetic models of schizophrenia - p. Page 225 12. Chapter 12 : Animal models of environmental manipulations causing epigenetic modifications that increase risk for major depressive disorder and anxiety disorders - p. Page 247 13. Chapter 13 : 5-Methylcytosine and 5-hydroxymethylcytosine in psychiatric epigenetics - p. Page 265 14. Chapter 14 : Pathogenic histone modifications in schizophrenia are targets for therapy - p. Page 299 15. Chapter 15 : Non-coding RNAs and psychiatric disorders - p. Page 316 16. Chapter 16 : Epigenetics of bipolar disorder - p. Page 330 17. Chapter 17 : Epigenetics of major depressive disorder - p. Page 347 18. Chapter 18 : The epigenetics of suicide: The critical impact of environment on epigenetic regulation in suicide - p. Page 380 19. Chapter 19 : Epigenetics in posttraumatic stress disorder - p. Page 413 20. Chapter 20 : Epigenetics and cognitive disorders - p. Page 441 21. Chapter 21 : Epigenetics in intellectual disability - p. Page 477 22. Chapter 22 : Epigenetics and pervasive developmental disorders - p. Page 505 23. Chapter 23 : Epigenetics in child psychiatry - p. Page 544 24. Chapter 24 : Epigenetic mechanisms of drug addiction vulnerability - p. Page 564 25. Chapter 25 : Alcohol use disorder and associated alterations in brain epigenetic marks - p. Page 593 26. Chapter 26 : Epigenetic effects of currently used psychotropic drugs - p. Page 608 27. Chapter 27 : DNA methyltransferase inhibitors and psychiatric disorders - p. Page 633 28. Chapter 28 : Histone Deacetylase Inhibitors and Psychiatric Disorders - p. Page 651 29. Chapter 29 : Epigenetics in psychotherapy - p. Page 687 30. Chapter 30 : Functional genomics of psychiatric disease risk using genome engineering - p. Page 705 31. Chapter 31 : Nutritional effects on epigenetics in psychiatry - p. Page 724 32. Chapter 32 : Systems biology and the epigenetics of psychiatric disorders - p. Page 746 33. Chapter 33 : Transgenerational epigenetics and psychiatric disorders - p. Page 757 34. Chapter 34 : Epigenetic aspects of the microbiota and psychiatric disorders - p. Page 776 35. Index - p. Page 789
Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry.
This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.
1. Chapter 1 : Introduction to epigenetics in psychiatry - p. Page xi 2. Chapter 2 : Outline of epigenetics - p. Page 19 3. Chapter 3 : A brief history of epigenetics in psychiatry - p. Page 41 4. Chapter 4 : Roles of epigenetics in the neural stem cell and neuron - p. Page 51 5. Chapter 5 : Role of epigenetics in the brain - p. Page 76 6. Chapter 6 : Epigenetic epidemiology of psychiatric disorders - p. Page 102 7. Chapter 7 : ATAC-seq and psychiatric disorders - p. Page 135 8. Chapter 8 : Single cell RNA sequencing in psychiatric disorders - p. Page 154 9. Chapter 9 : Single cell transcriptomics and epigenomics methods provide high resolution genomics profiling of brain disorders - p. Page 172 10. Chapter 10 : Laboratory techniques in psychiatric epigenetics - p. Page 188 11. Chapter 11 : Laboratory epigenetic models of schizophrenia - p. Page 225 12. Chapter 12 : Animal models of environmental manipulations causing epigenetic modifications that increase risk for major depressive disorder and anxiety disorders - p. Page 247 13. Chapter 13 : 5-Methylcytosine and 5-hydroxymethylcytosine in psychiatric epigenetics - p. Page 265 14. Chapter 14 : Pathogenic histone modifications in schizophrenia are targets for therapy - p. Page 299 15. Chapter 15 : Non-coding RNAs and psychiatric disorders - p. Page 316 16. Chapter 16 : Epigenetics of bipolar disorder - p. Page 330 17. Chapter 17 : Epigenetics of major depressive disorder - p. Page 347 18. Chapter 18 : The epigenetics of suicide: The critical impact of environment on epigenetic regulation in suicide - p. Page 380 19. Chapter 19 : Epigenetics in posttraumatic stress disorder - p. Page 413 20. Chapter 20 : Epigenetics and cognitive disorders - p. Page 441 21. Chapter 21 : Epigenetics in intellectual disability - p. Page 477 22. Chapter 22 : Epigenetics and pervasive developmental disorders - p. Page 505 23. Chapter 23 : Epigenetics in child psychiatry - p. Page 544 24. Chapter 24 : Epigenetic mechanisms of drug addiction vulnerability - p. Page 564 25. Chapter 25 : Alcohol use disorder and associated alterations in brain epigenetic marks - p. Page 593 26. Chapter 26 : Epigenetic effects of currently used psychotropic drugs - p. Page 608 27. Chapter 27 : DNA methyltransferase inhibitors and psychiatric disorders - p. Page 633 28. Chapter 28 : Histone Deacetylase Inhibitors and Psychiatric Disorders - p. Page 651 29. Chapter 29 : Epigenetics in psychotherapy - p. Page 687 30. Chapter 30 : Functional genomics of psychiatric disease risk using genome engineering - p. Page 705 31. Chapter 31 : Nutritional effects on epigenetics in psychiatry - p. Page 724 32. Chapter 32 : Systems biology and the epigenetics of psychiatric disorders - p. Page 746 33. Chapter 33 : Transgenerational epigenetics and psychiatric disorders - p. Page 757 34. Chapter 34 : Epigenetic aspects of the microbiota and psychiatric disorders - p. Page 776 35. Index - p. Page 789
