Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies.
The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Preface - p. xiii 7. Chapter 1: Epigenetic Tools in Chronic Pain Studies - p. xiv 8. Chapter 2: Epigenetic Regulation of Peripheral Macrophages in Neuropathic Pain - p. 48 9. Chapter 3: Emphasizing Histone-Related Chromatin Remodeling in the Central Nervous System of Animal Models of Chronic Pain - p. 67 10. Chapter 4: Role of Histone Modifications in Chronic Pain Development - p. 83 11. Chapter 5: Role of DNA Methylation in Chronic Pain - p. 98 12. Chapter 6: Pain-Induced Chromatin Modifications - p. 110 13. Chapter 7: DNA Methylation/Demethylation Homeostasis and Various Pain Conditions - p. 124 14. Chapter 8: Epigenetic Modulation of Visceral Pain - p. 140 15. Chapter 9: Noncoding RNAs Are New Players in Chronic Pain - p. 156 16. Chapter 10: Epigenetics of Chronic Visceral Nociception - p. 167 17. Chapter 11: An Overview of Epigenetic Correlates of Human Chronic Pain Conditions - p. 181 18. Index - p. 229
Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies.
The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Preface - p. xiii 7. Chapter 1: Epigenetic Tools in Chronic Pain Studies - p. xiv 8. Chapter 2: Epigenetic Regulation of Peripheral Macrophages in Neuropathic Pain - p. 48 9. Chapter 3: Emphasizing Histone-Related Chromatin Remodeling in the Central Nervous System of Animal Models of Chronic Pain - p. 67 10. Chapter 4: Role of Histone Modifications in Chronic Pain Development - p. 83 11. Chapter 5: Role of DNA Methylation in Chronic Pain - p. 98 12. Chapter 6: Pain-Induced Chromatin Modifications - p. 110 13. Chapter 7: DNA Methylation/Demethylation Homeostasis and Various Pain Conditions - p. 124 14. Chapter 8: Epigenetic Modulation of Visceral Pain - p. 140 15. Chapter 9: Noncoding RNAs Are New Players in Chronic Pain - p. 156 16. Chapter 10: Epigenetics of Chronic Visceral Nociception - p. 167 17. Chapter 11: An Overview of Epigenetic Correlates of Human Chronic Pain Conditions - p. 181 18. Index - p. 229
