First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.
1. Part I: Introduction to Stem Cells - p. XXI 2. Chapter 1. Why Stem Cell Research? Advances in the Field - p. XXI 3. Chapter 2. ‘Stemness’: Definitions, Criteria, and Standards - p. 6 4. Chapter 3. Pluripotent Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges - p. 17 5. Chapter 4. Embryonic Stem Cells in Perspective - p. 34 6. Chapter 5. The Development of Epithelial Stem Cell Concepts - p. 38 7. Part II: Basic Biology and Mechanisms - p. 56 8. Chapter 6. Stem Cell Niches - p. 56 9. Chapter 7. Mechanisms of Stem Cell Self-Renewal - p. 78 10. Chapter 8. Cell Cycle Regulators in Stem Cells - p. 93 11. Chapter 9. How Cells Change Their Phenotype - p. 105 12. Part III: Tissue and Organ Development - p. 117 13. Chapter 10. Differentiation in Early Development - p. 117 14. Chapter 11. Stem Cells Derived from Amniotic Fluid - p. 139 15. Chapter 12. Stem and Progenitor Cells Isolated from Cord Blood - p. 155 16. Chapter 13. The Nervous System - p. 160 17. Chapter 14. Sensory Epithelium of the Eye and Ear - p. 184 18. Chapter 15. Epithelial Skin Stem Cells - p. 202 19. Chapter 16. Hematopoietic Stem Cells - p. 218 20. Chapter 17. Peripheral Blood Stem Cells - p. 226 21. Chapter 18. Multipotent Adult Progenitor Cells - p. 244 22. Chapter 19. Mesenchymal Stem Cells - p. 253 23. Chapter 20. Skeletal Muscle Stem Cells - p. 266 24. Chapter 21. Stem Cells and the Regenerating Heart - p. 278 25. Chapter 22. Cell Lineages and Stem Cells in the Embryonic Kidney - p. 289 26. Chapter 23. Adult Liver Stem Cells - p. 307 27. Chapter 24. Pancreatic Stem Cells - p. 327 28. Chapter 25. Stem Cells in the Gastrointestinal Tract - p. 342 29. Part IV: Methods - p. 371 30. Chapter 26. Induced Pluripotent Stem Cells - p. 371 31. Chapter 27. Embryonic Stem Cells: Derivation and Properties - p. 385 32. Chapter 28. Isolation and Maintenance of Murine Embryonic Stem Cells - p. 398 33. Chapter 29. Approaches for Derivation and Maintenance of Human Embryonic Stem Cells: Detailed Procedures and Alternatives - p. 407 34. Chapter 30. Derivation and Differentiation of Human Embryonic Germ Cells - p. 434 35. Chapter 31. Genomic Reprogramming - p. 451 36. Part V: Applications - p. 462 37. Chapter 32. Neural Stem Cells – Therapeutic Applications in Neurodegenerative Diseases - p. 462 38. Chapter 33. Adult Progenitor Cells as a Potential Treatment for Diabetes - p. 489 39. Chapter 34. Burns and Skin Ulcers - p. 499 40. Chapter 35. Stem Cells and Heart Disease - p. 513 41. Chapter 36. Stem Cells for the Treatment of Muscular Dystrophy - p. 527 42. Chapter 37. Cell Therapy for Liver Disease: From Hepatocytes to Stem Cells - p. 541 43. Chapter 38. Orthopedic Applications of Stem Cells - p. 564 44. Chapter 39. Embryonic Stem Cells in Tissue Engineering - p. 580 45. Part VI: Regulation and Ethics - p. 591 46. Chapter 40. Ethical Considerations - p. 591 47. Chapter 41. Overview of the FDA Regulatory Process - p. 604 48. Chapter 42. It’s Not about Curiosity, It’s about Cures: Stem Cell Research – People Help Drive Progress - p. 632 49. Glossary - p. 644 50. Index - p. 644
First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.
1. Part I: Introduction to Stem Cells - p. XXI 2. Chapter 1. Why Stem Cell Research? Advances in the Field - p. XXI 3. Chapter 2. ‘Stemness’: Definitions, Criteria, and Standards - p. 6 4. Chapter 3. Pluripotent Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges - p. 17 5. Chapter 4. Embryonic Stem Cells in Perspective - p. 34 6. Chapter 5. The Development of Epithelial Stem Cell Concepts - p. 38 7. Part II: Basic Biology and Mechanisms - p. 56 8. Chapter 6. Stem Cell Niches - p. 56 9. Chapter 7. Mechanisms of Stem Cell Self-Renewal - p. 78 10. Chapter 8. Cell Cycle Regulators in Stem Cells - p. 93 11. Chapter 9. How Cells Change Their Phenotype - p. 105 12. Part III: Tissue and Organ Development - p. 117 13. Chapter 10. Differentiation in Early Development - p. 117 14. Chapter 11. Stem Cells Derived from Amniotic Fluid - p. 139 15. Chapter 12. Stem and Progenitor Cells Isolated from Cord Blood - p. 155 16. Chapter 13. The Nervous System - p. 160 17. Chapter 14. Sensory Epithelium of the Eye and Ear - p. 184 18. Chapter 15. Epithelial Skin Stem Cells - p. 202 19. Chapter 16. Hematopoietic Stem Cells - p. 218 20. Chapter 17. Peripheral Blood Stem Cells - p. 226 21. Chapter 18. Multipotent Adult Progenitor Cells - p. 244 22. Chapter 19. Mesenchymal Stem Cells - p. 253 23. Chapter 20. Skeletal Muscle Stem Cells - p. 266 24. Chapter 21. Stem Cells and the Regenerating Heart - p. 278 25. Chapter 22. Cell Lineages and Stem Cells in the Embryonic Kidney - p. 289 26. Chapter 23. Adult Liver Stem Cells - p. 307 27. Chapter 24. Pancreatic Stem Cells - p. 327 28. Chapter 25. Stem Cells in the Gastrointestinal Tract - p. 342 29. Part IV: Methods - p. 371 30. Chapter 26. Induced Pluripotent Stem Cells - p. 371 31. Chapter 27. Embryonic Stem Cells: Derivation and Properties - p. 385 32. Chapter 28. Isolation and Maintenance of Murine Embryonic Stem Cells - p. 398 33. Chapter 29. Approaches for Derivation and Maintenance of Human Embryonic Stem Cells: Detailed Procedures and Alternatives - p. 407 34. Chapter 30. Derivation and Differentiation of Human Embryonic Germ Cells - p. 434 35. Chapter 31. Genomic Reprogramming - p. 451 36. Part V: Applications - p. 462 37. Chapter 32. Neural Stem Cells – Therapeutic Applications in Neurodegenerative Diseases - p. 462 38. Chapter 33. Adult Progenitor Cells as a Potential Treatment for Diabetes - p. 489 39. Chapter 34. Burns and Skin Ulcers - p. 499 40. Chapter 35. Stem Cells and Heart Disease - p. 513 41. Chapter 36. Stem Cells for the Treatment of Muscular Dystrophy - p. 527 42. Chapter 37. Cell Therapy for Liver Disease: From Hepatocytes to Stem Cells - p. 541 43. Chapter 38. Orthopedic Applications of Stem Cells - p. 564 44. Chapter 39. Embryonic Stem Cells in Tissue Engineering - p. 580 45. Part VI: Regulation and Ethics - p. 591 46. Chapter 40. Ethical Considerations - p. 591 47. Chapter 41. Overview of the FDA Regulatory Process - p. 604 48. Chapter 42. It’s Not about Curiosity, It’s about Cures: Stem Cell Research – People Help Drive Progress - p. 632 49. Glossary - p. 644 50. Index - p. 644
