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This issue of Clinics in Chest Medicine, edited by Dr. Denis O'Donnell and Dr. Alberto Neder, focuses on Clinical Respiratory Physiology. Articles include: The Pathophysiology of Obstructive Sleep Apnea; The Physiology of Mechanical Ventilation; Exercise Pathophysiology in Congestive Heart Failure; Control of Breathing; Breathing at Extremes; Exercise Pathophysiology in Interstitial Lung Disease; Importance of Physiology in Clinical Decision-Making in the ICU; Pulmonary Hypertension and Exercise; Physiologic Effects of Oxygen Supplementation During Exercise in COPD; Benefits and Pitfalls of DLCO measurements in Clinical Practice; Cardio-pulmonary Interactions in COPD-CHF; Exercise Physiology in COPD; Dyspnea of Unknown Origin: The Role of Exercise Testing; Assessment of Ventilatory Limitation During Exercise; Respiratory Muscle Assessment in Clinical Practice; Exertional Periodic Breathing in Heart Failure; and Strategies to Increase Physical Activity in Chronic Respiratory Diseases

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xii 7. Preface - p. xiii 8. Why Physiology Is Critical to the Practice of Medicine: A 40-year Personal Perspective - p. 243 9. The Control of Breathing During Mechanical Ventilation - p. 259 10. Update on Chemoreception: Influence on Cardiorespiratory Regulation and Pathophysiology - p. 269 11. Incorporating Lung Diffusing Capacity for Carbon Monoxide in Clinical Decision Making in Chest Medicine - p. 285 12. Respiratory Muscle Assessment in Clinical Practice - p. 307 13. Pathogenesis of Obstructive Sleep Apnea - p. 317 14. Respiratory Determinants of Exercise Limitation: Focus on Phrenic Afferents and the Lung Vasculature - p. 331 15. The Pathophysiology of Dyspnea and Exercise Intolerance in Chronic Obstructive Pulmonary Disease - p. 343 16. The Relevance of Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: A Review For Clinicians - p. 367 17. Physiologic Effects of Oxygen Supplementation During Exercise in Chronic Obstructive Pulmonary Disease - p. 385 18. Strategies to Increase Physical Activity in Chronic Respiratory Diseases - p. 397 19. Exercise Pathophysiology in Interstitial Lung Disease - p. 405 20. Clinical and Physiologic Implications of Negative Cardiopulmonary Interactions in Coexisting Chronic Obstructive Pulmonary Disease-Heart Failure - p. 421 21. Pulmonary Limitations in Heart Failure - p. 439 22. Exertional Periodic Breathing in Heart Failure: Mechanisms and Clinical Implications - p. 449 23. Pulmonary Hypertension and Exercise - p. 459 24. Unraveling the Causes of Unexplained Dyspnea: The Value of Exercise Testing - p. 471

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This issue of Clinics in Chest Medicine, edited by Dr. Denis O'Donnell and Dr. Alberto Neder, focuses on Clinical Respiratory Physiology. Articles include: The Pathophysiology of Obstructive Sleep Apnea; The Physiology of Mechanical Ventilation; Exercise Pathophysiology in Congestive Heart Failure; Control of Breathing; Breathing at Extremes; Exercise Pathophysiology in Interstitial Lung Disease; Importance of Physiology in Clinical Decision-Making in the ICU; Pulmonary Hypertension and Exercise; Physiologic Effects of Oxygen Supplementation During Exercise in COPD; Benefits and Pitfalls of DLCO measurements in Clinical Practice; Cardio-pulmonary Interactions in COPD-CHF; Exercise Physiology in COPD; Dyspnea of Unknown Origin: The Role of Exercise Testing; Assessment of Ventilatory Limitation During Exercise; Respiratory Muscle Assessment in Clinical Practice; Exertional Periodic Breathing in Heart Failure; and Strategies to Increase Physical Activity in Chronic Respiratory Diseases

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xii 7. Preface - p. xiii 8. Why Physiology Is Critical to the Practice of Medicine: A 40-year Personal Perspective - p. 243 9. The Control of Breathing During Mechanical Ventilation - p. 259 10. Update on Chemoreception: Influence on Cardiorespiratory Regulation and Pathophysiology - p. 269 11. Incorporating Lung Diffusing Capacity for Carbon Monoxide in Clinical Decision Making in Chest Medicine - p. 285 12. Respiratory Muscle Assessment in Clinical Practice - p. 307 13. Pathogenesis of Obstructive Sleep Apnea - p. 317 14. Respiratory Determinants of Exercise Limitation: Focus on Phrenic Afferents and the Lung Vasculature - p. 331 15. The Pathophysiology of Dyspnea and Exercise Intolerance in Chronic Obstructive Pulmonary Disease - p. 343 16. The Relevance of Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: A Review For Clinicians - p. 367 17. Physiologic Effects of Oxygen Supplementation During Exercise in Chronic Obstructive Pulmonary Disease - p. 385 18. Strategies to Increase Physical Activity in Chronic Respiratory Diseases - p. 397 19. Exercise Pathophysiology in Interstitial Lung Disease - p. 405 20. Clinical and Physiologic Implications of Negative Cardiopulmonary Interactions in Coexisting Chronic Obstructive Pulmonary Disease-Heart Failure - p. 421 21. Pulmonary Limitations in Heart Failure - p. 439 22. Exertional Periodic Breathing in Heart Failure: Mechanisms and Clinical Implications - p. 449 23. Pulmonary Hypertension and Exercise - p. 459 24. Unraveling the Causes of Unexplained Dyspnea: The Value of Exercise Testing - p. 471

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