Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes
in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical
disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference
source for clinicians, physicians, and research scientists who wish to gain insight into the most
recent advances in this rapidly growing field.
The exosome revolution may well be the greatest advance in physiology and medicine since
antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a
major breakthrough in our understanding of how cells function.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xvii 6. Editor biography - p. xxi 7. Preface - p. xxiii 8. Acknowledgments - p. xxv 9. Special acknowledgment - p. xxvii 10. Chapter 1: Exosome basic mechanisms - p. xxvii 11. Chapter 2: Methods for exosome isolation and characterization - p. 21 12. Chapter 3: Exosomes, microvesicles, and their friends in solid tumors - p. 38 13. Chapter 4: Hematologic malignancies: The exosome contribution in tumor progression - p. 80 14. Chapter 5: Physiological and pathological functions of prostasomes: From basic research to clinical application - p. 100 15. Chapter 6: The function and therapeutic use of exosomes in bacterial infections - p. 121 16. Chapter 7: Emerging therapeutic roles of exosomes in HIV-1 infection - p. 146 17. Chapter 8: Extracellular vesicles in parasitic disease - p. 178 18. Chapter 9: Exosomes as intercellular communication messengers for cardiovascular and cerebrovascular diseases - p. 198 19. Chapter 10: Exosomes in cutaneous biology and dermatologic disease - p. 238 20. Chapter 11: Exosomes in nephrology - p. 255 21. Chapter 12: Extracellular vesicles in neurodegenerative disorders - p. 283 22. Chapter 13: Extracellular vesicles in fibrotic diseases: New applications for fibrosis diagnosis and treatment - p. 305 23. Chapter 14: Mechanisms of exosome-mediated immune cell crosstalk in inflammation and disease - p. 323 24. Chapter 15: Exosomes in metabolic syndrome - p. 342 25. Chapter 16: Potential role of exosomes in reproductive medicine and pregnancy - p. 356 26. Chapter 17: Exosomes in respiratory disease - p. 381 27. Chapter 18: Exosomes in retinal diseases - p. 414 28. Chapter 19: MSC-exosomes in regenerative medicine - p. 431 29. Chapter 20: The potential of exosomes as theragnostics in various clinical situations - p. 465 30. Chapter 21: Exosomes, gemmules, pangenesis and Darwin - p. 486 31. Index - p. 503
Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes
in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical
disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference
source for clinicians, physicians, and research scientists who wish to gain insight into the most
recent advances in this rapidly growing field.
The exosome revolution may well be the greatest advance in physiology and medicine since
antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a
major breakthrough in our understanding of how cells function.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xvii 6. Editor biography - p. xxi 7. Preface - p. xxiii 8. Acknowledgments - p. xxv 9. Special acknowledgment - p. xxvii 10. Chapter 1: Exosome basic mechanisms - p. xxvii 11. Chapter 2: Methods for exosome isolation and characterization - p. 21 12. Chapter 3: Exosomes, microvesicles, and their friends in solid tumors - p. 38 13. Chapter 4: Hematologic malignancies: The exosome contribution in tumor progression - p. 80 14. Chapter 5: Physiological and pathological functions of prostasomes: From basic research to clinical application - p. 100 15. Chapter 6: The function and therapeutic use of exosomes in bacterial infections - p. 121 16. Chapter 7: Emerging therapeutic roles of exosomes in HIV-1 infection - p. 146 17. Chapter 8: Extracellular vesicles in parasitic disease - p. 178 18. Chapter 9: Exosomes as intercellular communication messengers for cardiovascular and cerebrovascular diseases - p. 198 19. Chapter 10: Exosomes in cutaneous biology and dermatologic disease - p. 238 20. Chapter 11: Exosomes in nephrology - p. 255 21. Chapter 12: Extracellular vesicles in neurodegenerative disorders - p. 283 22. Chapter 13: Extracellular vesicles in fibrotic diseases: New applications for fibrosis diagnosis and treatment - p. 305 23. Chapter 14: Mechanisms of exosome-mediated immune cell crosstalk in inflammation and disease - p. 323 24. Chapter 15: Exosomes in metabolic syndrome - p. 342 25. Chapter 16: Potential role of exosomes in reproductive medicine and pregnancy - p. 356 26. Chapter 17: Exosomes in respiratory disease - p. 381 27. Chapter 18: Exosomes in retinal diseases - p. 414 28. Chapter 19: MSC-exosomes in regenerative medicine - p. 431 29. Chapter 20: The potential of exosomes as theragnostics in various clinical situations - p. 465 30. Chapter 21: Exosomes, gemmules, pangenesis and Darwin - p. 486 31. Index - p. 503
