Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xix 7. Preface - p. xxv 8. Part I: Genetics, molecular and cellular biology - p. xxvi 9. Chapter 1. Genetics of frontotemporal dementia - p. 3 10. Chapter 2. Aging, brain-derived neurotrophic factor (BDNF) and its Val66Met polymorphism: a focus on neuropsychology, the visual system, and brain structures - p. 17 11. Chapter 3. Aging, demented patients and polymorphisms in cytokine genes - p. 27 12. Chapter 4. RNA fragments and brain aging - p. 37 13. Chapter 5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in aging - p. 49 14. Chapter 6. Brain aging and microarray analysis - p. 59 15. Chapter 7. Human nuclear tau and aging - p. 71 16. Chapter 8. Lipoxidation: features, neurological tissues, and aging - p. 83 17. Chapter 9. Aging modifies concentration and metabolism of amino acids and associated receptor functionality in the brain - p. 97 18. Chapter 10. How 3′,5′-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementia - p. 109 19. Chapter 11. The prohibitin complex in aging and neurodegeneration - p. 119 20. Chapter 12. Synaptic ATPases and energy metabolism in the nervous system: roles and changes during aging - p. 129 21. Part II: Neurological and imaging features - p. 139 22. Chapter 13. Microstructural imaging of the human brain with normal and “abnormal” aging using diffusion magnetic resonance imaging - p. 143 23. Chapter 14. Imaging the brain and its vasculature in aging: applications of optical coherence tomography angiography - p. 153 24. Chapter 15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view - p. 163 25. Chapter 16. Grey-matter networks in aging - p. 173 26. Chapter 17. Changes in brain synapse–related molecules with age - p. 185 27. Chapter 18. Macroautophagy and chaperone-mediated autophagy in aging - p. 199 28. Chapter 19. Neuronal L-type calcium channels in aging - p. 213 29. The impact of aged microglia on D-serine-regulated glutamatergic transmission - p. 227 30. Chapter 21. Ion channels and the aging brain - p. 237 31. Chapter 22. Dendritic spine remodeling and aging - p. 247 32. Chapter 23. High-density lipoprotein-cholesterol and neuroaging: memory and gyrification of the insular and frontal opercular cortex - p. 259 33. Chapter 24. Astrocyte and microglial aging: morphology and modeling - p. 269 34. Chapter 25. Cerebellum—aging of the neuronal machine - p. 281 35. Chapter 26. Lipids, beta-secretase 1, and Alzheimer disease - p. 289 36. Chapter 27. Aging, myelination, and the optic nerve - p. 301 37. Chapter 28. Linking proteostasis, aging, and brain ischemia - p. 313 38. Chapter 29. Luteinizing hormone and the aging nervous system - p. 325 39. Chapter 30. Insights into aging using transcranial magnetic stimulation - p. 337 40. Chapter 31. Alpha rhythms: what they are and how they alter with aging - p. 349 41. Chapter 32. Nicotine and its derivatives in healthy brain aging - p. 361 42. Part III: Physiological aspects - p. 370 43. Chapter 33. Environmental enrichment and physiological aging - p. 373 44. Chapter 34. Treadmill exercise and neuroinflammation: Links with aging - p. 385 45. Chapter 35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyond - p. 403 46. Chapter 36. The effects of cardiorespiratory fitness on brain and cognitive aging - p. 415 47. Chapter 37. Aging, babble noise, and the processing of speech perception - p. 427 48. Chapter 38. The blood-brain barrier in aging - p. 439 49. Part IV: Behavior and psychopathological aspects - p. 449 50. Chapter 39. Linking aging, anticholinergic drugs use, and cognitive impairment - p. 453 51. Chapter 40. Cognitive frailty: definitions, components, and impact on disability and mortality - p. 463 52. Chapter 41. Cognitive impairment (brain) and (et) dynapenia (D) “BED” in older persons: role of arterial tree - p. 477 53. Chapter 42. Disentangling the effects of aging and ovarian hormone loss on sleep: implications for health and disease - p. 485 54. Chapter 43. Role of DNA methylation in aging-related cognitive functioning - p. 499 55. Chapter 44. Depression in the elderly and psychobiotics - p. 509 56. Part V: Diet and nutrition - p. 520 57. Chapter 45. Aging, dietary patterns, and cognition - p. 523 58. Chapter 46. Geriatric nutritional risk index: applications and limitations - p. 535 59. Chapter 47. Diet, inflammation, and neurocognitive aging - p. 545 60. Chapter 48. The dietary approaches to stop hypertension (DASH) and Mediterranean-DASH intervention for neurodegenerative delay (MIND) diets and brain aging - p. 553 61. Chapter 49. The ketogenic diet and healthy brain aging - p. 567 62. Chapter 50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC) - p. 577 63. Chapter 51. Dietary flavonoids and brain health in aging: food for thought - p. 589 64. Chapter 52. Antioxidant effects of curcumin and neuroaging - p. 603 65. Chapter 53. Lipoic acid and vitamin D3 and their use in preventing brain aging - p. 617 66. Chapter 54. Effects of β−hydroxy-β-methylbutyrate (HMB) supplementation on biomarkers for cognitive function and electrophysiological processes in aging - p. 627 67. Chapter 55. Hydration, the brain, and aging - p. 637 68. Index - p. 647
Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xix 7. Preface - p. xxv 8. Part I: Genetics, molecular and cellular biology - p. xxvi 9. Chapter 1. Genetics of frontotemporal dementia - p. 3 10. Chapter 2. Aging, brain-derived neurotrophic factor (BDNF) and its Val66Met polymorphism: a focus on neuropsychology, the visual system, and brain structures - p. 17 11. Chapter 3. Aging, demented patients and polymorphisms in cytokine genes - p. 27 12. Chapter 4. RNA fragments and brain aging - p. 37 13. Chapter 5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in aging - p. 49 14. Chapter 6. Brain aging and microarray analysis - p. 59 15. Chapter 7. Human nuclear tau and aging - p. 71 16. Chapter 8. Lipoxidation: features, neurological tissues, and aging - p. 83 17. Chapter 9. Aging modifies concentration and metabolism of amino acids and associated receptor functionality in the brain - p. 97 18. Chapter 10. How 3′,5′-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementia - p. 109 19. Chapter 11. The prohibitin complex in aging and neurodegeneration - p. 119 20. Chapter 12. Synaptic ATPases and energy metabolism in the nervous system: roles and changes during aging - p. 129 21. Part II: Neurological and imaging features - p. 139 22. Chapter 13. Microstructural imaging of the human brain with normal and “abnormal” aging using diffusion magnetic resonance imaging - p. 143 23. Chapter 14. Imaging the brain and its vasculature in aging: applications of optical coherence tomography angiography - p. 153 24. Chapter 15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view - p. 163 25. Chapter 16. Grey-matter networks in aging - p. 173 26. Chapter 17. Changes in brain synapse–related molecules with age - p. 185 27. Chapter 18. Macroautophagy and chaperone-mediated autophagy in aging - p. 199 28. Chapter 19. Neuronal L-type calcium channels in aging - p. 213 29. The impact of aged microglia on D-serine-regulated glutamatergic transmission - p. 227 30. Chapter 21. Ion channels and the aging brain - p. 237 31. Chapter 22. Dendritic spine remodeling and aging - p. 247 32. Chapter 23. High-density lipoprotein-cholesterol and neuroaging: memory and gyrification of the insular and frontal opercular cortex - p. 259 33. Chapter 24. Astrocyte and microglial aging: morphology and modeling - p. 269 34. Chapter 25. Cerebellum—aging of the neuronal machine - p. 281 35. Chapter 26. Lipids, beta-secretase 1, and Alzheimer disease - p. 289 36. Chapter 27. Aging, myelination, and the optic nerve - p. 301 37. Chapter 28. Linking proteostasis, aging, and brain ischemia - p. 313 38. Chapter 29. Luteinizing hormone and the aging nervous system - p. 325 39. Chapter 30. Insights into aging using transcranial magnetic stimulation - p. 337 40. Chapter 31. Alpha rhythms: what they are and how they alter with aging - p. 349 41. Chapter 32. Nicotine and its derivatives in healthy brain aging - p. 361 42. Part III: Physiological aspects - p. 370 43. Chapter 33. Environmental enrichment and physiological aging - p. 373 44. Chapter 34. Treadmill exercise and neuroinflammation: Links with aging - p. 385 45. Chapter 35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyond - p. 403 46. Chapter 36. The effects of cardiorespiratory fitness on brain and cognitive aging - p. 415 47. Chapter 37. Aging, babble noise, and the processing of speech perception - p. 427 48. Chapter 38. The blood-brain barrier in aging - p. 439 49. Part IV: Behavior and psychopathological aspects - p. 449 50. Chapter 39. Linking aging, anticholinergic drugs use, and cognitive impairment - p. 453 51. Chapter 40. Cognitive frailty: definitions, components, and impact on disability and mortality - p. 463 52. Chapter 41. Cognitive impairment (brain) and (et) dynapenia (D) “BED” in older persons: role of arterial tree - p. 477 53. Chapter 42. Disentangling the effects of aging and ovarian hormone loss on sleep: implications for health and disease - p. 485 54. Chapter 43. Role of DNA methylation in aging-related cognitive functioning - p. 499 55. Chapter 44. Depression in the elderly and psychobiotics - p. 509 56. Part V: Diet and nutrition - p. 520 57. Chapter 45. Aging, dietary patterns, and cognition - p. 523 58. Chapter 46. Geriatric nutritional risk index: applications and limitations - p. 535 59. Chapter 47. Diet, inflammation, and neurocognitive aging - p. 545 60. Chapter 48. The dietary approaches to stop hypertension (DASH) and Mediterranean-DASH intervention for neurodegenerative delay (MIND) diets and brain aging - p. 553 61. Chapter 49. The ketogenic diet and healthy brain aging - p. 567 62. Chapter 50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC) - p. 577 63. Chapter 51. Dietary flavonoids and brain health in aging: food for thought - p. 589 64. Chapter 52. Antioxidant effects of curcumin and neuroaging - p. 603 65. Chapter 53. Lipoic acid and vitamin D3 and their use in preventing brain aging - p. 617 66. Chapter 54. Effects of β−hydroxy-β-methylbutyrate (HMB) supplementation on biomarkers for cognitive function and electrophysiological processes in aging - p. 627 67. Chapter 55. Hydration, the brain, and aging - p. 637 68. Index - p. 647
