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Fetal and Neonatal Physiology

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A must-have resource for all clinicians who work with sick and premature infants, Polin and Fox Fetal and Neonatal Physiology, 7th Edition, provides the comprehensive, authoritative information needed for effective management of this vulnerable patient population. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the foundational knowledge of fetal and newborn physiology necessary for board review, clinical rounds, scientific research, and day-to-day practice.

  • Focuses on the developmental physiology of the fetus and newborn, offering expert guidance on how to effectively manage the many health problems seen in newborn and premature infants
  • Provides comprehensive updates throughout, including new knowledge of the genetic underpinnings of physiologic processes and many new and improved tables and figures
  • Contains new chapters covering genetic control of development, multi-omics, sleep, neuroinflammation, climate change, intrauterine inflammation, and gas transport in the blood
  • Features 1,000 full-color diagrams, graphs and anatomic illustrations, nearly 170 chapters, and more than 350 global contributors
  • Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout
  • Shares the knowledge and fresh perspectives of many new authors, as well as new co-editor Dr. Wendy Chung, who brings further expertise in genetics and genomics to the editorial board
  • Any additional digital ancillary content may publish up to 6 weeks following the publication date

1. INTRODUCTION - p. 1452 2. AIRWAY REFLEXES - p. 1452 3. MECHANICAL AND BIOCHEMICAL BARRIERS - p. 1453 4. KEY CONCEPTS IN IMMUNOLOGY AND ITS DEVELOPMENT - p. 1460 5. INNATE IMMUNITY - p. 1461 6. THE INTERFACE OF INNATE AND ADAPTIVE IMMUNITY - p. 1471 7. CYTOKINES AND CHEMOKINES - p. 1473 8. ADAPTIVE IMMUNITY - p. 1479 9. MICROBIOME - p. 1484 10. CONCLUSION - p. 1485 11. ACKNOWLEDGMENT - p. 1485 12. References - p. 1485.e1 13. SECTION 21: NEUROLOGY - p. S1487 14. 117. Development of the Nervous System - p. 1488 15. 118. Mechanisms of Cell Death in the Developing Brain - p. 1515 16. 119. Development of the Blood-Brain Barrier - p. 1527 17. 120. Developmental Aspects of Pain - p. 1544 18. 121. Neonatal Sleep in Brain Development and Injury - p. 1552 19. 122. Cerebellar Development—The Impact of Preterm Birth and Comorbidities - p. 1567 20. 123. Electroencephalography in the Preterm and Term Infant - p. 1583 21. 124. Intraventricular Hemorrhage in the Neonate - p. 1617 22. 125. Pathophysiology of Neonatal Cerebral White and Gray Matter Injury - p. 1642 23. 126. Fetal and Neonatal Physiology: Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection - p. 1652 24. 127. Neuroimmune Interaction in Brain Development and Diseases - p. 1663 25. 128. Neuroprotective Therapeutic Hypothermia - p. 1674 26. SECTION 22: SPECIAL SENSORY SYSTEMS IN THE FETUS AND NEONATE - p. S1683 27. 129. Early Development of the Human Auditory System - p. 1684 28. 130. Gustatory Sensation (Taste) - p. 1701 29. 131. Development of Olfaction - p. 1707 30. SECTION 23: ENDOCRINE FUNCTION - p. S1717 31. 132. Hypothalamus: Neuroendometabolic Center - p. 1718 32. 133. Growth Factor Regulation of Fetal Growth - p. 1730 33. 134. Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn - p. 1742 34. 135. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant - p. 1749 35. 136. Development of the Hypothalamus-Pituitary-Adrenal Axis in the Fetus - p. 1764 36. 137. Fetal and Neonatal Adrenocortical Physiology - p. 1774 37. 138. Fetal and Neonatal Thyroid Physiology - p. 1784 38. SECTION 24: OVARY AND TESTIS - p. S1794 39. 139. Genetics of Sex Determination and Differentiation - p. 1794 40. 140. Differentiation of the Ovary - p. 1807 41. 141. Testicular Development and Descent - p. 1817 42. SECTION 25: PATHOPHYSIOLOGY OF NEONATAL DISEASES - p. S1827 43. 142. Physiology of Twin-Twin Transfusion - p. 1828 44. 143. Physiology of Neonatal Resuscitation - p. 1835 45. 144. Pathophysiology of Neonatal Sepsis - p. 1854 46. 145. Pathophysiology of Neonatal Hypoglycemia - p. 1875 47. 146. Pathophysiology of Cardiomyopathies - p. 1886 48. 147. Pathophysiology of Persistent Pulmonary Hypertension of the Newborn - p. 1905 49. 148. Pathophysiology of Shock in the Fetus and Neonate - p. 1923 50. 149. Pathophysiology of Apnea of Prematurity and Intermittent Hypoxemia - p. 1934 51. 150. Pathophysiology of Respiratory Distress Syndrome - p. 1944 52. 151. Pathophysiology of Meconium Aspiration Syndrome - p. 1962 53. 152. Pathophysiology of Bronchopulmonary Dysplasia - p. 1972 54. 153. Pathophysiology of Ventilator-Dependent Infants - p. 1980 55. 154. Pathophysiology of Gastroesophageal Reflux - p. 1996 56. 155. Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis - p. 2007 57. 156. Pathophysiology of Acute Bilirubin Encephalopathy and Kernicterus Spectrum Disorders - p. 2013 58. 157. Pathophysiology of Neonatal Acute Kidney Injury - p. 2024 59. 158. The Pathophysiology of Pulmonary Edema in the Developing Lung - p. 2041 60. 159. Pathophysiology of Retinopathy of Prematurity - p. 2047 61. 160. Pathophysiology of Neonatal Hypoxic-Ischemic Brain Injury - p. 2058 62. 161. Pathophysiology of Neonatal Acute Bacterial Meningitis - p. 2071 63. 162. Pathophysiology of Neural Tube Defects - p. 2084 64. 163. Pathophysiology of Preeclampsia - p. 2101 65. 164. Pathophysiology of Preterm Birth - p. 2112 66. 165. Climate Change Stressors and Impacts on Pregnancy - p. 2122 67. 166. Pathophysiology of Chorioamnionitis: Host Immunity and Microbial Virulence - p. 2134 68. 167. Pathophysiology of Genetic Neonatal Disease - p. 2145 69. 168. Genetic Variants and Neonatal Disease - p. 2155 70. 169. Understanding Fetal and Neonatal Responses to Hypoxia - p. 2167 71. Index - p. I-1

Descripcion
Descripción

A must-have resource for all clinicians who work with sick and premature infants, Polin and Fox Fetal and Neonatal Physiology, 7th Edition, provides the comprehensive, authoritative information needed for effective management of this vulnerable patient population. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the foundational knowledge of fetal and newborn physiology necessary for board review, clinical rounds, scientific research, and day-to-day practice.

  • Focuses on the developmental physiology of the fetus and newborn, offering expert guidance on how to effectively manage the many health problems seen in newborn and premature infants
  • Provides comprehensive updates throughout, including new knowledge of the genetic underpinnings of physiologic processes and many new and improved tables and figures
  • Contains new chapters covering genetic control of development, multi-omics, sleep, neuroinflammation, climate change, intrauterine inflammation, and gas transport in the blood
  • Features 1,000 full-color diagrams, graphs and anatomic illustrations, nearly 170 chapters, and more than 350 global contributors
  • Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout
  • Shares the knowledge and fresh perspectives of many new authors, as well as new co-editor Dr. Wendy Chung, who brings further expertise in genetics and genomics to the editorial board
  • Any additional digital ancillary content may publish up to 6 weeks following the publication date

1. INTRODUCTION - p. 1452 2. AIRWAY REFLEXES - p. 1452 3. MECHANICAL AND BIOCHEMICAL BARRIERS - p. 1453 4. KEY CONCEPTS IN IMMUNOLOGY AND ITS DEVELOPMENT - p. 1460 5. INNATE IMMUNITY - p. 1461 6. THE INTERFACE OF INNATE AND ADAPTIVE IMMUNITY - p. 1471 7. CYTOKINES AND CHEMOKINES - p. 1473 8. ADAPTIVE IMMUNITY - p. 1479 9. MICROBIOME - p. 1484 10. CONCLUSION - p. 1485 11. ACKNOWLEDGMENT - p. 1485 12. References - p. 1485.e1 13. SECTION 21: NEUROLOGY - p. S1487 14. 117. Development of the Nervous System - p. 1488 15. 118. Mechanisms of Cell Death in the Developing Brain - p. 1515 16. 119. Development of the Blood-Brain Barrier - p. 1527 17. 120. Developmental Aspects of Pain - p. 1544 18. 121. Neonatal Sleep in Brain Development and Injury - p. 1552 19. 122. Cerebellar Development—The Impact of Preterm Birth and Comorbidities - p. 1567 20. 123. Electroencephalography in the Preterm and Term Infant - p. 1583 21. 124. Intraventricular Hemorrhage in the Neonate - p. 1617 22. 125. Pathophysiology of Neonatal Cerebral White and Gray Matter Injury - p. 1642 23. 126. Fetal and Neonatal Physiology: Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection - p. 1652 24. 127. Neuroimmune Interaction in Brain Development and Diseases - p. 1663 25. 128. Neuroprotective Therapeutic Hypothermia - p. 1674 26. SECTION 22: SPECIAL SENSORY SYSTEMS IN THE FETUS AND NEONATE - p. S1683 27. 129. Early Development of the Human Auditory System - p. 1684 28. 130. Gustatory Sensation (Taste) - p. 1701 29. 131. Development of Olfaction - p. 1707 30. SECTION 23: ENDOCRINE FUNCTION - p. S1717 31. 132. Hypothalamus: Neuroendometabolic Center - p. 1718 32. 133. Growth Factor Regulation of Fetal Growth - p. 1730 33. 134. Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn - p. 1742 34. 135. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant - p. 1749 35. 136. Development of the Hypothalamus-Pituitary-Adrenal Axis in the Fetus - p. 1764 36. 137. Fetal and Neonatal Adrenocortical Physiology - p. 1774 37. 138. Fetal and Neonatal Thyroid Physiology - p. 1784 38. SECTION 24: OVARY AND TESTIS - p. S1794 39. 139. Genetics of Sex Determination and Differentiation - p. 1794 40. 140. Differentiation of the Ovary - p. 1807 41. 141. Testicular Development and Descent - p. 1817 42. SECTION 25: PATHOPHYSIOLOGY OF NEONATAL DISEASES - p. S1827 43. 142. Physiology of Twin-Twin Transfusion - p. 1828 44. 143. Physiology of Neonatal Resuscitation - p. 1835 45. 144. Pathophysiology of Neonatal Sepsis - p. 1854 46. 145. Pathophysiology of Neonatal Hypoglycemia - p. 1875 47. 146. Pathophysiology of Cardiomyopathies - p. 1886 48. 147. Pathophysiology of Persistent Pulmonary Hypertension of the Newborn - p. 1905 49. 148. Pathophysiology of Shock in the Fetus and Neonate - p. 1923 50. 149. Pathophysiology of Apnea of Prematurity and Intermittent Hypoxemia - p. 1934 51. 150. Pathophysiology of Respiratory Distress Syndrome - p. 1944 52. 151. Pathophysiology of Meconium Aspiration Syndrome - p. 1962 53. 152. Pathophysiology of Bronchopulmonary Dysplasia - p. 1972 54. 153. Pathophysiology of Ventilator-Dependent Infants - p. 1980 55. 154. Pathophysiology of Gastroesophageal Reflux - p. 1996 56. 155. Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis - p. 2007 57. 156. Pathophysiology of Acute Bilirubin Encephalopathy and Kernicterus Spectrum Disorders - p. 2013 58. 157. Pathophysiology of Neonatal Acute Kidney Injury - p. 2024 59. 158. The Pathophysiology of Pulmonary Edema in the Developing Lung - p. 2041 60. 159. Pathophysiology of Retinopathy of Prematurity - p. 2047 61. 160. Pathophysiology of Neonatal Hypoxic-Ischemic Brain Injury - p. 2058 62. 161. Pathophysiology of Neonatal Acute Bacterial Meningitis - p. 2071 63. 162. Pathophysiology of Neural Tube Defects - p. 2084 64. 163. Pathophysiology of Preeclampsia - p. 2101 65. 164. Pathophysiology of Preterm Birth - p. 2112 66. 165. Climate Change Stressors and Impacts on Pregnancy - p. 2122 67. 166. Pathophysiology of Chorioamnionitis: Host Immunity and Microbial Virulence - p. 2134 68. 167. Pathophysiology of Genetic Neonatal Disease - p. 2145 69. 168. Genetic Variants and Neonatal Disease - p. 2155 70. 169. Understanding Fetal and Neonatal Responses to Hypoxia - p. 2167 71. Index - p. I-1

Indice
Autores
Muestra
Ficha Técnica