Flavonoids Against Cancer Hallmarks provides an in-depth exploration of the anti-cancer potential of flavonoids and their ability to target key cancer hallmarks. The book encompasses a thorough analysis of flavonoids' sources, bioavailability, metabolic disposition, long-term safety, and adverse effects. It highlights the mechanisms through which flavonoids inhibit cancer growth and proliferation, focusing on their immunomodulatory, anti-angiogenic, anti-metastatic, and cell cycle inhibitory effects. Designed for oncology specialists, pharmacology and pharmacy students, cancer research scholars, and pharmaceutical industry researchers, this comprehensive guide also reviews recent cancer epidemiology and updates on existing therapeutic strategies.
By detailing how flavonoids counteract cancer stemness and influence immune responses, this book offers innovative insights into utilizing plant-derived compounds for cancer treatment. It stands out by providing a detailed overview of flavonoids' cellular and molecular mechanisms while also evaluating the pros and cons of current therapeutic options, making it essential reading for a global audience.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. Contributors - p. xi 8. Foreword - p. xiii 9. Preface - p. xv 10. Acknowledgments - p. xvii 11. Chapter 1. Cancer epidemiology: Current global worst burden and future prediction - p. 1 12. Chapter 2. Pros and cons of currently available chemotherapy - p. 23 13. Chapter 3. Flavonoids, their classification, chemistry, and therapeutic potential against various types of cancer - p. 37 14. Chapter 4. Dietary source of flavonoids, mode of intake, bioavailability, and toxicity - p. 53 15. Chapter 5. Flavonoids fighting immune evasion during carcinogenesis - p. 71 16. Chapter 6. The apoptosis-inducing potential of flavonoids in cancer - p. 99 17. Chapter 7. Flavonoids as inhibitors of the cell cycle in cancer - p. 133 18. Chapter 8. Flavonoids with anti-angiogenic potential in cancer - p. 169 19. Chapter 9. Flavonoids as promising plant-derived agents for combating cancer invasion and metastasis - p. 199 20. Chapter 10. The promising role of flavonoids in inhibiting epithelial to mesenchymal transition - p. 243 21. Chapter 11. Flavonoids and the regulation of cancer stemness phenotype - p. 281 22. Chapter 12. The role of flavonoids in epigenetic regulation—a mechanism behind their anti-cancer potential - p. 307 23. Chapter 13. Synergistic effects of flavonoids combined with other anti-cancer drugs, with a focus on targeted therapy and immunotherapy - p. 335 24. Chapter 14. Clinical implications of flavonoid: Integration with clinical trials and future directions - p. 357 25. Index - p. 377
Flavonoids Against Cancer Hallmarks provides an in-depth exploration of the anti-cancer potential of flavonoids and their ability to target key cancer hallmarks. The book encompasses a thorough analysis of flavonoids' sources, bioavailability, metabolic disposition, long-term safety, and adverse effects. It highlights the mechanisms through which flavonoids inhibit cancer growth and proliferation, focusing on their immunomodulatory, anti-angiogenic, anti-metastatic, and cell cycle inhibitory effects. Designed for oncology specialists, pharmacology and pharmacy students, cancer research scholars, and pharmaceutical industry researchers, this comprehensive guide also reviews recent cancer epidemiology and updates on existing therapeutic strategies.
By detailing how flavonoids counteract cancer stemness and influence immune responses, this book offers innovative insights into utilizing plant-derived compounds for cancer treatment. It stands out by providing a detailed overview of flavonoids' cellular and molecular mechanisms while also evaluating the pros and cons of current therapeutic options, making it essential reading for a global audience.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. Contributors - p. xi 8. Foreword - p. xiii 9. Preface - p. xv 10. Acknowledgments - p. xvii 11. Chapter 1. Cancer epidemiology: Current global worst burden and future prediction - p. 1 12. Chapter 2. Pros and cons of currently available chemotherapy - p. 23 13. Chapter 3. Flavonoids, their classification, chemistry, and therapeutic potential against various types of cancer - p. 37 14. Chapter 4. Dietary source of flavonoids, mode of intake, bioavailability, and toxicity - p. 53 15. Chapter 5. Flavonoids fighting immune evasion during carcinogenesis - p. 71 16. Chapter 6. The apoptosis-inducing potential of flavonoids in cancer - p. 99 17. Chapter 7. Flavonoids as inhibitors of the cell cycle in cancer - p. 133 18. Chapter 8. Flavonoids with anti-angiogenic potential in cancer - p. 169 19. Chapter 9. Flavonoids as promising plant-derived agents for combating cancer invasion and metastasis - p. 199 20. Chapter 10. The promising role of flavonoids in inhibiting epithelial to mesenchymal transition - p. 243 21. Chapter 11. Flavonoids and the regulation of cancer stemness phenotype - p. 281 22. Chapter 12. The role of flavonoids in epigenetic regulation—a mechanism behind their anti-cancer potential - p. 307 23. Chapter 13. Synergistic effects of flavonoids combined with other anti-cancer drugs, with a focus on targeted therapy and immunotherapy - p. 335 24. Chapter 14. Clinical implications of flavonoid: Integration with clinical trials and future directions - p. 357 25. Index - p. 377
