Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis.
This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. List of contributors - p. ix 6. Preface - p. xiii 7. Acknowledgments - p. xv 8. Part One: Fundamentals of cardiovascular stents - p. xv 9. 1: Overview of cardiovascular stent designs - p. xv 10. 2: Fundamentals of bare-metal stents - p. 26 11. 3: Development of drug-eluting stents (DES) - p. 44 12. 4: Polymer-free drug-eluting stents - p. 56 13. 5: Fundamentals of bioresorbable stents - p. 74 14. 6: Bioabsorbable metallic stents - p. 97 15. Part Two: Coatings and surface modification of cardiovascular stents - p. 134 16. 7: Physico-chemical stent surface modifications - p. 134 17. 8: Chemical vapor deposition of cardiac stents - p. 148 18. 9: Polymer coatings for biocompatibility and reduced nonspecific adsorption - p. 154 19. 10: Coating stability for stents - p. 198 20. 11: Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings - p. 209 21. Part Three: Biofunctionalisation of cardiovascular stent surfaces - p. 228 22. 12: Chemistry of targeted immobilization of biomediators - p. 228 23. 13: Functionalized cardiovascular stents: Cardiovascular stents incorporated with stem cells - p. 250 24. 14: Nitric oxide donor delivery - p. 290 25. 15: Immobilization of peptides on cardiovascular stent - p. 304 26. 16: Immobilization of antibodies on cardiovascular stents - p. 318 27. Index - p. 343
Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis.
This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. List of contributors - p. ix 6. Preface - p. xiii 7. Acknowledgments - p. xv 8. Part One: Fundamentals of cardiovascular stents - p. xv 9. 1: Overview of cardiovascular stent designs - p. xv 10. 2: Fundamentals of bare-metal stents - p. 26 11. 3: Development of drug-eluting stents (DES) - p. 44 12. 4: Polymer-free drug-eluting stents - p. 56 13. 5: Fundamentals of bioresorbable stents - p. 74 14. 6: Bioabsorbable metallic stents - p. 97 15. Part Two: Coatings and surface modification of cardiovascular stents - p. 134 16. 7: Physico-chemical stent surface modifications - p. 134 17. 8: Chemical vapor deposition of cardiac stents - p. 148 18. 9: Polymer coatings for biocompatibility and reduced nonspecific adsorption - p. 154 19. 10: Coating stability for stents - p. 198 20. 11: Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings - p. 209 21. Part Three: Biofunctionalisation of cardiovascular stent surfaces - p. 228 22. 12: Chemistry of targeted immobilization of biomediators - p. 228 23. 13: Functionalized cardiovascular stents: Cardiovascular stents incorporated with stem cells - p. 250 24. 14: Nitric oxide donor delivery - p. 290 25. 15: Immobilization of peptides on cardiovascular stent - p. 304 26. 16: Immobilization of antibodies on cardiovascular stents - p. 318 27. Index - p. 343
