Fundamentals of Toxicology: Essential Concepts and Applications provides a crisp, easy-to-understand overview of the most important concepts, applications, and ideas needed to learn the basics of toxicology. Written by a pre-eminent toxicologist with over five decades of teaching experience, this comprehensive resource offers the hands-on knowledge needed for a strong foundation in the wide field of toxicology. Fundamentals of Toxicology includes a clear structure divided into five units to assist learning and understanding.
The first unit provides extensive coverage on the background of toxicology including commonly used definitions and historical perspective, while following units cover: basic concepts; regulatory requirements and good laboratory practices, including types of toxicology testing and evaluation; toxic agents and adverse effects on health; and analytical, forensic, and diagnostic toxicology. This is an essential book for advanced students in toxicology and across the biomedical sciences, life sciences, and environmental sciences who want to learn the concepts of toxicology, as well as early researchers needing to refresh outside of their specialty.
1. Chapter 1. Introduction and historical background - p. 3 2. Chapter 2. Definitions and scope of toxicology - p. 9 3. Chapter 3. Classification of poisons/toxicants - p. 19 4. Chapter 4. Factors affecting toxicity - p. 23 5. Chapter 5. Natural laws concerning toxicology - p. 31 6. Chapter 6. Hazard and risk assessment - p. 45 7. Unit II - p. 51 8. Chapter 7. Absorption, distribution, and excretion of toxicants - p. 55 9. Chapter 8. Biotransformation - p. 73 10. Chapter 9. Principles and basic concepts of toxicokinetics - p. 87 11. Unit III - p. 107 12. Chapter 10. Toxicological testing: Genesis - p. 111 13. Chapter 11. Toxicological testing: In vitro models - p. 123 14. Chapter 12. Toxicological testing: In vivo systems - p. 131 15. Chapter 13. Genotoxicity - p. 151 16. Chapter 14. Preclinical toxicological investigations of pharmaceutical products - p. 165 17. Chapter 15. Preclinical safety evaluation of biotechnology-derived products - p. 173 18. Chapter 16. Preclinical regulatory toxicology for biomaterials and medical devices - p. 177 19. Unit IV - p. 182 20. Chapter 17. Toxic effects of pesticides (agrochemicals) - p. 185 21. Chapter 18. Toxic effects of metals - p. 203 22. Chapter 19. Toxic effects of nonmetallics - p. 215 23. Chapter 20. Neurotoxic agents - p. 221 24. Chapter 21. Toxic effects of cardiac poisons - p. 245 25. Chapter 22. Toxic effects of asphyxiants - p. 253 26. Chapter 23. Toxic effects of caustics (corrosives) - p. 267 27. Chapter 24. Drug toxicity, dependence, and abuse - p. 277 28. Chapter 25. Toxic effects of domestic chemicals - p. 287 29. Chapter 26. Toxic effects of poisonous plants - p. 293 30. Chapter 27. Poisonous foods and food poisoning - p. 305 31. Chapter 28. Poisons of animal origin - p. 311 32. Chapter 29. Chemical food poisoning - p. 327 33. Chapter 30. Health effects of radioactive materials - p. 333 34. Unit V - p. 339 35. Chapter 31. Basic concepts of forensic toxicology - p. 343 36. Chapter 32. Applications in toxicology - p. 347 37. Chapter 33. Clinical toxicology - p. 355 38. Chapter 34. Treatment of poisoning - p. 365 39. Further Reading - p. 369 40. Index - p. 381
Fundamentals of Toxicology: Essential Concepts and Applications provides a crisp, easy-to-understand overview of the most important concepts, applications, and ideas needed to learn the basics of toxicology. Written by a pre-eminent toxicologist with over five decades of teaching experience, this comprehensive resource offers the hands-on knowledge needed for a strong foundation in the wide field of toxicology. Fundamentals of Toxicology includes a clear structure divided into five units to assist learning and understanding.
The first unit provides extensive coverage on the background of toxicology including commonly used definitions and historical perspective, while following units cover: basic concepts; regulatory requirements and good laboratory practices, including types of toxicology testing and evaluation; toxic agents and adverse effects on health; and analytical, forensic, and diagnostic toxicology. This is an essential book for advanced students in toxicology and across the biomedical sciences, life sciences, and environmental sciences who want to learn the concepts of toxicology, as well as early researchers needing to refresh outside of their specialty.
1. Chapter 1. Introduction and historical background - p. 3 2. Chapter 2. Definitions and scope of toxicology - p. 9 3. Chapter 3. Classification of poisons/toxicants - p. 19 4. Chapter 4. Factors affecting toxicity - p. 23 5. Chapter 5. Natural laws concerning toxicology - p. 31 6. Chapter 6. Hazard and risk assessment - p. 45 7. Unit II - p. 51 8. Chapter 7. Absorption, distribution, and excretion of toxicants - p. 55 9. Chapter 8. Biotransformation - p. 73 10. Chapter 9. Principles and basic concepts of toxicokinetics - p. 87 11. Unit III - p. 107 12. Chapter 10. Toxicological testing: Genesis - p. 111 13. Chapter 11. Toxicological testing: In vitro models - p. 123 14. Chapter 12. Toxicological testing: In vivo systems - p. 131 15. Chapter 13. Genotoxicity - p. 151 16. Chapter 14. Preclinical toxicological investigations of pharmaceutical products - p. 165 17. Chapter 15. Preclinical safety evaluation of biotechnology-derived products - p. 173 18. Chapter 16. Preclinical regulatory toxicology for biomaterials and medical devices - p. 177 19. Unit IV - p. 182 20. Chapter 17. Toxic effects of pesticides (agrochemicals) - p. 185 21. Chapter 18. Toxic effects of metals - p. 203 22. Chapter 19. Toxic effects of nonmetallics - p. 215 23. Chapter 20. Neurotoxic agents - p. 221 24. Chapter 21. Toxic effects of cardiac poisons - p. 245 25. Chapter 22. Toxic effects of asphyxiants - p. 253 26. Chapter 23. Toxic effects of caustics (corrosives) - p. 267 27. Chapter 24. Drug toxicity, dependence, and abuse - p. 277 28. Chapter 25. Toxic effects of domestic chemicals - p. 287 29. Chapter 26. Toxic effects of poisonous plants - p. 293 30. Chapter 27. Poisonous foods and food poisoning - p. 305 31. Chapter 28. Poisons of animal origin - p. 311 32. Chapter 29. Chemical food poisoning - p. 327 33. Chapter 30. Health effects of radioactive materials - p. 333 34. Unit V - p. 339 35. Chapter 31. Basic concepts of forensic toxicology - p. 343 36. Chapter 32. Applications in toxicology - p. 347 37. Chapter 33. Clinical toxicology - p. 355 38. Chapter 34. Treatment of poisoning - p. 365 39. Further Reading - p. 369 40. Index - p. 381
