G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes.
1. Cover image - p. i 2. Table of Contents - p. iii 3. Copyright - p. iii 4. Contributors - p. iii 5. Preface - p. iii 6. Chapter One: Computational and experimental approaches to probe GPCR activation and signaling - p. 7 7. Chapter Two: Adrenergic receptors in breast cancer - p. 37 8. Chapter Three: Tools for adapting to a complex habitat: G-protein coupled receptors in Trichoderma - p. 65 9. Chapter Four: Targeting G protein coupled receptors for alleviating neuropathic pain - p. 99 10. Chapter Five: Crosstalk between neurons and glia through G-protein coupled receptors: Insights from Caenorhabditis elegans - p. 124 11. Chapter Six: Cardiovascular GPCR regulation by regulator of G protein signaling proteins - p. 151 12. Chapter Seven: The interaction, mechanism and function of GPR158-RGS7 cross-talk - p. 167 13. Chapter Eight: Taste GPCRs and their ligands - p. 177 14. Chapter Nine: Palmitoylation and G-protein coupled receptors - p. 195 15. Index - p. 211
G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes.
1. Cover image - p. i 2. Table of Contents - p. iii 3. Copyright - p. iii 4. Contributors - p. iii 5. Preface - p. iii 6. Chapter One: Computational and experimental approaches to probe GPCR activation and signaling - p. 7 7. Chapter Two: Adrenergic receptors in breast cancer - p. 37 8. Chapter Three: Tools for adapting to a complex habitat: G-protein coupled receptors in Trichoderma - p. 65 9. Chapter Four: Targeting G protein coupled receptors for alleviating neuropathic pain - p. 99 10. Chapter Five: Crosstalk between neurons and glia through G-protein coupled receptors: Insights from Caenorhabditis elegans - p. 124 11. Chapter Six: Cardiovascular GPCR regulation by regulator of G protein signaling proteins - p. 151 12. Chapter Seven: The interaction, mechanism and function of GPR158-RGS7 cross-talk - p. 167 13. Chapter Eight: Taste GPCRs and their ligands - p. 177 14. Chapter Nine: Palmitoylation and G-protein coupled receptors - p. 195 15. Index - p. 211
