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This issue will be an informative treatise on gastroparesis, a symptomatic chronic disorder of the stomach characterized by delayed gastric emptying in the absence of mechanical obstruction. Gastroparesis is an increasingly recognized and diagnosed disorder. Treatment can be challenging due to several mechanisms which play a role in causing the symptoms. Symptoms of gastroparesis are variable and include early satiety, nausea, vomiting, bloating, and upper abdominal discomfort. These symptoms can range from mild to severe leading to such complications as malnutrition, functional disability, and multiple hospitalizations. The three most common etiologies are diabetes, post-surgical, and idiopathic (unknown). Treatment consists of dietary manipulation, medical, and surgical therapy. The articles will provide a comprehensive review and in-depth information on gastroparesis. Each chapter will be written by an expert in the area. This issue will give the reader a better appreciation for the breadth of gastroparesis.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 9 7. Foreword: Gastroparesis - p. 10 8. Preface: Improving Our Understanding of Gastroparesis - p. 11 9. Gastroparesis - p. 12 10. Epidemiology and Natural History of Gastroparesis - p. 16 11. Clinical Presentation and Pathophysiology of Gastroparesis - p. 23 12. Histologic Changes in Diabetic Gastroparesis - p. 29 13. Diabetic Gastroparesis - p. 33 14. Idiopathic Gastroparesis - p. 42 15. Other Forms of Gastroparesis - p. 48 16. Nutritional Considerations in the Patient with Gastroparesis - p. 56 17. Prokinetics in Gastroparesis - p. 62 18. Symptomatic Management for Gastroparesis - p. 70 19. Pyloric Sphincter Therapy - p. 73 20. Complementary and Alternative Medicine for Gastroparesis - p. 79 21. Surgical Approaches to Treatment of Gastroparesis - p. 85 22. Gastric Arrhythmias in Gastroparesis - p. 94 23. Future Directions in the Treatment of Gastroparesis - p. 102 24. Index - p. 105

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This issue will be an informative treatise on gastroparesis, a symptomatic chronic disorder of the stomach characterized by delayed gastric emptying in the absence of mechanical obstruction. Gastroparesis is an increasingly recognized and diagnosed disorder. Treatment can be challenging due to several mechanisms which play a role in causing the symptoms. Symptoms of gastroparesis are variable and include early satiety, nausea, vomiting, bloating, and upper abdominal discomfort. These symptoms can range from mild to severe leading to such complications as malnutrition, functional disability, and multiple hospitalizations. The three most common etiologies are diabetes, post-surgical, and idiopathic (unknown). Treatment consists of dietary manipulation, medical, and surgical therapy. The articles will provide a comprehensive review and in-depth information on gastroparesis. Each chapter will be written by an expert in the area. This issue will give the reader a better appreciation for the breadth of gastroparesis.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 9 7. Foreword: Gastroparesis - p. 10 8. Preface: Improving Our Understanding of Gastroparesis - p. 11 9. Gastroparesis - p. 12 10. Epidemiology and Natural History of Gastroparesis - p. 16 11. Clinical Presentation and Pathophysiology of Gastroparesis - p. 23 12. Histologic Changes in Diabetic Gastroparesis - p. 29 13. Diabetic Gastroparesis - p. 33 14. Idiopathic Gastroparesis - p. 42 15. Other Forms of Gastroparesis - p. 48 16. Nutritional Considerations in the Patient with Gastroparesis - p. 56 17. Prokinetics in Gastroparesis - p. 62 18. Symptomatic Management for Gastroparesis - p. 70 19. Pyloric Sphincter Therapy - p. 73 20. Complementary and Alternative Medicine for Gastroparesis - p. 79 21. Surgical Approaches to Treatment of Gastroparesis - p. 85 22. Gastric Arrhythmias in Gastroparesis - p. 94 23. Future Directions in the Treatment of Gastroparesis - p. 102 24. Index - p. 105

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