Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome’s intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders.
Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Acknowledgments - p. page_xi 6. Epigraph - p. page_xiii 7. 1: Interacting with the environment receiving and interpreting signals - p. page_xiii 8. 2: Environment as provider - p. page_31 9. 3: Evolution - p. page_54 10. 4: Gene and environment interactions and phenotypes - p. page_78 11. 5: Signals, epigenetics, regulation of gene expression - p. page_107 12. 6: Maintaining homeostasis and mitigating effects of harmful factors in the intrinsic or extrinsic environment - p. page_138 13. 7: Microorganisms and microbiome - p. page_175 14. 8: Genomic changes and environmental factors in causation of birth defects and neurodevelopmental disorders - p. page_203 15. 9A: Personalized precision medicine—Part A: Concepts and relevance in Mendelian disorders - p. page_225 16. 9B: Personalized medicine. Precision medicine: PART B multifactorial diseases, genes, environments, interactions - p. page_257 17. 10: Integrating genetic, epigenetic and environmental information to improve health and well-being - p. page_290 18. 11: Environments, resources, and health - p. page_332 19. 12: Summary chapter epilogue - p. page_374 20. Index - p. page_397
Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome’s intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders.
Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Acknowledgments - p. page_xi 6. Epigraph - p. page_xiii 7. 1: Interacting with the environment receiving and interpreting signals - p. page_xiii 8. 2: Environment as provider - p. page_31 9. 3: Evolution - p. page_54 10. 4: Gene and environment interactions and phenotypes - p. page_78 11. 5: Signals, epigenetics, regulation of gene expression - p. page_107 12. 6: Maintaining homeostasis and mitigating effects of harmful factors in the intrinsic or extrinsic environment - p. page_138 13. 7: Microorganisms and microbiome - p. page_175 14. 8: Genomic changes and environmental factors in causation of birth defects and neurodevelopmental disorders - p. page_203 15. 9A: Personalized precision medicine—Part A: Concepts and relevance in Mendelian disorders - p. page_225 16. 9B: Personalized medicine. Precision medicine: PART B multifactorial diseases, genes, environments, interactions - p. page_257 17. 10: Integrating genetic, epigenetic and environmental information to improve health and well-being - p. page_290 18. 11: Environments, resources, and health - p. page_332 19. 12: Summary chapter epilogue - p. page_374 20. Index - p. page_397
