The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice.
In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency.
1. Chapter 1 : Introduction to genomic and molecular biology - p. Page x 2. Chapter 2 : Genetic and genomic technologies for inherited cardiovascular conditions - p. Page 22 3. Chapter 3 : Cardiovascular embryology and foetal heart development - p. Page 38 4. Chapter 4 : Genomic basis of heart rate and rhythm generation - p. Page 49 5. Chapter 5 : Molecular and immunological basis of pulmonary arterial hypertension and pulmonary veno-occlusive disease - p. Page 62 6. Chapter 6 : Genetic and immunogenetic basis of myocarditis - p. Page 81 7. Chapter 7 : Cardiovascular metabolomics - p. Page 97 8. Chapter 8 : Developmental disorders of the heart - p. Page 114 9. Chapter 9 : Application of molecular genetics to congenital vascular anomalies - p. Page 136 10. Chapter 10 : Aortic and arterial diseases (Aortopathies) - p. Page 142 11. Chapter 11 : Collagenopathies – The Ehlers-Danlos syndromes - p. Page 158 12. Chapter 12 : Collagenopathies: Osteogenesis imperfecta and related disorders - p. Page 175 13. Chapter 13 : Cardiomyopathies – Inherited subtypes and phenocopies - p. Page 186 14. Chapter 14 : Inherited channelopathies and acquired phenocopies - p. Page 214 15. Chapter 15 : Genetics of pulmonary arterial hypertension - p. Page 245 16. Chapter 16 : Genetic and metabolic perspectives of heart failure - p. Page 262 17. Chapter 17 : Disorders manifesting with systemic hypertension - p. Page 272 18. Chapter 18 : Monogenic causes of stroke - p. Page 289 19. Chapter 19 : Cardiovascular pharmacogenomics – Molecular basis of protective and adverse drug response - p. Page 311 20. Chapter 20 : Cardiovascular precision and personalised medicine - p. Page 324 21. Chapter 21 : Principles of novel cellular and molecular cardiovascular therapeutics - p. Page 347 22. Chapter 22 : Gene annotation: Resources for the heart - p. Page 361 23. Chapter 23 : Nursing care and genetic counselling in inherited cardiovascular conditions - p. Page 373 24. Chapter 24 : Preventive cardiology - p. Page 385 25. Chapter 25 : Inherited cardiac conditions in sports medicine - p. Page 400 26. Chapter 26 : Community and population cardiology - p. Page 411 27. Glossary – Commonly used terms and phrases in cardiovascular genomic and molecular medicine - p. Page 419 28. Index - p. Page 432
The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice.
In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency.
1. Chapter 1 : Introduction to genomic and molecular biology - p. Page x 2. Chapter 2 : Genetic and genomic technologies for inherited cardiovascular conditions - p. Page 22 3. Chapter 3 : Cardiovascular embryology and foetal heart development - p. Page 38 4. Chapter 4 : Genomic basis of heart rate and rhythm generation - p. Page 49 5. Chapter 5 : Molecular and immunological basis of pulmonary arterial hypertension and pulmonary veno-occlusive disease - p. Page 62 6. Chapter 6 : Genetic and immunogenetic basis of myocarditis - p. Page 81 7. Chapter 7 : Cardiovascular metabolomics - p. Page 97 8. Chapter 8 : Developmental disorders of the heart - p. Page 114 9. Chapter 9 : Application of molecular genetics to congenital vascular anomalies - p. Page 136 10. Chapter 10 : Aortic and arterial diseases (Aortopathies) - p. Page 142 11. Chapter 11 : Collagenopathies – The Ehlers-Danlos syndromes - p. Page 158 12. Chapter 12 : Collagenopathies: Osteogenesis imperfecta and related disorders - p. Page 175 13. Chapter 13 : Cardiomyopathies – Inherited subtypes and phenocopies - p. Page 186 14. Chapter 14 : Inherited channelopathies and acquired phenocopies - p. Page 214 15. Chapter 15 : Genetics of pulmonary arterial hypertension - p. Page 245 16. Chapter 16 : Genetic and metabolic perspectives of heart failure - p. Page 262 17. Chapter 17 : Disorders manifesting with systemic hypertension - p. Page 272 18. Chapter 18 : Monogenic causes of stroke - p. Page 289 19. Chapter 19 : Cardiovascular pharmacogenomics – Molecular basis of protective and adverse drug response - p. Page 311 20. Chapter 20 : Cardiovascular precision and personalised medicine - p. Page 324 21. Chapter 21 : Principles of novel cellular and molecular cardiovascular therapeutics - p. Page 347 22. Chapter 22 : Gene annotation: Resources for the heart - p. Page 361 23. Chapter 23 : Nursing care and genetic counselling in inherited cardiovascular conditions - p. Page 373 24. Chapter 24 : Preventive cardiology - p. Page 385 25. Chapter 25 : Inherited cardiac conditions in sports medicine - p. Page 400 26. Chapter 26 : Community and population cardiology - p. Page 411 27. Glossary – Commonly used terms and phrases in cardiovascular genomic and molecular medicine - p. Page 419 28. Index - p. Page 432
