Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management.
Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.
1. An introduction to “Gigantism and Acromegaly: Genetics, Diagnosis, and Treatment” - p. xvii 2. Chapter 1. History of the identification of gigantism and acromegaly - p. 1 3. Chapter 2. Pathology of pituitary growth hormone excess - p. 17 4. Chapter 3. Gigantism: clinical diagnosis and description - p. 39 5. Chapter 4. Acromegaly: clinical description and diagnosis - p. 53 6. Chapter 5. GPR101, an orphan G-protein coupled receptor, with roles in growth, puberty, and possibly appetite regulation - p. 79 7. Chapter 6. The role of the aryl hydrocarbon receptor interacting protein in pituitary tumorigenesis - p. 89 8. Chapter 7. The 3PAs syndrome and succinate dehydrogenase deficiency in pituitary tumors - p. 127 9. CDKN1B (p27) defects leading to pituitary tumors - p. 157 10. Chapter 9. Multiple endocrine neoplasia syndromes and somatotroph adenomas - p. 173 11. Chapter 10. GNAS, McCune–Albright syndrome, and GH-producing tumors - p. 197 12. Chapter 11. Surgical management of growth hormone-secreting adenomas - p. 225 13. Chapter 12. Medical management of pituitary gigantism and acromegaly - p. 245 14. Chapter 13. GHRH-producing tumors and other neuroendocrine neoplasms associated with acromegaly and/or gigantism - p. 259 15. Chapter 14. Increased growth hormone secretion from lesions outside the anterior pituitary - p. 275 16. Index - p. 283
Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management.
Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.
1. An introduction to “Gigantism and Acromegaly: Genetics, Diagnosis, and Treatment” - p. xvii 2. Chapter 1. History of the identification of gigantism and acromegaly - p. 1 3. Chapter 2. Pathology of pituitary growth hormone excess - p. 17 4. Chapter 3. Gigantism: clinical diagnosis and description - p. 39 5. Chapter 4. Acromegaly: clinical description and diagnosis - p. 53 6. Chapter 5. GPR101, an orphan G-protein coupled receptor, with roles in growth, puberty, and possibly appetite regulation - p. 79 7. Chapter 6. The role of the aryl hydrocarbon receptor interacting protein in pituitary tumorigenesis - p. 89 8. Chapter 7. The 3PAs syndrome and succinate dehydrogenase deficiency in pituitary tumors - p. 127 9. CDKN1B (p27) defects leading to pituitary tumors - p. 157 10. Chapter 9. Multiple endocrine neoplasia syndromes and somatotroph adenomas - p. 173 11. Chapter 10. GNAS, McCune–Albright syndrome, and GH-producing tumors - p. 197 12. Chapter 11. Surgical management of growth hormone-secreting adenomas - p. 225 13. Chapter 12. Medical management of pituitary gigantism and acromegaly - p. 245 14. Chapter 13. GHRH-producing tumors and other neuroendocrine neoplasms associated with acromegaly and/or gigantism - p. 259 15. Chapter 14. Increased growth hormone secretion from lesions outside the anterior pituitary - p. 275 16. Index - p. 283
