Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field.
Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood.
1. Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Cover Image Legend - p. Page vi 7. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. Page vii 8. About the Series Editor - p. Page vii 9. Aims and Scope of the Volume - p. Page ix 10. About the Volume Editors - p. Page x 11. Preface - p. Page x 12. Contributors - p. Page xii 13. List of Illustrations - p. Page xvii 14. List of Tables - p. Page xviii 15. Chapter 1 : Overview of glioblastoma biological hallmarks and molecular pathology - p. Page xviii 16. Chapter 2 : Past and present drug treatments for glioblastoma - p. Page 10 17. Chapter 3 : Investigational new drugs against glioblastoma - p. Page 27 18. Chapter 4 : Molecular mechanisms in temozolomide-resistant glioblastoma - p. Page 58 19. Chapter 5 : Glioma stem cells and associated molecular mechanisms in Glioblastoma Chemoresistance - p. Page 121 20. Chapter 6 : Signaling in the tumor microenvironment of therapy-resistant glioblastoma - p. Page 144 21. Chapter 7 : Intratumoral heterogeneity associated with glioblastoma drug response and resistance - p. Page 172 22. Chapter 8 : Role of apoptosis, autophagy, and the unfolded protein response in glioblastoma chemoresistance - p. Page 194 23. Chapter 9 : Role of multidrug resistance in glioblastoma chemoresistance: Focus on ABC transporters - p. Page 231 24. Chapter 10 : Role of mitochondrial reactive oxygen species in glioblastoma drug resistance and strategies for therapeutic intervention - p. Page 256 25. Chapter 11 : Glioblastoma cell-induced immunosuppression causing chemoresistance - p. Page 286 26. Chapter 12 : Role of cell quiescence in glioblastoma cytotoxic resistance and strategies for therapeutic intervention - p. Page 307 27. Chapter 13 : The molecular and cellular effects of radiotherapy-induced microenvironment changes on potential chemoresistance in glioblastoma - p. Page 328 28. Chapter 14 : Molecular and cellular mechanisms in recurrent glioblastoma chemoresistance - p. Page 352 29. Chapter 15 : Role of long noncoding RNAs in temozolomide-resistant glioblastoma - p. Page 389 30. Chapter 16 : Mechanisms of glioblastoma resistance to antiangiogenic agents and reversal approaches - p. Page 421 31. Chapter 17 : Treatment and resistance of glioblastoma to CAR T-cell immunotherapies - p. Page 444 32. Chapter 18 : On-chip analysis of glioblastoma cell chemoresistance - p. Page 464 33. Chapter 19 : Three-dimensional in vitro models to study potentiation of glioblastoma resistance by hypoxia - p. Page 488 34. Chapter 20 : Chemoresistance mechanisms in mouse models of glioblastoma - p. Page 495 35. Chapter 21 : Therapeutic approaches to overcome temozolomide resistance in glioblastoma - p. Page 503 36. Chapter 22 : Understanding signal transduction pathways to overcome targeted therapy resistance in glioblastoma - p. Page 535 37. Chapter 23 : Targeting the molecular mechanisms of glioma stem cell resistance to chemotherapy - p. Page 575 38. Chapter 24 : Immunotherapy for glioblastoma as a means to overcome resistance to standard therapy - p. Page 621 39. Chapter 25 : Role of microRNA therapy in presensitizing glioblastoma cells to temozolomide treatment - p. Page 653 40. Chapter 26 : Drug penetration through the blood–brain barrier after radiotherapy: New approaches to bypass glioblastoma chemoresistance - p. Page 683 41. Chapter 27 : Nanoparticles beyond the blood-brain barrier for glioblastoma - p. Page 700 42. Chapter 28 : Small molecules targeting misfolded mutants of p53 as a rescue strategy to improve glioblastoma chemotherapy - p. Page 736 43. Chapter 29 : p53 supplementation as a targeted cancer gene therapy for glioblastoma - p. Page 766 44. Index - p. Page 784
Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field.
Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood.
1. Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Cover Image Legend - p. Page vi 7. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. Page vii 8. About the Series Editor - p. Page vii 9. Aims and Scope of the Volume - p. Page ix 10. About the Volume Editors - p. Page x 11. Preface - p. Page x 12. Contributors - p. Page xii 13. List of Illustrations - p. Page xvii 14. List of Tables - p. Page xviii 15. Chapter 1 : Overview of glioblastoma biological hallmarks and molecular pathology - p. Page xviii 16. Chapter 2 : Past and present drug treatments for glioblastoma - p. Page 10 17. Chapter 3 : Investigational new drugs against glioblastoma - p. Page 27 18. Chapter 4 : Molecular mechanisms in temozolomide-resistant glioblastoma - p. Page 58 19. Chapter 5 : Glioma stem cells and associated molecular mechanisms in Glioblastoma Chemoresistance - p. Page 121 20. Chapter 6 : Signaling in the tumor microenvironment of therapy-resistant glioblastoma - p. Page 144 21. Chapter 7 : Intratumoral heterogeneity associated with glioblastoma drug response and resistance - p. Page 172 22. Chapter 8 : Role of apoptosis, autophagy, and the unfolded protein response in glioblastoma chemoresistance - p. Page 194 23. Chapter 9 : Role of multidrug resistance in glioblastoma chemoresistance: Focus on ABC transporters - p. Page 231 24. Chapter 10 : Role of mitochondrial reactive oxygen species in glioblastoma drug resistance and strategies for therapeutic intervention - p. Page 256 25. Chapter 11 : Glioblastoma cell-induced immunosuppression causing chemoresistance - p. Page 286 26. Chapter 12 : Role of cell quiescence in glioblastoma cytotoxic resistance and strategies for therapeutic intervention - p. Page 307 27. Chapter 13 : The molecular and cellular effects of radiotherapy-induced microenvironment changes on potential chemoresistance in glioblastoma - p. Page 328 28. Chapter 14 : Molecular and cellular mechanisms in recurrent glioblastoma chemoresistance - p. Page 352 29. Chapter 15 : Role of long noncoding RNAs in temozolomide-resistant glioblastoma - p. Page 389 30. Chapter 16 : Mechanisms of glioblastoma resistance to antiangiogenic agents and reversal approaches - p. Page 421 31. Chapter 17 : Treatment and resistance of glioblastoma to CAR T-cell immunotherapies - p. Page 444 32. Chapter 18 : On-chip analysis of glioblastoma cell chemoresistance - p. Page 464 33. Chapter 19 : Three-dimensional in vitro models to study potentiation of glioblastoma resistance by hypoxia - p. Page 488 34. Chapter 20 : Chemoresistance mechanisms in mouse models of glioblastoma - p. Page 495 35. Chapter 21 : Therapeutic approaches to overcome temozolomide resistance in glioblastoma - p. Page 503 36. Chapter 22 : Understanding signal transduction pathways to overcome targeted therapy resistance in glioblastoma - p. Page 535 37. Chapter 23 : Targeting the molecular mechanisms of glioma stem cell resistance to chemotherapy - p. Page 575 38. Chapter 24 : Immunotherapy for glioblastoma as a means to overcome resistance to standard therapy - p. Page 621 39. Chapter 25 : Role of microRNA therapy in presensitizing glioblastoma cells to temozolomide treatment - p. Page 653 40. Chapter 26 : Drug penetration through the blood–brain barrier after radiotherapy: New approaches to bypass glioblastoma chemoresistance - p. Page 683 41. Chapter 27 : Nanoparticles beyond the blood-brain barrier for glioblastoma - p. Page 700 42. Chapter 28 : Small molecules targeting misfolded mutants of p53 as a rescue strategy to improve glioblastoma chemotherapy - p. Page 736 43. Chapter 29 : p53 supplementation as a targeted cancer gene therapy for glioblastoma - p. Page 766 44. Index - p. Page 784
