Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue.
After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process.
Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry 2e encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work.
This first volume of the second edition covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources including plants and agricultural materials.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. About the editor - p. xv 8. Preface - p. xvii 9. Acknowledgment - p. xix 10. Section 1: Nanotechnology - p. xx 11. Chapter 1. Nanocatalyzed organic transformations for synthesis of drug-like small molecules with medicinally privileged heterocycles - p. 3 12. Chapter 2. Nano-based drug delivery of anticancer agents - p. 43 13. Chapter 3. Green synthesis of silver nanoparticles for antibacterial properties - p. 61 14. Chapter 4. Green synthesis of nanoparticles and nanocomposites: medical aspect - p. 71 15. Chapter 5. Nanomaterial-mediated synthesis of β-lactams and exploration of their enhanced biological activities: recent advances - p. 79 16. Section 2: Combinatorial chemistry - p. 95 17. Chapter 6. Green combinatorial chemistry in medicinal science - p. 103 18. Chapter 7. Combinatorial chemistry in cancer drug discovery - p. 111 19. Section 3: Energy - p. 131 20. Chapter 8. The use of ultrasound in drug synthesis: a sustainable method - p. 137 21. Chapter 9. Solar-powered chemistry: new catalytic solutions for a greener planet - p. 161 22. Chapter 10. Photocatalytic reactions for the synthesis and derivatization of pharmaceutically significant heterocycles - p. 183 23. Chapter 11. Visible light-induced dye degradation potential of green synthesized nanoparticles: an approach toward polluted water treatment - p. 223 24. Chapter 12. Green synthetic approach for biologically relevant heterocyclic compounds by using ball mill - p. 233 25. Chapter 13. Synthesis of natural products by photochemistry - p. 259 26. Chapter 14. Recent magneto/electrochemical/biosensors and analytical approaches to detect β-lactam antibiotics in food and environment - p. 285 27. Section 4: Methods and synthesis - p. 298 28. Chapter 15. Use of sustainable organic transformations in the construction of heterocyclic scaffolds - p. 303 29. Chapter 16. Diverse synthesis of medicinally active steroids - p. 355 30. Chapter 17. Solvent-less reactions: green and sustainable approaches in medicinal chemistry - p. 387 31. Chapter 18. Versatile thiosugars in medicinal chemistry - p. 409 32. Section 5: Microwave-induced chemistry - p. 439 33. Chapter 19. Microwave-assisted synthesis of antitubercular agents: a novel approach - p. 445 34. Chapter 20. Microwave-induced synthesis as a part of green chemistry approach for novel antiinflammatory agents - p. 475 35. Section 6: Computers in drug discovery - p. 517 36. Chapter 21. Dipole moment studies on beta lactams - p. 523 37. Chapter 22. Computational approaches for development of anti-COVID-19 agents - p. 543 38. Chapter 23. Dipole moment in medicinal research: green and sustainable approach - p. 561 39. Chapter 24. Computational methods and tools for sustainable and green approaches in drug discovery - p. 603 40. Index - p. 617
Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue.
After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process.
Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry 2e encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work.
This first volume of the second edition covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources including plants and agricultural materials.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. About the editor - p. xv 8. Preface - p. xvii 9. Acknowledgment - p. xix 10. Section 1: Nanotechnology - p. xx 11. Chapter 1. Nanocatalyzed organic transformations for synthesis of drug-like small molecules with medicinally privileged heterocycles - p. 3 12. Chapter 2. Nano-based drug delivery of anticancer agents - p. 43 13. Chapter 3. Green synthesis of silver nanoparticles for antibacterial properties - p. 61 14. Chapter 4. Green synthesis of nanoparticles and nanocomposites: medical aspect - p. 71 15. Chapter 5. Nanomaterial-mediated synthesis of β-lactams and exploration of their enhanced biological activities: recent advances - p. 79 16. Section 2: Combinatorial chemistry - p. 95 17. Chapter 6. Green combinatorial chemistry in medicinal science - p. 103 18. Chapter 7. Combinatorial chemistry in cancer drug discovery - p. 111 19. Section 3: Energy - p. 131 20. Chapter 8. The use of ultrasound in drug synthesis: a sustainable method - p. 137 21. Chapter 9. Solar-powered chemistry: new catalytic solutions for a greener planet - p. 161 22. Chapter 10. Photocatalytic reactions for the synthesis and derivatization of pharmaceutically significant heterocycles - p. 183 23. Chapter 11. Visible light-induced dye degradation potential of green synthesized nanoparticles: an approach toward polluted water treatment - p. 223 24. Chapter 12. Green synthetic approach for biologically relevant heterocyclic compounds by using ball mill - p. 233 25. Chapter 13. Synthesis of natural products by photochemistry - p. 259 26. Chapter 14. Recent magneto/electrochemical/biosensors and analytical approaches to detect β-lactam antibiotics in food and environment - p. 285 27. Section 4: Methods and synthesis - p. 298 28. Chapter 15. Use of sustainable organic transformations in the construction of heterocyclic scaffolds - p. 303 29. Chapter 16. Diverse synthesis of medicinally active steroids - p. 355 30. Chapter 17. Solvent-less reactions: green and sustainable approaches in medicinal chemistry - p. 387 31. Chapter 18. Versatile thiosugars in medicinal chemistry - p. 409 32. Section 5: Microwave-induced chemistry - p. 439 33. Chapter 19. Microwave-assisted synthesis of antitubercular agents: a novel approach - p. 445 34. Chapter 20. Microwave-induced synthesis as a part of green chemistry approach for novel antiinflammatory agents - p. 475 35. Section 6: Computers in drug discovery - p. 517 36. Chapter 21. Dipole moment studies on beta lactams - p. 523 37. Chapter 22. Computational approaches for development of anti-COVID-19 agents - p. 543 38. Chapter 23. Dipole moment in medicinal research: green and sustainable approach - p. 561 39. Chapter 24. Computational methods and tools for sustainable and green approaches in drug discovery - p. 603 40. Index - p. 617
