Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue.
After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process.
Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work.
This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods.
1. Green Approaches in Medicinal Chemistry for Sustainable Drug Design - p. i 2. Cover - p. i 3. Title page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. List of contributors - p. xiii 7. About the editor - p. xv 8. Preface - p. xvi 9. Acknowledgment - p. xix 10. Chapter 1 Green metal catalyzed reactions under sustainable conditions toward medicinally potent biomolecules - p. 3 11. Chapter 2 Graphene oxide and modified graphene oxide-mediated synthesis of medicinally active compounds - p. 13 12. Chapter 3 Organocatalytic cycloaddition reaction: a gateway for molecular complexity - p. 45 13. Chapter 4 Baker’s yeast-induced synthesis of medicinally important compounds - p. 65 14. Chapter 5 New methods for the manufacturing of pharmaceuticals and their intermediates using lipase - p. 77 15. Chapter 6 Green synthesis of biologically active pyrroles and related substrates via C–H bond functionalization - p. 101 16. Chapter 7 Ionic liquids in pharmaceutics and bioanalytics - p. 133 17. Chapter 8 Synthesis of bioactive heterocyclic compounds using green solvents - p. 139 18. Chapter 9 Reactions in water: synthesis of biologically active compounds - p. 157 19. Chapter 10 Sustainable green technologies for synthesis of potential drugs targeted toward tropical diseases - p. 191 20. Chapter 11 Clay-mediated synthesis of biologically active molecules: green and sustainable approaches - p. 205 21. Chapter 12 The role of ionic liquid in medicinal chemistry - p. 239 22. Chapter 13 Green chemistry for the synthesis of sulfur-containing compounds with medicinal properties - p. 281 23. Chapter 14 Green synthesis of bioactive flavonoids as cardioprotective and anticancer drug agents - p. 305 24. Chapter 15 Polysaccharide-derived hydroge ls: an approach toward cancer - p. 345 25. Chapter 16 Environmental-benign pathways for the synthesis of medicinally relevant heterocycles - p. 361 26. Chapter 17 Utilization of medicinally important plants as antidiabetic medicines in a sustainable manner - p. 397 27. Chapter 18 One-pot synthesis of biologically active oxazole, isoxazole, and pyranopyrazoles—an overview - p. 411 28. Chapter 19 Green synthesis of organometallic compounds and their medicinal aspects - p. 433 29. Chapter 20 Therapeutic role of biologically active macrocycles in medicine - p. 449 30. Chapter 21 Green synthesis and biological evaluation of anticancer drugs - p. 467 31. Chapter 22 Green chemistry and synthetic approaches in the development of antidepressant and antipsychotic agents - p. 513 32. Chapter 23 Organocatalyzed multicomponent synthesis of densely functionalized bioactive pyridines - p. 531 33. Chapter 24 Multicomponent reaction strategy to heterocyclic compounds in anticancer drug design - p. 551 34. Chapter 25 Recent advances in asymmetric synthesis of β-lactams - p. 597 35. Index - p. 653 36. Index - Continued - p. 653 37. Index - Continued - p. 653
Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue.
After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process.
Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work.
This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods.
1. Green Approaches in Medicinal Chemistry for Sustainable Drug Design - p. i 2. Cover - p. i 3. Title page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. List of contributors - p. xiii 7. About the editor - p. xv 8. Preface - p. xvi 9. Acknowledgment - p. xix 10. Chapter 1 Green metal catalyzed reactions under sustainable conditions toward medicinally potent biomolecules - p. 3 11. Chapter 2 Graphene oxide and modified graphene oxide-mediated synthesis of medicinally active compounds - p. 13 12. Chapter 3 Organocatalytic cycloaddition reaction: a gateway for molecular complexity - p. 45 13. Chapter 4 Baker’s yeast-induced synthesis of medicinally important compounds - p. 65 14. Chapter 5 New methods for the manufacturing of pharmaceuticals and their intermediates using lipase - p. 77 15. Chapter 6 Green synthesis of biologically active pyrroles and related substrates via C–H bond functionalization - p. 101 16. Chapter 7 Ionic liquids in pharmaceutics and bioanalytics - p. 133 17. Chapter 8 Synthesis of bioactive heterocyclic compounds using green solvents - p. 139 18. Chapter 9 Reactions in water: synthesis of biologically active compounds - p. 157 19. Chapter 10 Sustainable green technologies for synthesis of potential drugs targeted toward tropical diseases - p. 191 20. Chapter 11 Clay-mediated synthesis of biologically active molecules: green and sustainable approaches - p. 205 21. Chapter 12 The role of ionic liquid in medicinal chemistry - p. 239 22. Chapter 13 Green chemistry for the synthesis of sulfur-containing compounds with medicinal properties - p. 281 23. Chapter 14 Green synthesis of bioactive flavonoids as cardioprotective and anticancer drug agents - p. 305 24. Chapter 15 Polysaccharide-derived hydroge ls: an approach toward cancer - p. 345 25. Chapter 16 Environmental-benign pathways for the synthesis of medicinally relevant heterocycles - p. 361 26. Chapter 17 Utilization of medicinally important plants as antidiabetic medicines in a sustainable manner - p. 397 27. Chapter 18 One-pot synthesis of biologically active oxazole, isoxazole, and pyranopyrazoles—an overview - p. 411 28. Chapter 19 Green synthesis of organometallic compounds and their medicinal aspects - p. 433 29. Chapter 20 Therapeutic role of biologically active macrocycles in medicine - p. 449 30. Chapter 21 Green synthesis and biological evaluation of anticancer drugs - p. 467 31. Chapter 22 Green chemistry and synthetic approaches in the development of antidepressant and antipsychotic agents - p. 513 32. Chapter 23 Organocatalyzed multicomponent synthesis of densely functionalized bioactive pyridines - p. 531 33. Chapter 24 Multicomponent reaction strategy to heterocyclic compounds in anticancer drug design - p. 551 34. Chapter 25 Recent advances in asymmetric synthesis of β-lactams - p. 597 35. Index - p. 653 36. Index - Continued - p. 653 37. Index - Continued - p. 653
