Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions.
This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xvii 8. Editor - p. xxi 9. Foreword - p. xxiii 10. Preface - p. xxv 11. Chapter 1. Green synthetic approaches for biologically relevant heterocycles: advanced synthetic techniques—an overview - p. 1 12. Chapter 2. High-pressure cycloaddition reactions in the synthesis of biologically relevant heterocycles - p. 9 13. Chapter 3. Microwave-assisted synthesis of medicinally privileged heterocycles - p. 49 14. Chapter 4. Application of microwave irradiation in the synthesis of P-heterocycles - p. 111 15. Chapter 5. Microwave-assisted multicomponent reactions as a green synthetic approach to heterocycles: special reference to Hantzsch, Biginelli, and Groebke–Blackburn–Bienayme reactions - p. 143 16. Chapter 6. Use of ball milling for the synthesis of biologically active heterocycles - p. 167 17. Chapter 7. Recent advances in photocatalytic Minisci reaction: an eco-friendly functionalization of biologically relevant heteroarenes - p. 189 18. Chapter 8. Recent advances for construction and late-stage diversification of indole core via C–H bond activation/functionalization - p. 207 19. Chapter 9. Cycloaddition reactions in ionic liquids for the synthesis of biologically relevant heterocycles - p. 249 20. Chapter 10. Advances in greener processes for triazole synthesis via azide-alkyne cycloaddition reactions - p. 297 21. Chapter 11. Employing arynes in transition-metal-free synthesis of benzo-fused five and six-membered heterocycles: an update - p. 355 22. Chapter 12. Multicomponent approach for the sustainable synthesis of lawsone-based heterocycles - p. 383 23. Chapter 13. Synthesis of biologically relevant heterocyclic skeletons under solvent-free condition - p. 421 24. Chapter 14. Ultrasound-promoted metal-catalyzed synthesis of heterocyclic compounds of medicinal interest - p. 461 25. Chapter 15. Ultrasonication under catalyst-free condition: an advanced synthetic technique toward the green synthesis of bioactive heterocycles - p. 497 26. Chapter 16. Self-catalytic techniques for the synthesis of biologically relevant heterocyclic scaffolds at room temperature: a recent update - p. 563 27. Index - p. 589
Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions.
This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xvii 8. Editor - p. xxi 9. Foreword - p. xxiii 10. Preface - p. xxv 11. Chapter 1. Green synthetic approaches for biologically relevant heterocycles: advanced synthetic techniques—an overview - p. 1 12. Chapter 2. High-pressure cycloaddition reactions in the synthesis of biologically relevant heterocycles - p. 9 13. Chapter 3. Microwave-assisted synthesis of medicinally privileged heterocycles - p. 49 14. Chapter 4. Application of microwave irradiation in the synthesis of P-heterocycles - p. 111 15. Chapter 5. Microwave-assisted multicomponent reactions as a green synthetic approach to heterocycles: special reference to Hantzsch, Biginelli, and Groebke–Blackburn–Bienayme reactions - p. 143 16. Chapter 6. Use of ball milling for the synthesis of biologically active heterocycles - p. 167 17. Chapter 7. Recent advances in photocatalytic Minisci reaction: an eco-friendly functionalization of biologically relevant heteroarenes - p. 189 18. Chapter 8. Recent advances for construction and late-stage diversification of indole core via C–H bond activation/functionalization - p. 207 19. Chapter 9. Cycloaddition reactions in ionic liquids for the synthesis of biologically relevant heterocycles - p. 249 20. Chapter 10. Advances in greener processes for triazole synthesis via azide-alkyne cycloaddition reactions - p. 297 21. Chapter 11. Employing arynes in transition-metal-free synthesis of benzo-fused five and six-membered heterocycles: an update - p. 355 22. Chapter 12. Multicomponent approach for the sustainable synthesis of lawsone-based heterocycles - p. 383 23. Chapter 13. Synthesis of biologically relevant heterocyclic skeletons under solvent-free condition - p. 421 24. Chapter 14. Ultrasound-promoted metal-catalyzed synthesis of heterocyclic compounds of medicinal interest - p. 461 25. Chapter 15. Ultrasonication under catalyst-free condition: an advanced synthetic technique toward the green synthesis of bioactive heterocycles - p. 497 26. Chapter 16. Self-catalytic techniques for the synthesis of biologically relevant heterocyclic scaffolds at room temperature: a recent update - p. 563 27. Index - p. 589
