Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Dedication - p. iii 7. Contributors - p. xxiii 8. Preface - p. xxix 9. Part I: Alzheimer’s disease and dementias - p. xxx 10. Chapter 1. Alzheimer’s disease preliminary screening in zebrafish integrating behavioral models and molecular markers - p. 3 11. Chapter 2. Sporadic Alzheimer’s disease animal model using streptozotocin and APP/PS1 mice - p. 19 12. Chapter 3. Current mouse models of Alzheimer’s disease for investigating therapeutic agents - p. 31 13. Chapter 4. A rat model of pre-clinical Alzheimer’s disease - p. 43 14. Chapter 5. Modeling menopause and dementia in rodents: Investigations on cognition and coordination - p. 57 15. Part II: Amyotrophic lateral sclerosis - p. 63 16. Drosophila model of amyotrophic lateral sclerosis targeting FUS and ubiquilin - p. 67 17. The amyotrophic lateral sclerosis SOD1G93A mouse model and applications: Studies into the P2X7 receptor - p. 81 18. Chapter 8. Modeling amyotrophic lateral sclerosis through Ataxin-2 pathology - p. 95 19. Part III: Brain injury - p. 106 20. Drosophila melanogaster model of traumatic brain injury: Investigating the pharmacodynamics of volatile anesthetics - p. 109 21. Chapter 10. Mouse model of repetitive mild traumatic brain injury (investigating cognitive impairment) - p. 121 22. Chapter 11. Blood–brain barrier damage following mild traumatic brain injury - p. 133 23. Chapter 12. Rodent modeling of neonatal hypoxic–ischemic brain injury - p. 147 24. Chapter 13. Modeling brain injury: Neonatal intraventricular hemorrhage - p. 159 25. Chapter 14. Penetrating traumatic brain injury model in rats: Applications to studying duraplasty following decompressive craniectomy - p. 171 26. Part IV: Cerebral palsy - p. 179 27. Chapter 15. The spa transgenic mouse model of hypertonia and use for studying cerebral palsy - p. 183 28. Chapter 16. Transient occlusion of uterine arteries and intra-amniotic injection of lipopolysaccharide in rats as a model of cerebral palsy - p. 193 29. Chapter 17. Experimental cerebral palsy in animals and developmental plasticity - p. 205 30. Part V: Epilepsy and seizures - p. 214 31. Chapter 18. Second-hit pentylenetetrazole-induced seizure model in zebrafish - p. 217 32. Chapter 19. The zebrafish model of Tuberous sclerosis complex to study epilepsy - p. 235 33. The Brd2+/− mouse model of juvenile myoclonic epilepsy (JME) - p. 241 34. Chapter 21. Modeling the link between traumatic brain injury and epileptiform activity in rats - p. 253 35. Chapter 22. Animal models of infantile spasms: Focus on new treatments - p. 265 36. Part VI: Headaches, migraines and pain - p. 275 37. Chapter 23. Light flash in rats as a model for the triggering of migraine headache - p. 279 38. Chapter 24. Inhibition of diacylglycerol lipase alpha (DAGLα) as a model for episodic headache in rats: Features and applications - p. 293 39. Chapter 25. Animal models of headache - p. 305 40. Chapter 26. Animal models of orofacial pain comorbidity in mice - p. 317 41. Part VII: Meningitis - p. 325 42. Experimental meningitis by Streptococcus pneumoniae and Neisseria meningitidis in rodents - p. 329 43. Chapter 28. The rabbit model: Pathological manifestations of tuberculous meningitis - p. 343 44. Novel Streptococcus suis meningitis model in pigs: Longitudinal assessment of oxygen values, neutrophil function, and DNase activity in the central nervous system - p. 353 45. Part VIII: Multiple sclerosis - p. 365 46. R-Ras1−/− and R-Ras2−/− mice as models for investigating multiple sclerosis - p. 369 47. Chapter 31. Animal models of multiple sclerosis and the lower urinary tract - p. 377 48. Part IX: Neuroinflammation - p. 388 49. Chapter 32. The mouse model of experimental autoimmune encephalomyelitis: Methods to study neuroinflammation in optic neuritis - p. 391 50. Chapter 33. Modeling neurotoxin-induced neuroinflammation with chemotherapy - p. 404 51. Chapter 34. Modeling and investigating neuroinflammation in cardiopulmonary resuscitation in pigs - p. 419 52. Chapter 35. Investigating neuroinflammation in lateral fluid percussion injury - p. 429 53. Part X: Neurotoxins - p. 439 54. Chapter 36. Use of zebrafish embryos to study molecular and cellular neurotoxic effects of drugs: A focus on signaling and ketamine - p. 443 55. Rodent models of anesthesia-induced developmental neurotoxicity☆ - p. 455 56. Part XI: Parkinson’s disease - p. 464 57. Modeling of Parkinson’s disease in Drosophila based on DJ-1 deficiency - p. 476 58. Chapter 39. Drosophila model of Parkinson’s disease using rotenone - p. 484 59. Chapter 40. 6-Hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease: Investigating neural control of cardiorespiratory function - p. 493 60. Chapter 41. The use of the proteasome inhibitor lactacystin for modeling Parkinson’s disease: Early neurophysiological biomarkers and candidates for intranigral and extranigral neuroprotection - p. 507 61. Part XII: Peripheral neuropathy - p. 523 62. Chapter 42. Zebrafish as a model for studying peripheral neuropathy - p. 527 63. Part XIII: Prenatal related injury and neurodevelopmental disorders - p. 538 64. Chapter 43. Prenatal systemic hypoxia-ischemia: A rat model of neurodevelopmental disorders related to prematurity - p. 541 65. Chapter 44. Modeling prenatal stress in rats: Impact on the hippocampus - p. 553 66. Chapter 45. The use of oxcarbazepine during gestation has adverse effects in rats - p. 565 67. Chapter 46. Modeling the effect of anesthesia in pregnancy and impact on the fetal brain: Studies in rabbits - p. 579 68. Part XIV: Stroke - p. 597 69. Chapter 47. Murine subarachnoid hemorrhage: Delayed injury - p. 601 70. Chapter 48. Intraluminal filament induced middle cerebral artery occlusion model of transient focal cerebral ischemia in rats - p. 613 71. Chapter 49. Modeling subarachnoid hemorrhage in rabbits: Investigating drugs - p. 631 72. Non-human primates models of stroke: Imaging studies in cerebral ischemia in Macaca fascicularis - p. 641 73. Part XV: Resources - p. 653 74. Chapter 51. Recommended resources and online material for investigating neurological disorders and the use of animal models - p. 659 75. Index - p. 667
Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Dedication - p. iii 7. Contributors - p. xxiii 8. Preface - p. xxix 9. Part I: Alzheimer’s disease and dementias - p. xxx 10. Chapter 1. Alzheimer’s disease preliminary screening in zebrafish integrating behavioral models and molecular markers - p. 3 11. Chapter 2. Sporadic Alzheimer’s disease animal model using streptozotocin and APP/PS1 mice - p. 19 12. Chapter 3. Current mouse models of Alzheimer’s disease for investigating therapeutic agents - p. 31 13. Chapter 4. A rat model of pre-clinical Alzheimer’s disease - p. 43 14. Chapter 5. Modeling menopause and dementia in rodents: Investigations on cognition and coordination - p. 57 15. Part II: Amyotrophic lateral sclerosis - p. 63 16. Drosophila model of amyotrophic lateral sclerosis targeting FUS and ubiquilin - p. 67 17. The amyotrophic lateral sclerosis SOD1G93A mouse model and applications: Studies into the P2X7 receptor - p. 81 18. Chapter 8. Modeling amyotrophic lateral sclerosis through Ataxin-2 pathology - p. 95 19. Part III: Brain injury - p. 106 20. Drosophila melanogaster model of traumatic brain injury: Investigating the pharmacodynamics of volatile anesthetics - p. 109 21. Chapter 10. Mouse model of repetitive mild traumatic brain injury (investigating cognitive impairment) - p. 121 22. Chapter 11. Blood–brain barrier damage following mild traumatic brain injury - p. 133 23. Chapter 12. Rodent modeling of neonatal hypoxic–ischemic brain injury - p. 147 24. Chapter 13. Modeling brain injury: Neonatal intraventricular hemorrhage - p. 159 25. Chapter 14. Penetrating traumatic brain injury model in rats: Applications to studying duraplasty following decompressive craniectomy - p. 171 26. Part IV: Cerebral palsy - p. 179 27. Chapter 15. The spa transgenic mouse model of hypertonia and use for studying cerebral palsy - p. 183 28. Chapter 16. Transient occlusion of uterine arteries and intra-amniotic injection of lipopolysaccharide in rats as a model of cerebral palsy - p. 193 29. Chapter 17. Experimental cerebral palsy in animals and developmental plasticity - p. 205 30. Part V: Epilepsy and seizures - p. 214 31. Chapter 18. Second-hit pentylenetetrazole-induced seizure model in zebrafish - p. 217 32. Chapter 19. The zebrafish model of Tuberous sclerosis complex to study epilepsy - p. 235 33. The Brd2+/− mouse model of juvenile myoclonic epilepsy (JME) - p. 241 34. Chapter 21. Modeling the link between traumatic brain injury and epileptiform activity in rats - p. 253 35. Chapter 22. Animal models of infantile spasms: Focus on new treatments - p. 265 36. Part VI: Headaches, migraines and pain - p. 275 37. Chapter 23. Light flash in rats as a model for the triggering of migraine headache - p. 279 38. Chapter 24. Inhibition of diacylglycerol lipase alpha (DAGLα) as a model for episodic headache in rats: Features and applications - p. 293 39. Chapter 25. Animal models of headache - p. 305 40. Chapter 26. Animal models of orofacial pain comorbidity in mice - p. 317 41. Part VII: Meningitis - p. 325 42. Experimental meningitis by Streptococcus pneumoniae and Neisseria meningitidis in rodents - p. 329 43. Chapter 28. The rabbit model: Pathological manifestations of tuberculous meningitis - p. 343 44. Novel Streptococcus suis meningitis model in pigs: Longitudinal assessment of oxygen values, neutrophil function, and DNase activity in the central nervous system - p. 353 45. Part VIII: Multiple sclerosis - p. 365 46. R-Ras1−/− and R-Ras2−/− mice as models for investigating multiple sclerosis - p. 369 47. Chapter 31. Animal models of multiple sclerosis and the lower urinary tract - p. 377 48. Part IX: Neuroinflammation - p. 388 49. Chapter 32. The mouse model of experimental autoimmune encephalomyelitis: Methods to study neuroinflammation in optic neuritis - p. 391 50. Chapter 33. Modeling neurotoxin-induced neuroinflammation with chemotherapy - p. 404 51. Chapter 34. Modeling and investigating neuroinflammation in cardiopulmonary resuscitation in pigs - p. 419 52. Chapter 35. Investigating neuroinflammation in lateral fluid percussion injury - p. 429 53. Part X: Neurotoxins - p. 439 54. Chapter 36. Use of zebrafish embryos to study molecular and cellular neurotoxic effects of drugs: A focus on signaling and ketamine - p. 443 55. Rodent models of anesthesia-induced developmental neurotoxicity☆ - p. 455 56. Part XI: Parkinson’s disease - p. 464 57. Modeling of Parkinson’s disease in Drosophila based on DJ-1 deficiency - p. 476 58. Chapter 39. Drosophila model of Parkinson’s disease using rotenone - p. 484 59. Chapter 40. 6-Hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease: Investigating neural control of cardiorespiratory function - p. 493 60. Chapter 41. The use of the proteasome inhibitor lactacystin for modeling Parkinson’s disease: Early neurophysiological biomarkers and candidates for intranigral and extranigral neuroprotection - p. 507 61. Part XII: Peripheral neuropathy - p. 523 62. Chapter 42. Zebrafish as a model for studying peripheral neuropathy - p. 527 63. Part XIII: Prenatal related injury and neurodevelopmental disorders - p. 538 64. Chapter 43. Prenatal systemic hypoxia-ischemia: A rat model of neurodevelopmental disorders related to prematurity - p. 541 65. Chapter 44. Modeling prenatal stress in rats: Impact on the hippocampus - p. 553 66. Chapter 45. The use of oxcarbazepine during gestation has adverse effects in rats - p. 565 67. Chapter 46. Modeling the effect of anesthesia in pregnancy and impact on the fetal brain: Studies in rabbits - p. 579 68. Part XIV: Stroke - p. 597 69. Chapter 47. Murine subarachnoid hemorrhage: Delayed injury - p. 601 70. Chapter 48. Intraluminal filament induced middle cerebral artery occlusion model of transient focal cerebral ischemia in rats - p. 613 71. Chapter 49. Modeling subarachnoid hemorrhage in rabbits: Investigating drugs - p. 631 72. Non-human primates models of stroke: Imaging studies in cerebral ischemia in Macaca fascicularis - p. 641 73. Part XV: Resources - p. 653 74. Chapter 51. Recommended resources and online material for investigating neurological disorders and the use of animal models - p. 659 75. Index - p. 667
