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Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist.

Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism’s physiology and survival.

  • Presents hormones in groups according to their origin so that readers can easily understand their inter-relation
  • Includes 47 new hormones, such as neuropeptides, cytokines, growth hormones, biogenic amines and amino acids that are important for cell to cell communication via endocrine, paracrine and neurotransmitter signaling
  • Summarizes the current knowledge of hormone evolution based on comparative genome resources, such as synteny, genome sequence and comprehensive phylogeny
  • Covers a wide range of information on hormones, from basic information on structure and function across vertebrate and invertebrate phyla to clinical applications
  • Collates key information on 259 hormones and 47 groups/families

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. iv 5. List of editors - p. v 6. Contents of the companion site - p. xix 7. Contributors - p. xxi 8. Preface to first edition - p. xxv 9. Preface to the second edition - p. xxvii 10. Abbreviations - p. xxix 11. Chapter 1 Evolution and diversity of animals - p. 1 12. Volume 1 - p. 3 13. Part I: Peptides and proteins in vertebrates - p. 3 14. Chapter 2 Molecular evolution of peptide and protein hormones in vertebrates - p. 7 15. Section I.1: Neuropeptides - p. 9 16. Chapter 3 RFamide peptide family - p. 13 17. Subchapter 3A Gonadotropin-inhibitory hormone - p. 17 18. Subchapter 3B Kisspeptin - p. 21 19. Subchapter 3C PQRFamide peptide - p. 25 20. Subchapter 3D Pyroglutamylated RFamide peptide - p. 29 21. Subchapter 3E Prolactin-releasing peptide - p. 33 22. Chapter 4 Corticotropin-releasing hormone family - p. 37 23. Subchapter 4A Corticotropin-releasing hormone - p. 41 24. Subchapter 4B Urotensin I - p. 45 25. Subchapter 4C Urocortins - p. 49 26. Subchapter 4D Sauvagine - p. 53 27. Chapter 5 Gonadotropin-releasing hormone - p. 55 28. Chapter 6 Thyrotropin-releasing hormone - p. 59 29. Chapter 7 Somatostatin - p. 63 30. Chapter 8 Neurohypophysial hormone family - p. 67 31. Subchapter 8A Vasopressin - p. 71 32. Subchapter 8B Vasotocin - p. 75 33. Subchapter 8C Oxytocin - p. 79 34. Subchapter 8D Nonmammalian OT-family peptides - p. 83 35. Chapter 9 Opioid peptide family - p. 87 36. Subchapter 9A Enkephalin - p. 91 37. Subchapter 9B Dynorphin/α-neo-endorphin - p. 95 38. Subchapter 9C Nociceptin/orphanin FQ - p. 99 39. Subchapter 9D Endomorphin - p. 103 40. Subchapter 9E Dermorphin - p. 107 41. Chapter 10 Agouti family - p. 111 42. Subchapter 10A Agouti-signaling protein - p. 113 43. Subchapter 10B Agouti-related protein - p. 115 44. Chapter 11 Tachykinin family - p. 117 45. Subchapter 11A Substance P/neurokinin A - p. 119 46. Subchapter 11B Neurokinin B - p. 123 47. Chapter 12 Appetite-regulating peptides - p. 125 48. Subchapter 12A Melanin-concentrating hormone - p. 129 49. Subchapter 12B Orexin - p. 133 50. Subchapter 12C Cocaine- and amphetamine-regulated transcript - p. 137 51. Chapter 13 Urotensin II - p. 141 52. Chapter 14 Neurotensin - p. 145 53. Chapter 15 Neuromedin U/S - p. 149 54. Chapter 16 Neuropeptide S - p. 153 55. Chapter 17 Neuropeptide W - p. 157 56. Chapter 18 Neuroendocrine regulatory peptides - p. 161 57. Chapter 19 Neurosecretory protein GL/neurosecretory protein GM - p. 165 58. Chapter 20 Nesfatin-1 - p. 169 59. Chapter 21 Mexneurin - p. 173 60. Chapter 22 Phoenixin - p. 175 61. Section I.2: Adenohypophyseal hormones - p. 178 62. Chapter 23 Glycoprotein hormone family - p. 181 63. Subchapter 23A Follicle-stimulating hormone - p. 185 64. Subchapter 23B Luteinizing hormone - p. 189 65. Subchapter 23C Thyroid-stimulating hormone - p. 193 66. Chapter 24 Growth hormone/prolactin family - p. 197 67. Subchapter 24A Growth hormone - p. 199 68. Subchapter 24B Prolactin - p. 203 69. Subchapter 24C Somatolactin - p. 207 70. Chapter 25 Proopiomelanocortin family - p. 211 71. Subchapter 25A Adrenocorticotropic hormone - p. 215 72. Subchapter 25B Melanocyte-stimulating hormone - p. 219 73. Subchapter 25C Endorphin - p. 223 74. Section I.3: Gastrointestinal hormones - p. 225 75. Chapter 26 Glucagon family - p. 229 76. Subchapter 26A Glucagon - p. 231 77. Subchapter 26B Gastric inhibitory peptide - p. 235 78. Subchapter 26C Glucagon-like peptide-1 - p. 239 79. Subchapter 26D Glucagon-like peptide-2 - p. 243 80. Chapter 27 Secretin/pituitary adenylate cyclase-activating polypeptide family - p. 247 81. Subchapter 27A Secretin - p. 251 82. Subchapter 27B Growth hormone-releasing hormone - p. 255 83. Subchapter 27C Pituitary adenylate cyclase-activating polypeptide - p. 259 84. Subchapter 27D Pituitary adenylate cyclase-activating polypeptide-related peptide - p. 263 85. Subchapter 27E Vasoactive intestinal peptide - p. 267 86. Subchapter 27F Peptide histidine isoleucine/methionine - p. 271 87. Chapter 28 Insulin family - p. 275 88. Subchapter 28A Insulin - p. 279 89. Subchapter 28B Insulin-like growth factor-1 - p. 285 90. Subchapter 28C Insulin-like growth factor-2 - p. 289 91. Subchapter 28D Insulin-like growth factor binding proteins - p. 293 92. Subchapter 28E Relaxins - p. 297 93. Chapter 29 Gastrin family - p. 301 94. Subchapter 29A Gastrin - p. 305 95. Subchapter 29B Cholecystokinin - p. 309 96. Subchapter 29C Caerulein - p. 313 97. Chapter 30 Ghrelin-motilin family - p. 317 98. Subchapter 30A Ghrelin - p. 321 99. Subchapter 30B Motilin - p. 325 100. Chapter 31 Bombesin-like peptide family - p. 329 101. Subchapter 31A Gastrin-releasing peptide - p. 333 102. Subchapter 31B Neuromedin B - p. 337 103. Chapter 32 Guanylin family - p. 341 104. Subchapter 32A Guanylin - p. 345 105. Subchapter 32B Uroguanylin - p. 349 106. Chapter 33 Galanin peptide family - p. 353 107. Subchapter 33A Galanin - p. 355 108. Subchapter 33B Galanin-like peptide - p. 359 109. Subchapter 33C Alarin - p. 361 110. Chapter 34 Neuropeptide Y family - p. 363 111. Subchapter 34A Pancreatic polypeptide - p. 367 112. Subchapter 34B Neuropeptide Y - p. 371 113. Subchapter 34C Peptide YY - p. 375 114. Chapter 35 Xenin - p. 379 115. Section I.4: Parathyroid gland, ultimobranchial gland and stannius corpuscle hormones - p. 381 116. Chapter 36 Parathyroid hormone family - p. 385 117. Subchapter 36A Parathyroid hormone - p. 389 118. Subchapter 36B Parathyroid hormone-related protein - p. 393 119. Subchapter 36C Tuberoinfundibular peptide of 39 amino acids - p. 397 120. Chapter 37 Calcitonin/calcitonin gene-related peptide family - p. 401 121. Subchapter 37A Calcitonin - p. 405 122. Subchapter 37B Calcitonin gene-related peptide - p. 409 123. Subchapter 37C Calcitonin receptor-stimulating peptide - p. 413 124. Subchapter 37D Adrenomedullin - p. 417 125. Subchapter 37E Adrenomedullin 2 and 5 - p. 421 126. Subchapter 37F Amylin - p. 425 127. Chapter 38 Stanniocalcin - p. 429 128. Section I.5: Cytokines - p. 432 129. Chapter 39 Immunological modulators - p. 435 130. Subchapter 39A Interleukins - p. 437 131. Subchapter 39B Tumor necrosis factor - p. 441 132. Subchapter 39C Interferons - p. 447 133. Chapter 40 Hematopoietic growth factors - p. 453 134. Subchapter 40A Erythropoietin - p. 457 135. Subchapter 40B Thrombopoietin - p. 461 136. Subchapter 40C Granulocyte colony-stimulating factor - p. 467 137. Chapter 41 Neurotrophin family - p. 471 138. Subchapter 41A Nerve growth factor - p. 475 139. Subchapter 41B Brain-derived neurotrophic factor - p. 479 140. Subchapter 41C Neurotrophin-3 - p. 483 141. Section I.6: Other peripheral hormones - p. 485 142. Chapter 42 Renin-angiotensin system - p. 489 143. Subchapter 42A Renin - p. 493 144. Subchapter 42B Angiotensin II - p. 497 145. Subchapter 42C Other angiotensins - p. 501 146. Subchapter 42D Angiotensin converting enzyme - p. 505 147. Chapter 43 Kallikrein-kinin system - p. 509 148. Subchapter 43A Kininogen - p. 513 149. Subchapter 43B Kallikrein - p. 517 150. Subchapter 43C Bradykinin - p. 521 151. Chapter 44 Apelin - p. 525 152. Chapter 45 Elabela - p. 529 153. Chapter 46 Natriuretic peptide family - p. 533 154. Subchapter 46A Atrial natriuretic peptide - p. 537 155. Subchapter 46B B-type natriuretic peptide - p. 541 156. Subchapter 46C C-type natriuretic peptides - p. 545 157. Subchapter 46D Ventricular natriuretic peptide - p. 549 158. Chapter 47 Gonadal hormones - p. 553 159. Subchapter 47A Inhibin - p. 555 160. Subchapter 47B Activin - p. 559 161. Subchapter 47C Follistatin - p. 563 162. Subchapter 47D Anti-Müllerian hormone - p. 567 163. Chapter 48 Adipocyte hormones - p. 571 164. Subchapter 48A Leptin - p. 573 165. Subchapter 48B Adiponectin - p. 577 166. Subchapter 48C Acylation stimulating protein - p. 581 167. Subchapter 48D Resistin - p. 585 168. Chapter 49 Endothelins - p. 589 169. Chapter 50 Irisin - p. 593 170. Chapter 51 Osteopontin - p. 597 171. Chapter 52 Osteocrin - p. 601 172. Chapter 53 Hepcidin antimicrobial peptide - p. 605 173. Chapter 54 Adropin - p. 609 174. Chapter 55 Lipocalin-2 - p. 613 175. Volume 2 - p. 615 176. Part II: Peptides and proteins in invertebrates - p. 615 177. Chapter 56 Molecular evolution of peptide and protein hormones in invertebrates - p. 619 178. Section II-1: Neuropeptides related to vertebrate hormones - p. 621 179. Chapter 57 Gonadotropin-releasing hormone-like peptide family - p. 625 180. Subchapter 57A Protochordate gonadotropin-releasing hormone - p. 627 181. Subchapter 57B Molluscan gonadotropin-releasing hormone - p. 631 182. Subchapter 57C Echinoderm gonadotropin-releasing hormone - p. 635 183. Chapter 58 Corticotropin-releasing factor-like peptide - p. 637 184. Chapter 59 Oxytocin/vasopressin superfamily - p. 639 185. Subchapter 59A Lys-conopressin - p. 643 186. Subchapter 59B Cephalotocin/octopressin - p. 645 187. Subchapter 59C Annetocin - p. 647 188. Subchapter 59D Inotocin - p. 649 189. Subchapter 59E Nematocin - p. 653 190. Subchapter 59F Ci vasopressin - p. 655 191. Chapter 60 Neuropeptide F - p. 657 192. Chapter 61 Short neuropeptide F - p. 659 193. Chapter 62 RYamide - p. 661 194. Chapter 63 Invertebrate tachykinin-like peptide family - p. 663 195. Subchapter 63A Protochordata tachykinin - p. 665 196. Subchapter 63B Invertebrate tachykinin-related peptide family - p. 667 197. Chapter 64 Insulin superfamily - p. 669 198. Subchapter 64A Insect insulin-like peptides - p. 673 199. Subchapter 64B Insect insulin-like growth factor-like peptides - p. 677 200. Subchapter 64C Molluscan insulin-related peptides - p. 681 201. Subchapter 64D Androgenic gland hormone - p. 685 202. Subchapter 64E Relaxin-like gonad-stimulating peptide - p. 689 203. Chapter 65 Sulfakinin - p. 693 204. Chapter 66 Cionin: Ciona intestinalis cholecystokinin - p. 695 205. Chapter 67 Ci-galanin-like peptide - p. 697 206. Chapter 68 Allatostatin-C - p. 699 207. Chapter 69 Allatostatin-CC - p. 703 208. Chapter 70 Allatostatin-CCC - p. 705 209. Chapter 71 Calcitonin-like diuretic peptide - p. 707 210. Chapter 72 Ciona intestinalis calcitonin - p. 709 211. Chapter 73 Amphioxus calcitonin family peptide - p. 711 212. Chapter 74 Echinoderm calcitonin-type peptide - p. 713 213. Section II-2: Invertebrate-unique peptides - p. 714 214. Subsection II-2.1: Regulation of development and metabolism - p. 714 215. Chapter 75 FXPRLamide peptide family - p. 717 216. Subchapter 75A Diapause hormone - p. 721 217. Subchapter 75B Pheromone biosynthesis activating neuropeptide - p. 725 218. Subchapter 75C Pyrokinin - p. 729 219. Chapter 76 Crustacean hyperglycemic hormone - p. 731 220. Chapter 77 Ion transport peptide - p. 735 221. Chapter 78 Prothoracicotropic hormone - p. 739 222. Chapter 79 Bursicon - p. 743 223. Chapter 80 Allatotropin - p. 747 224. Chapter 81 Allatostatin-A - p. 751 225. Chapter 82 Adipokinetic hormone - p. 755 226. Chapter 83 Adipokinetic hormone/corazonin-related peptide - p. 759 227. Chapter 84 Neuroparsin - p. 761 228. Chapter 85 Ovary maturating parsin - p. 765 229. Subsection II-2.2: Regulation of myo/cardio-activities - p. 766 230. Chapter 86 LF peptides - p. 769 231. Subchapter 86A Head activator - p. 771 232. Subchapter 86B Hym-323 - p. 773 233. Subchapter 86C Ciona LF peptide - p. 777 234. Chapter 87 Invertebrate kinins - p. 779 235. Chapter 88 FMRFamides - p. 781 236. Chapter 89 Myoinhibiting peptide - p. 783 237. Chapter 90 Myosuppressin - p. 785 238. Chapter 91 Proctolin - p. 789 239. Chapter 92 Orcokinins - p. 791 240. Chapter 93 Crustacean cardioactive peptide - p. 795 241. Chapter 94 Cardioacceleratory peptide 2b/CAPA - p. 799 242. Chapter 95 Achatina cardio-excitatory peptide-1 - p. 801 243. Chapter 96 Fulicins - p. 805 244. Chapter 97 Buccalins - p. 809 245. Chapter 98 Eisenia inhibitory pentapeptides - p. 815 246. Chapter 99 GGNG peptides - p. 819 247. Subsection II-2.3: Regulation of behaviors - p. 821 248. Chapter 100 Eclosion hormone - p. 825 249. Chapter 101 Ecdysis triggering hormone - p. 829 250. Chapter 102 Sex peptide - p. 833 251. Chapter 103 APWGamide - p. 837 252. Chapter 104 SIFamide - p. 839 253. Chapter 105 Egg-laying hormone - p. 841 254. Subsection II-2.4: Other hormones and neuropeptides - p. 847 255. Chapter 106 Growth blocking peptide - p. 851 256. Chapter 107 CCHamide - p. 855 257. Chapter 108 Corazonin - p. 857 258. Chapter 109 Pigment dispersing hormone - p. 861 259. Chapter 110 GLWamide - p. 863 260. Chapter 111 Hym-176 - p. 867 261. Chapter 112 Hym-301 - p. 869 262. Chapter 113 Leech osmoregulatory factor - p. 871 263. Chapter 114 Ciona YFV/L peptide - p. 873 264. Chapter 115 CNMamide - p. 875 265. Chapter 116 Natalisin - p. 877 266. Chapter 117 Elevenin - p. 879 267. Chapter 118 Glycoprotein hormone subunit A2/B5 - p. 880 268. Chapter 119 Trissin - p. 883 269. Chapter 120 EFLamide - p. 885 270. Part III: Lipophilic hormones in vertebrates - p. 886 271. Chapter 121 Thyroid hormones - p. 889 272. Subchapter 121A 3,3′,5-Triiodothyronine - p. 891 273. Subchapter 121B Thyroxine - p. 895 274. Subchapter 121C Thyronamines - p. 899 275. Chapter 122 Gonadal steroids - p. 903 276. Subchapter 122A Progesterone - p. 907 277. Subchapter 122B 17,20β-Dihydroxy-4-pregnen-3-one - p. 911 278. Subchapter 122C 17,20β,21-Trihydroxy-4-pregnen-3-one - p. 913 279. Subchapter 122D Dehydroepiandrosterone - p. 915 280. Subchapter 122E Testosterone/dihydrotestosterone - p. 917 281. Subchapter 122F 11-Ketotestosterone - p. 921 282. Subchapter 122G Estradiol-17β - p. 923 283. Subchapter 122H Estrone - p. 927 284. Chapter 123 Corticosteroids - p. 931 285. Subchapter 123A Corticosterone - p. 935 286. Subchapter 123B 18-Hydroxycorticosterone - p. 939 287. Subchapter 123C 1α-Hydroxycorticosterone - p. 943 288. Subchapter 123D Cortisol - p. 947 289. Subchapter 123E Aldosterone - p. 951 290. Chapter 124 Neurosteroids - p. 955 291. Subchapter 124A Pregnenolone sulfate - p. 959 292. Subchapter 124B 7α-Hydroxypregnenolone - p. 961 293. Subchapter 124C Allopregnanolone - p. 963 294. Chapter 125 Vitamin D derivatives - p. 967 295. Subchapter 125A Calcitriol - p. 971 296. Subchapter 125B Cholecalciferol - p. 975 297. Part IV: Lipophilic hormones in invertebrates - p. 977 298. Chapter 126 Ecdysteroid - p. 981 299. Subchapter 126A 20-Hydroxyecdysone - p. 983 300. Chapter 127 Juvenile hormone - p. 987 301. Chapter 128 Methyl farnesoate - p. 991 302. Part V: Endocrine disrupting chemicals - p. 992 303. Chapter 129 Endocrine disruptors - p. 995 304. Subchapter 129A Nonylphenol - p. 999 305. Subchapter 129B Octylphenol - p. 1001 306. Subchapter 129C Bisphenol A - p. 1003 307. Subchapter 129D Dichlorodiphenyltrichloroethane - p. 1005 308. Subchapter 129E 17α-Ethinylestradiol - p. 1007 309. Subchapter 129F Equilin - p. 1009 310. Subchapter 129G 2,3,7,8-Tetrachlorodibenzo-p-dioxin/polychlorinated biphenyls - p. 1011 311. Subchapter 129H 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene - p. 1015 312. Subchapter 129I Vinclozolin - p. 1017 313. Subchapter 129J Polybrominated diphenyl ether - p. 1019 314. Chapter 130 Antithyroid hormone active chemicals - p. 1021 315. Subchapter 130A Tetrabromobisphenol A - p. 1025 316. Subchapter 130B Perchlorate - p. 1029 317. Part VI: Amines and amino acids - p. 1031 318. Chapter 131 Amines - p. 1035 319. Subchapter 131A Dopamine - p. 1037 320. Subchapter 131B Noradrenaline/adrenaline - p. 1041 321. Subchapter 131C Octopamine - p. 1045 322. Subchapter 131D Serotonin - p. 1049 323. Subchapter 131E Melatonin - p. 1053 324. Subchapter 131F Histamine - p. 1057 325. Chapter 132 Amino acids - p. 1061 326. Subchapter 132A Glutamic acid - p. 1063 327. Subchapter 132B γ-Aminobutyric acid - p. 1067 328. Subchapter 132C Glycine - p. 1071 329. Chapter 133 Acetylcholine - p. 1075 330. Part VII: Gasotransmitters - p. 1077 331. Chapter 134 Gasotransmitter family - p. 1081 332. Subchapter 134A Nitric oxide - p. 1083 333. Subchapter 134B Carbon monoxide - p. 1087 334. Subchapter 134C Hydrogen sulfide - p. 1091 335. Index - p. 1095

Descripcion
Descripción

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist.

Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism’s physiology and survival.

  • Presents hormones in groups according to their origin so that readers can easily understand their inter-relation
  • Includes 47 new hormones, such as neuropeptides, cytokines, growth hormones, biogenic amines and amino acids that are important for cell to cell communication via endocrine, paracrine and neurotransmitter signaling
  • Summarizes the current knowledge of hormone evolution based on comparative genome resources, such as synteny, genome sequence and comprehensive phylogeny
  • Covers a wide range of information on hormones, from basic information on structure and function across vertebrate and invertebrate phyla to clinical applications
  • Collates key information on 259 hormones and 47 groups/families

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. iv 5. List of editors - p. v 6. Contents of the companion site - p. xix 7. Contributors - p. xxi 8. Preface to first edition - p. xxv 9. Preface to the second edition - p. xxvii 10. Abbreviations - p. xxix 11. Chapter 1 Evolution and diversity of animals - p. 1 12. Volume 1 - p. 3 13. Part I: Peptides and proteins in vertebrates - p. 3 14. Chapter 2 Molecular evolution of peptide and protein hormones in vertebrates - p. 7 15. Section I.1: Neuropeptides - p. 9 16. Chapter 3 RFamide peptide family - p. 13 17. Subchapter 3A Gonadotropin-inhibitory hormone - p. 17 18. Subchapter 3B Kisspeptin - p. 21 19. Subchapter 3C PQRFamide peptide - p. 25 20. Subchapter 3D Pyroglutamylated RFamide peptide - p. 29 21. Subchapter 3E Prolactin-releasing peptide - p. 33 22. Chapter 4 Corticotropin-releasing hormone family - p. 37 23. Subchapter 4A Corticotropin-releasing hormone - p. 41 24. Subchapter 4B Urotensin I - p. 45 25. Subchapter 4C Urocortins - p. 49 26. Subchapter 4D Sauvagine - p. 53 27. Chapter 5 Gonadotropin-releasing hormone - p. 55 28. Chapter 6 Thyrotropin-releasing hormone - p. 59 29. Chapter 7 Somatostatin - p. 63 30. Chapter 8 Neurohypophysial hormone family - p. 67 31. Subchapter 8A Vasopressin - p. 71 32. Subchapter 8B Vasotocin - p. 75 33. Subchapter 8C Oxytocin - p. 79 34. Subchapter 8D Nonmammalian OT-family peptides - p. 83 35. Chapter 9 Opioid peptide family - p. 87 36. Subchapter 9A Enkephalin - p. 91 37. Subchapter 9B Dynorphin/α-neo-endorphin - p. 95 38. Subchapter 9C Nociceptin/orphanin FQ - p. 99 39. Subchapter 9D Endomorphin - p. 103 40. Subchapter 9E Dermorphin - p. 107 41. Chapter 10 Agouti family - p. 111 42. Subchapter 10A Agouti-signaling protein - p. 113 43. Subchapter 10B Agouti-related protein - p. 115 44. Chapter 11 Tachykinin family - p. 117 45. Subchapter 11A Substance P/neurokinin A - p. 119 46. Subchapter 11B Neurokinin B - p. 123 47. Chapter 12 Appetite-regulating peptides - p. 125 48. Subchapter 12A Melanin-concentrating hormone - p. 129 49. Subchapter 12B Orexin - p. 133 50. Subchapter 12C Cocaine- and amphetamine-regulated transcript - p. 137 51. Chapter 13 Urotensin II - p. 141 52. Chapter 14 Neurotensin - p. 145 53. Chapter 15 Neuromedin U/S - p. 149 54. Chapter 16 Neuropeptide S - p. 153 55. Chapter 17 Neuropeptide W - p. 157 56. Chapter 18 Neuroendocrine regulatory peptides - p. 161 57. Chapter 19 Neurosecretory protein GL/neurosecretory protein GM - p. 165 58. Chapter 20 Nesfatin-1 - p. 169 59. Chapter 21 Mexneurin - p. 173 60. Chapter 22 Phoenixin - p. 175 61. Section I.2: Adenohypophyseal hormones - p. 178 62. Chapter 23 Glycoprotein hormone family - p. 181 63. Subchapter 23A Follicle-stimulating hormone - p. 185 64. Subchapter 23B Luteinizing hormone - p. 189 65. Subchapter 23C Thyroid-stimulating hormone - p. 193 66. Chapter 24 Growth hormone/prolactin family - p. 197 67. Subchapter 24A Growth hormone - p. 199 68. Subchapter 24B Prolactin - p. 203 69. Subchapter 24C Somatolactin - p. 207 70. Chapter 25 Proopiomelanocortin family - p. 211 71. Subchapter 25A Adrenocorticotropic hormone - p. 215 72. Subchapter 25B Melanocyte-stimulating hormone - p. 219 73. Subchapter 25C Endorphin - p. 223 74. Section I.3: Gastrointestinal hormones - p. 225 75. Chapter 26 Glucagon family - p. 229 76. Subchapter 26A Glucagon - p. 231 77. Subchapter 26B Gastric inhibitory peptide - p. 235 78. Subchapter 26C Glucagon-like peptide-1 - p. 239 79. Subchapter 26D Glucagon-like peptide-2 - p. 243 80. Chapter 27 Secretin/pituitary adenylate cyclase-activating polypeptide family - p. 247 81. Subchapter 27A Secretin - p. 251 82. Subchapter 27B Growth hormone-releasing hormone - p. 255 83. Subchapter 27C Pituitary adenylate cyclase-activating polypeptide - p. 259 84. Subchapter 27D Pituitary adenylate cyclase-activating polypeptide-related peptide - p. 263 85. Subchapter 27E Vasoactive intestinal peptide - p. 267 86. Subchapter 27F Peptide histidine isoleucine/methionine - p. 271 87. Chapter 28 Insulin family - p. 275 88. Subchapter 28A Insulin - p. 279 89. Subchapter 28B Insulin-like growth factor-1 - p. 285 90. Subchapter 28C Insulin-like growth factor-2 - p. 289 91. Subchapter 28D Insulin-like growth factor binding proteins - p. 293 92. Subchapter 28E Relaxins - p. 297 93. Chapter 29 Gastrin family - p. 301 94. Subchapter 29A Gastrin - p. 305 95. Subchapter 29B Cholecystokinin - p. 309 96. Subchapter 29C Caerulein - p. 313 97. Chapter 30 Ghrelin-motilin family - p. 317 98. Subchapter 30A Ghrelin - p. 321 99. Subchapter 30B Motilin - p. 325 100. Chapter 31 Bombesin-like peptide family - p. 329 101. Subchapter 31A Gastrin-releasing peptide - p. 333 102. Subchapter 31B Neuromedin B - p. 337 103. Chapter 32 Guanylin family - p. 341 104. Subchapter 32A Guanylin - p. 345 105. Subchapter 32B Uroguanylin - p. 349 106. Chapter 33 Galanin peptide family - p. 353 107. Subchapter 33A Galanin - p. 355 108. Subchapter 33B Galanin-like peptide - p. 359 109. Subchapter 33C Alarin - p. 361 110. Chapter 34 Neuropeptide Y family - p. 363 111. Subchapter 34A Pancreatic polypeptide - p. 367 112. Subchapter 34B Neuropeptide Y - p. 371 113. Subchapter 34C Peptide YY - p. 375 114. Chapter 35 Xenin - p. 379 115. Section I.4: Parathyroid gland, ultimobranchial gland and stannius corpuscle hormones - p. 381 116. Chapter 36 Parathyroid hormone family - p. 385 117. Subchapter 36A Parathyroid hormone - p. 389 118. Subchapter 36B Parathyroid hormone-related protein - p. 393 119. Subchapter 36C Tuberoinfundibular peptide of 39 amino acids - p. 397 120. Chapter 37 Calcitonin/calcitonin gene-related peptide family - p. 401 121. Subchapter 37A Calcitonin - p. 405 122. Subchapter 37B Calcitonin gene-related peptide - p. 409 123. Subchapter 37C Calcitonin receptor-stimulating peptide - p. 413 124. Subchapter 37D Adrenomedullin - p. 417 125. Subchapter 37E Adrenomedullin 2 and 5 - p. 421 126. Subchapter 37F Amylin - p. 425 127. Chapter 38 Stanniocalcin - p. 429 128. Section I.5: Cytokines - p. 432 129. Chapter 39 Immunological modulators - p. 435 130. Subchapter 39A Interleukins - p. 437 131. Subchapter 39B Tumor necrosis factor - p. 441 132. Subchapter 39C Interferons - p. 447 133. Chapter 40 Hematopoietic growth factors - p. 453 134. Subchapter 40A Erythropoietin - p. 457 135. Subchapter 40B Thrombopoietin - p. 461 136. Subchapter 40C Granulocyte colony-stimulating factor - p. 467 137. Chapter 41 Neurotrophin family - p. 471 138. Subchapter 41A Nerve growth factor - p. 475 139. Subchapter 41B Brain-derived neurotrophic factor - p. 479 140. Subchapter 41C Neurotrophin-3 - p. 483 141. Section I.6: Other peripheral hormones - p. 485 142. Chapter 42 Renin-angiotensin system - p. 489 143. Subchapter 42A Renin - p. 493 144. Subchapter 42B Angiotensin II - p. 497 145. Subchapter 42C Other angiotensins - p. 501 146. Subchapter 42D Angiotensin converting enzyme - p. 505 147. Chapter 43 Kallikrein-kinin system - p. 509 148. Subchapter 43A Kininogen - p. 513 149. Subchapter 43B Kallikrein - p. 517 150. Subchapter 43C Bradykinin - p. 521 151. Chapter 44 Apelin - p. 525 152. Chapter 45 Elabela - p. 529 153. Chapter 46 Natriuretic peptide family - p. 533 154. Subchapter 46A Atrial natriuretic peptide - p. 537 155. Subchapter 46B B-type natriuretic peptide - p. 541 156. Subchapter 46C C-type natriuretic peptides - p. 545 157. Subchapter 46D Ventricular natriuretic peptide - p. 549 158. Chapter 47 Gonadal hormones - p. 553 159. Subchapter 47A Inhibin - p. 555 160. Subchapter 47B Activin - p. 559 161. Subchapter 47C Follistatin - p. 563 162. Subchapter 47D Anti-Müllerian hormone - p. 567 163. Chapter 48 Adipocyte hormones - p. 571 164. Subchapter 48A Leptin - p. 573 165. Subchapter 48B Adiponectin - p. 577 166. Subchapter 48C Acylation stimulating protein - p. 581 167. Subchapter 48D Resistin - p. 585 168. Chapter 49 Endothelins - p. 589 169. Chapter 50 Irisin - p. 593 170. Chapter 51 Osteopontin - p. 597 171. Chapter 52 Osteocrin - p. 601 172. Chapter 53 Hepcidin antimicrobial peptide - p. 605 173. Chapter 54 Adropin - p. 609 174. Chapter 55 Lipocalin-2 - p. 613 175. Volume 2 - p. 615 176. Part II: Peptides and proteins in invertebrates - p. 615 177. Chapter 56 Molecular evolution of peptide and protein hormones in invertebrates - p. 619 178. Section II-1: Neuropeptides related to vertebrate hormones - p. 621 179. Chapter 57 Gonadotropin-releasing hormone-like peptide family - p. 625 180. Subchapter 57A Protochordate gonadotropin-releasing hormone - p. 627 181. Subchapter 57B Molluscan gonadotropin-releasing hormone - p. 631 182. Subchapter 57C Echinoderm gonadotropin-releasing hormone - p. 635 183. Chapter 58 Corticotropin-releasing factor-like peptide - p. 637 184. Chapter 59 Oxytocin/vasopressin superfamily - p. 639 185. Subchapter 59A Lys-conopressin - p. 643 186. Subchapter 59B Cephalotocin/octopressin - p. 645 187. Subchapter 59C Annetocin - p. 647 188. Subchapter 59D Inotocin - p. 649 189. Subchapter 59E Nematocin - p. 653 190. Subchapter 59F Ci vasopressin - p. 655 191. Chapter 60 Neuropeptide F - p. 657 192. Chapter 61 Short neuropeptide F - p. 659 193. Chapter 62 RYamide - p. 661 194. Chapter 63 Invertebrate tachykinin-like peptide family - p. 663 195. Subchapter 63A Protochordata tachykinin - p. 665 196. Subchapter 63B Invertebrate tachykinin-related peptide family - p. 667 197. Chapter 64 Insulin superfamily - p. 669 198. Subchapter 64A Insect insulin-like peptides - p. 673 199. Subchapter 64B Insect insulin-like growth factor-like peptides - p. 677 200. Subchapter 64C Molluscan insulin-related peptides - p. 681 201. Subchapter 64D Androgenic gland hormone - p. 685 202. Subchapter 64E Relaxin-like gonad-stimulating peptide - p. 689 203. Chapter 65 Sulfakinin - p. 693 204. Chapter 66 Cionin: Ciona intestinalis cholecystokinin - p. 695 205. Chapter 67 Ci-galanin-like peptide - p. 697 206. Chapter 68 Allatostatin-C - p. 699 207. Chapter 69 Allatostatin-CC - p. 703 208. Chapter 70 Allatostatin-CCC - p. 705 209. Chapter 71 Calcitonin-like diuretic peptide - p. 707 210. Chapter 72 Ciona intestinalis calcitonin - p. 709 211. Chapter 73 Amphioxus calcitonin family peptide - p. 711 212. Chapter 74 Echinoderm calcitonin-type peptide - p. 713 213. Section II-2: Invertebrate-unique peptides - p. 714 214. Subsection II-2.1: Regulation of development and metabolism - p. 714 215. Chapter 75 FXPRLamide peptide family - p. 717 216. Subchapter 75A Diapause hormone - p. 721 217. Subchapter 75B Pheromone biosynthesis activating neuropeptide - p. 725 218. Subchapter 75C Pyrokinin - p. 729 219. Chapter 76 Crustacean hyperglycemic hormone - p. 731 220. Chapter 77 Ion transport peptide - p. 735 221. Chapter 78 Prothoracicotropic hormone - p. 739 222. Chapter 79 Bursicon - p. 743 223. Chapter 80 Allatotropin - p. 747 224. Chapter 81 Allatostatin-A - p. 751 225. Chapter 82 Adipokinetic hormone - p. 755 226. Chapter 83 Adipokinetic hormone/corazonin-related peptide - p. 759 227. Chapter 84 Neuroparsin - p. 761 228. Chapter 85 Ovary maturating parsin - p. 765 229. Subsection II-2.2: Regulation of myo/cardio-activities - p. 766 230. Chapter 86 LF peptides - p. 769 231. Subchapter 86A Head activator - p. 771 232. Subchapter 86B Hym-323 - p. 773 233. Subchapter 86C Ciona LF peptide - p. 777 234. Chapter 87 Invertebrate kinins - p. 779 235. Chapter 88 FMRFamides - p. 781 236. Chapter 89 Myoinhibiting peptide - p. 783 237. Chapter 90 Myosuppressin - p. 785 238. Chapter 91 Proctolin - p. 789 239. Chapter 92 Orcokinins - p. 791 240. Chapter 93 Crustacean cardioactive peptide - p. 795 241. Chapter 94 Cardioacceleratory peptide 2b/CAPA - p. 799 242. Chapter 95 Achatina cardio-excitatory peptide-1 - p. 801 243. Chapter 96 Fulicins - p. 805 244. Chapter 97 Buccalins - p. 809 245. Chapter 98 Eisenia inhibitory pentapeptides - p. 815 246. Chapter 99 GGNG peptides - p. 819 247. Subsection II-2.3: Regulation of behaviors - p. 821 248. Chapter 100 Eclosion hormone - p. 825 249. Chapter 101 Ecdysis triggering hormone - p. 829 250. Chapter 102 Sex peptide - p. 833 251. Chapter 103 APWGamide - p. 837 252. Chapter 104 SIFamide - p. 839 253. Chapter 105 Egg-laying hormone - p. 841 254. Subsection II-2.4: Other hormones and neuropeptides - p. 847 255. Chapter 106 Growth blocking peptide - p. 851 256. Chapter 107 CCHamide - p. 855 257. Chapter 108 Corazonin - p. 857 258. Chapter 109 Pigment dispersing hormone - p. 861 259. Chapter 110 GLWamide - p. 863 260. Chapter 111 Hym-176 - p. 867 261. Chapter 112 Hym-301 - p. 869 262. Chapter 113 Leech osmoregulatory factor - p. 871 263. Chapter 114 Ciona YFV/L peptide - p. 873 264. Chapter 115 CNMamide - p. 875 265. Chapter 116 Natalisin - p. 877 266. Chapter 117 Elevenin - p. 879 267. Chapter 118 Glycoprotein hormone subunit A2/B5 - p. 880 268. Chapter 119 Trissin - p. 883 269. Chapter 120 EFLamide - p. 885 270. Part III: Lipophilic hormones in vertebrates - p. 886 271. Chapter 121 Thyroid hormones - p. 889 272. Subchapter 121A 3,3′,5-Triiodothyronine - p. 891 273. Subchapter 121B Thyroxine - p. 895 274. Subchapter 121C Thyronamines - p. 899 275. Chapter 122 Gonadal steroids - p. 903 276. Subchapter 122A Progesterone - p. 907 277. Subchapter 122B 17,20β-Dihydroxy-4-pregnen-3-one - p. 911 278. Subchapter 122C 17,20β,21-Trihydroxy-4-pregnen-3-one - p. 913 279. Subchapter 122D Dehydroepiandrosterone - p. 915 280. Subchapter 122E Testosterone/dihydrotestosterone - p. 917 281. Subchapter 122F 11-Ketotestosterone - p. 921 282. Subchapter 122G Estradiol-17β - p. 923 283. Subchapter 122H Estrone - p. 927 284. Chapter 123 Corticosteroids - p. 931 285. Subchapter 123A Corticosterone - p. 935 286. Subchapter 123B 18-Hydroxycorticosterone - p. 939 287. Subchapter 123C 1α-Hydroxycorticosterone - p. 943 288. Subchapter 123D Cortisol - p. 947 289. Subchapter 123E Aldosterone - p. 951 290. Chapter 124 Neurosteroids - p. 955 291. Subchapter 124A Pregnenolone sulfate - p. 959 292. Subchapter 124B 7α-Hydroxypregnenolone - p. 961 293. Subchapter 124C Allopregnanolone - p. 963 294. Chapter 125 Vitamin D derivatives - p. 967 295. Subchapter 125A Calcitriol - p. 971 296. Subchapter 125B Cholecalciferol - p. 975 297. Part IV: Lipophilic hormones in invertebrates - p. 977 298. Chapter 126 Ecdysteroid - p. 981 299. Subchapter 126A 20-Hydroxyecdysone - p. 983 300. Chapter 127 Juvenile hormone - p. 987 301. Chapter 128 Methyl farnesoate - p. 991 302. Part V: Endocrine disrupting chemicals - p. 992 303. Chapter 129 Endocrine disruptors - p. 995 304. Subchapter 129A Nonylphenol - p. 999 305. Subchapter 129B Octylphenol - p. 1001 306. Subchapter 129C Bisphenol A - p. 1003 307. Subchapter 129D Dichlorodiphenyltrichloroethane - p. 1005 308. Subchapter 129E 17α-Ethinylestradiol - p. 1007 309. Subchapter 129F Equilin - p. 1009 310. Subchapter 129G 2,3,7,8-Tetrachlorodibenzo-p-dioxin/polychlorinated biphenyls - p. 1011 311. Subchapter 129H 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene - p. 1015 312. Subchapter 129I Vinclozolin - p. 1017 313. Subchapter 129J Polybrominated diphenyl ether - p. 1019 314. Chapter 130 Antithyroid hormone active chemicals - p. 1021 315. Subchapter 130A Tetrabromobisphenol A - p. 1025 316. Subchapter 130B Perchlorate - p. 1029 317. Part VI: Amines and amino acids - p. 1031 318. Chapter 131 Amines - p. 1035 319. Subchapter 131A Dopamine - p. 1037 320. Subchapter 131B Noradrenaline/adrenaline - p. 1041 321. Subchapter 131C Octopamine - p. 1045 322. Subchapter 131D Serotonin - p. 1049 323. Subchapter 131E Melatonin - p. 1053 324. Subchapter 131F Histamine - p. 1057 325. Chapter 132 Amino acids - p. 1061 326. Subchapter 132A Glutamic acid - p. 1063 327. Subchapter 132B γ-Aminobutyric acid - p. 1067 328. Subchapter 132C Glycine - p. 1071 329. Chapter 133 Acetylcholine - p. 1075 330. Part VII: Gasotransmitters - p. 1077 331. Chapter 134 Gasotransmitter family - p. 1081 332. Subchapter 134A Nitric oxide - p. 1083 333. Subchapter 134B Carbon monoxide - p. 1087 334. Subchapter 134C Hydrogen sulfide - p. 1091 335. Index - p. 1095

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