Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xiii 6. Preface: Sleep Research in the 21st Century—Advances and Challenges - p. xvii 7. Part A: Brain Activity During Sleep and Waking - p. xvii 8. Chapter 1: Neuronal Activity During the Sleep-Wake Cycle - p. xvii 9. Chapter 2: Timing and Topography of Sleep Onset: Asynchronies and Regional Changes of Brain Activity - p. 17 10. Chapter 3: Local Patterns of Sleep and Wakefulness - p. 31 11. Chapter 4: Hippocampal Information Processing and Homeostatic Regulation During REM and Non-REM Sleep - p. 47 12. Part B: Regulation Of Waking And Sleeping - p. 62 13. Chapter 5: The Circuit, Cellular, and Synaptic Bases of Sleep-Wake Regulation - p. 62 14. Chapter 6: Hypocretin and the Regulation of Sleep-Wake Transitions - p. 88 15. Chapter 7: Serotonergic Systems in Sleep and Waking - p. 99 16. Chapter 8: Adenosinergic Control of Sleep/Wake Behavior - p. 123 17. Chapter 9: NREM Sleep Regulation From Neuronal Assembly to Ion - p. 136 18. Chapter 10: Neurobiological Mechanism of Non-REM Sleep - p. 159 19. Chapter 11: The Genetic Regulation of Human Sleep-Wake Rhythms and Patterns - p. 168 20. Chapter 12: Genes and Ion Channels in the Circadian and Homeostatic Regulation of Sleep - p. 180 21. Chapter 13: The Role of Glia in Sleep-Wake Regulation and Function - p. 193 22. Chapter 14: Interactions Between Sleep and Breathing - p. 204 23. Chapter 15: Neurobiological Parallels, Overlaps, and Divergences of Sleep and Anesthesia - p. 221 24. Part C: Rem Sleep And Dreaming - p. 236 25. Chapter 16: Neuroanatomical and Neurochemical Systems Involved in Paradoxical Sleep (PS) Generation - p. 236 26. Chapter 17: Functions and Circuits of REM Sleep - p. 248 27. Chapter 18: Structural and Functional Differences in Brain Mechanisms of Dream Recall - p. 267 28. Chapter 19: Consciousness and Meta-Consciousness During Sleep - p. 281 29. Part D: Evolution, Cross-Cultural and Comparative Approaches, and Novel Model Systems - p. 295 30. Chapter 20: Evolution of Sleep and Adaptive Sleeplessness - p. 295 31. Chapter 21: Hunter-Gatherer Sleep and Novel Human Sleep Adaptations - p. 316 32. Chapter 22: Sleep in Drosophila - p. 331 33. Chapter 23: Sleep, Immunity, and Stress: Novel Insights From Drosophila - p. 347 34. Chapter 24: Sleep in Fish Models - p. 362 35. Chapter 25: Sleep in Aquatic Mammals - p. 374 36. Chapter 26: The Role of Sleep in Song Learning Processes in Songbird - p. 393 37. Part E: Sleep, Plasticity, and Memory - p. 410 38. Chapter 27: Sleep and Brain Development - p. 410 39. Chapter 28: Sleep and Plasticity - p. 424 40. Chapter 29: Sleep-Wake and Cortical Synaptic Plasticity - p. 442 41. Chapter 30: Sleep Stages and Neural Oscillations: A Window into Sleep's Role in Memory Consolidation and Cognitive Abilities - p. 454 42. Chapter 31: Cued Memory Reactivation: A Tool to Manipulate Memory Consolidation During Sleep - p. 470 43. Chapter 32: Sleep and Memory Consolidation: Conceptual and Methodological Challenges - p. 488 44. Part F: Sleep, Emotion, and Motivation - p. 501 45. Chapter 33: The Role of Sleep in Processing Emotional Information - p. 501 46. Chapter 34: Sleep, Emotional Memories, and Depression - p. 518 47. Chapter 35: Motivational Processes in the Regulation of Sleep/Wake States - p. 531 48. Part G: Disturbed Sleep - p. 541 49. Chapter 36: The Effects of Sleep Loss on Brain Functioning - p. 541 50. Chapter 37: Physiological and Neurobehavioral Consequences of Chronic Sleep Restriction in Rodent Models - p. 556 51. Chapter 38: Imaging of the Sleep-Disordered Brain - p. 567 52. Chapter 39: Sleep Impact on Perception, Memory, and Emotion in Adults and the Effects of Early-Life Experience - p. 591 53. Chapter 40: Sleep and Driving - p. 610 54. Chapter 41: Drug Discovery and Emerging Treatments for Sleep Disorders - p. 622 55. Chapter 42: Insomnia Pharmacotherapies: Pharmacodynamics, Strategies, New Directions, and Key Measures in Clinical Trials - p. 637 56. Part H: Sleep In Aging and Disease - p. 648 57. Chapter 43: Sleep and Aging: Circadian Influences - p. 648 58. Chapter 44: Sleep, Physical Activity, and Cognitive Health in Older Adults - p. 664 59. Chapter 45: Sleep in Normal Aging, Alzheimer's Disease, and Mild Cognitive Impairment - p. 676 60. Chapter 46: Sleep in Major Depression - p. 692 61. Chapter 47: Closing the Loop Between Circadian Rhythms, Sleep, and Attention Deficit Hyperactivity Disorder - p. 706 62. Chapter 48: Dissecting Brain Circuitry for Sleep Disorder Narcolepsy in Murine Models - p. 716 63. Chapter 49: Rapid Eye Movement Sleep Behavior Disorder: Pathological Neural Circuits and Association with Parkinson's Disease - p. 722 64. Index - p. 731
Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xiii 6. Preface: Sleep Research in the 21st Century—Advances and Challenges - p. xvii 7. Part A: Brain Activity During Sleep and Waking - p. xvii 8. Chapter 1: Neuronal Activity During the Sleep-Wake Cycle - p. xvii 9. Chapter 2: Timing and Topography of Sleep Onset: Asynchronies and Regional Changes of Brain Activity - p. 17 10. Chapter 3: Local Patterns of Sleep and Wakefulness - p. 31 11. Chapter 4: Hippocampal Information Processing and Homeostatic Regulation During REM and Non-REM Sleep - p. 47 12. Part B: Regulation Of Waking And Sleeping - p. 62 13. Chapter 5: The Circuit, Cellular, and Synaptic Bases of Sleep-Wake Regulation - p. 62 14. Chapter 6: Hypocretin and the Regulation of Sleep-Wake Transitions - p. 88 15. Chapter 7: Serotonergic Systems in Sleep and Waking - p. 99 16. Chapter 8: Adenosinergic Control of Sleep/Wake Behavior - p. 123 17. Chapter 9: NREM Sleep Regulation From Neuronal Assembly to Ion - p. 136 18. Chapter 10: Neurobiological Mechanism of Non-REM Sleep - p. 159 19. Chapter 11: The Genetic Regulation of Human Sleep-Wake Rhythms and Patterns - p. 168 20. Chapter 12: Genes and Ion Channels in the Circadian and Homeostatic Regulation of Sleep - p. 180 21. Chapter 13: The Role of Glia in Sleep-Wake Regulation and Function - p. 193 22. Chapter 14: Interactions Between Sleep and Breathing - p. 204 23. Chapter 15: Neurobiological Parallels, Overlaps, and Divergences of Sleep and Anesthesia - p. 221 24. Part C: Rem Sleep And Dreaming - p. 236 25. Chapter 16: Neuroanatomical and Neurochemical Systems Involved in Paradoxical Sleep (PS) Generation - p. 236 26. Chapter 17: Functions and Circuits of REM Sleep - p. 248 27. Chapter 18: Structural and Functional Differences in Brain Mechanisms of Dream Recall - p. 267 28. Chapter 19: Consciousness and Meta-Consciousness During Sleep - p. 281 29. Part D: Evolution, Cross-Cultural and Comparative Approaches, and Novel Model Systems - p. 295 30. Chapter 20: Evolution of Sleep and Adaptive Sleeplessness - p. 295 31. Chapter 21: Hunter-Gatherer Sleep and Novel Human Sleep Adaptations - p. 316 32. Chapter 22: Sleep in Drosophila - p. 331 33. Chapter 23: Sleep, Immunity, and Stress: Novel Insights From Drosophila - p. 347 34. Chapter 24: Sleep in Fish Models - p. 362 35. Chapter 25: Sleep in Aquatic Mammals - p. 374 36. Chapter 26: The Role of Sleep in Song Learning Processes in Songbird - p. 393 37. Part E: Sleep, Plasticity, and Memory - p. 410 38. Chapter 27: Sleep and Brain Development - p. 410 39. Chapter 28: Sleep and Plasticity - p. 424 40. Chapter 29: Sleep-Wake and Cortical Synaptic Plasticity - p. 442 41. Chapter 30: Sleep Stages and Neural Oscillations: A Window into Sleep's Role in Memory Consolidation and Cognitive Abilities - p. 454 42. Chapter 31: Cued Memory Reactivation: A Tool to Manipulate Memory Consolidation During Sleep - p. 470 43. Chapter 32: Sleep and Memory Consolidation: Conceptual and Methodological Challenges - p. 488 44. Part F: Sleep, Emotion, and Motivation - p. 501 45. Chapter 33: The Role of Sleep in Processing Emotional Information - p. 501 46. Chapter 34: Sleep, Emotional Memories, and Depression - p. 518 47. Chapter 35: Motivational Processes in the Regulation of Sleep/Wake States - p. 531 48. Part G: Disturbed Sleep - p. 541 49. Chapter 36: The Effects of Sleep Loss on Brain Functioning - p. 541 50. Chapter 37: Physiological and Neurobehavioral Consequences of Chronic Sleep Restriction in Rodent Models - p. 556 51. Chapter 38: Imaging of the Sleep-Disordered Brain - p. 567 52. Chapter 39: Sleep Impact on Perception, Memory, and Emotion in Adults and the Effects of Early-Life Experience - p. 591 53. Chapter 40: Sleep and Driving - p. 610 54. Chapter 41: Drug Discovery and Emerging Treatments for Sleep Disorders - p. 622 55. Chapter 42: Insomnia Pharmacotherapies: Pharmacodynamics, Strategies, New Directions, and Key Measures in Clinical Trials - p. 637 56. Part H: Sleep In Aging and Disease - p. 648 57. Chapter 43: Sleep and Aging: Circadian Influences - p. 648 58. Chapter 44: Sleep, Physical Activity, and Cognitive Health in Older Adults - p. 664 59. Chapter 45: Sleep in Normal Aging, Alzheimer's Disease, and Mild Cognitive Impairment - p. 676 60. Chapter 46: Sleep in Major Depression - p. 692 61. Chapter 47: Closing the Loop Between Circadian Rhythms, Sleep, and Attention Deficit Hyperactivity Disorder - p. 706 62. Chapter 48: Dissecting Brain Circuitry for Sleep Disorder Narcolepsy in Murine Models - p. 716 63. Chapter 49: Rapid Eye Movement Sleep Behavior Disorder: Pathological Neural Circuits and Association with Parkinson's Disease - p. 722 64. Index - p. 731
