Handbook of Synthetic Organic Chemistry, Second Edition updates and expands the author’s popular 2007 work, Synthetic Organic Chemist’s Companion. This new handbook provides valuable, practical guidance; incorporates corrections, and includes coverage on important topics, such as lyophylization, crystallization, precipitation, HPLC detectors, gases, and microwave reactions.
The book maintains the useful organization of the author’s earlier work, beginning with a basic overview and walking through every practical step of the process of organic synthesis, from reagents, solvents, and temperature control, to documentation, implementation, purification, and analytical methods for the product.
From planning and setting up reactions, to recording them, the book provides insight and valuable guidance into every step of the process.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Foreword - p. ix 6. Preface to the First Edition - p. xi 7. Preface to the Second Edition - p. xiii 8. Acknowledgments - p. xv 9. 1. Safety - p. 1 10. 2. Searching the Literature - p. 7 11. 3. Reagents - p. 17 12. 4. Gases - p. 29 13. 5. Reactions on a Small Scale—1–25mmol - p. 35 14. 6. Temperature Control - p. 55 15. 7. Solvents - p. 65 16. 8. The Research Notebook - p. 77 17. 9. Conducting the Reaction Itself - p. 83 18. 10. Following the Reaction - p. 111 19. 11. Working Up Reactions - p. 127 20. 12. Evaporation - p. 139 21. 13. Vacuum Systems - p. 143 22. 14. Purification of Products - p. 151 23. 15. Methods for Structure Elucidation - p. 165 24. 16. Cleaning Up After the Reaction - p. 181 25. 17. Specific Example - p. 185 26. 18. Strategies for Reaction Optimization - p. 187 27. Appendix 1. Safety Protocols - p. 191 28. Appendix 2. Synthetic Solvent Selection Chart - p. 233 29. Appendix 3. Solvent Miscibility - p. 235 30. Appendix 4. Freezing Points of Common Organic Solvents - p. 237 31. Appendix 5. Toxicities of Common Organic Solvents - p. 239 32. Appendix 6. Recipes for TLC Stains - p. 243 33. Appendix 7. NMR Spectral Data of Common Contaminants of Organic and Organometallic Reaction Products - p. 245 34. Appendix 8. Acidities of Organic Functional Groups - p. 259 35. Appendix 9. Acidities of Organic Functional Groups in DMSO - p. 261 36. Appendix 10. Stuck Joints - p. 263 37. Index - p. 265
Handbook of Synthetic Organic Chemistry, Second Edition updates and expands the author’s popular 2007 work, Synthetic Organic Chemist’s Companion. This new handbook provides valuable, practical guidance; incorporates corrections, and includes coverage on important topics, such as lyophylization, crystallization, precipitation, HPLC detectors, gases, and microwave reactions.
The book maintains the useful organization of the author’s earlier work, beginning with a basic overview and walking through every practical step of the process of organic synthesis, from reagents, solvents, and temperature control, to documentation, implementation, purification, and analytical methods for the product.
From planning and setting up reactions, to recording them, the book provides insight and valuable guidance into every step of the process.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Foreword - p. ix 6. Preface to the First Edition - p. xi 7. Preface to the Second Edition - p. xiii 8. Acknowledgments - p. xv 9. 1. Safety - p. 1 10. 2. Searching the Literature - p. 7 11. 3. Reagents - p. 17 12. 4. Gases - p. 29 13. 5. Reactions on a Small Scale—1–25mmol - p. 35 14. 6. Temperature Control - p. 55 15. 7. Solvents - p. 65 16. 8. The Research Notebook - p. 77 17. 9. Conducting the Reaction Itself - p. 83 18. 10. Following the Reaction - p. 111 19. 11. Working Up Reactions - p. 127 20. 12. Evaporation - p. 139 21. 13. Vacuum Systems - p. 143 22. 14. Purification of Products - p. 151 23. 15. Methods for Structure Elucidation - p. 165 24. 16. Cleaning Up After the Reaction - p. 181 25. 17. Specific Example - p. 185 26. 18. Strategies for Reaction Optimization - p. 187 27. Appendix 1. Safety Protocols - p. 191 28. Appendix 2. Synthetic Solvent Selection Chart - p. 233 29. Appendix 3. Solvent Miscibility - p. 235 30. Appendix 4. Freezing Points of Common Organic Solvents - p. 237 31. Appendix 5. Toxicities of Common Organic Solvents - p. 239 32. Appendix 6. Recipes for TLC Stains - p. 243 33. Appendix 7. NMR Spectral Data of Common Contaminants of Organic and Organometallic Reaction Products - p. 245 34. Appendix 8. Acidities of Organic Functional Groups - p. 259 35. Appendix 9. Acidities of Organic Functional Groups in DMSO - p. 261 36. Appendix 10. Stuck Joints - p. 263 37. Index - p. 265
