Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters.
Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.
1. Chapter 1. Toxicologic Pathology: An Introduction - p. 1 2. Part 1: Principles of Toxicologic Pathology - p. 12 3. Chapter 2. Biochemical and Molecular Basis of Toxicity - p. 15 4. Chapter 3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective - p. 51 5. Chapter 4. Biotherapeutics ADME and PK/PD Principles - p. 77 6. Chapter 5. Principles of Pharmacodynamics and Toxicodynamics - p. 101 7. Chapter 6. Morphologic Manifestations of Toxic Cell Injury - p. 113 8. Chapter 7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity - p. 149 9. Chapter 8. Carcinogenesis: Mechanisms and Evaluation - p. 205 10. Part 2: Methods in Toxicologic Pathology - p. 254 11. Chapter 9. Basic Approaches in Anatomic Toxicologic Pathology - p. 257 12. Chapter 10. Clinical Pathology in Nonclinical Toxicity Testing - p. 295 13. Chapter 11. Special Techniques in Toxicologic Pathology - p. 335 14. Chapter 12. Digital Pathology and Tissue Image Analysis - p. 395 15. Chapter 13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models - p. 423 16. Chapter 14. Biomarkers: Discovery, Qualification, and Application - p. 459 17. Chapter 15. Toxicogenomics: A Primer for Toxicologic Pathologists - p. 491 18. Chapter 16. Experimental Design and Statistical Analysis for Toxicologic Pathologists - p. 545 19. Abstract - p. 545 20. 1 Introduction - p. 546 21. 2 Considerations Made Before Designing the Experiment - p. 553 22. 3 Experimental Design - p. 555 23. 4 Designs Commonly Used in Toxicologic Pathology - p. 562 24. 5 Functions of Statistical Analyses - p. 565 25. 6 Prerequisites to Statistical Analysis - p. 568 26. 7 Statistical Methods - p. 582 27. 8 Interpretation of Results - p. 629 28. 9 Data Analysis Applications in Toxicologic Pathology - p. 632 29. 10 Assumptions of Statistical Tests - p. 638 30. 11 Summary and Conclusions - p. 638 31. Glossary - p. 639 32. References - p. 648 33. Part 3: Animal and Alternative Models in Toxicologic Research - p. 649 34. Chapter 17. Animal Models in Toxicologic Research: Rodents - p. 653 35. Chapter 18. Animal Models in Toxicologic Research: Rabbit - p. 695 36. Chapter 19. Animal Models in Toxicologic Research: Dog - p. 721 37. Chapter 20. Animal Models in Toxicologic Research: Pig - p. 751 38. Chapter 21. Animal Models in Toxicologic Research: Nonhuman Primate - p. 777 39. Chapter 22. Animal Models in Toxicologic Research: Nonmammalian - p. 811 40. Chapter 23. Genetically Engineered Animal Models in Toxicologic Research - p. 859 41. Chapter 24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Nontraditional In Vivo Approaches - p. 925 42. Part 4: Practice of Toxicologic Pathology - p. 966 43. Chapter 25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology - p. 969 44. Chapter 26. Pathology Peer Review - p. 987 45. Chapter 27. Pathology and GLPs, Quality Control, and Quality Assurance - p. 1009 46. Chapter 28. Practices to Optimize Generation, Interpretation, and Reporting of Pathology Data from Toxicity Studies - p. 1029 47. Chapter 29. Issues in Laboratory Animal Science That Impact Toxicologic Pathology - p. 1077 48. Index - p. 1107
Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters.
Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.
1. Chapter 1. Toxicologic Pathology: An Introduction - p. 1 2. Part 1: Principles of Toxicologic Pathology - p. 12 3. Chapter 2. Biochemical and Molecular Basis of Toxicity - p. 15 4. Chapter 3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective - p. 51 5. Chapter 4. Biotherapeutics ADME and PK/PD Principles - p. 77 6. Chapter 5. Principles of Pharmacodynamics and Toxicodynamics - p. 101 7. Chapter 6. Morphologic Manifestations of Toxic Cell Injury - p. 113 8. Chapter 7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity - p. 149 9. Chapter 8. Carcinogenesis: Mechanisms and Evaluation - p. 205 10. Part 2: Methods in Toxicologic Pathology - p. 254 11. Chapter 9. Basic Approaches in Anatomic Toxicologic Pathology - p. 257 12. Chapter 10. Clinical Pathology in Nonclinical Toxicity Testing - p. 295 13. Chapter 11. Special Techniques in Toxicologic Pathology - p. 335 14. Chapter 12. Digital Pathology and Tissue Image Analysis - p. 395 15. Chapter 13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models - p. 423 16. Chapter 14. Biomarkers: Discovery, Qualification, and Application - p. 459 17. Chapter 15. Toxicogenomics: A Primer for Toxicologic Pathologists - p. 491 18. Chapter 16. Experimental Design and Statistical Analysis for Toxicologic Pathologists - p. 545 19. Abstract - p. 545 20. 1 Introduction - p. 546 21. 2 Considerations Made Before Designing the Experiment - p. 553 22. 3 Experimental Design - p. 555 23. 4 Designs Commonly Used in Toxicologic Pathology - p. 562 24. 5 Functions of Statistical Analyses - p. 565 25. 6 Prerequisites to Statistical Analysis - p. 568 26. 7 Statistical Methods - p. 582 27. 8 Interpretation of Results - p. 629 28. 9 Data Analysis Applications in Toxicologic Pathology - p. 632 29. 10 Assumptions of Statistical Tests - p. 638 30. 11 Summary and Conclusions - p. 638 31. Glossary - p. 639 32. References - p. 648 33. Part 3: Animal and Alternative Models in Toxicologic Research - p. 649 34. Chapter 17. Animal Models in Toxicologic Research: Rodents - p. 653 35. Chapter 18. Animal Models in Toxicologic Research: Rabbit - p. 695 36. Chapter 19. Animal Models in Toxicologic Research: Dog - p. 721 37. Chapter 20. Animal Models in Toxicologic Research: Pig - p. 751 38. Chapter 21. Animal Models in Toxicologic Research: Nonhuman Primate - p. 777 39. Chapter 22. Animal Models in Toxicologic Research: Nonmammalian - p. 811 40. Chapter 23. Genetically Engineered Animal Models in Toxicologic Research - p. 859 41. Chapter 24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Nontraditional In Vivo Approaches - p. 925 42. Part 4: Practice of Toxicologic Pathology - p. 966 43. Chapter 25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology - p. 969 44. Chapter 26. Pathology Peer Review - p. 987 45. Chapter 27. Pathology and GLPs, Quality Control, and Quality Assurance - p. 1009 46. Chapter 28. Practices to Optimize Generation, Interpretation, and Reporting of Pathology Data from Toxicity Studies - p. 1029 47. Chapter 29. Issues in Laboratory Animal Science That Impact Toxicologic Pathology - p. 1077 48. Index - p. 1107
