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Helicobacter pylori (H. pylori) infection is a worldwide disease with a significant morbidity and mortality; it is the leading cause of non-ulcer dyspepsia, peptic ulcers and gastric tumors, including low-grade mucosa-associated lymphoid tissue-lymphoma and adenocarcinoma. In addition, it has also been recognized that the interaction between H. pylori and non-steroidal, anti-inflammatory drugs is damaging to the gastroduodenal mucosa. H. pylori treatment still remains a challenge for physicians, since no current first-line therapy is able to cure the infection in all treated patients. This issue will serve to update gastroenterologists on current therapies, evaluation and management of disease progression, and the future of management of H. pylori infection.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright Page - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 6 7. Foreword: Helicobacter pylori - p. 7 8. Preface: Helicobacter pylori: New Thoughts and Practices - p. 8 9. Diagnosis of Helicobacter pylori Infection in the Proton Pump Inhibitor Era - p. 9 10. Practical Aspects in Choosing a Helicobacter pylori Therapy - p. 17 11. How to Effectively Use Bismuth Quadruple Therapy - p. 26 12. Is There a Role for Probiotics in Helicobacter pylori Therapy? - p. 40 13. Molecular Approaches to Identify Helicobacter pylori Antimicrobial Resistance - p. 47 14. When Is Endoscopic Follow-up Appropriate After Helicobacter pylori Eradication Therapy? - p. 58 15. Gastric Cancer Risk in Patients with Helicobacter pylori Infection and Following Its Eradication - p. 65 16. Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer - p. 74 17. Helicobacter pylori Eradication to Eliminate Gastric Cancer - p. 83 18. Treatment Strategy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma - p. 88 19. Rationale for a Helicobacter pylori Test and Treatment Strategy in Gastroesophageal Reflux Disease - p. 95 20. Screening to Identify and Eradicate Helicobacter pylori Infection in Teenagers in Japan - p. 98 21. Current Status and Prospects for a Helicobacter pylori Vaccine - p. 103 22. Index - p. 112

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Helicobacter pylori (H. pylori) infection is a worldwide disease with a significant morbidity and mortality; it is the leading cause of non-ulcer dyspepsia, peptic ulcers and gastric tumors, including low-grade mucosa-associated lymphoid tissue-lymphoma and adenocarcinoma. In addition, it has also been recognized that the interaction between H. pylori and non-steroidal, anti-inflammatory drugs is damaging to the gastroduodenal mucosa. H. pylori treatment still remains a challenge for physicians, since no current first-line therapy is able to cure the infection in all treated patients. This issue will serve to update gastroenterologists on current therapies, evaluation and management of disease progression, and the future of management of H. pylori infection.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright Page - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 6 7. Foreword: Helicobacter pylori - p. 7 8. Preface: Helicobacter pylori: New Thoughts and Practices - p. 8 9. Diagnosis of Helicobacter pylori Infection in the Proton Pump Inhibitor Era - p. 9 10. Practical Aspects in Choosing a Helicobacter pylori Therapy - p. 17 11. How to Effectively Use Bismuth Quadruple Therapy - p. 26 12. Is There a Role for Probiotics in Helicobacter pylori Therapy? - p. 40 13. Molecular Approaches to Identify Helicobacter pylori Antimicrobial Resistance - p. 47 14. When Is Endoscopic Follow-up Appropriate After Helicobacter pylori Eradication Therapy? - p. 58 15. Gastric Cancer Risk in Patients with Helicobacter pylori Infection and Following Its Eradication - p. 65 16. Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer - p. 74 17. Helicobacter pylori Eradication to Eliminate Gastric Cancer - p. 83 18. Treatment Strategy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma - p. 88 19. Rationale for a Helicobacter pylori Test and Treatment Strategy in Gastroesophageal Reflux Disease - p. 95 20. Screening to Identify and Eradicate Helicobacter pylori Infection in Teenagers in Japan - p. 98 21. Current Status and Prospects for a Helicobacter pylori Vaccine - p. 103 22. Index - p. 112

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