Histone Deacetylases in Neurodegenerative Disease, Part A, Volume 733 in the Methods in Enzymology series, highlights new advances, with this volume presenting chapters on topics such as HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress, Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticity, Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis, Histone Deacetylase 6 modulates Tau structure and function, Histone Acetylation in Parkinson Disease, DNA methylation and histone modification in hypoxic conditions, The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cells, Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimer's disease, and much more.
Additional chapters explore Sirtunins in mitochondrial physiology and energy homeostasis, Sirtunins in metabolic homeostasis, Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4, Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channel, Histone deacetylase as a potential therapeutic target for memory disorders, Histone deacetylases in Neurodegeneration, Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer’s Disease, Histone deacetylases in Neurodegeneration and neuronal plasticity, and more.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. iii 6. Copyright - p. iv 7. Contributors - p. xvii 8. Chapter One: Experimental strategies for evaluating the impact of HDACs and HDAC inhibitors on the epigenome. ChiP-seq - p. 1 9. Chapter Two: Methods for the kinetic analysis of time-dependent HDAC6 inhibitors - p. 17 10. Chapter Three: Synthesis and functional characterisation of small molecule activator of p300/CBP lysine acetyltransferase activity: Implications in spinal injury repair - p. 33 11. Chapter Four: Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis - p. 55 12. Chapter Five: Zinc-finger ubiquitin-binding domain of histone deacetylase 6 modulates Tau structure and function - p. 81 13. Chapter Six: Sirtuins in mitochondrial physiology and energy homeostasis - p. 111 14. Chapter Seven: DNA methylation and histone modifications in tumor hypoxia - p. 143 15. Chapter Eight: Epigenetic modulators as therapeutics for neurodegenerative disorders/Alzheimer’s disease - p. 163 16. Chapter Nine: Integrated SDH, COX histochemistry, and MHC fibre typing in skeletal muscles: Methods and interpretation - p. 223 17. Chapter Ten: Analysis of copper toxicity by western blotting of secretory proteins translocated via the Sec61 channel - p. 253 18. Chapter Eleven: Histone deacetylase as a potential therapeutic target for memory dysfunction during aging and neurodegenerative disorders - p. 279 19. Chapter Twelve: Synergetic inhibition of deubiquitinases and acetyltransferases to regulate tau acetylation and aggregation in SH-SY5Y cell line model of Alzheimer’s disease - p. 297 20. Chapter Thirteen: Histone deacetylases in neurodegeneration and neuronal plasticity - p. 321 21. Chapter Fourteen: ChIPmentation-based mapping of histone modifications in aging: Experimental design and analytical considerations - p. 367 22. Chapter Fifteen: Histone Decatylase 6 and Tau-induced microglial chemotaxis by trans-well migration and wound-scratch assay - p. 385 23. Chapter Sixteen: Experimental techniques to evaluate IA-MSCs–mediated alleviation of vasogenic edema following ischemic stroke - p. 407
Histone Deacetylases in Neurodegenerative Disease, Part A, Volume 733 in the Methods in Enzymology series, highlights new advances, with this volume presenting chapters on topics such as HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress, Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticity, Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis, Histone Deacetylase 6 modulates Tau structure and function, Histone Acetylation in Parkinson Disease, DNA methylation and histone modification in hypoxic conditions, The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cells, Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimer's disease, and much more.
Additional chapters explore Sirtunins in mitochondrial physiology and energy homeostasis, Sirtunins in metabolic homeostasis, Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4, Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channel, Histone deacetylase as a potential therapeutic target for memory disorders, Histone deacetylases in Neurodegeneration, Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer’s Disease, Histone deacetylases in Neurodegeneration and neuronal plasticity, and more.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. iii 6. Copyright - p. iv 7. Contributors - p. xvii 8. Chapter One: Experimental strategies for evaluating the impact of HDACs and HDAC inhibitors on the epigenome. ChiP-seq - p. 1 9. Chapter Two: Methods for the kinetic analysis of time-dependent HDAC6 inhibitors - p. 17 10. Chapter Three: Synthesis and functional characterisation of small molecule activator of p300/CBP lysine acetyltransferase activity: Implications in spinal injury repair - p. 33 11. Chapter Four: Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis - p. 55 12. Chapter Five: Zinc-finger ubiquitin-binding domain of histone deacetylase 6 modulates Tau structure and function - p. 81 13. Chapter Six: Sirtuins in mitochondrial physiology and energy homeostasis - p. 111 14. Chapter Seven: DNA methylation and histone modifications in tumor hypoxia - p. 143 15. Chapter Eight: Epigenetic modulators as therapeutics for neurodegenerative disorders/Alzheimer’s disease - p. 163 16. Chapter Nine: Integrated SDH, COX histochemistry, and MHC fibre typing in skeletal muscles: Methods and interpretation - p. 223 17. Chapter Ten: Analysis of copper toxicity by western blotting of secretory proteins translocated via the Sec61 channel - p. 253 18. Chapter Eleven: Histone deacetylase as a potential therapeutic target for memory dysfunction during aging and neurodegenerative disorders - p. 279 19. Chapter Twelve: Synergetic inhibition of deubiquitinases and acetyltransferases to regulate tau acetylation and aggregation in SH-SY5Y cell line model of Alzheimer’s disease - p. 297 20. Chapter Thirteen: Histone deacetylases in neurodegeneration and neuronal plasticity - p. 321 21. Chapter Fourteen: ChIPmentation-based mapping of histone modifications in aging: Experimental design and analytical considerations - p. 367 22. Chapter Fifteen: Histone Decatylase 6 and Tau-induced microglial chemotaxis by trans-well migration and wound-scratch assay - p. 385 23. Chapter Sixteen: Experimental techniques to evaluate IA-MSCs–mediated alleviation of vasogenic edema following ischemic stroke - p. 407
