MRI with hyperpolarized carbon-13 agents is a powerful emerging imaging modality that can measure real-time metabolism in cells, animals, and humans. It uses endogenous, non-toxic contrast agents that a hyperpolarized, resulting in up to 100,000-fold increases in sensitivity. This technique uses no ionizing radiation, and is being applied in a range of human trials. It’s primary use is for metabolic imaging, but it can also measure perfusion, pH, and necrosis.
Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy is designed to be a one stop shop for understanding hyperpolarized 13C MRI. This book explains the principles of this imaging modality, the requirements for performing studies, shows how to interpret the results, and gives an overview of current biomedical applications. It is suitable for engineers, scientists and clinicians in radiology and biomedical imaging who want to understand this technology.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Series list - p. iii 6. Contributors - p. iii 7. Preface - p. xiii 8. 1: The physics of dissolution Dynamic Nuclear Polarization - p. 1 9. 2: Hardware for preparing HP 13C-molecules: from polarizer to patient - p. 29 10. 3: HP acquisition methods: pulse sequences, reconstruction, and RF coils - p. 49 11. 4: HP experimental methods: cells and animals - p. 75 12. 5: HP agents and biochemical interactions - p. 93 13. 6: Analysis and visualization of hyperpolarized 13C MR data - p. 129 14. 7: Integration into cancer studies - p. 157 15. 8: Neurological applications of hyperpolarized 13C MR - p. 187 16. 9: Hyperpolarized MR in cardiology: probing the heart of life - p. 217 17. 10: Integration of Hyperpolarized 13C MRI into Liver Studies - p. 257 18. Index - p. 270
MRI with hyperpolarized carbon-13 agents is a powerful emerging imaging modality that can measure real-time metabolism in cells, animals, and humans. It uses endogenous, non-toxic contrast agents that a hyperpolarized, resulting in up to 100,000-fold increases in sensitivity. This technique uses no ionizing radiation, and is being applied in a range of human trials. It’s primary use is for metabolic imaging, but it can also measure perfusion, pH, and necrosis.
Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy is designed to be a one stop shop for understanding hyperpolarized 13C MRI. This book explains the principles of this imaging modality, the requirements for performing studies, shows how to interpret the results, and gives an overview of current biomedical applications. It is suitable for engineers, scientists and clinicians in radiology and biomedical imaging who want to understand this technology.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Series list - p. iii 6. Contributors - p. iii 7. Preface - p. xiii 8. 1: The physics of dissolution Dynamic Nuclear Polarization - p. 1 9. 2: Hardware for preparing HP 13C-molecules: from polarizer to patient - p. 29 10. 3: HP acquisition methods: pulse sequences, reconstruction, and RF coils - p. 49 11. 4: HP experimental methods: cells and animals - p. 75 12. 5: HP agents and biochemical interactions - p. 93 13. 6: Analysis and visualization of hyperpolarized 13C MR data - p. 129 14. 7: Integration into cancer studies - p. 157 15. 8: Neurological applications of hyperpolarized 13C MR - p. 187 16. 9: Hyperpolarized MR in cardiology: probing the heart of life - p. 217 17. 10: Integration of Hyperpolarized 13C MRI into Liver Studies - p. 257 18. Index - p. 270
