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The relationship between testosterone and prostate cancer physiology resulted in a Nobel Prize almost 5 decades ago; scientists have been studying testosterone and its relationship to heart health, diabetes, bone density, and muscle development throughout the subsequent 50 years. Included in this issue is the clinical experience and research expertise of many of the leaders in this field.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. CME Accreditation Page - p. 5 6. Contributors - p. 6 7. Forthcoming Issues - p. 9 8. Foreword: Hypogonadism - p. 10 9. Preface: Hypogonadism - p. 11 10. Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male - p. 12 11. Hypogonadism - p. 21 12. Assays of Serum Testosterone - p. 31 13. Testosterone Therapies - p. 38 14. Testosterone and Male Infertility - p. 44 15. Testosterone Deficiency and the Prostate - p. 51 16. Testosterone Therapy and Prostate Cancer - p. 56 17. Testosterone and Sexual Function - p. 63 18. Testosterone and Varicocele - p. 68 19. Testosterone Deficiency and Sleep Apnea - p. 76 20. Obesity and Hypogonadism - p. 80 21. Management of Hypogonadism in Cardiovascular Patients - p. 86 22. Trends in Testosterone Prescription and Public Health Concerns - p. 93 23. Index - p. 102

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The relationship between testosterone and prostate cancer physiology resulted in a Nobel Prize almost 5 decades ago; scientists have been studying testosterone and its relationship to heart health, diabetes, bone density, and muscle development throughout the subsequent 50 years. Included in this issue is the clinical experience and research expertise of many of the leaders in this field.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. CME Accreditation Page - p. 5 6. Contributors - p. 6 7. Forthcoming Issues - p. 9 8. Foreword: Hypogonadism - p. 10 9. Preface: Hypogonadism - p. 11 10. Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male - p. 12 11. Hypogonadism - p. 21 12. Assays of Serum Testosterone - p. 31 13. Testosterone Therapies - p. 38 14. Testosterone and Male Infertility - p. 44 15. Testosterone Deficiency and the Prostate - p. 51 16. Testosterone Therapy and Prostate Cancer - p. 56 17. Testosterone and Sexual Function - p. 63 18. Testosterone and Varicocele - p. 68 19. Testosterone Deficiency and Sleep Apnea - p. 76 20. Obesity and Hypogonadism - p. 80 21. Management of Hypogonadism in Cardiovascular Patients - p. 86 22. Trends in Testosterone Prescription and Public Health Concerns - p. 93 23. Index - p. 102

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