Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future.
Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.
These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.
1. Cover image 2. Title page 3. Table of Contents 4. Copyright 5. Contributors 6. Foreword 7. Abbreviations 8. CH 1. Overview of the immune biology of allogeneic hematopoietic stem cell transplantation 9. CH 2. The HLA system in hematopoietic stem cell transplantation 10. CH 3. The impact of minor histocompatibility antigens in allogeneic stem cell transplantation 11. CH 4. In vivo imaging of graft-versus-host disease and graft-versus-leukemia 12. CH 5. Immune rejection: the immune biology of allogeneic hematopoietic stem cell transplantation (from mice to humans) 13. CH 6. Strategies to improve post-transplant immunity 14. CH 7. Tumor-associated antigens 15. CH 8. Impact of the conditioning regimen 16. CH 9. Antigen presentation and antigen-presenting cells in graft-versus-host disease 17. CH 10. T-cell costimulation in graft-versus-host disease and graft-versus-leukemia effect 18. CH 11. Th1/Th2 and Tc1/Tc2 cells: biology, experimental models and clinical translation 19. CH 12. Natural CD4+CD25+FOXP3+ regulatory T cells in graft-versus-host disease 20. CH 13. Role of Th17 cells and interleukin 17 in graft-versus-host disease and graft-versus-leukemia reactivity 21. CH 14. B and T cells in chronic graft-versus-host disease and graft-versus-leukemia 22. CH 15. Natural killer cells in graft-versus-host disease and graft-versus-leukemia 23. CH 16. Cytokines in graft-versus-host disease and graft-versus-leukemia 24. CH 17. Chemokines and graft-versus-host disease 25. CH 18. Intracellular sensors of immunity and allogeneic hematopoietic stem cell transplantation 26. CH 19. Proteomics in graft-versus-host disease and graft-versus-leukemia 27. CH 20. The endothelium in graft-versus-host disease and graft-versus-leukemia 28. CH 21. Looking toward the future: an individualized approach to allogeneic transplantation 29. Index
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future.
Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.
These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.
1. Cover image 2. Title page 3. Table of Contents 4. Copyright 5. Contributors 6. Foreword 7. Abbreviations 8. CH 1. Overview of the immune biology of allogeneic hematopoietic stem cell transplantation 9. CH 2. The HLA system in hematopoietic stem cell transplantation 10. CH 3. The impact of minor histocompatibility antigens in allogeneic stem cell transplantation 11. CH 4. In vivo imaging of graft-versus-host disease and graft-versus-leukemia 12. CH 5. Immune rejection: the immune biology of allogeneic hematopoietic stem cell transplantation (from mice to humans) 13. CH 6. Strategies to improve post-transplant immunity 14. CH 7. Tumor-associated antigens 15. CH 8. Impact of the conditioning regimen 16. CH 9. Antigen presentation and antigen-presenting cells in graft-versus-host disease 17. CH 10. T-cell costimulation in graft-versus-host disease and graft-versus-leukemia effect 18. CH 11. Th1/Th2 and Tc1/Tc2 cells: biology, experimental models and clinical translation 19. CH 12. Natural CD4+CD25+FOXP3+ regulatory T cells in graft-versus-host disease 20. CH 13. Role of Th17 cells and interleukin 17 in graft-versus-host disease and graft-versus-leukemia reactivity 21. CH 14. B and T cells in chronic graft-versus-host disease and graft-versus-leukemia 22. CH 15. Natural killer cells in graft-versus-host disease and graft-versus-leukemia 23. CH 16. Cytokines in graft-versus-host disease and graft-versus-leukemia 24. CH 17. Chemokines and graft-versus-host disease 25. CH 18. Intracellular sensors of immunity and allogeneic hematopoietic stem cell transplantation 26. CH 19. Proteomics in graft-versus-host disease and graft-versus-leukemia 27. CH 20. The endothelium in graft-versus-host disease and graft-versus-leukemia 28. CH 21. Looking toward the future: an individualized approach to allogeneic transplantation 29. Index
