This volume provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus and its impact on human health. Written by a team of expert contributors, the book covers various aspects of the virus, including its structure, life cycle, and genomic replication. It delves into the epidemiology of COVID-19, comparing it with other related coronaviruses and discussing the concept of herd immunity. The structural biology of SARS-CoV-2 is examined, with a focus on techniques such as electron microscopy and cryo-electron tomography. The book also explores the biology of SARS-CoV-2 variants and their immune evasion strategies. Furthermore, it delves into the pathogenesis of COVID-19, examining its multiorgan manifestations and the long-term effects of the disease. The innate and adaptive immune responses to SARS-CoV-2 are discussed in detail, along with the role of B cells and T cells in the immune response. The volume concludes with a look at future insights and potential developments in the field. Accompanied by illustrative diagrams and visuals, this volume would aid in grasping complex concepts, serving as a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the intricate details of SARS-CoV-2 and its impact on global health.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Contributors - p. iii 6. Preface - p. iii 7. Chapter One: SARS-CoV-2—Virus structure and life cycle - p. 1 8. Chapter Two: Epidemiology of COVID-19 - p. 25 9. Chapter Three: Structural biology of SARS-CoV-2 - p. 39 10. Chapter Four: SARS-CoV-2 variant biology and immune evasion - p. 54 11. Chapter Five: COVID-19 pathogenesis - p. 75 12. Chapter Six: Long Covid - p. 121 13. Chapter Seven: Innate immune responses to SARS-CoV-2 - p. 135 14. Chapter Eight: B cell responses to SARS-CoV-2 - p. 163 15. Chapter Nine: T cell responses to SARS-CoV-2 - p. 191 16. Chapter Ten: Future insights - p. 227 17. Index - p. 230
This volume provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus and its impact on human health. Written by a team of expert contributors, the book covers various aspects of the virus, including its structure, life cycle, and genomic replication. It delves into the epidemiology of COVID-19, comparing it with other related coronaviruses and discussing the concept of herd immunity. The structural biology of SARS-CoV-2 is examined, with a focus on techniques such as electron microscopy and cryo-electron tomography. The book also explores the biology of SARS-CoV-2 variants and their immune evasion strategies. Furthermore, it delves into the pathogenesis of COVID-19, examining its multiorgan manifestations and the long-term effects of the disease. The innate and adaptive immune responses to SARS-CoV-2 are discussed in detail, along with the role of B cells and T cells in the immune response. The volume concludes with a look at future insights and potential developments in the field. Accompanied by illustrative diagrams and visuals, this volume would aid in grasping complex concepts, serving as a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the intricate details of SARS-CoV-2 and its impact on global health.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Contributors - p. iii 6. Preface - p. iii 7. Chapter One: SARS-CoV-2—Virus structure and life cycle - p. 1 8. Chapter Two: Epidemiology of COVID-19 - p. 25 9. Chapter Three: Structural biology of SARS-CoV-2 - p. 39 10. Chapter Four: SARS-CoV-2 variant biology and immune evasion - p. 54 11. Chapter Five: COVID-19 pathogenesis - p. 75 12. Chapter Six: Long Covid - p. 121 13. Chapter Seven: Innate immune responses to SARS-CoV-2 - p. 135 14. Chapter Eight: B cell responses to SARS-CoV-2 - p. 163 15. Chapter Nine: T cell responses to SARS-CoV-2 - p. 191 16. Chapter Ten: Future insights - p. 227 17. Index - p. 230
